Adenylate kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Adenylate kinase

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4HD19_LEIBR

TriTrypDb:

LbrM.23.1580 , LBRM2903_230026500

Length:

275

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HD19

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD19

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	1
GO:0003824	catalytic activity	1	1
GO:0005488	binding	1	1
GO:0005524	ATP binding	5	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0017076	purine nucleotide binding	4	1
GO:0019205	nucleobase-containing compound kinase activity	5	1
GO:0030554	adenyl nucleotide binding	5	1
GO:0032553	ribonucleotide binding	3	1
GO:0032555	purine ribonucleotide binding	4	1
GO:0032559	adenyl ribonucleotide binding	5	1
GO:0035639	purine ribonucleoside triphosphate binding	4	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:0097367	carbohydrate derivative binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	226	228	PF00675	0.522
CLV_NRD_NRD_1	266	268	PF00675	0.316
CLV_PCSK_KEX2_1	226	228	PF00082	0.540
CLV_PCSK_KEX2_1	266	268	PF00082	0.316
CLV_PCSK_SKI1_1	133	137	PF00082	0.489
CLV_PCSK_SKI1_1	184	188	PF00082	0.282
CLV_PCSK_SKI1_1	266	270	PF00082	0.449
CLV_PCSK_SKI1_1	42	46	PF00082	0.588
DEG_APCC_DBOX_1	265	273	PF00400	0.448
DEG_APCC_DBOX_1	37	45	PF00400	0.579
DOC_ANK_TNKS_1	49	56	PF00023	0.466
DOC_CKS1_1	69	74	PF01111	0.472
DOC_CYCLIN_RxL_1	36	49	PF00134	0.454
DOC_MAPK_RevD_3	212	227	PF00069	0.454
DOC_PP1_RVXF_1	182	188	PF00149	0.311
DOC_USP7_MATH_1	102	106	PF00917	0.444
DOC_WW_Pin1_4	172	177	PF00397	0.713
DOC_WW_Pin1_4	226	231	PF00397	0.493
DOC_WW_Pin1_4	36	41	PF00397	0.606
DOC_WW_Pin1_4	56	61	PF00397	0.556
DOC_WW_Pin1_4	68	73	PF00397	0.539
LIG_14-3-3_CanoR_1	217	223	PF00244	0.385
LIG_APCC_ABBA_1	239	244	PF00400	0.290
LIG_BIR_II_1	1	5	PF00653	0.505
LIG_BIR_III_3	1	5	PF00653	0.543
LIG_BRCT_BRCA1_1	182	186	PF00533	0.512
LIG_CtBP_PxDLS_1	147	151	PF00389	0.451
LIG_FHA_1	218	224	PF00498	0.349
LIG_FHA_1	23	29	PF00498	0.409
LIG_FHA_1	263	269	PF00498	0.429
LIG_FHA_1	69	75	PF00498	0.425
LIG_FHA_2	173	179	PF00498	0.567
LIG_FHA_2	193	199	PF00498	0.427
LIG_GBD_Chelix_1	151	159	PF00786	0.299
LIG_LIR_LC3C_4	149	152	PF02991	0.282
LIG_LIR_Nem_3	183	189	PF02991	0.436
LIG_LIR_Nem_3	240	245	PF02991	0.424
LIG_Pex14_2	242	246	PF04695	0.433
LIG_SH2_STAT3	123	126	PF00017	0.349
LIG_SH2_STAT3	7	10	PF00017	0.551
LIG_SH2_STAT5	123	126	PF00017	0.496
LIG_SH3_1	227	233	PF00018	0.492
LIG_SH3_2	37	42	PF14604	0.584
LIG_SH3_3	119	125	PF00018	0.528
LIG_SH3_3	227	233	PF00018	0.492
LIG_SH3_3	34	40	PF00018	0.494
LIG_SUMO_SIM_anti_2	209	215	PF11976	0.263
LIG_TRAF2_1	206	209	PF00917	0.453
LIG_UBA3_1	76	85	PF00899	0.279
MOD_CDC14_SPxK_1	39	42	PF00782	0.578
MOD_CDK_SPxK_1	36	42	PF00069	0.573
MOD_CK2_1	172	178	PF00069	0.620
MOD_CK2_1	192	198	PF00069	0.426
MOD_CK2_1	20	26	PF00069	0.585
MOD_CK2_1	237	243	PF00069	0.298
MOD_DYRK1A_RPxSP_1	36	40	PF00069	0.564
MOD_GlcNHglycan	2	5	PF01048	0.549
MOD_GlcNHglycan	246	249	PF01048	0.494
MOD_GSK3_1	16	23	PF00069	0.412
MOD_GSK3_1	208	215	PF00069	0.437
MOD_GSK3_1	32	39	PF00069	0.569
MOD_GSK3_1	83	90	PF00069	0.495
MOD_NEK2_2	237	242	PF00069	0.330
MOD_PKA_2	216	222	PF00069	0.395
MOD_Plk_1	208	214	PF00069	0.350
MOD_Plk_2-3	20	26	PF00069	0.362
MOD_Plk_4	102	108	PF00069	0.424
MOD_Plk_4	237	243	PF00069	0.323
MOD_Plk_4	24	30	PF00069	0.359
MOD_ProDKin_1	172	178	PF00069	0.710
MOD_ProDKin_1	226	232	PF00069	0.490
MOD_ProDKin_1	36	42	PF00069	0.609
MOD_ProDKin_1	56	62	PF00069	0.556
MOD_ProDKin_1	68	74	PF00069	0.527
TRG_DiLeu_BaLyEn_6	150	155	PF01217	0.303
TRG_ER_diArg_1	266	268	PF00400	0.336
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.464

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4ILX8	Bodo saltans	24%	100%
A0A3Q8ICN4	Leishmania donovani	74%	96%
A4I0K5	Leishmania infantum	74%	96%
E9AWG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	96%
Q4QB05	Leishmania major	75%	100%