Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCZ5_LEIBR

TriTrypDb:

LbrM.23.1340 , LBRM2903_230023300 , LBRM2903_230023400

Length:

715

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCZ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCZ5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.610
CLV_C14_Caspase3-7	275	279	PF00656	0.723
CLV_C14_Caspase3-7	429	433	PF00656	0.329
CLV_C14_Caspase3-7	591	595	PF00656	0.521
CLV_NRD_NRD_1	244	246	PF00675	0.432
CLV_NRD_NRD_1	3	5	PF00675	0.283
CLV_NRD_NRD_1	311	313	PF00675	0.534
CLV_NRD_NRD_1	317	319	PF00675	0.573
CLV_NRD_NRD_1	361	363	PF00675	0.374
CLV_NRD_NRD_1	372	374	PF00675	0.425
CLV_NRD_NRD_1	463	465	PF00675	0.441
CLV_NRD_NRD_1	468	470	PF00675	0.452
CLV_NRD_NRD_1	478	480	PF00675	0.462
CLV_NRD_NRD_1	56	58	PF00675	0.364
CLV_NRD_NRD_1	644	646	PF00675	0.409
CLV_NRD_NRD_1	651	653	PF00675	0.399
CLV_NRD_NRD_1	665	667	PF00675	0.512
CLV_NRD_NRD_1	688	690	PF00675	0.454
CLV_NRD_NRD_1	694	696	PF00675	0.503
CLV_NRD_NRD_1	94	96	PF00675	0.502
CLV_PCSK_FUR_1	370	374	PF00082	0.543
CLV_PCSK_KEX2_1	244	246	PF00082	0.458
CLV_PCSK_KEX2_1	3	5	PF00082	0.265
CLV_PCSK_KEX2_1	316	318	PF00082	0.639
CLV_PCSK_KEX2_1	361	363	PF00082	0.374
CLV_PCSK_KEX2_1	372	374	PF00082	0.425
CLV_PCSK_KEX2_1	463	465	PF00082	0.445
CLV_PCSK_KEX2_1	468	470	PF00082	0.454
CLV_PCSK_KEX2_1	478	480	PF00082	0.455
CLV_PCSK_KEX2_1	58	60	PF00082	0.361
CLV_PCSK_KEX2_1	644	646	PF00082	0.414
CLV_PCSK_KEX2_1	664	666	PF00082	0.381
CLV_PCSK_KEX2_1	687	689	PF00082	0.473
CLV_PCSK_KEX2_1	94	96	PF00082	0.502
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.356
CLV_PCSK_PC1ET2_1	687	689	PF00082	0.473
CLV_PCSK_PC7_1	312	318	PF00082	0.597
CLV_PCSK_PC7_1	464	470	PF00082	0.347
CLV_PCSK_PC7_1	90	96	PF00082	0.573
CLV_PCSK_SKI1_1	105	109	PF00082	0.507
CLV_PCSK_SKI1_1	228	232	PF00082	0.522
CLV_PCSK_SKI1_1	239	243	PF00082	0.345
CLV_PCSK_SKI1_1	494	498	PF00082	0.555
CLV_PCSK_SKI1_1	52	56	PF00082	0.457
CLV_PCSK_SKI1_1	59	63	PF00082	0.497
CLV_PCSK_SKI1_1	613	617	PF00082	0.453
DEG_APCC_DBOX_1	195	203	PF00400	0.530
DEG_Nend_Nbox_1	1	3	PF02207	0.475
DEG_SPOP_SBC_1	109	113	PF00917	0.637
DEG_SPOP_SBC_1	119	123	PF00917	0.575
DOC_CKS1_1	413	418	PF01111	0.388
DOC_CKS1_1	616	621	PF01111	0.338
DOC_CYCLIN_yCln2_LP_2	304	310	PF00134	0.527
