S-adenosyl-methyltransferase mraW-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

S-adenosyl-methyltransferase mraW-like protein

Species:

Leishmania braziliensis

UniProt:

A4HCZ1_LEIBR

TriTrypDb:

LbrM.23.1300 , LBRM2903_230022900

Length:

491

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCZ1

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	12
GO:0032259	methylation	2	12
GO:0000154	rRNA modification	6	1
GO:0001510	RNA methylation	4	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0031167	rRNA methylation	5	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0070475	rRNA base methylation	6	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008168	methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0008170	N-methyltransferase activity	5	1
GO:0008173	RNA methyltransferase activity	4	1
GO:0008649	rRNA methyltransferase activity	5	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016434	rRNA (cytosine) methyltransferase activity	6	1
GO:0071424	rRNA (cytosine-N4-)-methyltransferase activity	6	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140102	catalytic activity, acting on a rRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.441
CLV_NRD_NRD_1	183	185	PF00675	0.174
CLV_NRD_NRD_1	294	296	PF00675	0.252
CLV_NRD_NRD_1	325	327	PF00675	0.261
CLV_NRD_NRD_1	467	469	PF00675	0.482
CLV_NRD_NRD_1	475	477	PF00675	0.499
CLV_NRD_NRD_1	62	64	PF00675	0.461
CLV_NRD_NRD_1	77	79	PF00675	0.641
CLV_NRD_NRD_1	89	91	PF00675	0.653
CLV_NRD_NRD_1	96	98	PF00675	0.727
CLV_PCSK_FUR_1	292	296	PF00082	0.275
CLV_PCSK_KEX2_1	139	141	PF00082	0.489
CLV_PCSK_KEX2_1	193	195	PF00082	0.174
CLV_PCSK_KEX2_1	2	4	PF00082	0.479
CLV_PCSK_KEX2_1	294	296	PF00082	0.253
CLV_PCSK_KEX2_1	325	327	PF00082	0.261
CLV_PCSK_KEX2_1	475	477	PF00082	0.513
CLV_PCSK_KEX2_1	48	50	PF00082	0.534
CLV_PCSK_KEX2_1	62	64	PF00082	0.424
CLV_PCSK_KEX2_1	8	10	PF00082	0.474
CLV_PCSK_KEX2_1	89	91	PF00082	0.723
CLV_PCSK_KEX2_1	96	98	PF00082	0.747
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.489
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.174
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.479
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.558
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.474
CLV_PCSK_PC7_1	135	141	PF00082	0.411
CLV_PCSK_SKI1_1	140	144	PF00082	0.345
CLV_PCSK_SKI1_1	206	210	PF00082	0.258
CLV_PCSK_SKI1_1	233	237	PF00082	0.257
CLV_PCSK_SKI1_1	24	28	PF00082	0.423
CLV_PCSK_SKI1_1	62	66	PF00082	0.439
CLV_Separin_Metazoa	103	107	PF03568	0.506
