Elongator complex protein 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Elongator-like Protein 3b, putative

Species:

Leishmania braziliensis

UniProt:

A4HD08_LEIBR

TriTrypDb:

LbrM.23.1470 , LBRM2903_230025100

Length:

618

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	3
GO:0005634	nucleus	5	2
GO:0005635	nuclear envelope	4	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	2
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0032991	protein-containing complex	1	2
GO:0033588	elongator holoenzyme complex	3	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:0005819	spindle	5	1

Expansion

Sequence features

A4HD08

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD08

Function

Biological processes
Term	Name	Level	Count
GO:0002097	tRNA wobble base modification	7	2
GO:0002098	tRNA wobble uridine modification	8	2
GO:0002926	tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation	9	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	1
GO:0006396	RNA processing	6	2
GO:0006399	tRNA metabolic process	7	2
GO:0006400	tRNA modification	6	2
GO:0006473	protein acetylation	6	1
GO:0006475	internal protein amino acid acetylation	7	1
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006996	organelle organization	4	1
GO:0008033	tRNA processing	8	2
GO:0008152	metabolic process	1	2
GO:0009451	RNA modification	5	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	1
GO:0016070	RNA metabolic process	5	2
GO:0016570	histone modification	5	1
GO:0016573	histone acetylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0018393	internal peptidyl-lysine acetylation	8	1
GO:0018394	peptidyl-lysine acetylation	7	1
GO:0019538	protein metabolic process	3	1
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0036211	protein modification process	4	1
GO:0043007	maintenance of rDNA	6	1
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043543	protein acylation	5	1
GO:0043570	maintenance of DNA repeat elements	5	1
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	2
GO:0051276	chromosome organization	5	1
GO:0071704	organic substance metabolic process	2	2
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	23
GO:0003676	nucleic acid binding	3	23
GO:0003723	RNA binding	4	23
GO:0003824	catalytic activity	1	23
GO:0005488	binding	1	23
GO:0016407	acetyltransferase activity	5	23
GO:0016740	transferase activity	2	23
GO:0016746	acyltransferase activity	3	23
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	23
GO:0043167	ion binding	2	23
GO:0043169	cation binding	3	23
GO:0046872	metal ion binding	4	23
GO:0051536	iron-sulfur cluster binding	3	23
GO:0051539	4 iron, 4 sulfur cluster binding	4	23
GO:0051540	metal cluster binding	2	23
GO:0097159	organic cyclic compound binding	2	23
GO:0106261	tRNA uridine(34) acetyltransferase activity	6	12
GO:1901363	heterocyclic compound binding	2	23

