Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HD09_LEIBR

TriTrypDb:

LbrM.23.1480 , LBRM2903_230025200

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 9
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HD09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD09

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.341
CLV_NRD_NRD_1	146	148	PF00675	0.618
CLV_NRD_NRD_1	185	187	PF00675	0.608
CLV_NRD_NRD_1	204	206	PF00675	0.458
CLV_NRD_NRD_1	98	100	PF00675	0.651
CLV_PCSK_FUR_1	202	206	PF00082	0.602
CLV_PCSK_KEX2_1	204	206	PF00082	0.499
CLV_PCSK_KEX2_1	98	100	PF00082	0.677
CLV_PCSK_SKI1_1	186	190	PF00082	0.657
CLV_PCSK_SKI1_1	363	367	PF00082	0.563
DEG_APCC_DBOX_1	397	405	PF00400	0.553
DOC_CKS1_1	273	278	PF01111	0.678
DOC_MAPK_gen_1	334	342	PF00069	0.667
DOC_MAPK_MEF2A_6	336	344	PF00069	0.711
DOC_PP1_RVXF_1	366	372	PF00149	0.719
DOC_PP4_FxxP_1	256	259	PF00568	0.644
DOC_PP4_FxxP_1	273	276	PF00568	0.646
DOC_PP4_FxxP_1	32	35	PF00568	0.526
DOC_USP7_MATH_1	16	20	PF00917	0.368
DOC_USP7_MATH_1	2	6	PF00917	0.765
DOC_USP7_MATH_1	301	305	PF00917	0.703
DOC_USP7_MATH_1	335	339	PF00917	0.705
DOC_USP7_MATH_1	9	13	PF00917	0.444
DOC_USP7_UBL2_3	121	125	PF12436	0.398
DOC_WW_Pin1_4	101	106	PF00397	0.480
DOC_WW_Pin1_4	272	277	PF00397	0.622
DOC_WW_Pin1_4	351	356	PF00397	0.771
DOC_WW_Pin1_4	409	414	PF00397	0.589
LIG_14-3-3_CanoR_1	207	212	PF00244	0.339
LIG_14-3-3_CanoR_1	339	343	PF00244	0.767
LIG_14-3-3_CanoR_1	368	372	PF00244	0.671
LIG_14-3-3_CanoR_1	4	8	PF00244	0.686
LIG_14-3-3_CanoR_1	408	413	PF00244	0.680
LIG_14-3-3_CanoR_1	41	46	PF00244	0.505
LIG_14-3-3_CanoR_1	56	62	PF00244	0.497
LIG_14-3-3_CanoR_1	65	71	PF00244	0.483
LIG_Actin_WH2_2	395	412	PF00022	0.562
LIG_APCC_ABBA_1	316	321	PF00400	0.672
LIG_BIR_II_1	1	5	PF00653	0.594
LIG_BRCT_BRCA1_1	248	252	PF00533	0.649
LIG_FHA_1	12	18	PF00498	0.390
LIG_FHA_1	163	169	PF00498	0.429
LIG_FHA_2	139	145	PF00498	0.431
LIG_FHA_2	235	241	PF00498	0.582
LIG_FHA_2	275	281	PF00498	0.608
LIG_FHA_2	362	368	PF00498	0.724
LIG_LIR_Apic_2	255	259	PF02991	0.701
LIG_LIR_Apic_2	270	276	PF02991	0.716
LIG_LIR_Apic_2	31	35	PF02991	0.533
LIG_LIR_Gen_1	106	114	PF02991	0.506
LIG_LIR_Gen_1	364	374	PF02991	0.665
LIG_LIR_Gen_1	386	394	PF02991	0.641
LIG_LIR_Nem_3	106	111	PF02991	0.514
LIG_LIR_Nem_3	364	369	PF02991	0.672
LIG_LIR_Nem_3	370	374	PF02991	0.612
LIG_LIR_Nem_3	386	391	PF02991	0.622
LIG_LIR_Nem_3	73	79	PF02991	0.433
LIG_LIR_Nem_3	82	88	PF02991	0.401
LIG_MLH1_MIPbox_1	248	252	PF16413	0.649
LIG_NBox_RRM_1	215	225	PF00076	0.449
LIG_Pex14_2	252	256	PF04695	0.681
LIG_SH2_GRB2like	272	275	PF00017	0.718
LIG_SH2_SRC	171	174	PF00017	0.342
LIG_SH2_STAP1	231	235	PF00017	0.670
LIG_SH2_STAT3	288	291	PF00017	0.717
LIG_SH2_STAT3	307	310	PF00017	0.632
LIG_SH2_STAT5	171	174	PF00017	0.335
LIG_SH2_STAT5	177	180	PF00017	0.391
LIG_SH2_STAT5	235	238	PF00017	0.631
LIG_SH2_STAT5	251	254	PF00017	0.597
LIG_SH2_STAT5	272	275	PF00017	0.660
