Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DHHC palmitoyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HD17_LEIBR

TriTrypDb:

LbrM.23.1560 , LBRM2903_230026200 , LBRM2903_230026300

Length:

631

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0016020	membrane	2	7
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	7

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Expansion

Sequence features

A4HD17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD17

Function

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Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016409	palmitoyltransferase activity	5	7
GO:0016417	S-acyltransferase activity	5	7
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	7
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	7
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	7
GO:0019707	protein-cysteine S-acyltransferase activity	3	7
GO:0140096	catalytic activity, acting on a protein	2	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	344	348	PF00656	0.631
CLV_C14_Caspase3-7	573	577	PF00656	0.604
CLV_NRD_NRD_1	516	518	PF00675	0.386
CLV_NRD_NRD_1	559	561	PF00675	0.456
CLV_NRD_NRD_1	591	593	PF00675	0.418
CLV_PCSK_FUR_1	588	592	PF00082	0.368
CLV_PCSK_KEX2_1	516	518	PF00082	0.411
CLV_PCSK_KEX2_1	559	561	PF00082	0.456
CLV_PCSK_KEX2_1	590	592	PF00082	0.411
CLV_PCSK_PC1ET2_1	590	592	PF00082	0.331

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P628	Leptomonas seymouri	34%	97%
A0A3S7WXW1	Leishmania donovani	60%	99%
A4I0K3	Leishmania infantum	61%	99%
E9AWG4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	99%
Q4QB07	Leishmania major	60%	100%

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