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.441
CLV_NRD_NRD_1	262	264	PF00675	0.222
CLV_NRD_NRD_1	38	40	PF00675	0.409
CLV_NRD_NRD_1	551	553	PF00675	0.269
CLV_NRD_NRD_1	562	564	PF00675	0.280
CLV_NRD_NRD_1	79	81	PF00675	0.430
CLV_PCSK_KEX2_1	262	264	PF00082	0.222
CLV_PCSK_KEX2_1	38	40	PF00082	0.406
CLV_PCSK_KEX2_1	414	416	PF00082	0.218
CLV_PCSK_KEX2_1	551	553	PF00082	0.281
CLV_PCSK_KEX2_1	562	564	PF00082	0.289
CLV_PCSK_PC1ET2_1	414	416	PF00082	0.284
CLV_PCSK_SKI1_1	39	43	PF00082	0.403
CLV_PCSK_SKI1_1	543	547	PF00082	0.391
CLV_PCSK_SKI1_1	612	616	PF00082	0.579
DEG_APCC_DBOX_1	393	401	PF00400	0.418
DEG_APCC_DBOX_1	414	422	PF00400	0.418
DEG_SPOP_SBC_1	54	58	PF00917	0.324
DOC_MAPK_gen_1	109	120	PF00069	0.430
DOC_MAPK_gen_1	241	249	PF00069	0.380
DOC_MAPK_gen_1	262	269	PF00069	0.412
DOC_MAPK_gen_1	546	555	PF00069	0.401
DOC_MAPK_HePTP_8	107	123	PF00069	0.392
DOC_MAPK_MEF2A_6	241	249	PF00069	0.375
DOC_PP4_FxxP_1	124	127	PF00568	0.277
DOC_PP4_FxxP_1	130	133	PF00568	0.312
DOC_USP7_MATH_1	226	230	PF00917	0.458
DOC_USP7_MATH_1	319	323	PF00917	0.431
DOC_USP7_MATH_1	79	83	PF00917	0.371
DOC_USP7_UBL2_3	410	414	PF12436	0.540
LIG_14-3-3_CanoR_1	202	208	PF00244	0.334
LIG_14-3-3_CanoR_1	225	231	PF00244	0.443
LIG_14-3-3_CanoR_1	262	268	PF00244	0.450
LIG_14-3-3_CanoR_1	448	455	PF00244	0.280
LIG_14-3-3_CanoR_1	459	467	PF00244	0.242
LIG_14-3-3_CanoR_1	80	88	PF00244	0.415
LIG_AP2alpha_1	454	458	PF02296	0.275
LIG_BRCT_BRCA1_1	203	207	PF00533	0.461
LIG_EH1_1	378	386	PF00400	0.484
LIG_eIF4E_1	379	385	PF01652	0.451
LIG_FHA_1	349	355	PF00498	0.418
LIG_FHA_1	404	410	PF00498	0.442
LIG_FHA_1	426	432	PF00498	0.521
LIG_FHA_1	526	532	PF00498	0.349
LIG_FHA_1	573	579	PF00498	0.298
LIG_FHA_1	583	589	PF00498	0.493
LIG_FHA_2	215	221	PF00498	0.427
LIG_FHA_2	233	239	PF00498	0.415
LIG_FHA_2	249	255	PF00498	0.410
LIG_FHA_2	522	528	PF00498	0.299
LIG_LIR_Apic_2	11	15	PF02991	0.503
LIG_LIR_Apic_2	122	127	PF02991	0.264
LIG_LIR_Apic_2	129	133	PF02991	0.329
LIG_LIR_Gen_1	29	37	PF02991	0.516
LIG_LIR_Gen_1	328	336	PF02991	0.297
LIG_LIR_Gen_1	353	363	PF02991	0.418
LIG_LIR_Gen_1	4	12	PF02991	0.512
LIG_LIR_Gen_1	464	474	PF02991	0.280
LIG_LIR_LC3C_4	116	121	PF02991	0.382
LIG_LIR_Nem_3	195	199	PF02991	0.418
LIG_LIR_Nem_3	29	34	PF02991	0.455
LIG_LIR_Nem_3	328	333	PF02991	0.302
LIG_LIR_Nem_3	344	349	PF02991	0.431
LIG_LIR_Nem_3	353	359	PF02991	0.418
LIG_LIR_Nem_3	4	8	PF02991	0.511
LIG_LIR_Nem_3	464	470	PF02991	0.265
LIG_LIR_Nem_3	476	482	PF02991	0.248
LIG_LIR_Nem_3	512	516	PF02991	0.320
LIG_LIR_Nem_3	602	607	PF02991	0.643
LIG_LIR_Nem_3	85	91	PF02991	0.360
LIG_Pex14_2	160	164	PF04695	0.516
LIG_Pex14_2	330	334	PF04695	0.321
LIG_Pex14_2	454	458	PF04695	0.260
LIG_PTB_Apo_2	373	380	PF02174	0.539
LIG_PTB_Apo_2	387	394	PF02174	0.340
LIG_PTB_Phospho_1	373	379	PF10480	0.539
LIG_PTB_Phospho_1	387	393	PF10480	0.340
LIG_SH2_CRK	513	517	PF00017	0.275
LIG_SH2_CRK	565	569	PF00017	0.285
LIG_SH2_CRK	88	92	PF00017	0.362
LIG_SH2_NCK_1	12	16	PF00017	0.420
LIG_SH2_NCK_1	171	175	PF00017	0.429
LIG_SH2_NCK_1	219	223	PF00017	0.430
LIG_SH2_STAP1	203	207	PF00017	0.433
LIG_SH2_STAT5	138	141	PF00017	0.418
LIG_SH2_STAT5	149	152	PF00017	0.418
LIG_SH2_STAT5	255	258	PF00017	0.458
LIG_SH2_STAT5	386	389	PF00017	0.414
LIG_SH2_STAT5	408	411	PF00017	0.418
LIG_SH2_STAT5	467	470	PF00017	0.246
LIG_SH3_2	223	228	PF14604	0.484
LIG_SH3_3	137	143	PF00018	0.418
