Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HD02_LEIBR

TriTrypDb:

LbrM.23.1410 , LBRM2903_230024300

Length:

677

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HD02

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD02

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.684
CLV_C14_Caspase3-7	189	193	PF00656	0.654
CLV_C14_Caspase3-7	293	297	PF00656	0.772
CLV_C14_Caspase3-7	509	513	PF00656	0.640
CLV_NRD_NRD_1	112	114	PF00675	0.514
CLV_NRD_NRD_1	27	29	PF00675	0.507
CLV_NRD_NRD_1	288	290	PF00675	0.544
CLV_NRD_NRD_1	293	295	PF00675	0.519
CLV_NRD_NRD_1	343	345	PF00675	0.564
CLV_NRD_NRD_1	463	465	PF00675	0.420
CLV_PCSK_FUR_1	110	114	PF00082	0.485
CLV_PCSK_KEX2_1	112	114	PF00082	0.519
CLV_PCSK_KEX2_1	27	29	PF00082	0.507
CLV_PCSK_KEX2_1	287	289	PF00082	0.544
CLV_PCSK_KEX2_1	343	345	PF00082	0.564
CLV_PCSK_KEX2_1	395	397	PF00082	0.473
CLV_PCSK_KEX2_1	44	46	PF00082	0.592
CLV_PCSK_PC1ET2_1	395	397	PF00082	0.467
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.471
CLV_PCSK_SKI1_1	124	128	PF00082	0.466
CLV_PCSK_SKI1_1	45	49	PF00082	0.565
CLV_PCSK_SKI1_1	470	474	PF00082	0.446
CLV_PCSK_SKI1_1	534	538	PF00082	0.570
CLV_PCSK_SKI1_1	557	561	PF00082	0.482
CLV_PCSK_SKI1_1	596	600	PF00082	0.507
DEG_APCC_DBOX_1	27	35	PF00400	0.671
DEG_Nend_UBRbox_3	1	3	PF02207	0.669
DEG_SCF_FBW7_1	386	393	PF00400	0.666
DEG_SCF_FBW7_1	49	56	PF00400	0.656
DEG_SPOP_SBC_1	255	259	PF00917	0.655
DEG_SPOP_SBC_1	277	281	PF00917	0.656
DEG_SPOP_SBC_1	401	405	PF00917	0.758
DEG_SPOP_SBC_1	478	482	PF00917	0.744
DEG_SPOP_SBC_1	53	57	PF00917	0.654
DOC_ANK_TNKS_1	569	576	PF00023	0.639
DOC_CKS1_1	97	102	PF01111	0.767
DOC_MAPK_gen_1	110	118	PF00069	0.673
DOC_MAPK_gen_1	374	381	PF00069	0.650
DOC_MAPK_MEF2A_6	374	381	PF00069	0.650
DOC_MAPK_MEF2A_6	646	654	PF00069	0.682
DOC_MAPK_NFAT4_5	374	382	PF00069	0.650
DOC_PP1_RVXF_1	341	348	PF00149	0.764
DOC_PP2B_LxvP_1	271	274	PF13499	0.653
DOC_PP2B_LxvP_1	363	366	PF13499	0.654
DOC_USP7_MATH_1	153	157	PF00917	0.697
DOC_USP7_MATH_1	162	166	PF00917	0.740
DOC_USP7_MATH_1	177	181	PF00917	0.670
DOC_USP7_MATH_1	204	208	PF00917	0.742
DOC_USP7_MATH_1	222	226	PF00917	0.631
DOC_USP7_MATH_1	253	257	PF00917	0.705
DOC_USP7_MATH_1	303	307	PF00917	0.753
DOC_USP7_MATH_1	366	370	PF00917	0.684
DOC_USP7_MATH_1	388	392	PF00917	0.716
DOC_USP7_MATH_1	4	8	PF00917	0.674
DOC_USP7_MATH_1	401	405	PF00917	0.717
DOC_USP7_MATH_1	435	439	PF00917	0.748
DOC_USP7_MATH_1	506	510	PF00917	0.643
DOC_USP7_MATH_1	549	553	PF00917	0.787
DOC_USP7_MATH_1	636	640	PF00917	0.660
DOC_USP7_MATH_1	663	667	PF00917	0.320
DOC_USP7_MATH_1	73	77	PF00917	0.684
DOC_USP7_UBL2_3	534	538	PF12436	0.757
DOC_WW_Pin1_4	133	138	PF00397	0.715
