Putative Ran-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ran-binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HD13_LEIBR

TriTrypDb:

LbrM.23.1520 , LBRM2903_230025800

Length:

200

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HD13

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD13

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0033036	macromolecule localization	2	11
GO:0045184	establishment of protein localization	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0006606	protein import into nucleus	5	1
GO:0006886	intracellular protein transport	4	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0033365	protein localization to organelle	5	1
GO:0034504	protein localization to nucleus	6	1
GO:0046907	intracellular transport	3	1
GO:0051169	nuclear transport	4	1
GO:0051170	import into nucleus	6	1
GO:0051649	establishment of localization in cell	3	1
GO:0072594	establishment of protein localization to organelle	4	1

Molecular functions
Term	Name	Level	Count
GO:0005085	guanyl-nucleotide exchange factor activity	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0030234	enzyme regulator activity	2	1
GO:0030695	GTPase regulator activity	4	1
GO:0031267	small GTPase binding	5	1
GO:0051020	GTPase binding	4	1
GO:0060589	nucleoside-triphosphatase regulator activity	3	1
GO:0098772	molecular function regulator activity	1	1
GO:0140677	molecular function activator activity	2	1
GO:0140678	molecular function inhibitor activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	40	42	PF00675	0.250
CLV_PCSK_KEX2_1	168	170	PF00082	0.525
CLV_PCSK_KEX2_1	40	42	PF00082	0.250
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.424
CLV_PCSK_SKI1_1	165	169	PF00082	0.515
CLV_Separin_Metazoa	37	41	PF03568	0.450
DEG_APCC_KENBOX_2	125	129	PF00400	0.463
DEG_Nend_UBRbox_1	1	4	PF02207	0.347
DEG_SCF_FBW7_1	137	144	PF00400	0.507
DOC_CYCLIN_RxL_1	165	175	PF00134	0.520
DOC_MAPK_gen_1	124	132	PF00069	0.428
DOC_MAPK_MEF2A_6	126	134	PF00069	0.413
DOC_PP2B_LxvP_1	139	142	PF13499	0.429
DOC_PP2B_LxvP_1	194	197	PF13499	0.426
DOC_PP2B_LxvP_1	99	102	PF13499	0.398
DOC_USP7_MATH_1	159	163	PF00917	0.333
DOC_USP7_MATH_1	183	187	PF00917	0.358
DOC_USP7_MATH_1	26	30	PF00917	0.355
DOC_USP7_MATH_1	87	91	PF00917	0.408
DOC_WW_Pin1_4	137	142	PF00397	0.471
LIG_14-3-3_CanoR_1	169	177	PF00244	0.390
LIG_14-3-3_CanoR_1	46	54	PF00244	0.442
LIG_BRCT_BRCA1_1	103	107	PF00533	0.467
LIG_CaM_IQ_9	111	126	PF13499	0.469
LIG_deltaCOP1_diTrp_1	191	195	PF00928	0.366
LIG_FHA_1	109	115	PF00498	0.503
LIG_FHA_1	138	144	PF00498	0.445
LIG_FHA_1	30	36	PF00498	0.377
LIG_FHA_1	72	78	PF00498	0.476
LIG_FHA_2	170	176	PF00498	0.443
LIG_FHA_2	6	12	PF00498	0.437
LIG_LIR_Gen_1	104	114	PF02991	0.478
LIG_LIR_Nem_3	104	110	PF02991	0.501
LIG_LIR_Nem_3	129	134	PF02991	0.462
LIG_LIR_Nem_3	13	18	PF02991	0.424
LIG_LIR_Nem_3	191	195	PF02991	0.366
LIG_LIR_Nem_3	80	85	PF02991	0.427
LIG_LYPXL_yS_3	82	85	PF13949	0.401
LIG_SH2_NCK_1	25	29	PF00017	0.469
LIG_SH2_SRC	25	28	PF00017	0.385
LIG_SH3_3	148	154	PF00018	0.507
LIG_SUMO_SIM_anti_2	186	191	PF11976	0.413
LIG_SUMO_SIM_par_1	144	152	PF11976	0.439
LIG_SUMO_SIM_par_1	8	14	PF11976	0.471
LIG_TRAF2_1	172	175	PF00917	0.483
LIG_TRAF2_1	197	200	PF00917	0.488
LIG_TRAF2_1	70	73	PF00917	0.424
MOD_CK1_1	118	124	PF00069	0.426
MOD_CK1_1	29	35	PF00069	0.363
MOD_CK1_1	88	94	PF00069	0.429
MOD_CK2_1	169	175	PF00069	0.380
MOD_CK2_1	67	73	PF00069	0.515
MOD_GlcNHglycan	79	82	PF01048	0.286
MOD_GlcNHglycan	87	90	PF01048	0.256
MOD_GSK3_1	137	144	PF00069	0.471
MOD_GSK3_1	179	186	PF00069	0.406
MOD_GSK3_1	26	33	PF00069	0.419
MOD_GSK3_1	67	74	PF00069	0.510
MOD_N-GLC_2	62	64	PF02516	0.226
MOD_NEK2_1	179	184	PF00069	0.460
MOD_NEK2_1	85	90	PF00069	0.463
MOD_PIKK_1	67	73	PF00454	0.517
MOD_PKA_1	40	46	PF00069	0.450
MOD_PKA_2	115	121	PF00069	0.469
MOD_PKA_2	40	46	PF00069	0.467
MOD_Plk_1	72	78	PF00069	0.399
MOD_Plk_4	30	36	PF00069	0.479
MOD_Plk_4	5	11	PF00069	0.475
MOD_ProDKin_1	137	143	PF00069	0.471
TRG_AP2beta_CARGO_1	129	138	PF09066	0.462
TRG_DiLeu_BaEn_1	175	180	PF01217	0.376
TRG_DiLeu_BaEn_2	126	132	PF01217	0.489
TRG_DiLeu_BaEn_2	190	196	PF01217	0.505
TRG_DiLeu_BaEn_4	72	78	PF01217	0.424
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.516
TRG_ENDOCYTIC_2	55	58	PF00928	0.472
TRG_ENDOCYTIC_2	82	85	PF00928	0.401
TRG_ER_diArg_1	39	41	PF00400	0.450
TRG_NES_CRM1_1	178	191	PF08389	0.362
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBA3	Leptomonas seymouri	66%	97%
A0A0S4JIB8	Bodo saltans	47%	100%
A0A1X0NWS3	Trypanosomatidae	47%	90%
A0A3S7WY05	Leishmania donovani	86%	94%
A0A422NXZ5	Trypanosoma rangeli	51%	97%
A3KPP3	Danio rerio	32%	100%
A4I0J9	Leishmania infantum	86%	94%
C9ZVC7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	97%
E9AWG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	94%
Q32PE2	Bos taurus	29%	100%
Q4QB12	Leishmania major	86%	100%
Q54ML6	Dictyostelium discoideum	29%	100%
Q9HD47	Homo sapiens	33%	100%
Q9JIB0	Mus musculus	29%	100%