Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HD07_LEIBR

TriTrypDb:

LbrM.23.1460 , LBRM2903_230025000

Length:

775

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HD07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD07

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	14	16	PF00675	0.717
CLV_NRD_NRD_1	580	582	PF00675	0.389
CLV_NRD_NRD_1	727	729	PF00675	0.464
CLV_NRD_NRD_1	75	77	PF00675	0.698
CLV_PCSK_KEX2_1	14	16	PF00082	0.728
CLV_PCSK_KEX2_1	226	228	PF00082	0.690
CLV_PCSK_KEX2_1	419	421	PF00082	0.499
CLV_PCSK_KEX2_1	580	582	PF00082	0.389
CLV_PCSK_KEX2_1	727	729	PF00082	0.457
CLV_PCSK_KEX2_1	75	77	PF00082	0.698
CLV_PCSK_KEX2_1	754	756	PF00082	0.555
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.732
CLV_PCSK_PC1ET2_1	419	421	PF00082	0.538
CLV_PCSK_PC1ET2_1	727	729	PF00082	0.457
CLV_PCSK_PC1ET2_1	754	756	PF00082	0.555
CLV_PCSK_PC7_1	71	77	PF00082	0.701
CLV_PCSK_SKI1_1	390	394	PF00082	0.406
CLV_PCSK_SKI1_1	490	494	PF00082	0.506
CLV_PCSK_SKI1_1	515	519	PF00082	0.348
CLV_PCSK_SKI1_1	694	698	PF00082	0.390
CLV_PCSK_SKI1_1	702	706	PF00082	0.412
DEG_Nend_Nbox_1	1	3	PF02207	0.613
DEG_SCF_FBW7_2	500	505	PF00400	0.506
DEG_SPOP_SBC_1	161	165	PF00917	0.664
DEG_SPOP_SBC_1	85	89	PF00917	0.722
DOC_CYCLIN_yCln2_LP_2	634	640	PF00134	0.613
DOC_MAPK_HePTP_8	517	529	PF00069	0.348
DOC_MAPK_MEF2A_6	520	529	PF00069	0.347
DOC_PP1_RVXF_1	211	218	PF00149	0.531
DOC_PP1_RVXF_1	561	567	PF00149	0.378
DOC_PP2B_LxvP_1	449	452	PF13499	0.549
DOC_PP4_FxxP_1	28	31	PF00568	0.473
DOC_PP4_FxxP_1	747	750	PF00568	0.451
DOC_USP7_MATH_1	142	146	PF00917	0.552
DOC_USP7_MATH_1	250	254	PF00917	0.677
DOC_USP7_MATH_1	277	281	PF00917	0.617
DOC_USP7_MATH_1	45	49	PF00917	0.593
DOC_USP7_MATH_1	682	686	PF00917	0.441
DOC_USP7_MATH_1	94	98	PF00917	0.699
DOC_USP7_UBL2_3	723	727	PF12436	0.455
DOC_WW_Pin1_4	138	143	PF00397	0.649
DOC_WW_Pin1_4	258	263	PF00397	0.560
DOC_WW_Pin1_4	360	365	PF00397	0.485
DOC_WW_Pin1_4	368	373	PF00397	0.404
DOC_WW_Pin1_4	498	503	PF00397	0.501
DOC_WW_Pin1_4	591	596	PF00397	0.519
LIG_14-3-3_CanoR_1	109	114	PF00244	0.524
LIG_14-3-3_CanoR_1	118	124	PF00244	0.417
LIG_14-3-3_CanoR_1	14	23	PF00244	0.474
LIG_14-3-3_CanoR_1	44	50	PF00244	0.673
LIG_14-3-3_CanoR_1	55	65	PF00244	0.644
LIG_14-3-3_CanoR_1	706	714	PF00244	0.448
LIG_14-3-3_CanoR_1	761	765	PF00244	0.683
LIG_BRCT_BRCA1_1	370	374	PF00533	0.420
LIG_BRCT_BRCA1_1	96	100	PF00533	0.669
