Lathosterol oxidase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

lathosterol oxidase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HD03_LEIBR

TriTrypDb:

LbrM.23.1420 , LBRM2903_230024500

Length:

303

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0031090	organelle membrane	3	1

Expansion

Sequence features

A4HD03

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD03

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	11
GO:0008152	metabolic process	1	11
GO:0008610	lipid biosynthetic process	4	11
GO:0009058	biosynthetic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0006694	steroid biosynthetic process	5	1
GO:0008202	steroid metabolic process	4	1
GO:0016125	sterol metabolic process	4	1
GO:0016126	sterol biosynthetic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901615	organic hydroxy compound metabolic process	3	1
GO:1901617	organic hydroxy compound biosynthetic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0005506	iron ion binding	6	11
GO:0016491	oxidoreductase activity	2	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	11
GO:0000248	C-5 sterol desaturase activity	5	1
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	3
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	4	3
GO:0070704	sterol desaturase activity	4	3
GO:0050046	delta7-sterol 5(6)-desaturase activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	296	298	PF00675	0.635
CLV_PCSK_KEX2_1	296	298	PF00082	0.666
CLV_PCSK_KEX2_1	54	56	PF00082	0.377
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.373
CLV_PCSK_SKI1_1	281	285	PF00082	0.671
CLV_PCSK_SKI1_1	51	55	PF00082	0.374
DEG_Nend_UBRbox_2	1	3	PF02207	0.315
DOC_CKS1_1	158	163	PF01111	0.451
DOC_CYCLIN_yCln2_LP_2	119	125	PF00134	0.408
DOC_CYCLIN_yCln2_LP_2	140	146	PF00134	0.524
DOC_MAPK_MEF2A_6	75	82	PF00069	0.524
DOC_PP2B_LxvP_1	91	94	PF13499	0.354
DOC_USP7_MATH_1	161	165	PF00917	0.437
DOC_USP7_MATH_1	187	191	PF00917	0.192
DOC_USP7_MATH_1	81	85	PF00917	0.303
DOC_USP7_UBL2_3	147	151	PF12436	0.524
DOC_WW_Pin1_4	118	123	PF00397	0.405
DOC_WW_Pin1_4	157	162	PF00397	0.437
LIG_14-3-3_CanoR_1	216	226	PF00244	0.172
LIG_BRCT_BRCA1_1	163	167	PF00533	0.442
LIG_BRCT_BRCA1_1	189	193	PF00533	0.192
LIG_BRCT_BRCA1_1	83	87	PF00533	0.302
LIG_deltaCOP1_diTrp_1	112	118	PF00928	0.271
LIG_eIF4E_1	180	186	PF01652	0.315
LIG_FHA_1	202	208	PF00498	0.282
LIG_FHA_1	253	259	PF00498	0.322
LIG_FHA_1	65	71	PF00498	0.612
LIG_FHA_1	7	13	PF00498	0.348
LIG_FHA_2	238	244	PF00498	0.237
LIG_LIR_Apic_2	155	161	PF02991	0.437
LIG_LIR_Apic_2	266	272	PF02991	0.411
LIG_LIR_Gen_1	104	113	PF02991	0.370
LIG_LIR_Gen_1	190	200	PF02991	0.348
LIG_LIR_Gen_1	2	13	PF02991	0.254
LIG_LIR_Gen_1	239	249	PF02991	0.239
LIG_LIR_Gen_1	45	53	PF02991	0.370
LIG_LIR_Gen_1	77	87	PF02991	0.441
LIG_LIR_Nem_3	104	110	PF02991	0.271
LIG_LIR_Nem_3	112	118	PF02991	0.237
LIG_LIR_Nem_3	129	134	PF02991	0.282
LIG_LIR_Nem_3	164	170	PF02991	0.492
LIG_LIR_Nem_3	190	196	PF02991	0.348
LIG_LIR_Nem_3	2	8	PF02991	0.321
LIG_LIR_Nem_3	234	238	PF02991	0.252
LIG_LIR_Nem_3	239	245	PF02991	0.239
LIG_LIR_Nem_3	271	277	PF02991	0.403
LIG_LIR_Nem_3	43	49	PF02991	0.305
LIG_LIR_Nem_3	77	82	PF02991	0.447
LIG_LIR_Nem_3	84	90	PF02991	0.284
LIG_LIR_Nem_3	9	14	PF02991	0.280
LIG_NRBOX	257	263	PF00104	0.413
LIG_PDZ_Class_1	298	303	PF00595	0.320
LIG_Pex14_2	182	186	PF04695	0.282
LIG_Pex14_2	193	197	PF04695	0.282
LIG_Pex14_2	213	217	PF04695	0.122
LIG_PTB_Apo_2	229	236	PF02174	0.292