DOC_MAPK_gen_1	700	709	PF00069	0.605
DOC_MAPK_MEF2A_6	3	12	PF00069	0.359
DOC_MAPK_MEF2A_6	334	342	PF00069	0.452
DOC_PP1_SILK_1	308	313	PF00149	0.531
DOC_PP2B_LxvP_1	304	307	PF13499	0.657
DOC_PP2B_LxvP_1	321	324	PF13499	0.667
DOC_PP4_FxxP_1	496	499	PF00568	0.456
DOC_PP4_FxxP_1	581	584	PF00568	0.507
DOC_USP7_MATH_1	110	114	PF00917	0.693
DOC_USP7_MATH_1	142	146	PF00917	0.744
DOC_USP7_MATH_1	149	153	PF00917	0.792
DOC_USP7_MATH_1	529	533	PF00917	0.596
DOC_USP7_MATH_1	557	561	PF00917	0.716
DOC_WW_Pin1_4	297	302	PF00397	0.571
DOC_WW_Pin1_4	319	324	PF00397	0.584
DOC_WW_Pin1_4	408	413	PF00397	0.582
DOC_WW_Pin1_4	494	499	PF00397	0.515
DOC_WW_Pin1_4	513	518	PF00397	0.573
DOC_WW_Pin1_4	615	620	PF00397	0.347
LIG_14-3-3_CanoR_1	196	200	PF00244	0.526
LIG_14-3-3_CanoR_1	228	234	PF00244	0.455
LIG_14-3-3_CanoR_1	244	252	PF00244	0.303
LIG_14-3-3_CanoR_1	316	324	PF00244	0.475
LIG_14-3-3_CanoR_1	332	338	PF00244	0.446
LIG_14-3-3_CanoR_1	700	709	PF00244	0.695
LIG_Actin_WH2_2	204	220	PF00022	0.381
LIG_Actin_WH2_2	608	623	PF00022	0.566
LIG_APCC_ABBA_1	74	79	PF00400	0.569
LIG_BIR_III_2	141	145	PF00653	0.736
LIG_BRCT_BRCA1_1	245	249	PF00533	0.312
LIG_CtBP_PxDLS_1	78	82	PF00389	0.524
LIG_deltaCOP1_diTrp_1	26	33	PF00928	0.281
LIG_FHA_1	12	18	PF00498	0.281
LIG_FHA_1	158	164	PF00498	0.564
LIG_FHA_1	298	304	PF00498	0.600
LIG_FHA_1	347	353	PF00498	0.398
LIG_FHA_1	387	393	PF00498	0.401
LIG_FHA_1	413	419	PF00498	0.464
LIG_FHA_1	442	448	PF00498	0.424
LIG_FHA_1	528	534	PF00498	0.628
LIG_FHA_2	189	195	PF00498	0.511
LIG_FHA_2	556	562	PF00498	0.717
LIG_FHA_2	66	72	PF00498	0.501
LIG_IRF3_LxIS_1	11	18	PF10401	0.274
LIG_LIR_Apic_2	495	499	PF02991	0.454
LIG_LIR_Apic_2	578	584	PF02991	0.505
LIG_LIR_Gen_1	432	441	PF02991	0.400
LIG_LIR_Gen_1	46	54	PF02991	0.383
LIG_LIR_Nem_3	246	252	PF02991	0.308
LIG_LIR_Nem_3	26	30	PF02991	0.281
LIG_LIR_Nem_3	432	437	PF02991	0.408
LIG_LIR_Nem_3	46	51	PF02991	0.249
LIG_MLH1_MIPbox_1	245	249	PF16413	0.312
LIG_NRBOX	689	695	PF00104	0.473
LIG_Pex14_2	367	371	PF04695	0.390
LIG_SH2_CRK	13	17	PF00017	0.281
LIG_SH2_PTP2	48	51	PF00017	0.374
LIG_SH2_STAP1	13	17	PF00017	0.281
LIG_SH2_STAP1	363	367	PF00017	0.362
LIG_SH2_STAP1	642	646	PF00017	0.509
LIG_SH2_STAP1	711	715	PF00017	0.448
LIG_SH2_STAT3	363	366	PF00017	0.435
LIG_SH2_STAT5	13	16	PF00017	0.281
