Palmitoyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DHHC zinc finger domain-like protein

Species:

Leishmania braziliensis

UniProt:

A4HD16_LEIBR

TriTrypDb:

LbrM.23.1550 , LBRM2903_230026100

Length:

450

Annotations

LeishMANIAdb annotations

Related to other eukaryotic ZDHHC palmitoyltransferases, especially animal ZDHHC2.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HD16

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD16

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	1
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	1
GO:0018345	protein palmitoylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0033036	macromolecule localization	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016409	palmitoyltransferase activity	5	8
GO:0016417	S-acyltransferase activity	5	8
GO:0016740	transferase activity	2	8
GO:0016746	acyltransferase activity	3	8
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	8
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	8
GO:0019707	protein-cysteine S-acyltransferase activity	3	8
GO:0140096	catalytic activity, acting on a protein	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.692
CLV_C14_Caspase3-7	372	376	PF00656	0.531
CLV_NRD_NRD_1	281	283	PF00675	0.233
CLV_NRD_NRD_1	429	431	PF00675	0.424
CLV_PCSK_KEX2_1	281	283	PF00082	0.233
CLV_PCSK_KEX2_1	429	431	PF00082	0.424
CLV_PCSK_SKI1_1	418	422	PF00082	0.285
DEG_Nend_Nbox_1	1	3	PF02207	0.527
DEG_ODPH_VHL_1	54	67	PF01847	0.249
DEG_SPOP_SBC_1	143	147	PF00917	0.638
DOC_ANK_TNKS_1	91	98	PF00023	0.624
DOC_CKS1_1	6	11	PF01111	0.397
DOC_CYCLIN_RxL_1	412	424	PF00134	0.558
DOC_MAPK_MEF2A_6	300	309	PF00069	0.537
DOC_MAPK_MEF2A_6	40	49	PF00069	0.316
DOC_PP1_RVXF_1	337	343	PF00149	0.356
DOC_PP1_RVXF_1	421	428	PF00149	0.562
DOC_PP4_FxxP_1	67	70	PF00568	0.556
DOC_USP7_MATH_1	143	147	PF00917	0.667
DOC_USP7_MATH_1	187	191	PF00917	0.739
DOC_USP7_MATH_1	20	24	PF00917	0.501
DOC_USP7_MATH_1	202	206	PF00917	0.591
DOC_USP7_MATH_1	209	213	PF00917	0.644
DOC_USP7_MATH_1	335	339	PF00917	0.293
DOC_USP7_MATH_1	91	95	PF00917	0.766
DOC_WW_Pin1_4	168	173	PF00397	0.772
DOC_WW_Pin1_4	205	210	PF00397	0.758
DOC_WW_Pin1_4	230	235	PF00397	0.702
DOC_WW_Pin1_4	429	434	PF00397	0.591
DOC_WW_Pin1_4	5	10	PF00397	0.397
DOC_WW_Pin1_4	66	71	PF00397	0.549
DOC_WW_Pin1_4	97	102	PF00397	0.633
LIG_14-3-3_CanoR_1	141	151	PF00244	0.734
LIG_14-3-3_CanoR_1	261	271	PF00244	0.471
LIG_14-3-3_CanoR_1	40	46	PF00244	0.298
LIG_14-3-3_CanoR_1	415	421	PF00244	0.662
LIG_AP2alpha_2	334	336	PF02296	0.226
LIG_AP2alpha_2	76	78	PF02296	0.652
LIG_APCC_ABBA_1	194	199	PF00400	0.717
LIG_BIR_III_2	239	243	PF00653	0.606
LIG_BRCT_BRCA1_1	68	72	PF00533	0.580
LIG_Clathr_ClatBox_1	328	332	PF01394	0.475
LIG_FHA_1	134	140	PF00498	0.811
LIG_FHA_1	155	161	PF00498	0.655
LIG_FHA_1	193	199	PF00498	0.642
LIG_FHA_1	335	341	PF00498	0.327
LIG_FHA_1	49	55	PF00498	0.342
LIG_FHA_2	250	256	PF00498	0.603
LIG_FHA_2	439	445	PF00498	0.738
LIG_GBD_Chelix_1	42	50	PF00786	0.393
LIG_IBAR_NPY_1	247	249	PF08397	0.679
LIG_IRF3_LxIS_1	133	140	PF10401	0.634
LIG_LIR_Apic_2	76	81	PF02991	0.588
LIG_LIR_Gen_1	61	70	PF02991	0.450
LIG_LIR_Gen_1	8	19	PF02991	0.440
LIG_LIR_Nem_3	23	29	PF02991	0.286
LIG_LIR_Nem_3	37	42	PF02991	0.355
