Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DHHC palmitoyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HD17_LEIBR

TriTrypDb:

LbrM.23.1560 , LBRM2903_230026200 , LBRM2903_230026300

Length:

631

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HD17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD17

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	1
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	1
GO:0018345	protein palmitoylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0033036	macromolecule localization	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016409	palmitoyltransferase activity	5	7
GO:0016417	S-acyltransferase activity	5	7
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	7
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	7
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	7
GO:0019707	protein-cysteine S-acyltransferase activity	3	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	344	348	PF00656	0.631
CLV_C14_Caspase3-7	573	577	PF00656	0.604
CLV_NRD_NRD_1	516	518	PF00675	0.386
CLV_NRD_NRD_1	559	561	PF00675	0.456
CLV_NRD_NRD_1	591	593	PF00675	0.418
CLV_PCSK_FUR_1	588	592	PF00082	0.368
CLV_PCSK_KEX2_1	516	518	PF00082	0.411
CLV_PCSK_KEX2_1	559	561	PF00082	0.456
CLV_PCSK_KEX2_1	590	592	PF00082	0.411
CLV_PCSK_PC1ET2_1	590	592	PF00082	0.331
CLV_PCSK_SKI1_1	106	110	PF00082	0.311
CLV_PCSK_SKI1_1	240	244	PF00082	0.414
CLV_PCSK_SKI1_1	406	410	PF00082	0.255
CLV_PCSK_SKI1_1	428	432	PF00082	0.276
CLV_PCSK_SKI1_1	595	599	PF00082	0.404
CLV_PCSK_SKI1_1	604	608	PF00082	0.378
CLV_PCSK_SKI1_1	74	78	PF00082	0.544
DEG_APCC_DBOX_1	603	611	PF00400	0.641
DEG_SCF_FBW7_2	326	332	PF00400	0.613
DEG_SPOP_SBC_1	288	292	PF00917	0.750
DEG_SPOP_SBC_1	298	302	PF00917	0.686
DOC_CKS1_1	326	331	PF01111	0.614
DOC_CKS1_1	359	364	PF01111	0.616
DOC_CYCLIN_RxL_1	129	137	PF00134	0.533
DOC_CYCLIN_yCln2_LP_2	359	365	PF00134	0.614
DOC_MAPK_gen_1	590	600	PF00069	0.584
DOC_MAPK_MEF2A_6	26	33	PF00069	0.390
DOC_PP1_RVXF_1	104	110	PF00149	0.566
DOC_PP4_FxxP_1	285	288	PF00568	0.647
DOC_PP4_FxxP_1	600	603	PF00568	0.587
DOC_USP7_MATH_1	236	240	PF00917	0.765
DOC_USP7_MATH_1	250	254	PF00917	0.600
DOC_USP7_MATH_1	288	292	PF00917	0.664
DOC_USP7_MATH_1	293	297	PF00917	0.655
DOC_USP7_MATH_1	305	309	PF00917	0.687
DOC_USP7_MATH_1	318	322	PF00917	0.673
DOC_USP7_MATH_1	350	354	PF00917	0.651
DOC_USP7_MATH_1	365	369	PF00917	0.656
DOC_USP7_MATH_1	380	384	PF00917	0.551
DOC_USP7_MATH_1	395	399	PF00917	0.476
DOC_USP7_MATH_1	510	514	PF00917	0.558
DOC_WW_Pin1_4	192	197	PF00397	0.781
DOC_WW_Pin1_4	227	232	PF00397	0.734
DOC_WW_Pin1_4	289	294	PF00397	0.775
DOC_WW_Pin1_4	320	325	PF00397	0.822
DOC_WW_Pin1_4	339	344	PF00397	0.613
DOC_WW_Pin1_4	358	363	PF00397	0.654