LIG_SH2_STAT5	210	213	PF00017	0.472
LIG_SH2_STAT5	248	251	PF00017	0.392
LIG_SH2_STAT5	391	394	PF00017	0.565
LIG_SH2_STAT5	48	51	PF00017	0.374
LIG_SH3_2	414	419	PF14604	0.536
LIG_SH3_3	410	416	PF00018	0.608
LIG_SH3_3	495	501	PF00018	0.536
LIG_SH3_3	523	529	PF00018	0.740
LIG_SUMO_SIM_anti_2	270	278	PF11976	0.494
LIG_SUMO_SIM_anti_2	339	345	PF11976	0.478
LIG_SUMO_SIM_par_1	13	19	PF11976	0.274
LIG_SUMO_SIM_par_1	339	345	PF11976	0.549
LIG_TRAF2_1	672	675	PF00917	0.647
LIG_TYR_ITIM	11	16	PF00017	0.281
LIG_WW_3	322	326	PF00397	0.443
MOD_CDC14_SPxK_1	322	325	PF00782	0.448
MOD_CDK_SPxK_1	319	325	PF00069	0.467
MOD_CDK_SPxK_1	615	621	PF00069	0.344
MOD_CDK_SPxxK_3	412	419	PF00069	0.474
MOD_CK1_1	118	124	PF00069	0.713
MOD_CK1_1	154	160	PF00069	0.768
MOD_CK1_1	234	240	PF00069	0.454
MOD_CK1_1	319	325	PF00069	0.480
MOD_CK1_1	405	411	PF00069	0.499
MOD_CK1_1	492	498	PF00069	0.504
MOD_CK1_1	531	537	PF00069	0.670
MOD_CK1_1	656	662	PF00069	0.579
MOD_CK2_1	142	148	PF00069	0.555
MOD_CK2_1	188	194	PF00069	0.586
MOD_CK2_1	333	339	PF00069	0.467
MOD_CK2_1	342	348	PF00069	0.415
MOD_CK2_1	555	561	PF00069	0.664
MOD_CK2_1	65	71	PF00069	0.525
MOD_CK2_1	669	675	PF00069	0.646
MOD_GlcNHglycan	113	116	PF01048	0.732
MOD_GlcNHglycan	117	120	PF01048	0.748
MOD_GlcNHglycan	135	138	PF01048	0.516
MOD_GlcNHglycan	144	147	PF01048	0.688
MOD_GlcNHglycan	153	156	PF01048	0.737
MOD_GlcNHglycan	233	236	PF01048	0.440
MOD_GlcNHglycan	265	268	PF01048	0.473
MOD_GlcNHglycan	404	407	PF01048	0.731
MOD_GlcNHglycan	491	494	PF01048	0.486
MOD_GlcNHglycan	518	521	PF01048	0.588
MOD_GlcNHglycan	534	537	PF01048	0.680
MOD_GlcNHglycan	548	552	PF01048	0.657
MOD_GlcNHglycan	678	681	PF01048	0.537
MOD_GlcNHglycan	703	706	PF01048	0.585
MOD_GSK3_1	11	18	PF00069	0.305
MOD_GSK3_1	111	118	PF00069	0.599
MOD_GSK3_1	150	157	PF00069	0.663
MOD_GSK3_1	178	185	PF00069	0.583
MOD_GSK3_1	269	276	PF00069	0.750
MOD_GSK3_1	342	349	PF00069	0.479
MOD_GSK3_1	387	394	PF00069	0.525
MOD_GSK3_1	408	415	PF00069	0.720
MOD_GSK3_1	527	534	PF00069	0.630
MOD_GSK3_1	539	546	PF00069	0.648
MOD_LATS_1	162	168	PF00433	0.510
MOD_N-GLC_1	149	154	PF02516	0.519
MOD_N-GLC_1	170	175	PF02516	0.563
MOD_N-GLC_1	263	268	PF02516	0.618
MOD_N-GLC_1	574	579	PF02516	0.606
MOD_NEK2_1	11	16	PF00069	0.281
MOD_NEK2_1	263	268	PF00069	0.479
MOD_NEK2_1	342	347	PF00069	0.470
