Palmitoyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

palmitoyl acyltransferase 12, putative

Species:

Leishmania braziliensis

UniProt:

A4HD15_LEIBR

TriTrypDb:

LbrM.23.1540 , LBRM2903_230026000

Length:

320

Annotations

LeishMANIAdb annotations

Related to other eukaryotic ZDHHC palmitoyltransferases, especially animal ZDHHC2.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HD15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD15

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006897	endocytosis	5	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	1
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	1
GO:0018345	protein palmitoylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0033036	macromolecule localization	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016409	palmitoyltransferase activity	5	11
GO:0016417	S-acyltransferase activity	5	11
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	11
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	11
GO:0019707	protein-cysteine S-acyltransferase activity	3	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.535
CLV_C14_Caspase3-7	203	207	PF00656	0.222
CLV_NRD_NRD_1	262	264	PF00675	0.484
CLV_NRD_NRD_1	298	300	PF00675	0.371
CLV_NRD_NRD_1	306	308	PF00675	0.342
CLV_PCSK_KEX2_1	264	266	PF00082	0.389
CLV_PCSK_KEX2_1	298	300	PF00082	0.369
CLV_PCSK_KEX2_1	306	308	PF00082	0.372
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.404
CLV_PCSK_SKI1_1	131	135	PF00082	0.268
CLV_PCSK_SKI1_1	168	172	PF00082	0.243
CLV_PCSK_SKI1_1	286	290	PF00082	0.342
DEG_Nend_UBRbox_4	1	3	PF02207	0.572
DOC_CDC14_PxL_1	43	51	PF14671	0.218
DOC_MAPK_FxFP_2	194	197	PF00069	0.259
DOC_MAPK_gen_1	283	291	PF00069	0.522
DOC_MAPK_MEF2A_6	283	291	PF00069	0.554
DOC_PP4_FxxP_1	194	197	PF00568	0.259
DOC_PP4_FxxP_1	86	89	PF00568	0.564
DOC_USP7_MATH_1	205	209	PF00917	0.157
LIG_14-3-3_CanoR_1	10	19	PF00244	0.549
LIG_14-3-3_CanoR_1	106	115	PF00244	0.536
LIG_14-3-3_CanoR_1	125	130	PF00244	0.469
LIG_14-3-3_CanoR_1	241	247	PF00244	0.480
LIG_Actin_WH2_2	36	52	PF00022	0.420
LIG_BRCT_BRCA1_1	166	170	PF00533	0.459
LIG_BRCT_BRCA1_1	190	194	PF00533	0.312
LIG_BRCT_BRCA1_1	216	220	PF00533	0.290
LIG_BRCT_BRCA1_1	78	82	PF00533	0.170
LIG_deltaCOP1_diTrp_1	281	291	PF00928	0.498
LIG_eIF4E_1	62	68	PF01652	0.170
LIG_eIF4E_1	78	84	PF01652	0.170
LIG_FHA_1	208	214	PF00498	0.194
LIG_FHA_2	11	17	PF00498	0.414
LIG_FHA_2	256	262	PF00498	0.552
LIG_GBD_Chelix_1	68	76	PF00786	0.347
LIG_IBAR_NPY_1	111	113	PF08397	0.554
LIG_LIR_Apic_2	191	197	PF02991	0.268
LIG_LIR_Gen_1	110	121	PF02991	0.564
LIG_LIR_Gen_1	167	178	PF02991	0.459
LIG_LIR_Gen_1	187	197	PF02991	0.310
LIG_LIR_Gen_1	217	228	PF02991	0.332
LIG_LIR_Gen_1	313	320	PF02991	0.497
LIG_LIR_Gen_1	38	49	PF02991	0.205
LIG_LIR_Gen_1	79	89	PF02991	0.376
LIG_LIR_Nem_3	110	116	PF02991	0.557
LIG_LIR_Nem_3	16	20	PF02991	0.550
LIG_LIR_Nem_3	167	173	PF02991	0.530
LIG_LIR_Nem_3	187	193	PF02991	0.302
LIG_LIR_Nem_3	217	223	PF02991	0.332
LIG_LIR_Nem_3	269	275	PF02991	0.535
LIG_LIR_Nem_3	313	319	PF02991	0.491
LIG_LIR_Nem_3	38	44	PF02991	0.510
LIG_LIR_Nem_3	79	85	PF02991	0.250
LIG_MLH1_MIPbox_1	166	170	PF16413	0.459
LIG_PCNA_yPIPBox_3	241	250	PF02747	0.507
LIG_PDZ_Class_1	315	320	PF00595	0.600
LIG_Pex14_2	129	133	PF04695	0.459
LIG_Pex14_2	169	173	PF04695	0.380
LIG_Pex14_2	190	194	PF04695	0.351
LIG_Pex14_2	196	200	PF04695	0.242
LIG_Pex14_2	216	220	PF04695	0.263
LIG_Pex14_2	231	235	PF04695	0.267
LIG_Pex14_2	82	86	PF04695	0.224
LIG_PTB_Apo_2	54	61	PF02174	0.311
LIG_REV1ctd_RIR_1	197	204	PF16727	0.173
LIG_SH2_CRK	41	45	PF00017	0.181