DOC_WW_Pin1_4	515	520	PF00397	0.583
DOC_WW_Pin1_4	611	616	PF00397	0.628
LIG_14-3-3_CanoR_1	106	116	PF00244	0.512
LIG_14-3-3_CanoR_1	11	16	PF00244	0.635
LIG_14-3-3_CanoR_1	492	498	PF00244	0.489
LIG_14-3-3_CanoR_1	592	600	PF00244	0.684
LIG_Actin_WH2_2	465	480	PF00022	0.211
LIG_Actin_WH2_2	92	108	PF00022	0.219
LIG_BIR_III_2	347	351	PF00653	0.750
LIG_BRCT_BRCA1_1	33	37	PF00533	0.228
LIG_BRCT_BRCA1_1	382	386	PF00533	0.476
LIG_CSL_BTD_1	181	184	PF09270	0.558
LIG_CSL_BTD_1	466	469	PF09270	0.276
LIG_deltaCOP1_diTrp_1	460	467	PF00928	0.276
LIG_deltaCOP1_diTrp_1	481	488	PF00928	0.222
LIG_eIF4E_1	25	31	PF01652	0.237
LIG_EVH1_2	225	229	PF00568	0.621
LIG_FHA_1	243	249	PF00498	0.678
LIG_FHA_1	299	305	PF00498	0.650
LIG_FHA_1	321	327	PF00498	0.670
LIG_FHA_1	34	40	PF00498	0.419
LIG_FHA_1	444	450	PF00498	0.338
LIG_FHA_1	56	62	PF00498	0.434
LIG_FHA_1	564	570	PF00498	0.618
LIG_FHA_1	594	600	PF00498	0.505
LIG_FHA_2	124	130	PF00498	0.544
LIG_FHA_2	342	348	PF00498	0.831
LIG_FHA_2	67	73	PF00498	0.349
LIG_LIR_Apic_2	283	288	PF02991	0.645
LIG_LIR_Apic_2	464	469	PF02991	0.211
LIG_LIR_Gen_1	103	112	PF02991	0.557
LIG_LIR_Gen_1	383	393	PF02991	0.408
LIG_LIR_Nem_3	103	107	PF02991	0.553
LIG_LIR_Nem_3	14	18	PF02991	0.609
LIG_LIR_Nem_3	383	389	PF02991	0.476
LIG_LIR_Nem_3	464	468	PF02991	0.211
LIG_LIR_Nem_3	535	541	PF02991	0.537
LIG_Pex14_2	431	435	PF04695	0.313
LIG_REV1ctd_RIR_1	43	52	PF16727	0.317
LIG_SH2_CRK	25	29	PF00017	0.430
LIG_SH2_CRK	538	542	PF00017	0.529
LIG_SH2_CRK	608	612	PF00017	0.686
LIG_SH2_SRC	114	117	PF00017	0.534
LIG_SH2_STAT5	114	117	PF00017	0.530
LIG_SH2_STAT5	429	432	PF00017	0.390
LIG_SH2_STAT5	452	455	PF00017	0.208
LIG_SH2_STAT5	538	541	PF00017	0.535
LIG_SH2_STAT5	75	78	PF00017	0.423
LIG_SH3_2	116	121	PF14604	0.612
LIG_SH3_3	113	119	PF00018	0.685
LIG_SH3_3	181	187	PF00018	0.631
LIG_SH3_3	220	226	PF00018	0.710
LIG_SH3_3	323	329	PF00018	0.640
LIG_SH3_3	509	515	PF00018	0.629
LIG_SH3_3	576	582	PF00018	0.698
LIG_SH3_3	609	615	PF00018	0.563
LIG_SUMO_SIM_anti_2	58	65	PF11976	0.340
LIG_SUMO_SIM_par_1	58	65	PF11976	0.340
LIG_SUMO_SIM_par_1	580	586	PF11976	0.584
LIG_TRAF2_1	69	72	PF00917	0.351
LIG_TRFH_1	608	612	PF08558	0.611
LIG_WRC_WIRS_1	101	106	PF05994	0.333
MOD_CDK_SPK_2	227	232	PF00069	0.629
MOD_CK1_1	192	198	PF00069	0.713
MOD_CK1_1	199	205	PF00069	0.709
MOD_CK1_1	214	220	PF00069	0.694
MOD_CK1_1	230	236	PF00069	0.666
MOD_CK1_1	283	289	PF00069	0.692
MOD_CK1_1	291	297	PF00069	0.731
MOD_CK1_1	309	315	PF00069	0.695
MOD_CK1_1	316	322	PF00069	0.670
MOD_CK1_1	525	531	PF00069	0.691
MOD_CK1_1	555	561	PF00069	0.620
MOD_CK1_1	567	573	PF00069	0.747
MOD_CK2_1	123	129	PF00069	0.549
MOD_CK2_1	182	188	PF00069	0.574
MOD_CK2_1	291	297	PF00069	0.736
MOD_CK2_1	525	531	PF00069	0.580
MOD_CK2_1	66	72	PF00069	0.377