LIG_CSL_BTD_1	287	290	PF09270	0.431
LIG_CSL_BTD_1	378	381	PF09270	0.365
LIG_EH1_1	718	726	PF00400	0.554
LIG_EVH1_2	204	208	PF00568	0.427
LIG_FHA_1	108	114	PF00498	0.497
LIG_FHA_1	120	126	PF00498	0.439
LIG_FHA_1	259	265	PF00498	0.515
LIG_FHA_1	309	315	PF00498	0.483
LIG_FHA_1	361	367	PF00498	0.475
LIG_FHA_1	499	505	PF00498	0.466
LIG_FHA_1	642	648	PF00498	0.472
LIG_FHA_1	65	71	PF00498	0.684
LIG_FHA_1	720	726	PF00498	0.441
LIG_FHA_1	728	734	PF00498	0.438
LIG_FHA_1	87	93	PF00498	0.737
LIG_FHA_2	189	195	PF00498	0.605
LIG_FHA_2	220	226	PF00498	0.575
LIG_FHA_2	427	433	PF00498	0.500
LIG_FHA_2	489	495	PF00498	0.360
LIG_FHA_2	592	598	PF00498	0.508
LIG_FHA_2	651	657	PF00498	0.412
LIG_FHA_2	67	73	PF00498	0.692
LIG_FHA_2	755	761	PF00498	0.608
LIG_LIR_Apic_2	334	339	PF02991	0.365
LIG_LIR_Apic_2	466	470	PF02991	0.459
LIG_LIR_Apic_2	746	750	PF02991	0.447
LIG_LIR_Gen_1	117	126	PF02991	0.455
LIG_LIR_Gen_1	230	238	PF02991	0.630
LIG_LIR_Gen_1	284	294	PF02991	0.411
LIG_LIR_Gen_1	326	336	PF02991	0.375
LIG_LIR_Gen_1	33	42	PF02991	0.491
LIG_LIR_Gen_1	541	549	PF02991	0.479
LIG_LIR_LC3C_4	48	52	PF02991	0.503
LIG_LIR_LC3C_4	722	726	PF02991	0.561
LIG_LIR_Nem_3	230	235	PF02991	0.631
LIG_LIR_Nem_3	284	289	PF02991	0.420
LIG_LIR_Nem_3	326	332	PF02991	0.380
LIG_LIR_Nem_3	371	377	PF02991	0.357
LIG_LIR_Nem_3	512	517	PF02991	0.345
LIG_LIR_Nem_3	703	708	PF02991	0.435
LIG_NRBOX	100	106	PF00104	0.468
LIG_NRP_CendR_1	772	775	PF00754	0.674
LIG_PALB2_WD40_1	203	211	PF16756	0.429
LIG_PCNA_PIPBox_1	178	187	PF02747	0.606
LIG_Pex14_2	338	342	PF04695	0.499
LIG_Pex14_2	514	518	PF04695	0.489
LIG_Pex14_2	543	547	PF04695	0.429
LIG_Pex14_2	582	586	PF04695	0.398
LIG_PTB_Apo_2	21	28	PF02174	0.470
LIG_PTB_Apo_2	646	653	PF02174	0.426
LIG_PTB_Phospho_1	646	652	PF10480	0.427
LIG_SH2_CRK	16	20	PF00017	0.470
LIG_SH2_CRK	336	340	PF00017	0.386
LIG_SH2_NCK_1	467	471	PF00017	0.460
LIG_SH2_SRC	132	135	PF00017	0.583
LIG_SH2_SRC	448	451	PF00017	0.556
LIG_SH2_SRC	467	470	PF00017	0.278
LIG_SH2_STAP1	745	749	PF00017	0.445
LIG_SH2_STAT3	456	459	PF00017	0.526
LIG_SH2_STAT3	604	607	PF00017	0.371
LIG_SH2_STAT5	16	19	PF00017	0.470
LIG_SH2_STAT5	216	219	PF00017	0.576
LIG_SH2_STAT5	286	289	PF00017	0.410
LIG_SH2_STAT5	312	315	PF00017	0.476
LIG_SH2_STAT5	329	332	PF00017	0.265
LIG_SH2_STAT5	336	339	PF00017	0.366
LIG_SH2_STAT5	448	451	PF00017	0.521
LIG_SH2_STAT5	604	607	PF00017	0.394
LIG_SH2_STAT5	652	655	PF00017	0.418