LIG_SH3_3	220	226	PF00018	0.442
LIG_SH3_3	313	319	PF00018	0.420
LIG_SUMO_SIM_anti_2	116	122	PF11976	0.373
LIG_SUMO_SIM_anti_2	185	191	PF11976	0.418
LIG_SUMO_SIM_par_1	116	122	PF11976	0.373
LIG_SUMO_SIM_par_1	515	520	PF11976	0.260
LIG_TRAF2_1	491	494	PF00917	0.349
LIG_UBA3_1	506	515	PF00899	0.325
LIG_WRPW_2	368	371	PF00400	0.260
MOD_CK1_1	4	10	PF00069	0.527
MOD_CK1_1	45	51	PF00069	0.465
MOD_CK1_1	461	467	PF00069	0.262
MOD_CK1_1	586	592	PF00069	0.569
MOD_CK1_1	602	608	PF00069	0.536
MOD_CK1_1	82	88	PF00069	0.380
MOD_CK2_1	172	178	PF00069	0.275
MOD_CK2_1	226	232	PF00069	0.253
MOD_CK2_1	254	260	PF00069	0.313
MOD_CK2_1	318	324	PF00069	0.290
MOD_CK2_1	521	527	PF00069	0.283
MOD_GlcNHglycan	115	118	PF01048	0.412
MOD_GlcNHglycan	174	177	PF01048	0.275
MOD_GlcNHglycan	220	223	PF01048	0.305
MOD_GlcNHglycan	256	259	PF01048	0.239
MOD_GlcNHglycan	334	337	PF01048	0.499
MOD_GlcNHglycan	57	60	PF01048	0.532
MOD_GlcNHglycan	585	588	PF01048	0.544
MOD_GlcNHglycan	604	607	PF01048	0.620
MOD_GlcNHglycan	99	102	PF01048	0.391
MOD_GSK3_1	214	221	PF00069	0.271
MOD_GSK3_1	263	270	PF00069	0.291
MOD_GSK3_1	350	357	PF00069	0.266
MOD_GSK3_1	517	524	PF00069	0.275
MOD_GSK3_1	582	589	PF00069	0.527
MOD_GSK3_1	602	609	PF00069	0.558
MOD_GSK3_1	75	82	PF00069	0.436
MOD_N-GLC_1	337	342	PF02516	0.408
MOD_NEK2_1	119	124	PF00069	0.312
MOD_NEK2_1	192	197	PF00069	0.260
MOD_NEK2_1	208	213	PF00069	0.260
MOD_NEK2_1	267	272	PF00069	0.269
MOD_NEK2_1	329	334	PF00069	0.454
MOD_NEK2_1	42	47	PF00069	0.400
MOD_NEK2_1	572	577	PF00069	0.312
MOD_NEK2_1	607	612	PF00069	0.568
MOD_NEK2_1	75	80	PF00069	0.468
MOD_NEK2_2	194	199	PF00069	0.260
MOD_PIKK_1	165	171	PF00454	0.281
MOD_PIKK_1	425	431	PF00454	0.412
MOD_PIKK_1	473	479	PF00454	0.409
MOD_PIKK_1	517	523	PF00454	0.380
MOD_PIKK_1	525	531	PF00454	0.210
MOD_PIKK_1	532	538	PF00454	0.134
MOD_PKA_2	172	178	PF00069	0.294
MOD_PKA_2	201	207	PF00069	0.190
MOD_PKA_2	458	464	PF00069	0.247
MOD_PKA_2	79	85	PF00069	0.397
MOD_Plk_1	232	238	PF00069	0.296
MOD_Plk_1	337	343	PF00069	0.404
MOD_Plk_1	473	479	PF00069	0.328
MOD_Plk_1	572	578	PF00069	0.319
MOD_Plk_1	599	605	PF00069	0.660
MOD_Plk_2-3	232	238	PF00069	0.295
MOD_Plk_4	119	125	PF00069	0.348
MOD_Plk_4	208	214	PF00069	0.269
MOD_Plk_4	293	299	PF00069	0.334
MOD_Plk_4	329	335	PF00069	0.432
MOD_Plk_4	4	10	PF00069	0.564
MOD_Plk_4	404	410	PF00069	0.278
MOD_Plk_4	572	578	PF00069	0.330
MOD_Plk_4	599	605	PF00069	0.584
MOD_Plk_4	610	616	PF00069	0.517
MOD_SUMO_rev_2	11	21	PF00179	0.481
TRG_DiLeu_BaEn_4	493	499	PF01217	0.239
TRG_DiLeu_BaLyEn_6	299	304	PF01217	0.253
TRG_ENDOCYTIC_2	371	374	PF00928	0.368
TRG_ENDOCYTIC_2	467	470	PF00928	0.239
TRG_ENDOCYTIC_2	479	482	PF00928	0.228
TRG_ENDOCYTIC_2	513	516	PF00928	0.261
TRG_ENDOCYTIC_2	550	553	PF00928	0.314
TRG_ENDOCYTIC_2	565	568	PF00928	0.261
TRG_ENDOCYTIC_2	604	607	PF00928	0.632
TRG_ENDOCYTIC_2	88	91	PF00928	0.343
TRG_ER_diArg_1	241	244	PF00400	0.262
TRG_ER_diArg_1	261	263	PF00400	0.266
TRG_ER_diArg_1	393	396	PF00400	0.252
TRG_ER_diArg_1	482	485	PF00400	0.260
TRG_ER_diArg_1	550	552	PF00400	0.277
TRG_ER_diArg_1	561	563	PF00400	0.268
TRG_ER_FFAT_2	250	260	PF00635	0.239
TRG_NES_CRM1_1	260	273	PF08389	0.275
TRG_NLS_MonoExtC_3	108	113	PF00514	0.452
TRG_NLS_MonoExtN_4	109	114	PF00514	0.457
TRG_Pf-PMV_PEXEL_1	228	232	PF00026	0.352
TRG_Pf-PMV_PEXEL_1	399	403	PF00026	0.299
TRG_Pf-PMV_PEXEL_1	89	94	PF00026	0.377