LIG_LIR_Nem_3	61	66	PF02991	0.413
LIG_LIR_Nem_3	8	14	PF02991	0.305
LIG_LYPXL_yS_3	80	83	PF13949	0.492
LIG_MYND_1	87	91	PF01753	0.746
LIG_Pex14_1	427	431	PF04695	0.548
LIG_Rb_LxCxE_1	385	405	PF01857	0.564
LIG_SH2_CRK	312	316	PF00017	0.430
LIG_SH2_CRK	6	10	PF00017	0.404
LIG_SH2_CRK	63	67	PF00017	0.430
LIG_SH2_CRK	84	88	PF00017	0.653
LIG_SH2_GRB2like	245	248	PF00017	0.536
LIG_SH2_NCK_1	63	67	PF00017	0.501
LIG_SH2_SRC	245	248	PF00017	0.536
LIG_SH2_SRC	63	66	PF00017	0.249
LIG_SH2_STAP1	63	67	PF00017	0.501
LIG_SH2_STAT3	264	267	PF00017	0.524
LIG_SH2_STAT5	225	228	PF00017	0.808
LIG_SH2_STAT5	245	248	PF00017	0.691
LIG_SH2_STAT5	26	29	PF00017	0.195
LIG_SH2_STAT5	264	267	PF00017	0.397
LIG_SH2_STAT5	360	363	PF00017	0.346
LIG_SH2_STAT5	6	9	PF00017	0.390
LIG_SH3_3	198	204	PF00018	0.675
LIG_SH3_3	50	56	PF00018	0.249
LIG_SH3_3	71	77	PF00018	0.596
LIG_SH3_3	85	91	PF00018	0.681
LIG_SUMO_SIM_anti_2	10	16	PF11976	0.348
LIG_SUMO_SIM_anti_2	189	195	PF11976	0.636
LIG_SUMO_SIM_anti_2	44	52	PF11976	0.249
LIG_SUMO_SIM_par_1	44	52	PF11976	0.420
LIG_SUMO_SIM_par_1	55	61	PF11976	0.400
LIG_TRAF2_2	234	239	PF00917	0.616
LIG_TYR_ITIM	310	315	PF00017	0.341
LIG_WW_1	242	245	PF00397	0.592
LIG_WW_1	81	84	PF00397	0.622
MOD_CDK_SPK_2	429	434	PF00069	0.492
MOD_CK1_1	102	108	PF00069	0.640
MOD_CK1_1	154	160	PF00069	0.712
MOD_CK1_1	171	177	PF00069	0.705
MOD_CK1_1	205	211	PF00069	0.634
MOD_CK1_1	250	256	PF00069	0.554
MOD_GlcNHglycan	146	149	PF01048	0.618
MOD_GlcNHglycan	181	184	PF01048	0.513
MOD_GlcNHglycan	312	315	PF01048	0.311
MOD_GlcNHglycan	382	385	PF01048	0.503
MOD_GlcNHglycan	93	96	PF01048	0.504
MOD_GSK3_1	133	140	PF00069	0.712
MOD_GSK3_1	167	174	PF00069	0.702
MOD_GSK3_1	205	212	PF00069	0.690
MOD_GSK3_1	369	376	PF00069	0.595
MOD_GSK3_1	378	385	PF00069	0.690
MOD_GSK3_1	392	399	PF00069	0.519
MOD_GSK3_1	438	445	PF00069	0.710
MOD_GSK3_1	91	98	PF00069	0.621
MOD_N-GLC_2	295	297	PF02516	0.299
MOD_NEK2_1	137	142	PF00069	0.639
MOD_NEK2_1	144	149	PF00069	0.635
MOD_NEK2_1	262	267	PF00069	0.517
MOD_NEK2_1	310	315	PF00069	0.429
MOD_NEK2_1	352	357	PF00069	0.346
MOD_NEK2_1	48	53	PF00069	0.374
MOD_PIKK_1	382	388	PF00454	0.626
MOD_PKA_2	187	193	PF00069	0.764
MOD_PKA_2	91	97	PF00069	0.608
MOD_Plk_1	172	178	PF00069	0.660
MOD_Plk_1	442	448	PF00069	0.737
MOD_Plk_4	352	358	PF00069	0.365
MOD_Plk_4	41	47	PF00069	0.382
MOD_Plk_4	49	55	PF00069	0.446
MOD_Plk_4	7	13	PF00069	0.430
MOD_ProDKin_1	168	174	PF00069	0.775
MOD_ProDKin_1	205	211	PF00069	0.760
MOD_ProDKin_1	230	236	PF00069	0.700
MOD_ProDKin_1	429	435	PF00069	0.595
MOD_ProDKin_1	5	11	PF00069	0.397
MOD_ProDKin_1	66	72	PF00069	0.550
MOD_ProDKin_1	97	103	PF00069	0.635
MOD_SUMO_rev_2	399	403	PF00179	0.541
TRG_DiLeu_BaLyEn_6	159	164	PF01217	0.644
TRG_ENDOCYTIC_2	29	32	PF00928	0.277
TRG_ENDOCYTIC_2	303	306	PF00928	0.529
TRG_ENDOCYTIC_2	312	315	PF00928	0.290
TRG_ENDOCYTIC_2	62	65	PF00928	0.417
TRG_ENDOCYTIC_2	80	83	PF00928	0.622
TRG_ER_diArg_1	428	430	PF00400	0.626

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G9	Leptomonas seymouri	40%	90%
A0A3Q8ICN3	Leishmania donovani	55%	100%
A4I0K2	Leishmania infantum	55%	100%
D0A6R2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	96%
E9AWG3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
Q4QB08	Leishmania major	52%	98%