DEG_Nend_UBRbox_1	1	4	PF02207	0.496
DEG_SCF_FBW7_1	278	284	PF00400	0.475
DEG_SPOP_SBC_1	115	119	PF00917	0.510
DOC_CKS1_1	278	283	PF01111	0.475
DOC_CYCLIN_yClb5_NLxxxL_5	37	46	PF00134	0.448
DOC_MAPK_FxFP_2	454	457	PF00069	0.559
DOC_PP1_RVXF_1	363	370	PF00149	0.461
DOC_PP2B_LxvP_1	102	105	PF13499	0.610
DOC_PP4_FxxP_1	454	457	PF00568	0.559
DOC_USP7_MATH_1	113	117	PF00917	0.657
DOC_USP7_MATH_1	179	183	PF00917	0.536
DOC_USP7_MATH_1	221	225	PF00917	0.476
DOC_USP7_MATH_1	272	276	PF00917	0.519
DOC_USP7_MATH_1	281	285	PF00917	0.386
DOC_USP7_MATH_1	482	486	PF00917	0.703
DOC_USP7_MATH_1	77	81	PF00917	0.623
DOC_WW_Pin1_4	277	282	PF00397	0.463
LIG_14-3-3_CanoR_1	140	145	PF00244	0.434
LIG_14-3-3_CanoR_1	200	209	PF00244	0.492
LIG_14-3-3_CanoR_1	325	331	PF00244	0.508
LIG_14-3-3_CanoR_1	418	426	PF00244	0.378
LIG_14-3-3_CanoR_1	96	104	PF00244	0.728
LIG_BRCT_BRCA1_1	330	334	PF00533	0.461
LIG_CaM_NSCaTE_8	374	381	PF13499	0.536
LIG_FHA_1	141	147	PF00498	0.453
LIG_FHA_1	155	161	PF00498	0.484
LIG_FHA_1	166	172	PF00498	0.419
LIG_FHA_2	224	230	PF00498	0.459
LIG_Integrin_isoDGR_2	163	165	PF01839	0.355
LIG_LIR_Apic_2	453	457	PF02991	0.467
LIG_LIR_Gen_1	143	151	PF02991	0.262
LIG_LIR_Gen_1	211	221	PF02991	0.450
LIG_LIR_Gen_1	224	231	PF02991	0.450
LIG_LIR_Gen_1	275	281	PF02991	0.536
LIG_LIR_Gen_1	329	338	PF02991	0.563
LIG_LIR_Gen_1	392	399	PF02991	0.480
LIG_LIR_LC3C_4	363	368	PF02991	0.461
LIG_LIR_Nem_3	143	147	PF02991	0.304
LIG_LIR_Nem_3	211	217	PF02991	0.434
LIG_LIR_Nem_3	224	228	PF02991	0.450
LIG_LIR_Nem_3	275	279	PF02991	0.503
LIG_LIR_Nem_3	329	335	PF02991	0.388
LIG_LIR_Nem_3	392	396	PF02991	0.480
LIG_LIR_Nem_3	470	474	PF02991	0.491
LIG_MYND_1	19	23	PF01753	0.545
LIG_Pex14_2	151	155	PF04695	0.536
LIG_SH2_CRK	167	171	PF00017	0.461
LIG_SH2_CRK	198	202	PF00017	0.532
LIG_SH2_GRB2like	260	263	PF00017	0.450
LIG_SH2_STAP1	167	171	PF00017	0.461
LIG_SH2_STAP1	393	397	PF00017	0.475
LIG_SH2_STAT5	167	170	PF00017	0.461
LIG_SH2_STAT5	260	263	PF00017	0.450
LIG_SH2_STAT5	424	427	PF00017	0.470
LIG_SH3_2	69	74	PF14604	0.470
LIG_SH3_3	13	19	PF00018	0.461
LIG_SH3_3	64	70	PF00018	0.515
LIG_SUMO_SIM_par_1	302	309	PF11976	0.471
LIG_TRAF2_1	436	439	PF00917	0.566
LIG_TYR_ITIM	142	147	PF00017	0.349
LIG_TYR_ITIM	391	396	PF00017	0.374
LIG_WW_3	103	107	PF00397	0.506
MOD_CK1_1	116	122	PF00069	0.577
MOD_CK1_1	124	130	PF00069	0.534
MOD_CK1_1	321	327	PF00069	0.422
MOD_CK1_1	408	414	PF00069	0.508
MOD_CK2_1	223	229	PF00069	0.450
MOD_CK2_1	389	395	PF00069	0.477
MOD_GlcNHglycan	152	155	PF01048	0.298
MOD_GlcNHglycan	181	184	PF01048	0.343