MOD_GlcNHglycan	198	201	PF01048	0.469
MOD_GlcNHglycan	259	262	PF01048	0.443
MOD_GlcNHglycan	272	275	PF01048	0.567
MOD_GlcNHglycan	316	319	PF01048	0.521
MOD_GlcNHglycan	33	36	PF01048	0.313
MOD_GlcNHglycan	336	339	PF01048	0.404
MOD_GlcNHglycan	454	457	PF01048	0.432
MOD_GlcNHglycan	502	506	PF01048	0.330
MOD_GlcNHglycan	512	515	PF01048	0.450
MOD_GlcNHglycan	570	573	PF01048	0.495
MOD_GSK3_1	188	195	PF00069	0.719
MOD_GSK3_1	206	213	PF00069	0.657
MOD_GSK3_1	214	221	PF00069	0.680
MOD_GSK3_1	283	290	PF00069	0.707
MOD_GSK3_1	292	299	PF00069	0.709
MOD_GSK3_1	303	310	PF00069	0.796
MOD_GSK3_1	312	319	PF00069	0.630
MOD_GSK3_1	443	450	PF00069	0.395
MOD_GSK3_1	515	522	PF00069	0.609
MOD_GSK3_1	561	568	PF00069	0.725
MOD_GSK3_1	66	73	PF00069	0.464
MOD_GSK3_1	77	84	PF00069	0.324
MOD_N-GLC_1	443	448	PF02516	0.325
MOD_N-GLC_1	56	61	PF02516	0.509
MOD_N-GLC_2	419	421	PF02516	0.298
MOD_NEK2_1	100	105	PF00069	0.382
MOD_NEK2_1	134	139	PF00069	0.647
MOD_NEK2_1	189	194	PF00069	0.621
MOD_NEK2_1	218	223	PF00069	0.635
MOD_NEK2_1	314	319	PF00069	0.637
MOD_NEK2_1	331	336	PF00069	0.597
MOD_NEK2_1	435	440	PF00069	0.350
MOD_NEK2_1	447	452	PF00069	0.349
MOD_NEK2_1	508	513	PF00069	0.595
MOD_NEK2_1	583	588	PF00069	0.585
MOD_NEK2_1	616	621	PF00069	0.578
MOD_NEK2_1	77	82	PF00069	0.350
MOD_NEK2_2	380	385	PF00069	0.553
MOD_PIKK_1	242	248	PF00454	0.613
MOD_PKA_2	552	558	PF00069	0.596
MOD_Plk_1	280	286	PF00069	0.656
MOD_Plk_1	331	337	PF00069	0.619
MOD_Plk_1	366	372	PF00069	0.571
MOD_Plk_1	443	449	PF00069	0.325
MOD_Plk_1	70	76	PF00069	0.343
MOD_Plk_4	177	183	PF00069	0.533
MOD_Plk_4	214	220	PF00069	0.791
MOD_Plk_4	33	39	PF00069	0.234
MOD_Plk_4	443	449	PF00069	0.474
MOD_Plk_4	461	467	PF00069	0.213
MOD_ProDKin_1	192	198	PF00069	0.781
MOD_ProDKin_1	227	233	PF00069	0.733
MOD_ProDKin_1	289	295	PF00069	0.775
MOD_ProDKin_1	320	326	PF00069	0.823
MOD_ProDKin_1	339	345	PF00069	0.614
MOD_ProDKin_1	358	364	PF00069	0.652
MOD_ProDKin_1	515	521	PF00069	0.582
MOD_ProDKin_1	611	617	PF00069	0.635
TRG_DiLeu_BaLyEn_6	25	30	PF01217	0.390
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.298
TRG_ENDOCYTIC_2	101	104	PF00928	0.532
TRG_ENDOCYTIC_2	42	45	PF00928	0.267
TRG_ENDOCYTIC_2	427	430	PF00928	0.503
TRG_ENDOCYTIC_2	538	541	PF00928	0.535
TRG_ENDOCYTIC_2	608	611	PF00928	0.691
TRG_ER_diArg_1	515	517	PF00400	0.597
TRG_ER_diArg_1	559	561	PF00400	0.710
TRG_ER_diArg_1	602	605	PF00400	0.629
TRG_ER_diArg_1	620	623	PF00400	0.657
TRG_NLS_MonoExtN_4	588	594	PF00514	0.536
TRG_Pf-PMV_PEXEL_1	546	550	PF00026	0.334

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P628	Leptomonas seymouri	34%	97%
A0A3S7WXW1	Leishmania donovani	60%	99%
A4I0K3	Leishmania infantum	61%	99%
E9AWG4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	99%
Q4QB07	Leishmania major	60%	100%