LIG_SH2_STAT5	88	91	PF00017	0.421
LIG_SH3_3	12	18	PF00018	0.419
LIG_SH3_3	256	262	PF00018	0.604
LIG_SH3_3	339	345	PF00018	0.719
LIG_SH3_5	264	268	PF00018	0.633
LIG_SUMO_SIM_par_1	10	19	PF11976	0.223
LIG_TRAF2_1	156	159	PF00917	0.468
LIG_UBA3_1	253	260	PF00899	0.548
LIG_UBA3_1	54	62	PF00899	0.677
LIG_WRC_WIRS_1	253	258	PF05994	0.602
MOD_CDK_SPxxK_3	351	358	PF00069	0.530
MOD_CK1_1	11	17	PF00069	0.294
MOD_CK1_1	338	344	PF00069	0.734
MOD_CK1_1	357	363	PF00069	0.717
MOD_CK2_1	274	280	PF00069	0.595
MOD_CK2_1	361	367	PF00069	0.726
MOD_CK2_1	394	400	PF00069	0.689
MOD_CK2_1	41	47	PF00069	0.549
MOD_GlcNHglycan	121	124	PF01048	0.326
MOD_GlcNHglycan	284	287	PF01048	0.553
MOD_GlcNHglycan	32	35	PF01048	0.716
MOD_GlcNHglycan	359	363	PF01048	0.675
MOD_GlcNHglycan	72	75	PF01048	0.650
MOD_GSK3_1	213	220	PF00069	0.419
MOD_GSK3_1	3	10	PF00069	0.576
MOD_GSK3_1	354	361	PF00069	0.740
MOD_GSK3_1	389	396	PF00069	0.630
MOD_GSK3_1	41	48	PF00069	0.618
MOD_GSK3_1	65	72	PF00069	0.695
MOD_N-GLC_1	207	212	PF02516	0.557
MOD_N-GLC_1	50	55	PF02516	0.563
MOD_NEK2_1	172	177	PF00069	0.575
MOD_NEK2_1	252	257	PF00069	0.547
MOD_NEK2_1	377	382	PF00069	0.522
MOD_NEK2_1	45	50	PF00069	0.598
MOD_NEK2_1	57	62	PF00069	0.612
MOD_NEK2_1	7	12	PF00069	0.376
MOD_PIKK_1	389	395	PF00454	0.543
MOD_PKA_1	99	105	PF00069	0.645
MOD_PKA_2	3	9	PF00069	0.666
MOD_PKA_2	302	308	PF00069	0.562
MOD_PKA_2	335	341	PF00069	0.561
MOD_PKA_2	357	363	PF00069	0.777
MOD_PKA_2	367	373	PF00069	0.602
MOD_PKA_2	389	395	PF00069	0.570
MOD_PKA_2	64	70	PF00069	0.599
MOD_PKB_1	205	213	PF00069	0.561
MOD_Plk_1	172	178	PF00069	0.466
MOD_Plk_1	198	204	PF00069	0.598
MOD_Plk_1	207	213	PF00069	0.444
MOD_Plk_1	323	329	PF00069	0.649
MOD_Plk_1	50	56	PF00069	0.664
MOD_Plk_2-3	367	373	PF00069	0.662
MOD_Plk_4	172	178	PF00069	0.531
MOD_Plk_4	207	213	PF00069	0.413
MOD_Plk_4	252	258	PF00069	0.568
MOD_Plk_4	3	9	PF00069	0.724
MOD_Plk_4	50	56	PF00069	0.638
MOD_ProDKin_1	101	107	PF00069	0.609
MOD_ProDKin_1	272	278	PF00069	0.533
MOD_ProDKin_1	351	357	PF00069	0.743
MOD_SUMO_for_1	129	132	PF00179	0.583
MOD_SUMO_rev_2	113	123	PF00179	0.545
MOD_SUMO_rev_2	278	285	PF00179	0.400
MOD_SUMO_rev_2	326	335	PF00179	0.611
TRG_DiLeu_BaEn_4	132	138	PF01217	0.578
TRG_DiLeu_BaEn_4	311	317	PF01217	0.505
TRG_ENDOCYTIC_2	185	188	PF00928	0.568
TRG_ENDOCYTIC_2	231	234	PF00928	0.344
TRG_ENDOCYTIC_2	251	254	PF00928	0.498
TRG_ER_diArg_1	202	205	PF00400	0.388
TRG_ER_diArg_1	97	99	PF00400	0.698
TRG_NES_CRM1_1	132	144	PF08389	0.350

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4S8	Leptomonas seymouri	65%	98%
A0A0S4IRC9	Bodo saltans	34%	100%
A0A1X0NWQ4	Trypanosomatidae	47%	97%
A0A3Q8IMB7	Leishmania donovani	78%	100%
A0A422NXY7	Trypanosoma rangeli	43%	100%
A4I0J5	Leishmania infantum	78%	100%
C9ZVC2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AWF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4QB16	Leishmania major	77%	100%
V5BJ93	Trypanosoma cruzi	42%	98%