Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HCZ9_LEIBR

TriTrypDb:

LbrM.23.1380 , LBRM2903_230023900

Length:

378

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HCZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCZ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	16	18	PF00675	0.438
CLV_NRD_NRD_1	224	226	PF00675	0.558
CLV_PCSK_KEX2_1	16	18	PF00082	0.438
CLV_PCSK_KEX2_1	224	226	PF00082	0.558
CLV_PCSK_SKI1_1	103	107	PF00082	0.404
CLV_PCSK_SKI1_1	129	133	PF00082	0.477
DEG_COP1_1	249	258	PF00400	0.630
DEG_Nend_UBRbox_2	1	3	PF02207	0.602
DOC_CKS1_1	212	217	PF01111	0.643
DOC_MAPK_gen_1	16	23	PF00069	0.575
DOC_PP2B_LxvP_1	264	267	PF13499	0.628
DOC_PP4_FxxP_1	212	215	PF00568	0.641
DOC_PP4_FxxP_1	350	353	PF00568	0.627
DOC_USP7_MATH_1	133	137	PF00917	0.735
DOC_USP7_MATH_1	166	170	PF00917	0.644
DOC_USP7_MATH_1	171	175	PF00917	0.753
DOC_USP7_MATH_1	182	186	PF00917	0.706
DOC_USP7_MATH_1	204	208	PF00917	0.706
DOC_USP7_MATH_1	213	217	PF00917	0.754
DOC_USP7_MATH_1	285	289	PF00917	0.650
DOC_USP7_MATH_1	313	317	PF00917	0.629
DOC_WW_Pin1_4	116	121	PF00397	0.668
DOC_WW_Pin1_4	122	127	PF00397	0.690
DOC_WW_Pin1_4	137	142	PF00397	0.712
DOC_WW_Pin1_4	211	216	PF00397	0.756
DOC_WW_Pin1_4	227	232	PF00397	0.601
DOC_WW_Pin1_4	289	294	PF00397	0.712
DOC_WW_Pin1_4	368	373	PF00397	0.661
LIG_14-3-3_CanoR_1	137	141	PF00244	0.697
LIG_14-3-3_CanoR_1	208	215	PF00244	0.687
LIG_14-3-3_CanoR_1	224	229	PF00244	0.720
LIG_APCC_ABBA_1	95	100	PF00400	0.653
LIG_BRCT_BRCA1_1	173	177	PF00533	0.698
LIG_BRCT_BRCA1_1	185	189	PF00533	0.774
LIG_BRCT_BRCA1_1	268	272	PF00533	0.630
LIG_Clathr_ClatBox_1	146	150	PF01394	0.648
LIG_CSL_BTD_1	303	306	PF09270	0.719
LIG_FHA_1	27	33	PF00498	0.308
LIG_FHA_1	49	55	PF00498	0.247
LIG_LIR_Apic_2	210	215	PF02991	0.640
LIG_LIR_Gen_1	186	196	PF02991	0.716
LIG_LIR_Nem_3	186	192	PF02991	0.713
LIG_PAM2_1	118	130	PF00658	0.623
LIG_PCNA_yPIPBox_3	85	95	PF02747	0.676
LIG_Pex14_1	127	131	PF04695	0.624
LIG_Pex14_1	55	59	PF04695	0.405
LIG_SH2_STAT5	66	69	PF00017	0.548
LIG_SH2_STAT5	98	101	PF00017	0.694
LIG_SH3_3	114	120	PF00018	0.634
LIG_SH3_3	300	306	PF00018	0.655
LIG_SH3_3	31	37	PF00018	0.405
LIG_SH3_3	91	97	PF00018	0.695
LIG_SUMO_SIM_par_1	352	357	PF11976	0.628
LIG_SUMO_SIM_par_1	38	45	PF11976	0.480
LIG_TRAF2_1	197	200	PF00917	0.736
MOD_CDK_SPK_2	227	232	PF00069	0.576
MOD_CDK_SPxK_1	211	217	PF00069	0.558
MOD_CDK_SPxxK_3	122	129	PF00069	0.507
MOD_CDK_SPxxK_3	137	144	PF00069	0.485
MOD_CK1_1	118	124	PF00069	0.711
MOD_CK1_1	136	142	PF00069	0.487
