Mitochondrial carrier protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial carrier protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4HD10_LEIBR

TriTrypDb:

LbrM.23.1490 , LBRM2903_230025300

Length:

400

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005743	mitochondrial inner membrane	5	1
GO:0019866	organelle inner membrane	4	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1

Expansion

Sequence features

A4HD10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD10

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0009987	cellular process	1	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1

Molecular functions
Term	Name	Level	Count
GO:0000095	S-adenosyl-L-methionine transmembrane transporter activity	4	1
GO:0005215	transporter activity	1	1
GO:0008324	monoatomic cation transmembrane transporter activity	4	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	1
GO:0015101	organic cation transmembrane transporter activity	5	1
GO:0022857	transmembrane transporter activity	2	1
GO:1901682	sulfur compound transmembrane transporter activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.429
CLV_PCSK_SKI1_1	145	149	PF00082	0.299
CLV_PCSK_SKI1_1	303	307	PF00082	0.335
CLV_PCSK_SKI1_1	337	341	PF00082	0.177
CLV_PCSK_SKI1_1	383	387	PF00082	0.337
CLV_PCSK_SKI1_1	76	80	PF00082	0.258
DEG_APCC_DBOX_1	118	126	PF00400	0.334
DEG_Nend_Nbox_1	1	3	PF02207	0.690
DEG_SPOP_SBC_1	284	288	PF00917	0.391
DOC_CKS1_1	132	137	PF01111	0.250
DOC_CYCLIN_RxL_1	300	307	PF00134	0.177
DOC_CYCLIN_yClb1_LxF_4	143	148	PF00134	0.248
DOC_MAPK_DCC_7	239	247	PF00069	0.177
DOC_MAPK_MEF2A_6	239	247	PF00069	0.272
DOC_PP1_RVXF_1	143	149	PF00149	0.248
DOC_PP1_RVXF_1	362	368	PF00149	0.258
DOC_PP2B_LxvP_1	203	206	PF13499	0.337
DOC_PP2B_LxvP_1	240	243	PF13499	0.390
DOC_PP2B_LxvP_1	318	321	PF13499	0.390
DOC_PP4_FxxP_1	148	151	PF00568	0.248
DOC_USP7_MATH_1	219	223	PF00917	0.379
DOC_USP7_MATH_1	284	288	PF00917	0.612
DOC_USP7_MATH_1	289	293	PF00917	0.590
DOC_USP7_MATH_1	45	49	PF00917	0.666
DOC_WW_Pin1_4	131	136	PF00397	0.272
DOC_WW_Pin1_4	94	99	PF00397	0.192
LIG_14-3-3_CanoR_1	337	342	PF00244	0.272
LIG_APCC_ABBA_1	1	6	PF00400	0.470
LIG_BIR_III_4	176	180	PF00653	0.498
LIG_BIR_III_4	44	48	PF00653	0.486
LIG_BRCT_BRCA1_1	289	293	PF00533	0.452
LIG_FHA_1	153	159	PF00498	0.177
LIG_FHA_1	317	323	PF00498	0.275
LIG_FHA_1	340	346	PF00498	0.272
LIG_FHA_1	73	79	PF00498	0.270
LIG_FHA_2	338	344	PF00498	0.318
LIG_FHA_2	38	44	PF00498	0.649
LIG_LIR_Apic_2	55	61	PF02991	0.493
LIG_LIR_Gen_1	159	167	PF02991	0.197
LIG_LIR_Gen_1	222	229	PF02991	0.177
LIG_LIR_Gen_1	249	260	PF02991	0.302
LIG_LIR_Nem_3	100	106	PF02991	0.303
LIG_LIR_Nem_3	222	226	PF02991	0.177
LIG_LIR_Nem_3	249	255	PF02991	0.269
LIG_LIR_Nem_3	259	263	PF02991	0.241
LIG_LIR_Nem_3	290	296	PF02991	0.493
LIG_NRBOX	309	315	PF00104	0.177
LIG_Pex14_1	230	234	PF04695	0.262
LIG_SH2_CRK	139	143	PF00017	0.258
LIG_SH2_CRK	252	256	PF00017	0.302
LIG_SH2_NCK_1	252	256	PF00017	0.302
LIG_SH2_NCK_1	58	62	PF00017	0.522
LIG_SH2_SRC	58	61	PF00017	0.519
LIG_SH2_STAT3	109	112	PF00017	0.177
LIG_SH2_STAT3	129	132	PF00017	0.358
LIG_SH2_STAT5	129	132	PF00017	0.194
LIG_SH2_STAT5	149	152	PF00017	0.349
LIG_SH2_STAT5	156	159	PF00017	0.457
LIG_SH2_STAT5	185	188	PF00017	0.420
LIG_SH2_STAT5	375	378	PF00017	0.277
LIG_SH3_3	75	81	PF00018	0.442
LIG_SH3_3	96	102	PF00018	0.369
LIG_SUMO_SIM_anti_2	62	69	PF11976	0.177
LIG_TYR_ITIM	250	255	PF00017	0.286
LIG_TYR_ITIM	258	263	PF00017	0.264
MOD_CK1_1	21	27	PF00069	0.756
MOD_CK1_1	287	293	PF00069	0.564
MOD_CK1_1	316	322	PF00069	0.268
MOD_CK1_1	381	387	PF00069	0.177
MOD_CK1_1	39	45	PF00069	0.722
MOD_CK1_1	393	399	PF00069	0.313
MOD_CK1_1	48	54	PF00069	0.490
MOD_CK1_1	69	75	PF00069	0.320
MOD_GlcNHglycan	199	202	PF01048	0.331
MOD_GlcNHglycan	20	23	PF01048	0.656
MOD_GlcNHglycan	215	218	PF01048	0.288
MOD_GlcNHglycan	287	290	PF01048	0.631
MOD_GlcNHglycan	306	309	PF01048	0.288
MOD_GlcNHglycan	310	313	PF01048	0.280
MOD_GSK3_1	127	134	PF00069	0.186
MOD_GSK3_1	152	159	PF00069	0.370
MOD_GSK3_1	2	9	PF00069	0.733
MOD_GSK3_1	215	222	PF00069	0.385
MOD_GSK3_1	283	290	PF00069	0.503
MOD_GSK3_1	304	311	PF00069	0.351
MOD_GSK3_1	393	400	PF00069	0.383
MOD_GSK3_1	61	68	PF00069	0.305
MOD_GSK3_1	70	77	PF00069	0.245
MOD_N-GLC_1	390	395	PF02516	0.450
MOD_NEK2_1	117	122	PF00069	0.386
MOD_NEK2_1	163	168	PF00069	0.365
MOD_NEK2_1	283	288	PF00069	0.616
MOD_NEK2_1	301	306	PF00069	0.275
MOD_NEK2_1	313	318	PF00069	0.331
MOD_NEK2_1	366	371	PF00069	0.277
MOD_NEK2_1	378	383	PF00069	0.277
MOD_NEK2_1	65	70	PF00069	0.330
MOD_NEK2_2	206	211	PF00069	0.302
MOD_NEK2_2	81	86	PF00069	0.291
MOD_PIKK_1	108	114	PF00454	0.151
MOD_PIKK_1	264	270	PF00454	0.456
MOD_PIKK_1	97	103	PF00454	0.177
MOD_PKA_2	345	351	PF00069	0.177
MOD_PKA_2	393	399	PF00069	0.342
MOD_PKA_2	48	54	PF00069	0.481
MOD_PKB_1	335	343	PF00069	0.244
MOD_Plk_1	390	396	PF00069	0.395
MOD_Plk_1	61	67	PF00069	0.394
MOD_Plk_2-3	6	12	PF00069	0.467
MOD_Plk_4	152	158	PF00069	0.334
MOD_Plk_4	250	256	PF00069	0.260
MOD_Plk_4	289	295	PF00069	0.524
MOD_Plk_4	313	319	PF00069	0.414
MOD_Plk_4	53	59	PF00069	0.549
MOD_Plk_4	74	80	PF00069	0.303
MOD_ProDKin_1	131	137	PF00069	0.272
MOD_ProDKin_1	94	100	PF00069	0.192
MOD_SUMO_rev_2	171	177	PF00179	0.415
TRG_ENDOCYTIC_2	139	142	PF00928	0.258
TRG_ENDOCYTIC_2	160	163	PF00928	0.239
TRG_ENDOCYTIC_2	252	255	PF00928	0.273
TRG_ENDOCYTIC_2	260	263	PF00928	0.240
TRG_ENDOCYTIC_2	375	378	PF00928	0.259
TRG_ER_diArg_1	118	121	PF00400	0.334
TRG_ER_diArg_1	325	328	PF00400	0.258
TRG_ER_diArg_1	334	337	PF00400	0.258
TRG_Pf-PMV_PEXEL_1	123	128	PF00026	0.326
TRG_Pf-PMV_PEXEL_1	227	231	PF00026	0.382

