Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCZ8_LEIBR

TriTrypDb:

LbrM.23.1370 , LBRM2903_230023800

Length:

269

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCZ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCZ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.738
CLV_C14_Caspase3-7	28	32	PF00656	0.555
CLV_NRD_NRD_1	178	180	PF00675	0.610
CLV_NRD_NRD_1	188	190	PF00675	0.547
CLV_NRD_NRD_1	239	241	PF00675	0.489
CLV_NRD_NRD_1	33	35	PF00675	0.569
CLV_NRD_NRD_1	94	96	PF00675	0.652
CLV_PCSK_KEX2_1	178	180	PF00082	0.688
CLV_PCSK_KEX2_1	190	192	PF00082	0.596
CLV_PCSK_KEX2_1	239	241	PF00082	0.489
CLV_PCSK_KEX2_1	264	266	PF00082	0.544
CLV_PCSK_KEX2_1	33	35	PF00082	0.569
CLV_PCSK_KEX2_1	49	51	PF00082	0.591
CLV_PCSK_KEX2_1	93	95	PF00082	0.657
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.663
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.468
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.562
CLV_PCSK_PC7_1	260	266	PF00082	0.489
CLV_PCSK_SKI1_1	158	162	PF00082	0.607
CLV_PCSK_SKI1_1	178	182	PF00082	0.397
CLV_PCSK_SKI1_1	191	195	PF00082	0.575
CLV_PCSK_SKI1_1	34	38	PF00082	0.570
CLV_PCSK_SKI1_1	50	54	PF00082	0.706
CLV_PCSK_SKI1_1	97	101	PF00082	0.756
DEG_SPOP_SBC_1	16	20	PF00917	0.778
DOC_CYCLIN_RxL_1	152	164	PF00134	0.709
DOC_CYCLIN_RxL_1	93	105	PF00134	0.647
DOC_CYCLIN_yCln2_LP_2	53	56	PF00134	0.550
DOC_MAPK_gen_1	93	101	PF00069	0.622
DOC_PP2B_LxvP_1	213	216	PF13499	0.528
DOC_PP2B_LxvP_1	53	56	PF13499	0.550
DOC_USP7_MATH_1	119	123	PF00917	0.476
DOC_USP7_MATH_1	148	152	PF00917	0.741
DOC_USP7_MATH_1	17	21	PF00917	0.781
DOC_USP7_MATH_1	195	199	PF00917	0.629
DOC_USP7_MATH_1	43	47	PF00917	0.693
DOC_USP7_MATH_1	56	60	PF00917	0.747
DOC_USP7_MATH_1	8	12	PF00917	0.733
DOC_USP7_MATH_2	27	33	PF00917	0.555
DOC_WW_Pin1_4	23	28	PF00397	0.584
DOC_WW_Pin1_4	79	84	PF00397	0.594
LIG_14-3-3_CanoR_1	158	163	PF00244	0.607
LIG_14-3-3_CanoR_1	94	100	PF00244	0.601
LIG_BRCT_BRCA1_1	103	107	PF00533	0.738
LIG_FHA_1	140	146	PF00498	0.616
LIG_FHA_1	96	102	PF00498	0.627
LIG_FHA_2	112	118	PF00498	0.557
LIG_FHA_2	159	165	PF00498	0.599
LIG_FHA_2	224	230	PF00498	0.600
LIG_FHA_2	85	91	PF00498	0.647
LIG_Integrin_RGD_1	12	14	PF01839	0.557
LIG_PCNA_yPIPBox_3	124	136	PF02747	0.452
LIG_Pex14_2	107	111	PF04695	0.635
LIG_SH2_SRC	221	224	PF00017	0.492
LIG_SH2_STAP1	168	172	PF00017	0.682
LIG_SH2_STAP1	241	245	PF00017	0.645
LIG_SH3_3	49	55	PF00018	0.557
LIG_SUMO_SIM_par_1	134	143	PF11976	0.435
LIG_SUMO_SIM_par_1	158	164	PF11976	0.704
LIG_TRAF2_1	161	164	PF00917	0.583
MOD_CDK_SPxK_1	79	85	PF00069	0.559
MOD_CK1_1	15	21	PF00069	0.735
MOD_CK1_1	151	157	PF00069	0.741
MOD_CK1_1	208	214	PF00069	0.763
MOD_CK1_1	22	28	PF00069	0.661
MOD_CK1_1	59	65	PF00069	0.569
MOD_CK1_1	76	82	PF00069	0.617
MOD_CK1_1	84	90	PF00069	0.698
MOD_CK2_1	111	117	PF00069	0.616
MOD_CK2_1	158	164	PF00069	0.604
MOD_CK2_1	223	229	PF00069	0.618
MOD_CK2_1	23	29	PF00069	0.691
MOD_CK2_1	84	90	PF00069	0.656
MOD_GlcNHglycan	148	151	PF01048	0.591
MOD_GlcNHglycan	197	200	PF01048	0.731
MOD_GlcNHglycan	21	24	PF01048	0.730
MOD_GlcNHglycan	210	213	PF01048	0.731
MOD_GSK3_1	19	26	PF00069	0.675
MOD_GSK3_1	191	198	PF00069	0.711
MOD_GSK3_1	62	69	PF00069	0.816
MOD_GSK3_1	75	82	PF00069	0.705
MOD_GSK3_1	8	15	PF00069	0.725
MOD_GSK3_1	84	91	PF00069	0.627
MOD_NEK2_1	111	116	PF00069	0.461
MOD_NEK2_1	138	143	PF00069	0.670
MOD_NEK2_1	146	151	PF00069	0.403
MOD_NEK2_1	258	263	PF00069	0.549
MOD_NEK2_2	119	124	PF00069	0.476
MOD_PK_1	12	18	PF00069	0.779
MOD_PKB_1	189	197	PF00069	0.748
MOD_PKB_1	93	101	PF00069	0.516
MOD_Plk_1	119	125	PF00069	0.529
MOD_Plk_2-3	223	229	PF00069	0.451
MOD_Plk_4	95	101	PF00069	0.621
MOD_ProDKin_1	23	29	PF00069	0.585
MOD_ProDKin_1	79	85	PF00069	0.594
TRG_DiLeu_BaLyEn_6	141	146	PF01217	0.445
TRG_ER_diArg_1	177	179	PF00400	0.718
TRG_ER_diArg_1	188	191	PF00400	0.579
TRG_ER_diArg_1	238	240	PF00400	0.479
TRG_ER_diArg_1	93	95	PF00400	0.595
TRG_NLS_Bipartite_1	178	193	PF00514	0.703
TRG_Pf-PMV_PEXEL_1	158	163	PF00026	0.597

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4W9	Leptomonas seymouri	49%	100%
A0A3S7WXU2	Leishmania donovani	71%	100%
A4I0I3	Leishmania infantum	70%	100%
E9AWE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
Q4QB27	Leishmania major	70%	100%