LIG_SH2_STAT5	664	667	PF00017	0.378
LIG_SH3_1	534	540	PF00018	0.418
LIG_SH3_2	168	173	PF14604	0.608
LIG_SH3_3	128	134	PF00018	0.528
LIG_SH3_3	136	142	PF00018	0.573
LIG_SH3_3	165	171	PF00018	0.676
LIG_SH3_3	257	263	PF00018	0.738
LIG_SH3_3	356	362	PF00018	0.505
LIG_SH3_3	369	375	PF00018	0.395
LIG_SH3_3	378	384	PF00018	0.458
LIG_SH3_3	530	536	PF00018	0.394
LIG_SH3_3	561	567	PF00018	0.378
LIG_SUMO_SIM_anti_2	48	53	PF11976	0.501
LIG_SUMO_SIM_par_1	108	117	PF11976	0.586
LIG_SUMO_SIM_par_1	292	298	PF11976	0.498
LIG_TRAF2_1	429	432	PF00917	0.605
LIG_TRFH_1	477	481	PF08558	0.484
LIG_UBA3_1	513	520	PF00899	0.489
LIG_WRC_WIRS_1	393	398	PF05994	0.499
MOD_CK1_1	143	149	PF00069	0.558
MOD_CK1_1	160	166	PF00069	0.496
MOD_CK1_1	253	259	PF00069	0.782
MOD_CK1_1	269	275	PF00069	0.716
MOD_CK1_1	32	38	PF00069	0.662
MOD_CK1_1	347	353	PF00069	0.435
MOD_CK1_1	360	366	PF00069	0.422
MOD_CK1_1	395	401	PF00069	0.445
MOD_CK1_1	43	49	PF00069	0.532
MOD_CK1_1	61	67	PF00069	0.588
MOD_CK1_1	86	92	PF00069	0.670
MOD_CK1_1	99	105	PF00069	0.542
MOD_CK2_1	188	194	PF00069	0.582
MOD_CK2_1	197	203	PF00069	0.567
MOD_CK2_1	426	432	PF00069	0.537
MOD_CK2_1	650	656	PF00069	0.417
MOD_CK2_1	66	72	PF00069	0.693
MOD_GlcNHglycan	101	104	PF01048	0.508
MOD_GlcNHglycan	159	162	PF01048	0.743
MOD_GlcNHglycan	199	202	PF01048	0.582
MOD_GlcNHglycan	253	256	PF01048	0.727
MOD_GlcNHglycan	257	260	PF01048	0.727
MOD_GlcNHglycan	272	275	PF01048	0.665
MOD_GlcNHglycan	36	39	PF01048	0.672
MOD_GlcNHglycan	45	48	PF01048	0.556
MOD_GlcNHglycan	529	532	PF01048	0.425
MOD_GlcNHglycan	684	687	PF01048	0.399
MOD_GlcNHglycan	96	99	PF01048	0.612
MOD_GSK3_1	109	116	PF00069	0.565
MOD_GSK3_1	138	145	PF00069	0.667
MOD_GSK3_1	157	164	PF00069	0.532
MOD_GSK3_1	251	258	PF00069	0.648
MOD_GSK3_1	266	273	PF00069	0.743
MOD_GSK3_1	30	37	PF00069	0.605
MOD_GSK3_1	306	313	PF00069	0.377
MOD_GSK3_1	343	350	PF00069	0.412
MOD_GSK3_1	391	398	PF00069	0.317
MOD_GSK3_1	484	491	PF00069	0.406
MOD_GSK3_1	523	530	PF00069	0.470
MOD_GSK3_1	54	61	PF00069	0.734
MOD_GSK3_1	585	592	PF00069	0.440
MOD_GSK3_1	66	73	PF00069	0.637
MOD_GSK3_1	750	757	PF00069	0.545
MOD_GSK3_1	81	88	PF00069	0.511
MOD_LATS_1	488	494	PF00433	0.494
MOD_N-GLC_2	319	321	PF02516	0.287
MOD_N-GLC_2	571	573	PF02516	0.526
MOD_N-GLC_2	58	60	PF02516	0.502
MOD_NEK2_1	113	118	PF00069	0.589
MOD_NEK2_1	197	202	PF00069	0.587
MOD_NEK2_1	332	337	PF00069	0.409
MOD_NEK2_1	34	39	PF00069	0.616