MOD_GlcNHglycan	269	272	PF01048	0.277
MOD_GlcNHglycan	379	382	PF01048	0.174
MOD_GSK3_1	104	111	PF00069	0.679
MOD_GSK3_1	115	122	PF00069	0.548
MOD_GSK3_1	150	157	PF00069	0.555
MOD_GSK3_1	277	284	PF00069	0.498
MOD_GSK3_1	321	328	PF00069	0.494
MOD_GSK3_1	377	384	PF00069	0.518
MOD_GSK3_1	414	421	PF00069	0.388
MOD_GSK3_1	426	433	PF00069	0.391
MOD_N-GLC_1	459	464	PF02516	0.418
MOD_NEK2_1	114	119	PF00069	0.621
MOD_NEK2_1	121	126	PF00069	0.527
MOD_NEK2_1	147	152	PF00069	0.475
MOD_NEK2_1	334	339	PF00069	0.450
MOD_NEK2_2	281	286	PF00069	0.475
MOD_PIKK_1	223	229	PF00454	0.449
MOD_PIKK_1	318	324	PF00454	0.475
MOD_PIKK_1	381	387	PF00454	0.555
MOD_PIKK_1	426	432	PF00454	0.454
MOD_PK_1	8	14	PF00069	0.345
MOD_PKA_1	325	331	PF00069	0.537
MOD_PKA_1	8	14	PF00069	0.508
MOD_PKA_2	105	111	PF00069	0.690
MOD_PKA_2	325	331	PF00069	0.555
MOD_PKA_2	408	414	PF00069	0.412
MOD_PKA_2	77	83	PF00069	0.691
MOD_PKA_2	8	14	PF00069	0.476
MOD_PKA_2	95	101	PF00069	0.755
MOD_Plk_1	147	153	PF00069	0.450
MOD_Plk_1	210	216	PF00069	0.475
MOD_Plk_1	438	444	PF00069	0.454
MOD_Plk_1	459	465	PF00069	0.418
MOD_Plk_4	124	130	PF00069	0.403
MOD_Plk_4	420	426	PF00069	0.477
MOD_ProDKin_1	277	283	PF00069	0.463
MOD_SUMO_rev_2	203	208	PF00179	0.475
MOD_SUMO_rev_2	370	379	PF00179	0.532
TRG_DiLeu_BaEn_1	232	237	PF01217	0.461
TRG_DiLeu_BaLyEn_6	368	373	PF01217	0.506
TRG_ENDOCYTIC_2	144	147	PF00928	0.337
TRG_ENDOCYTIC_2	167	170	PF00928	0.461
TRG_ENDOCYTIC_2	249	252	PF00928	0.513
TRG_ENDOCYTIC_2	276	279	PF00928	0.450
TRG_ENDOCYTIC_2	393	396	PF00928	0.487
TRG_ER_diArg_1	291	294	PF00400	0.463
TRG_ER_diArg_1	474	476	PF00400	0.529
TRG_ER_diArg_1	89	91	PF00400	0.706
TRG_ER_diArg_1	95	97	PF00400	0.708
TRG_NES_CRM1_1	347	363	PF08389	0.462
TRG_NLS_Bipartite_1	48	63	PF00514	0.564
TRG_NLS_MonoExtC_3	58	63	PF00514	0.365
TRG_NLS_MonoExtN_4	56	63	PF00514	0.530
TRG_NLS_MonoExtN_4	75	82	PF00514	0.633
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.306
TRG_Pf-PMV_PEXEL_1	289	293	PF00026	0.355
TRG_Pf-PMV_PEXEL_1	371	375	PF00026	0.174
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB41	Leptomonas seymouri	73%	99%
A0A0S4J2S9	Bodo saltans	42%	100%
A0A1X0NY59	Trypanosomatidae	58%	100%
A0A3Q8IM97	Leishmania donovani	85%	100%
A0A3R7KU88	Trypanosoma rangeli	60%	100%
A4I0H6	Leishmania infantum	86%	100%
B9JY62	Agrobacterium vitis (strain S4 / ATCC BAA-846)	26%	100%
C9ZVA0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AWD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QB34	Leishmania major	86%	100%
V5BEN6	Trypanosoma cruzi	61%	100%