DOC_WW_Pin1_4	192	197	PF00397	0.719
DOC_WW_Pin1_4	233	238	PF00397	0.845
DOC_WW_Pin1_4	266	271	PF00397	0.754
DOC_WW_Pin1_4	333	338	PF00397	0.708
DOC_WW_Pin1_4	34	39	PF00397	0.729
DOC_WW_Pin1_4	384	389	PF00397	0.708
DOC_WW_Pin1_4	49	54	PF00397	0.776
DOC_WW_Pin1_4	632	637	PF00397	0.828
DOC_WW_Pin1_4	96	101	PF00397	0.768
LIG_14-3-3_CanoR_1	147	153	PF00244	0.654
LIG_14-3-3_CanoR_1	27	32	PF00244	0.707
LIG_14-3-3_CanoR_1	408	412	PF00244	0.648
LIG_14-3-3_CanoR_1	434	444	PF00244	0.741
LIG_14-3-3_CanoR_1	563	569	PF00244	0.744
LIG_14-3-3_CanoR_1	596	602	PF00244	0.709
LIG_APCC_ABBA_1	668	673	PF00400	0.247
LIG_BRCT_BRCA1_1	226	230	PF00533	0.654
LIG_BRCT_BRCA1_1	414	418	PF00533	0.648
LIG_BRCT_BRCA1_1	75	79	PF00533	0.659
LIG_Clathr_ClatBox_1	669	673	PF01394	0.247
LIG_deltaCOP1_diTrp_1	512	517	PF00928	0.639
LIG_FHA_1	196	202	PF00498	0.758
LIG_FHA_1	266	272	PF00498	0.725
LIG_FHA_1	302	308	PF00498	0.760
LIG_FHA_1	358	364	PF00498	0.747
LIG_FHA_1	381	387	PF00498	0.709
LIG_FHA_1	597	603	PF00498	0.707
LIG_FHA_2	149	155	PF00498	0.652
LIG_FHA_2	387	393	PF00498	0.709
LIG_LIR_Gen_1	138	148	PF02991	0.661
LIG_LIR_Gen_1	326	333	PF02991	0.642
LIG_LIR_Gen_1	634	643	PF02991	0.651
LIG_LIR_Gen_1	666	675	PF02991	0.320
LIG_LIR_LC3C_4	198	201	PF02991	0.645
LIG_LIR_Nem_3	138	144	PF02991	0.757
LIG_LIR_Nem_3	326	331	PF02991	0.656
LIG_LIR_Nem_3	50	54	PF02991	0.676
LIG_LIR_Nem_3	511	517	PF02991	0.639
LIG_LIR_Nem_3	567	572	PF02991	0.641
LIG_LIR_Nem_3	634	640	PF02991	0.654
LIG_LIR_Nem_3	666	670	PF02991	0.343
LIG_Pex14_2	667	671	PF04695	0.247
LIG_SH2_CRK	637	641	PF00017	0.655
LIG_SH2_GRB2like	543	546	PF00017	0.644
LIG_SH2_NCK_1	328	332	PF00017	0.642
LIG_SH2_SRC	526	529	PF00017	0.752
LIG_SH2_STAP1	543	547	PF00017	0.646
LIG_SH2_STAT5	328	331	PF00017	0.671
LIG_SH2_STAT5	601	604	PF00017	0.717
LIG_SH3_2	40	45	PF14604	0.754
LIG_SH3_3	171	177	PF00018	0.824
LIG_SH3_3	264	270	PF00018	0.731
LIG_SH3_3	309	315	PF00018	0.831
LIG_SH3_3	33	39	PF00018	0.768
LIG_SH3_3	438	444	PF00018	0.648
LIG_SH3_3	525	531	PF00018	0.750
LIG_SH3_3	552	558	PF00018	0.656
LIG_SH3_3	581	587	PF00018	0.723
LIG_SH3_4	534	541	PF00018	0.756
LIG_SUMO_SIM_anti_2	195	201	PF11976	0.646
LIG_SUMO_SIM_anti_2	657	663	PF11976	0.247
LIG_SUMO_SIM_par_1	197	203	PF11976	0.695
LIG_SUMO_SIM_par_1	660	666	PF11976	0.344
LIG_TRAF2_1	87	90	PF00917	0.658
LIG_TYR_ITSM	633	640	PF00017	0.654
LIG_WRC_WIRS_1	48	53	PF05994	0.656
LIG_WRC_WIRS_1	664	669	PF05994	0.320
MOD_CDK_SPK_2	333	338	PF00069	0.638
MOD_CDK_SPxxK_3	233	240	PF00069	0.657
MOD_CDK_SPxxK_3	96	103	PF00069	0.768
MOD_CK1_1	10	16	PF00069	0.734
MOD_CK1_1	102	108	PF00069	0.717
MOD_CK1_1	175	181	PF00069	0.778
MOD_CK1_1	186	192	PF00069	0.722
