NAD-dependent protein deacylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

sir2-family protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4HCZ2_LEIBR

TriTrypDb:

LbrM.23.1310 , LBRM2903_230023000

Length:

320

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	8
GO:0031974	membrane-enclosed lumen	2	8
GO:0043233	organelle lumen	3	8
GO:0070013	intracellular organelle lumen	4	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HCZ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCZ2

Function

Biological processes
Term	Name	Level	Count
GO:0006476	protein deacetylation	6	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0019538	protein metabolic process	3	8
GO:0035601	protein deacylation	5	8
GO:0036211	protein modification process	4	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0044238	primary metabolic process	2	8
GO:0071704	organic substance metabolic process	2	8
GO:0098732	macromolecule deacylation	5	8
GO:1901564	organonitrogen compound metabolic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	9
GO:0005488	binding	1	9
GO:0008270	zinc ion binding	6	8
GO:0016740	transferase activity	2	9
GO:0016787	hydrolase activity	2	8
GO:0019213	deacetylase activity	3	8
GO:0033558	protein lysine deacetylase activity	3	8
GO:0034979	NAD-dependent protein deacetylase activity	4	8
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0046914	transition metal ion binding	5	8
GO:0051287	NAD binding	4	9
GO:0070403	NAD+ binding	4	9
GO:0097159	organic cyclic compound binding	2	9
GO:0140096	catalytic activity, acting on a protein	2	8
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.521
CLV_NRD_NRD_1	16	18	PF00675	0.585
CLV_NRD_NRD_1	314	316	PF00675	0.559
CLV_NRD_NRD_1	68	70	PF00675	0.307
CLV_PCSK_KEX2_1	67	69	PF00082	0.282
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.282
CLV_PCSK_SKI1_1	258	262	PF00082	0.448
CLV_PCSK_SKI1_1	73	77	PF00082	0.330
DOC_ANK_TNKS_1	184	191	PF00023	0.504
DOC_CYCLIN_yCln2_LP_2	266	272	PF00134	0.419
DOC_CYCLIN_yCln2_LP_2	305	311	PF00134	0.493
DOC_MAPK_gen_1	17	26	PF00069	0.554
DOC_MAPK_gen_1	46	55	PF00069	0.464
DOC_MAPK_MEF2A_6	264	272	PF00069	0.360
DOC_MAPK_MEF2A_6	49	57	PF00069	0.576
DOC_PP2B_LxvP_1	266	269	PF13499	0.478
DOC_PP2B_LxvP_1	305	308	PF13499	0.489
DOC_PP4_FxxP_1	157	160	PF00568	0.538
DOC_PP4_FxxP_1	213	216	PF00568	0.538
DOC_USP7_MATH_1	19	23	PF00917	0.361
DOC_USP7_MATH_1	198	202	PF00917	0.476
DOC_USP7_MATH_1	29	33	PF00917	0.487
DOC_USP7_MATH_1	6	10	PF00917	0.436
DOC_USP7_UBL2_3	128	132	PF12436	0.464
LIG_APCC_ABBA_1	218	223	PF00400	0.480