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P567	Leptomonas seymouri	87%	91%
A0A0N1PFU7	Leptomonas seymouri	45%	83%
A0A0S4IQT9	Bodo saltans	68%	96%
A0A0S4KPU1	Bodo saltans	45%	91%
A0A1C7D1B7	Dehalococcoides mccartyi (strain CBDB1)	37%	100%
A0A1X0NG94	Trypanosomatidae	41%	84%
A0A1X0NX69	Trypanosomatidae	76%	90%
A0A3Q8ICG0	Leishmania donovani	45%	81%
A0A3R7KUY9	Trypanosoma rangeli	77%	93%
A0A3S7WXV4	Leishmania donovani	94%	87%
A0A422NDG5	Trypanosoma rangeli	44%	83%
A4H8F0	Leishmania braziliensis	44%	81%
A4HWS3	Leishmania infantum	45%	81%
A4I0J4	Leishmania infantum	93%	87%
C9ZVC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	78%	93%
C9ZW50	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	91%
D5VRB9	Methanocaldococcus infernus (strain DSM 11812 / JCM 15783 / ME)	36%	100%
E9AQI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	80%
E9AWF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	88%
O14023	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
Q02908	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	100%
Q1ZXC6	Dictyostelium discoideum	33%	100%
Q23651	Caenorhabditis elegans	34%	100%
Q2KJ61	Bos taurus	33%	100%
Q4QB17	Leishmania major	94%	100%
Q4QEZ6	Leishmania major	45%	100%
Q58536	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	35%	100%
Q5HZM6	Xenopus laevis	33%	100%
Q5RIC0	Danio rerio	33%	100%
Q5ZHS1	Gallus gallus	35%	100%
Q60LW7	Caenorhabditis briggsae	33%	100%
Q6NVL5	Xenopus tropicalis	32%	100%
Q7X7L3	Oryza sativa subsp. japonica	35%	100%
Q93ZR1	Arabidopsis thaliana	34%	100%
Q9CZX0	Mus musculus	33%	100%
Q9H9T3	Homo sapiens	33%	100%
Q9VQZ6	Drosophila melanogaster	32%	100%
V5B5L2	Trypanosoma cruzi	43%	91%
V5BNQ5	Trypanosoma cruzi	76%	92%