LIG_PTB_Phospho_1	229	235	PF10480	0.292
LIG_SH2_CRK	107	111	PF00017	0.314
LIG_SH2_CRK	158	162	PF00017	0.486
LIG_SH2_NCK_1	107	111	PF00017	0.280
LIG_SH2_NCK_1	158	162	PF00017	0.468
LIG_SH2_SRC	233	236	PF00017	0.172
LIG_SH2_STAP1	103	107	PF00017	0.270
LIG_SH2_STAP1	238	242	PF00017	0.324
LIG_SH2_STAT5	117	120	PF00017	0.278
LIG_SH2_STAT5	134	137	PF00017	0.308
LIG_SH2_STAT5	158	161	PF00017	0.492
LIG_SH2_STAT5	180	183	PF00017	0.293
LIG_SH2_STAT5	184	187	PF00017	0.286
LIG_SH2_STAT5	238	241	PF00017	0.237
LIG_SH2_STAT5	38	41	PF00017	0.291
LIG_SH2_STAT5	46	49	PF00017	0.273
LIG_SUMO_SIM_par_1	203	209	PF11976	0.282
LIG_WRC_WIRS_1	8	13	PF05994	0.230
MOD_CK1_1	45	51	PF00069	0.287
MOD_GlcNHglycan	31	34	PF01048	0.380
MOD_GSK3_1	152	159	PF00069	0.441
MOD_GSK3_1	218	225	PF00069	0.242
MOD_GSK3_1	45	52	PF00069	0.445
MOD_N-GLC_1	108	113	PF02516	0.542
MOD_N-GLC_1	17	22	PF02516	0.504
MOD_N-GLC_1	218	223	PF02516	0.437
MOD_NEK2_1	152	157	PF00069	0.440
MOD_NEK2_1	188	193	PF00069	0.192
MOD_NEK2_1	217	222	PF00069	0.251
MOD_NEK2_1	245	250	PF00069	0.385
MOD_NEK2_1	298	303	PF00069	0.320
MOD_NEK2_1	40	45	PF00069	0.277
MOD_NEK2_1	7	12	PF00069	0.393
MOD_NEK2_2	203	208	PF00069	0.282
MOD_NEK2_2	222	227	PF00069	0.305
MOD_NEK2_2	49	54	PF00069	0.460
MOD_Plk_4	188	194	PF00069	0.355
MOD_Plk_4	237	243	PF00069	0.292
MOD_Plk_4	257	263	PF00069	0.285
MOD_Plk_4	7	13	PF00069	0.386
MOD_ProDKin_1	118	124	PF00069	0.405
MOD_ProDKin_1	157	163	PF00069	0.437
MOD_SUMO_rev_2	260	270	PF00179	0.400
TRG_DiLeu_BaEn_2	278	284	PF01217	0.440
TRG_DiLeu_BaEn_4	279	285	PF01217	0.385
TRG_ENDOCYTIC_2	103	106	PF00928	0.276
TRG_ENDOCYTIC_2	107	110	PF00928	0.273
TRG_ENDOCYTIC_2	117	120	PF00928	0.282
TRG_ENDOCYTIC_2	146	149	PF00928	0.437
TRG_ENDOCYTIC_2	179	182	PF00928	0.437
TRG_ENDOCYTIC_2	238	241	PF00928	0.237
TRG_ENDOCYTIC_2	38	41	PF00928	0.306
TRG_ER_diArg_1	296	299	PF00400	0.418
TRG_Pf-PMV_PEXEL_1	51	56	PF00026	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0E0SNE8	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	40%	94%
A0A0N1HQY0	Leptomonas seymouri	83%	100%
A0A0S4IWX4	Bodo saltans	55%	100%
A0A1X0NWS0	Trypanosomatidae	64%	100%
A0A3R7MRY7	Trypanosoma rangeli	59%	100%
A0A3S7WXZ2	Leishmania donovani	88%	100%
A4I0I8	Leishmania infantum	88%	100%
C9ZVB3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9AWF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
I1RFM2	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	39%	87%
O13666	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	92%
O75845	Homo sapiens	39%	100%
O88822	Mus musculus	41%	100%
O93875	Candida albicans	37%	78%
O94457	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	100%
P32353	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	83%
P50860	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	37%	83%
Q4QB22	Leishmania major	88%	100%
Q4WB51	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	35%	95%
Q4WDL3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	42%	86%
Q4WIX5	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	42%	90%
Q59VG6	Candida albicans (strain SC5314 / ATCC MYA-2876)	37%	78%
Q754B9	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	41%	86%
Q7SBB6	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	42%	88%
Q8J207	Leptosphaeria maculans	43%	85%
Q8NJ57	Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841)	40%	78%
Q9EQS5	Rattus norvegicus	42%	100%
Q9ZT29	Nicotiana tabacum	28%	100%