LIG_BRCT_BRCA1_1	153	157	PF00533	0.538
LIG_FHA_1	105	111	PF00498	0.491
LIG_FHA_1	194	200	PF00498	0.520
LIG_FHA_1	231	237	PF00498	0.538
LIG_FHA_1	87	93	PF00498	0.396
LIG_FHA_2	132	138	PF00498	0.521
LIG_FHA_2	276	282	PF00498	0.421
LIG_FHA_2	298	304	PF00498	0.523
LIG_Integrin_isoDGR_2	44	46	PF01839	0.196
LIG_Integrin_RGD_1	279	281	PF01839	0.498
LIG_LIR_Apic_2	154	160	PF02991	0.538
LIG_LIR_Apic_2	189	195	PF02991	0.504
LIG_LIR_Apic_2	211	216	PF02991	0.396
LIG_LIR_Apic_2	39	43	PF02991	0.480
LIG_LIR_Gen_1	56	61	PF02991	0.396
LIG_LIR_Nem_3	127	133	PF02991	0.500
LIG_LIR_Nem_3	173	179	PF02991	0.430
LIG_LIR_Nem_3	255	260	PF02991	0.440
LIG_LIR_Nem_3	51	55	PF02991	0.480
LIG_LIR_Nem_3	56	60	PF02991	0.576
LIG_PDZ_Class_2	315	320	PF00595	0.576
LIG_REV1ctd_RIR_1	211	215	PF16727	0.533
LIG_REV1ctd_RIR_1	310	320	PF16727	0.597
LIG_SH2_CRK	119	123	PF00017	0.533
LIG_SH2_CRK	192	196	PF00017	0.538
LIG_SH2_CRK	257	261	PF00017	0.403
LIG_SH2_CRK	40	44	PF00017	0.480
LIG_SH2_NCK_1	192	196	PF00017	0.504
LIG_SH2_STAT5	104	107	PF00017	0.396
LIG_SH2_STAT5	133	136	PF00017	0.463
LIG_SH2_STAT5	259	262	PF00017	0.445
LIG_SH3_3	202	208	PF00018	0.538
LIG_SH3_3	222	228	PF00018	0.490
LIG_SH3_3	304	310	PF00018	0.544
LIG_SH3_5	188	192	PF00018	0.504
LIG_WRC_WIRS_1	7	12	PF05994	0.471
MOD_CK1_1	193	199	PF00069	0.576
MOD_CK1_1	232	238	PF00069	0.464
MOD_CK1_1	275	281	PF00069	0.470
MOD_CK1_1	292	298	PF00069	0.387
MOD_CK1_1	32	38	PF00069	0.480
MOD_CK1_1	79	85	PF00069	0.460
MOD_CK2_1	297	303	PF00069	0.517
MOD_CK2_1	6	12	PF00069	0.469
MOD_GlcNHglycan	172	175	PF01048	0.379
MOD_GlcNHglycan	191	195	PF01048	0.327
MOD_GlcNHglycan	254	257	PF01048	0.304
MOD_GlcNHglycan	274	277	PF01048	0.453
MOD_GlcNHglycan	34	37	PF01048	0.280
MOD_GlcNHglycan	81	84	PF01048	0.300
MOD_GlcNHglycan	98	101	PF01048	0.297
MOD_GSK3_1	82	89	PF00069	0.435
MOD_GSK3_1	96	103	PF00069	0.386
MOD_N-GLC_1	86	91	PF02516	0.217
MOD_NEK2_1	247	252	PF00069	0.504
MOD_NEK2_1	297	302	PF00069	0.467
MOD_NEK2_1	76	81	PF00069	0.537
MOD_NEK2_1	96	101	PF00069	0.344
MOD_PIKK_1	104	110	PF00454	0.473
MOD_PKA_2	314	320	PF00069	0.564
MOD_Plk_1	181	187	PF00069	0.498
MOD_Plk_1	230	236	PF00069	0.538
MOD_Plk_1	86	92	PF00069	0.458
MOD_Plk_4	100	106	PF00069	0.444
MOD_Plk_4	232	238	PF00069	0.532
MOD_Plk_4	292	298	PF00069	0.405
MOD_Plk_4	6	12	PF00069	0.427
TRG_ENDOCYTIC_2	119	122	PF00928	0.533
TRG_ENDOCYTIC_2	257	260	PF00928	0.398
TRG_ENDOCYTIC_2	78	81	PF00928	0.480
TRG_ER_diArg_1	160	163	PF00400	0.538
TRG_ER_diArg_1	185	188	PF00400	0.538
TRG_ER_diArg_1	68	70	PF00400	0.505
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.308