MOD_NEK2_1	489	494	PF00069	0.428
MOD_NEK2_1	537	542	PF00069	0.724
MOD_NEK2_1	574	579	PF00069	0.527
MOD_NEK2_1	592	597	PF00069	0.523
MOD_PIKK_1	170	176	PF00454	0.585
MOD_PIKK_1	537	543	PF00454	0.727
MOD_PKA_1	316	322	PF00069	0.498
MOD_PKA_2	195	201	PF00069	0.604
MOD_PKA_2	243	249	PF00069	0.318
MOD_PKA_2	316	322	PF00069	0.660
MOD_PKA_2	333	339	PF00069	0.453
MOD_Plk_1	170	176	PF00069	0.561
MOD_Plk_1	269	275	PF00069	0.608
MOD_Plk_1	287	293	PF00069	0.572
MOD_Plk_4	11	17	PF00069	0.303
MOD_Plk_4	269	275	PF00069	0.488
MOD_Plk_4	355	361	PF00069	0.384
MOD_Plk_4	376	382	PF00069	0.380
MOD_Plk_4	387	393	PF00069	0.390
MOD_Plk_4	44	50	PF00069	0.384
MOD_Plk_4	653	659	PF00069	0.457
MOD_ProDKin_1	297	303	PF00069	0.567
MOD_ProDKin_1	319	325	PF00069	0.582
MOD_ProDKin_1	408	414	PF00069	0.575
MOD_ProDKin_1	494	500	PF00069	0.518
MOD_ProDKin_1	513	519	PF00069	0.574
MOD_ProDKin_1	615	621	PF00069	0.344
MOD_SUMO_for_1	82	85	PF00179	0.509
MOD_SUMO_rev_2	465	473	PF00179	0.517
TRG_DiLeu_BaEn_1	337	342	PF01217	0.548
TRG_DiLeu_BaEn_1	7	12	PF01217	0.281
TRG_ENDOCYTIC_2	13	16	PF00928	0.281
TRG_ENDOCYTIC_2	30	33	PF00928	0.281
TRG_ENDOCYTIC_2	434	437	PF00928	0.425
TRG_ENDOCYTIC_2	48	51	PF00928	0.374
TRG_ER_diArg_1	2	4	PF00400	0.415
TRG_ER_diArg_1	316	318	PF00400	0.540
TRG_ER_diArg_1	332	335	PF00400	0.563
TRG_ER_diArg_1	360	362	PF00400	0.375
TRG_ER_diArg_1	371	373	PF00400	0.392
TRG_ER_diArg_1	462	464	PF00400	0.483
TRG_ER_diArg_1	467	469	PF00400	0.476
TRG_ER_diArg_1	477	479	PF00400	0.427
TRG_ER_diArg_1	57	60	PF00400	0.469
TRG_ER_diArg_1	644	646	PF00400	0.432
TRG_ER_diArg_1	664	666	PF00400	0.381
TRG_ER_diArg_1	688	690	PF00400	0.467
TRG_NES_CRM1_1	64	80	PF08389	0.548
TRG_NLS_MonoExtN_4	685	691	PF00514	0.432
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.394
TRG_Pf-PMV_PEXEL_1	438	442	PF00026	0.394
TRG_Pf-PMV_PEXEL_1	688	692	PF00026	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJP3	Leptomonas seymouri	65%	92%
A0A1X0NWS4	Trypanosomatidae	48%	78%
A0A3S5IS90	Trypanosoma rangeli	52%	95%
A0A3S7WXT9	Leishmania donovani	85%	100%
A4I0I0	Leishmania infantum	85%	100%
C9ZVA6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	91%
E9AWE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QB30	Leishmania major	84%	100%
V5BJA5	Trypanosoma cruzi	51%	100%