ABC2_membrane domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HD12_LEIBR

TriTrypDb:

LbrM.23.1510 , LBRM2903_230025700

Length:

147

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HD12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	122	124	PF00675	0.360
CLV_NRD_NRD_1	133	135	PF00675	0.371
CLV_PCSK_KEX2_1	121	123	PF00082	0.354
CLV_PCSK_KEX2_1	133	135	PF00082	0.366
CLV_PCSK_SKI1_1	115	119	PF00082	0.335
DEG_APCC_DBOX_1	122	130	PF00400	0.627
DEG_APCC_KENBOX_2	60	64	PF00400	0.330
DOC_CYCLIN_yCln2_LP_2	67	73	PF00134	0.405
DOC_MAPK_gen_1	118	126	PF00069	0.591
DOC_PP2B_LxvP_1	124	127	PF13499	0.623
LIG_14-3-3_CanoR_1	20	25	PF00244	0.578
LIG_Actin_WH2_2	103	120	PF00022	0.408
LIG_BRCT_BRCA1_1	6	10	PF00533	0.347
LIG_deltaCOP1_diTrp_1	89	98	PF00928	0.384
LIG_FHA_1	112	118	PF00498	0.614
LIG_FHA_1	86	92	PF00498	0.316
LIG_FHA_2	12	18	PF00498	0.427
LIG_GBD_Chelix_1	37	45	PF00786	0.307
LIG_LIR_Gen_1	104	113	PF02991	0.500
LIG_LIR_Gen_1	47	56	PF02991	0.395
LIG_LIR_Gen_1	7	18	PF02991	0.209
LIG_LIR_Nem_3	104	110	PF02991	0.412
LIG_LIR_Nem_3	47	52	PF02991	0.400
LIG_LIR_Nem_3	69	75	PF02991	0.263
LIG_LIR_Nem_3	7	13	PF02991	0.209
LIG_Pex14_2	12	16	PF04695	0.361
LIG_Pex14_2	6	10	PF04695	0.209
LIG_SH2_CRK	49	53	PF00017	0.391
LIG_SH2_SRC	73	76	PF00017	0.385
LIG_SH2_STAT5	73	76	PF00017	0.385
LIG_SUMO_SIM_par_1	109	114	PF11976	0.549
LIG_UBA3_1	110	118	PF00899	0.586
LIG_WRC_WIRS_1	56	61	PF05994	0.380
MOD_CK2_1	11	17	PF00069	0.424
MOD_GlcNHglycan	27	30	PF01048	0.207
MOD_NEK2_1	11	16	PF00069	0.556
MOD_NEK2_1	117	122	PF00069	0.537
MOD_NEK2_1	39	44	PF00069	0.377
MOD_NEK2_1	45	50	PF00069	0.466
MOD_NEK2_1	52	57	PF00069	0.362
MOD_NEK2_1	87	92	PF00069	0.292
MOD_PK_1	20	26	PF00069	0.502
MOD_Plk_1	111	117	PF00069	0.549
MOD_Plk_4	11	17	PF00069	0.516
MOD_Plk_4	20	26	PF00069	0.615
MOD_Plk_4	30	36	PF00069	0.478
MOD_Plk_4	87	93	PF00069	0.250
MOD_SUMO_for_1	141	144	PF00179	0.535
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.577
TRG_ENDOCYTIC_2	49	52	PF00928	0.398
TRG_ER_diArg_1	121	123	PF00400	0.573
TRG_ER_diArg_1	132	134	PF00400	0.585
TRG_Pf-PMV_PEXEL_1	130	135	PF00026	0.325
TRG_Pf-PMV_PEXEL_1	79	84	PF00026	0.620

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJY8	Leptomonas seymouri	50%	86%
A0A1X0NXD5	Trypanosomatidae	32%	100%
A0A3S5H7C4	Leishmania donovani	72%	89%
A0A422NXW8	Trypanosoma rangeli	36%	100%
A4I0J8	Leishmania infantum	72%	89%
C9ZVC6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AWF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	89%
Q4QB13	Leishmania major	69%	100%