MOD_NEK2_1	484	489	PF00069	0.471
MOD_NEK2_1	54	59	PF00069	0.425
MOD_NEK2_1	70	75	PF00069	0.602
MOD_NEK2_2	598	603	PF00069	0.459
MOD_PIKK_1	233	239	PF00454	0.375
MOD_PIKK_1	347	353	PF00454	0.526
MOD_PIKK_1	395	401	PF00454	0.316
MOD_PIKK_1	427	433	PF00454	0.599
MOD_PIKK_1	547	553	PF00454	0.469
MOD_PIKK_1	714	720	PF00454	0.340
MOD_PKA_1	14	20	PF00069	0.476
MOD_PKA_1	727	733	PF00069	0.439
MOD_PKA_1	754	760	PF00069	0.599
MOD_PKA_2	14	20	PF00069	0.476
MOD_PKA_2	43	49	PF00069	0.671
MOD_PKA_2	54	60	PF00069	0.716
MOD_PKA_2	70	76	PF00069	0.579
MOD_PKA_2	727	733	PF00069	0.439
MOD_PKA_2	754	760	PF00069	0.599
MOD_Plk_1	107	113	PF00069	0.565
MOD_Plk_1	219	225	PF00069	0.623
MOD_Plk_1	277	283	PF00069	0.712
MOD_Plk_2-3	760	766	PF00069	0.572
MOD_Plk_4	284	290	PF00069	0.395
MOD_Plk_4	45	51	PF00069	0.622
MOD_Plk_4	509	515	PF00069	0.369
MOD_Plk_4	598	604	PF00069	0.461
MOD_Plk_4	96	102	PF00069	0.533
MOD_ProDKin_1	138	144	PF00069	0.658
MOD_ProDKin_1	258	264	PF00069	0.562
MOD_ProDKin_1	360	366	PF00069	0.476
MOD_ProDKin_1	368	374	PF00069	0.400
MOD_ProDKin_1	498	504	PF00069	0.492
MOD_ProDKin_1	591	597	PF00069	0.515
MOD_SUMO_rev_2	526	536	PF00179	0.396
TRG_DiLeu_BaEn_2	540	546	PF01217	0.458
TRG_DiLeu_BaLyEn_6	351	356	PF01217	0.496
TRG_DiLeu_BaLyEn_6	469	474	PF01217	0.464
TRG_DiLeu_BaLyEn_6	736	741	PF01217	0.468
TRG_DiLeu_BaLyEn_6	769	774	PF01217	0.645
TRG_ENDOCYTIC_2	120	123	PF00928	0.429
TRG_ENDOCYTIC_2	16	19	PF00928	0.470
TRG_ENDOCYTIC_2	286	289	PF00928	0.430
TRG_ENDOCYTIC_2	329	332	PF00928	0.361
TRG_ENDOCYTIC_2	603	606	PF00928	0.494
TRG_ER_diArg_1	14	16	PF00400	0.685
TRG_ER_diArg_1	580	582	PF00400	0.392
TRG_ER_diArg_1	621	624	PF00400	0.425
TRG_ER_diArg_1	74	76	PF00400	0.698
TRG_NES_CRM1_1	524	539	PF08389	0.529
TRG_NLS_MonoExtC_3	726	731	PF00514	0.464
TRG_Pf-PMV_PEXEL_1	354	358	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	563	568	PF00026	0.267
TRG_Pf-PMV_PEXEL_1	731	735	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	739	743	PF00026	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBN6	Leptomonas seymouri	75%	100%
A0A0S4ISW7	Bodo saltans	50%	100%
A0A1X0NY35	Trypanosomatidae	60%	100%
A0A3Q8IBV8	Leishmania donovani	86%	92%
A0A3R7MZ34	Trypanosoma rangeli	61%	100%
A4I0J3	Leishmania infantum	86%	92%
C9ZVC0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AWF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QB18	Leishmania major	90%	100%