MOD_CK1_1	207	213	PF00069	0.601
MOD_CK1_1	218	224	PF00069	0.613
MOD_CK1_1	227	233	PF00069	0.572
MOD_CK1_1	262	268	PF00069	0.775
MOD_CK1_1	273	279	PF00069	0.643
MOD_CK1_1	371	377	PF00069	0.554
MOD_CK2_1	194	200	PF00069	0.770
MOD_Cter_Amidation	222	225	PF01082	0.677
MOD_DYRK1A_RPxSP_1	137	141	PF00069	0.670
MOD_GlcNHglycan	158	161	PF01048	0.694
MOD_GlcNHglycan	162	165	PF01048	0.654
MOD_GlcNHglycan	168	171	PF01048	0.481
MOD_GlcNHglycan	178	181	PF01048	0.636
MOD_GlcNHglycan	185	188	PF01048	0.564
MOD_GlcNHglycan	221	224	PF01048	0.774
MOD_GlcNHglycan	23	26	PF01048	0.258
MOD_GlcNHglycan	268	271	PF01048	0.601
MOD_GlcNHglycan	285	288	PF01048	0.562
MOD_GlcNHglycan	327	330	PF01048	0.536
MOD_GlcNHglycan	373	376	PF01048	0.532
MOD_GSK3_1	115	122	PF00069	0.645
MOD_GSK3_1	133	140	PF00069	0.542
MOD_GSK3_1	152	159	PF00069	0.541
MOD_GSK3_1	166	173	PF00069	0.706
MOD_GSK3_1	178	185	PF00069	0.647
MOD_GSK3_1	207	214	PF00069	0.677
MOD_GSK3_1	215	222	PF00069	0.641
MOD_GSK3_1	246	253	PF00069	0.707
MOD_GSK3_1	262	269	PF00069	0.687
MOD_GSK3_1	273	280	PF00069	0.610
MOD_GSK3_1	283	290	PF00069	0.560
MOD_GSK3_1	318	325	PF00069	0.610
MOD_N-GLC_1	156	161	PF02516	0.697
MOD_N-GLC_1	270	275	PF02516	0.524
MOD_NEK2_1	105	110	PF00069	0.500
MOD_NEK2_1	176	181	PF00069	0.651
MOD_NEK2_1	183	188	PF00069	0.558
MOD_NEK2_1	192	197	PF00069	0.489
MOD_NEK2_1	21	26	PF00069	0.247
MOD_NEK2_1	373	378	PF00069	0.531
MOD_NEK2_1	81	86	PF00069	0.416
MOD_NEK2_2	318	323	PF00069	0.524
MOD_PIKK_1	287	293	PF00454	0.519
MOD_PKA_1	224	230	PF00069	0.542
MOD_PKA_2	106	112	PF00069	0.510
MOD_PKA_2	136	142	PF00069	0.517
MOD_PKA_2	207	213	PF00069	0.535
MOD_PKA_2	218	224	PF00069	0.574
MOD_PKB_1	217	225	PF00069	0.554
MOD_Plk_1	199	205	PF00069	0.523
MOD_Plk_1	99	105	PF00069	0.560
MOD_Plk_2-3	254	260	PF00069	0.613
MOD_Plk_4	259	265	PF00069	0.530
MOD_Plk_4	26	32	PF00069	0.308
MOD_Plk_4	48	54	PF00069	0.405
MOD_ProDKin_1	116	122	PF00069	0.572
MOD_ProDKin_1	137	143	PF00069	0.674
MOD_ProDKin_1	211	217	PF00069	0.698
MOD_ProDKin_1	227	233	PF00069	0.474
MOD_ProDKin_1	289	295	PF00069	0.636
MOD_ProDKin_1	368	374	PF00069	0.564
TRG_DiLeu_BaEn_1	100	105	PF01217	0.564
TRG_DiLeu_BaEn_1	259	264	PF01217	0.531
TRG_DiLeu_BaLyEn_6	34	39	PF01217	0.405
TRG_DiLeu_LyEn_5	100	105	PF01217	0.467
TRG_ER_diArg_1	15	17	PF00400	0.537
TRG_Pf-PMV_PEXEL_1	65	70	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WXU4	Leishmania donovani	64%	100%
A4I0I4	Leishmania infantum	64%	100%
E9AWE6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	97%
Q4QB26	Leishmania major	64%	100%