LIG_SH2_CRK	65	69	PF00017	0.325
LIG_SH2_CRK	78	82	PF00017	0.191
LIG_SH2_GRB2like	78	81	PF00017	0.260
LIG_SH2_PTP2	176	179	PF00017	0.247
LIG_SH2_STAP1	78	82	PF00017	0.260
LIG_SH2_STAT3	240	243	PF00017	0.507
LIG_SH2_STAT5	126	129	PF00017	0.426
LIG_SH2_STAT5	176	179	PF00017	0.267
LIG_SH2_STAT5	24	27	PF00017	0.335
LIG_SH2_STAT5	304	307	PF00017	0.508
LIG_SH2_STAT5	316	319	PF00017	0.498
LIG_SH2_STAT5	65	68	PF00017	0.289
LIG_SH3_3	287	293	PF00018	0.500
LIG_SH3_3	41	47	PF00018	0.182
LIG_SH3_3	90	96	PF00018	0.540
LIG_SUMO_SIM_anti_2	210	217	PF11976	0.276
LIG_SUMO_SIM_par_1	210	217	PF11976	0.253
LIG_TRAF2_1	258	261	PF00917	0.555
LIG_TYR_ITIM	174	179	PF00017	0.253
LIG_TYR_ITIM	314	319	PF00017	0.490
LIG_TYR_ITIM	76	81	PF00017	0.170
LIG_WRC_WIRS_1	126	131	PF05994	0.459
MOD_CK1_1	208	214	PF00069	0.177
MOD_CK2_1	10	16	PF00069	0.419
MOD_CK2_1	255	261	PF00069	0.627
MOD_GSK3_1	184	191	PF00069	0.269
MOD_GSK3_1	214	221	PF00069	0.322
MOD_N-GLC_2	159	161	PF02516	0.212
MOD_NEK2_1	20	25	PF00069	0.347
MOD_NEK2_1	214	219	PF00069	0.210
MOD_NEK2_1	249	254	PF00069	0.568
MOD_NEK2_1	35	40	PF00069	0.329
MOD_NEK2_1	76	81	PF00069	0.171
MOD_OFUCOSY	15	22	PF10250	0.149
MOD_Plk_1	205	211	PF00069	0.318
MOD_Plk_1	268	274	PF00069	0.405
MOD_Plk_4	185	191	PF00069	0.311
MOD_Plk_4	20	26	PF00069	0.336
MOD_Plk_4	208	214	PF00069	0.308
MOD_Plk_4	219	225	PF00069	0.325
TRG_ENDOCYTIC_2	113	116	PF00928	0.545
TRG_ENDOCYTIC_2	126	129	PF00928	0.507
TRG_ENDOCYTIC_2	176	179	PF00928	0.277
TRG_ENDOCYTIC_2	285	288	PF00928	0.492
TRG_ENDOCYTIC_2	316	319	PF00928	0.498
TRG_ENDOCYTIC_2	41	44	PF00928	0.255
TRG_ENDOCYTIC_2	64	67	PF00928	0.269
TRG_ENDOCYTIC_2	78	81	PF00928	0.380
TRG_ER_diArg_1	262	265	PF00400	0.646
TRG_ER_diArg_1	297	299	PF00400	0.552
TRG_ER_diArg_1	305	307	PF00400	0.525
TRG_ER_diArg_1	9	12	PF00400	0.582
TRG_NLS_Bipartite_1	253	267	PF00514	0.571
TRG_NLS_MonoExtC_3	262	268	PF00514	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I542	Leptomonas seymouri	25%	100%
A0A0N1PEH3	Leptomonas seymouri	69%	100%
A0A0S4IYT3	Bodo saltans	31%	100%
A0A0S4J1K8	Bodo saltans	31%	70%
A0A1X0NY23	Trypanosomatidae	45%	100%
A0A3Q8ICT4	Leishmania donovani	78%	100%
A0A3R7MRW9	Trypanosoma rangeli	30%	99%
A0A3S7WX91	Leishmania donovani	24%	100%
A0A422NSP1	Trypanosoma rangeli	25%	97%
A0A422NXW5	Trypanosoma rangeli	48%	100%
A2VDT6	Bos taurus	28%	100%
A4I0K1	Leishmania infantum	78%	100%
A4IBG8	Leishmania infantum	22%	100%
B1H1H3	Danio rerio	30%	100%
C9ZVD1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
D0A7S1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
D0A893	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	68%
E7F587	Danio rerio	26%	99%
E7FH11	Danio rerio	31%	69%
E9AH03	Leishmania infantum	24%	100%
E9AWG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
E9AWG3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	71%
F1RE57	Danio rerio	32%	100%
P59267	Mus musculus	28%	87%
Q2TGK3	Rattus norvegicus	30%	100%
Q4QB09	Leishmania major	78%	100%
Q4R7E2	Macaca fascicularis	24%	85%
Q555N7	Dictyostelium discoideum	26%	89%
Q58CU4	Bos taurus	24%	85%
Q5M757	Arabidopsis thaliana	30%	100%
Q5RB84	Pongo abelii	27%	100%
Q6DHI1	Danio rerio	30%	100%
Q8IVQ6	Homo sapiens	27%	100%
Q8R173	Mus musculus	30%	100%
Q8VYP5	Arabidopsis thaliana	30%	100%
Q94C49	Arabidopsis thaliana	30%	100%
Q969W1	Homo sapiens	25%	85%
Q9C0W9	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
Q9D270	Mus musculus	27%	100%
Q9ESG8	Mus musculus	26%	89%
Q9JKR5	Rattus norvegicus	28%	87%
Q9NYG2	Homo sapiens	31%	100%
Q9UIJ5	Homo sapiens	29%	87%
V5BJ88	Trypanosoma cruzi	43%	100%
V5DFI9	Trypanosoma cruzi	32%	100%