MOD_CK1_1	195	201	PF00069	0.742
MOD_CK1_1	214	220	PF00069	0.635
MOD_CK1_1	221	227	PF00069	0.713
MOD_CK1_1	235	241	PF00069	0.720
MOD_CK1_1	256	262	PF00069	0.725
MOD_CK1_1	269	275	PF00069	0.622
MOD_CK1_1	283	289	PF00069	0.733
MOD_CK1_1	290	296	PF00069	0.738
MOD_CK1_1	3	9	PF00069	0.770
MOD_CK1_1	302	308	PF00069	0.780
MOD_CK1_1	323	329	PF00069	0.709
MOD_CK1_1	370	376	PF00069	0.752
MOD_CK1_1	382	388	PF00069	0.752
MOD_CK1_1	404	410	PF00069	0.727
MOD_CK1_1	412	418	PF00069	0.712
MOD_CK1_1	456	462	PF00069	0.642
MOD_CK1_1	480	486	PF00069	0.852
MOD_CK1_1	495	501	PF00069	0.675
MOD_CK1_1	515	521	PF00069	0.630
MOD_CK1_1	541	547	PF00069	0.760
MOD_CK1_1	564	570	PF00069	0.677
MOD_CK1_1	589	595	PF00069	0.696
MOD_CK1_1	621	627	PF00069	0.762
MOD_CK1_1	639	645	PF00069	0.811
MOD_CK2_1	148	154	PF00069	0.652
MOD_CK2_1	315	321	PF00069	0.732
MOD_CK2_1	414	420	PF00069	0.647
MOD_CK2_1	473	479	PF00069	0.656
MOD_CK2_1	484	490	PF00069	0.640
MOD_CMANNOS	566	569	PF00535	0.555
MOD_GlcNHglycan	12	15	PF01048	0.583
MOD_GlcNHglycan	154	158	PF01048	0.517
MOD_GlcNHglycan	164	167	PF01048	0.525
MOD_GlcNHglycan	174	177	PF01048	0.631
MOD_GlcNHglycan	180	183	PF01048	0.618
MOD_GlcNHglycan	202	205	PF01048	0.554
MOD_GlcNHglycan	220	223	PF01048	0.440
MOD_GlcNHglycan	224	227	PF01048	0.512
MOD_GlcNHglycan	237	240	PF01048	0.534
MOD_GlcNHglycan	271	274	PF01048	0.506
MOD_GlcNHglycan	282	285	PF01048	0.512
MOD_GlcNHglycan	296	300	PF01048	0.505
MOD_GlcNHglycan	301	304	PF01048	0.503
MOD_GlcNHglycan	321	325	PF01048	0.535
MOD_GlcNHglycan	369	372	PF01048	0.513
MOD_GlcNHglycan	411	414	PF01048	0.513
MOD_GlcNHglycan	451	454	PF01048	0.619
MOD_GlcNHglycan	455	458	PF01048	0.578
MOD_GlcNHglycan	486	489	PF01048	0.534
MOD_GlcNHglycan	497	500	PF01048	0.541
MOD_GlcNHglycan	514	517	PF01048	0.493
MOD_GlcNHglycan	522	525	PF01048	0.450
MOD_GlcNHglycan	620	623	PF01048	0.629
MOD_GSK3_1	14	21	PF00069	0.672
MOD_GSK3_1	183	190	PF00069	0.816
MOD_GSK3_1	200	207	PF00069	0.696
MOD_GSK3_1	210	217	PF00069	0.682
MOD_GSK3_1	218	225	PF00069	0.697
MOD_GSK3_1	23	30	PF00069	0.718
MOD_GSK3_1	231	238	PF00069	0.649
MOD_GSK3_1	265	272	PF00069	0.717
MOD_GSK3_1	276	283	PF00069	0.699
MOD_GSK3_1	290	297	PF00069	0.753
MOD_GSK3_1	299	306	PF00069	0.811
MOD_GSK3_1	3	10	PF00069	0.809
MOD_GSK3_1	315	322	PF00069	0.775
MOD_GSK3_1	357	364	PF00069	0.801
MOD_GSK3_1	366	373	PF00069	0.758
MOD_GSK3_1	380	387	PF00069	0.714
MOD_GSK3_1	396	403	PF00069	0.725
MOD_GSK3_1	407	414	PF00069	0.706
MOD_GSK3_1	449	456	PF00069	0.733
MOD_GSK3_1	473	480	PF00069	0.756
MOD_GSK3_1	49	56	PF00069	0.771
MOD_GSK3_1	495	502	PF00069	0.670
MOD_GSK3_1	508	515	PF00069	0.690
MOD_GSK3_1	549	556	PF00069	0.720
MOD_GSK3_1	557	564	PF00069	0.622