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4H7	Leptomonas seymouri	74%	100%
A0A0S4IYQ1	Bodo saltans	49%	100%
A0A3S7WXV8	Leishmania donovani	87%	100%
A0QC96	Mycobacterium avium (strain 104)	26%	100%
A0QDH4	Mycobacterium avium (strain 104)	40%	100%
A4I0H7	Leishmania infantum	87%	100%
A8MBU4	Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)	30%	100%
A8NWP2	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	28%	100%
A9A0B2	Desulfococcus oleovorans (strain DSM 6200 / JCM 39069 / Hxd3)	27%	100%
A9SDL4	Physcomitrium patens	29%	99%
A9UVV1	Monosiga brevicollis	37%	100%
B0RM75	Xanthomonas campestris pv. campestris (strain B100)	38%	100%
B5YJW3	Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87)	30%	100%
C1DBX3	Laribacter hongkongensis (strain HLHK9)	27%	100%
C6A243	Thermococcus sibiricus (strain DSM 12597 / MM 739)	29%	100%
C9ZMP3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
C9ZVA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E1BRE2	Gallus gallus	26%	100%
E2RDZ6	Canis lupus familiaris	28%	100%
E9AWD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
E9GD30	Daphnia pulex	30%	100%
F4P804	Batrachochytrium dendrobatidis (strain JAM81 / FGSC 10211)	41%	100%
F7DKV7	Xenopus tropicalis	28%	100%
F7EZ75	Macaca mulatta	29%	100%
O07595	Bacillus subtilis (strain 168)	30%	100%
O28597	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	28%	100%
O30124	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	28%	100%
O58669	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	27%	100%
O67919	Aquifex aeolicus (strain VF5)	28%	100%
O94640	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	67%
P53688	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	86%
Q0P595	Bos taurus	27%	80%
Q1JQC6	Bos taurus	37%	100%
Q20480	Caenorhabditis elegans	35%	100%
Q20481	Caenorhabditis elegans	35%	100%
Q3ZBQ0	Bos taurus	28%	100%
Q4JBN2	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	29%	100%
Q4QB33	Leishmania major	86%	100%
Q4UZX0	Xanthomonas campestris pv. campestris (strain 8004)	38%	100%
Q57YZ9	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	53%	100%
Q5AI90	Candida albicans (strain SC5314 / ATCC MYA-2876)	28%	100%
Q5HZN8	Xenopus laevis	28%	100%
Q5JG47	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	29%	100%
Q5KZE8	Geobacillus kaustophilus (strain HTA426)	27%	100%
Q5L014	Geobacillus kaustophilus (strain HTA426)	28%	100%
Q5R6G3	Pongo abelii	28%	100%
Q5SIH7	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	26%	100%
Q5V4Q5	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	27%	100%
Q5WKC8	Alkalihalobacillus clausii (strain KSM-K16)	28%	100%
Q639M6	Bacillus cereus (strain ZK / E33L)	25%	100%
Q67KQ0	Symbiobacterium thermophilum (strain T / IAM 14863)	29%	100%
Q68F47	Xenopus laevis	27%	100%
Q68FX9	Rattus norvegicus	27%	100%
Q6A5T5	Cutibacterium acnes (strain DSM 16379 / KPA171202)	25%	100%
Q6DHI5	Danio rerio	28%	100%
Q6HH09	Bacillus thuringiensis subsp. konkukian (strain 97-27)	26%	100%
Q6N6U0	Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)	26%	100%
Q72IV5	Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)	26%	100%
Q72RR0	Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)	26%	100%
Q735N7	Bacillus cereus (strain ATCC 10987 / NRS 248)	25%	100%
Q73KE1	Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)	26%	100%
Q73WM7	Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)	27%	100%
Q7P1B9	Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)	29%	100%
Q7VX46	Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)	36%	100%
Q7WLE5	Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)	37%	100%
Q81BT4	Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)	25%	100%
Q81NT6	Bacillus anthracis	25%	100%
Q882K4	Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)	35%	100%
Q885X7	Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)	25%	100%
Q88ZA0	Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)	26%	100%
Q899G3	Clostridium tetani (strain Massachusetts / E88)	25%	100%
Q89EA6	Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)	39%	100%
Q89LY4	Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)	27%	100%
Q8CJM9	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	32%	100%
Q8CNF4	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	24%	100%
Q8ELR0	Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831)	26%	100%
Q8F3Z6	Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)	26%	100%
Q8FUC8	Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)	37%	100%
Q8IE47	Plasmodium falciparum (isolate 3D7)	25%	100%
Q8IRR5	Drosophila melanogaster	37%	100%
Q8K2C6	Mus musculus	29%	100%
Q8PDM9	Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)	38%	100%
Q8PQK3	Xanthomonas axonopodis pv. citri (strain 306)	39%	100%
Q8R216	Mus musculus	37%	96%
Q8R984	Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4)	28%	100%
Q8R9N6	Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4)	29%	100%
Q8REC3	Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355)	24%	100%
Q8TWG0	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	29%	100%
Q8U1Q1	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	29%	100%
Q8XNS6	Clostridium perfringens (strain 13 / Type A)	27%	100%
Q8ZT00	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	27%	100%
Q8ZU41	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	30%	100%
Q94AQ6	Arabidopsis thaliana	36%	86%
Q974M6	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	30%	100%
Q97MB4	Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)	29%	100%
Q97VX5	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	28%	100%
Q9FE17	Arabidopsis thaliana	27%	68%
Q9I4E1	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	27%	100%
Q9KEE5	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	27%	100%
Q9NRC8	Homo sapiens	26%	80%
Q9NTG7	Homo sapiens	28%	80%
Q9NXA8	Homo sapiens	29%	100%
Q9RL35	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	42%	100%
Q9UZE7	Pyrococcus abyssi (strain GE5 / Orsay)	27%	100%
Q9WYW0	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	28%	100%
Q9Y6E7	Homo sapiens	38%	100%
Q9YB13	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	28%	100%