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX21	Leptomonas seymouri	58%	100%
A0A0N1I6I9	Leptomonas seymouri	24%	100%
A0A0N1I8T5	Leptomonas seymouri	22%	100%
A0A0S4J045	Bodo saltans	22%	100%
A0A1X0NWP7	Trypanosomatidae	44%	80%
A0A1X0P6V9	Trypanosomatidae	24%	100%
A0A3R7M746	Trypanosoma rangeli	45%	100%
A0A3S7WXX9	Leishmania donovani	74%	100%
A4I0J6	Leishmania infantum	74%	100%
A6QR09	Bos taurus	21%	100%
A6ZV78	Saccharomyces cerevisiae (strain YJM789)	23%	100%
C9ZKK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	100%
C9ZVC3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AWF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
F4HT41	Arabidopsis thaliana	24%	100%
O60029	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	23%	100%
P38921	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P53257	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
Q03829	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
Q09461	Caenorhabditis elegans	20%	100%
Q17QI7	Bos taurus	21%	100%
Q4QB15	Leishmania major	72%	100%
Q4V9P0	Danio rerio	23%	100%
Q54FE6	Dictyostelium discoideum	22%	100%
Q55DY8	Dictyostelium discoideum	20%	100%
Q55E45	Dictyostelium discoideum	21%	100%
Q66H23	Rattus norvegicus	23%	100%
Q7S2H8	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	25%	100%
Q7XA87	Arabidopsis thaliana	26%	100%
Q8HXY2	Macaca fascicularis	21%	100%
Q8R0Z5	Mus musculus	24%	100%
Q920G8	Mus musculus	23%	100%
Q94AG6	Arabidopsis thaliana	23%	100%
Q96A46	Homo sapiens	24%	100%
Q9BZJ4	Homo sapiens	22%	100%
Q9NYZ2	Homo sapiens	24%	100%
Q9VBN7	Drosophila melanogaster	24%	100%
Q9VM51	Drosophila melanogaster	24%	100%
V5DFJ2	Trypanosoma cruzi	47%	100%