MOD_GSK3_1	627	634	PF00069	0.747
MOD_GSK3_1	635	642	PF00069	0.728
MOD_GSK3_1	92	99	PF00069	0.734
MOD_LATS_1	292	298	PF00433	0.661
MOD_N-GLC_1	160	165	PF02516	0.462
MOD_N-GLC_1	170	175	PF02516	0.467
MOD_N-GLC_1	183	188	PF02516	0.562
MOD_N-GLC_1	211	216	PF02516	0.543
MOD_N-GLC_1	248	253	PF02516	0.518
MOD_N-GLC_1	401	406	PF02516	0.558
MOD_N-GLC_1	483	488	PF02516	0.458
MOD_NEK2_1	230	235	PF00069	0.760
MOD_NEK2_1	278	283	PF00069	0.662
MOD_NEK2_1	301	306	PF00069	0.698
MOD_NEK2_1	379	384	PF00069	0.675
MOD_NEK2_1	409	414	PF00069	0.678
MOD_NEK2_1	517	522	PF00069	0.648
MOD_NEK2_1	54	59	PF00069	0.658
MOD_NEK2_1	559	564	PF00069	0.718
MOD_NEK2_1	8	13	PF00069	0.721
MOD_NEK2_1	92	97	PF00069	0.775
MOD_NEK2_2	636	641	PF00069	0.654
MOD_OFUCOSY	320	327	PF10250	0.441
MOD_PIKK_1	183	189	PF00454	0.666
MOD_PIKK_1	248	254	PF00454	0.719
MOD_PIKK_1	310	316	PF00454	0.649
MOD_PIKK_1	447	453	PF00454	0.643
MOD_PIKK_1	473	479	PF00454	0.656
MOD_PIKK_1	561	567	PF00454	0.642
MOD_PK_1	112	118	PF00069	0.673
MOD_PK_1	170	176	PF00069	0.698
MOD_PKA_1	112	118	PF00069	0.690
MOD_PKA_1	27	33	PF00069	0.673
MOD_PKA_1	287	293	PF00069	0.660
MOD_PKA_1	294	300	PF00069	0.647
MOD_PKA_2	102	108	PF00069	0.780
MOD_PKA_2	112	118	PF00069	0.710
MOD_PKA_2	23	29	PF00069	0.764
MOD_PKA_2	287	293	PF00069	0.701
MOD_PKA_2	315	321	PF00069	0.772
MOD_PKA_2	367	373	PF00069	0.757
MOD_PKA_2	407	413	PF00069	0.651
MOD_PKA_2	541	547	PF00069	0.756
MOD_PKA_2	59	65	PF00069	0.742
MOD_PKB_1	110	118	PF00069	0.673
MOD_PKB_1	145	153	PF00069	0.633
MOD_PKB_1	168	176	PF00069	0.666
MOD_Plk_1	103	109	PF00069	0.808
MOD_Plk_1	160	166	PF00069	0.685
MOD_Plk_1	183	189	PF00069	0.666
MOD_Plk_1	214	220	PF00069	0.694
MOD_Plk_2-3	104	110	PF00069	0.782
MOD_Plk_4	256	262	PF00069	0.697
MOD_Plk_4	589	595	PF00069	0.712
MOD_Plk_4	597	603	PF00069	0.707
MOD_Plk_4	657	663	PF00069	0.316
MOD_ProDKin_1	133	139	PF00069	0.715
MOD_ProDKin_1	192	198	PF00069	0.718
MOD_ProDKin_1	233	239	PF00069	0.844
MOD_ProDKin_1	266	272	PF00069	0.754
MOD_ProDKin_1	333	339	PF00069	0.708
MOD_ProDKin_1	34	40	PF00069	0.729
MOD_ProDKin_1	384	390	PF00069	0.706
MOD_ProDKin_1	49	55	PF00069	0.776
MOD_ProDKin_1	632	638	PF00069	0.827
MOD_ProDKin_1	96	102	PF00069	0.767
TRG_ENDOCYTIC_2	328	331	PF00928	0.671
TRG_ENDOCYTIC_2	637	640	PF00928	0.655
TRG_ER_diArg_1	110	113	PF00400	0.699
TRG_ER_diArg_1	144	147	PF00400	0.645
TRG_ER_diArg_1	287	289	PF00400	0.748
TRG_ER_diArg_1	343	345	PF00400	0.764
TRG_ER_diArg_1	374	377	PF00400	0.718
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IFX5	Leishmania donovani	52%	98%
A4I0I7	Leishmania infantum	52%	98%
E9AWE9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
Q4QB23	Leishmania major	52%	100%