LeishMANIAdb
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Membrane-bound acid phosphatase 2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Membrane-bound acid phosphatase 2
Gene product:
membrane-bound acid phosphatase 2
Species:
Leishmania braziliensis
UniProt:
A4HCZ0_LEIBR
TriTrypDb:
LbrM.23.1290 , LBRM2903_230022800 *
Length:
614

Annotations

LeishMANIAdb annotations

An extensively expanded family of exophosphatase enzymes presumed to be active at acidic pH

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 1
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 65
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 14
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 44, no: 5
NetGPI no yes: 0, no: 49
Cellular components
Term Name Level Count
GO:0016020 membrane 2 37
GO:0110165 cellular anatomical entity 1 37

Expansion

Sequence features

A4HCZ0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCZ0

Function

Biological processes
Term Name Level Count
GO:0006793 phosphorus metabolic process 3 5
GO:0006796 phosphate-containing compound metabolic process 4 5
GO:0008152 metabolic process 1 5
GO:0009987 cellular process 1 5
GO:0016311 dephosphorylation 5 5
GO:0044237 cellular metabolic process 2 5
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 8
GO:0003993 acid phosphatase activity 6 3
GO:0016787 hydrolase activity 2 8
GO:0016788 hydrolase activity, acting on ester bonds 3 8
GO:0016791 phosphatase activity 5 8
GO:0042578 phosphoric ester hydrolase activity 4 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 552 556 PF00656 0.638
CLV_NRD_NRD_1 283 285 PF00675 0.598
CLV_NRD_NRD_1 513 515 PF00675 0.534
CLV_NRD_NRD_1 605 607 PF00675 0.480
CLV_PCSK_KEX2_1 283 285 PF00082 0.572
CLV_PCSK_KEX2_1 515 517 PF00082 0.595
CLV_PCSK_PC1ET2_1 515 517 PF00082 0.464
CLV_PCSK_SKI1_1 204 208 PF00082 0.549
CLV_PCSK_SKI1_1 62 66 PF00082 0.588
DEG_SCF_FBW7_2 49 56 PF00400 0.406
DOC_ANK_TNKS_1 489 496 PF00023 0.307
DOC_CDC14_PxL_1 304 312 PF14671 0.428
DOC_CKS1_1 34 39 PF01111 0.361
DOC_CYCLIN_yCln2_LP_2 393 396 PF00134 0.238
DOC_MAPK_RevD_3 589 604 PF00069 0.282
DOC_PP1_RVXF_1 463 470 PF00149 0.446
DOC_PP2B_LxvP_1 393 396 PF13499 0.400
DOC_PP2B_LxvP_1 98 101 PF13499 0.486
DOC_USP7_MATH_1 126 130 PF00917 0.412
DOC_USP7_MATH_1 361 365 PF00917 0.383
DOC_USP7_MATH_1 473 477 PF00917 0.434
DOC_USP7_MATH_1 554 558 PF00917 0.529
DOC_USP7_UBL2_3 511 515 PF12436 0.305
DOC_USP7_UBL2_3 603 607 PF12436 0.696
DOC_WW_Pin1_4 136 141 PF00397 0.456
DOC_WW_Pin1_4 33 38 PF00397 0.427
DOC_WW_Pin1_4 49 54 PF00397 0.399
DOC_WW_Pin1_4 541 546 PF00397 0.434
DOC_WW_Pin1_4 606 611 PF00397 0.738
DOC_WW_Pin1_4 74 79 PF00397 0.373
LIG_14-3-3_CanoR_1 162 170 PF00244 0.390
LIG_14-3-3_CanoR_1 188 196 PF00244 0.344
LIG_14-3-3_CanoR_1 283 291 PF00244 0.382
LIG_14-3-3_CanoR_1 380 386 PF00244 0.370
LIG_14-3-3_CanoR_1 457 467 PF00244 0.379
LIG_14-3-3_CanoR_1 606 610 PF00244 0.729
LIG_BIR_III_4 445 449 PF00653 0.473
LIG_BRCT_BRCA1_1 65 69 PF00533 0.380
LIG_deltaCOP1_diTrp_1 256 262 PF00928 0.331
LIG_deltaCOP1_diTrp_1 432 439 PF00928 0.334
LIG_EH1_1 584 592 PF00400 0.420
LIG_FHA_1 103 109 PF00498 0.383
LIG_FHA_1 228 234 PF00498 0.331
LIG_FHA_1 398 404 PF00498 0.374
LIG_FHA_1 462 468 PF00498 0.380
LIG_FHA_1 567 573 PF00498 0.550
LIG_FHA_1 582 588 PF00498 0.429
LIG_FHA_1 594 600 PF00498 0.514
LIG_FHA_1 75 81 PF00498 0.503
LIG_FHA_1 84 90 PF00498 0.425
LIG_FHA_2 217 223 PF00498 0.365
LIG_FHA_2 386 392 PF00498 0.349
LIG_FHA_2 50 56 PF00498 0.586
LIG_GBD_Chelix_1 401 409 PF00786 0.438
LIG_GBD_Chelix_1 89 97 PF00786 0.574
LIG_LIR_Apic_2 256 260 PF02991 0.295
LIG_LIR_Gen_1 10 21 PF02991 0.404
LIG_LIR_Gen_1 261 269 PF02991 0.399
LIG_LIR_Gen_1 286 297 PF02991 0.329
LIG_LIR_Gen_1 461 471 PF02991 0.330
LIG_LIR_Gen_1 476 486 PF02991 0.326
LIG_LIR_Nem_3 10 16 PF02991 0.404
LIG_LIR_Nem_3 145 149 PF02991 0.456
LIG_LIR_Nem_3 211 217 PF02991 0.331
LIG_LIR_Nem_3 223 229 PF02991 0.319
LIG_LIR_Nem_3 256 262 PF02991 0.385
LIG_LIR_Nem_3 286 292 PF02991 0.302
LIG_LIR_Nem_3 305 310 PF02991 0.330
LIG_LIR_Nem_3 363 369 PF02991 0.348
LIG_LIR_Nem_3 461 466 PF02991 0.344
LIG_LIR_Nem_3 476 482 PF02991 0.370
LIG_LIR_Nem_3 483 489 PF02991 0.278
LIG_LIR_Nem_3 501 506 PF02991 0.358
LIG_LYPXL_S_1 1 5 PF13949 0.377
LIG_LYPXL_S_1 213 217 PF13949 0.567
LIG_LYPXL_yS_3 2 5 PF13949 0.574
LIG_LYPXL_yS_3 214 217 PF13949 0.351
LIG_LYPXL_yS_3 307 310 PF13949 0.434
LIG_NRBOX 90 96 PF00104 0.357
LIG_PCNA_yPIPBox_3 346 354 PF02747 0.331
LIG_PDZ_Class_1 609 614 PF00595 0.795
LIG_Pex14_2 20 24 PF04695 0.206
LIG_Pex14_2 202 206 PF04695 0.414
LIG_Pex14_2 236 240 PF04695 0.353
LIG_Pex14_2 431 435 PF04695 0.462
LIG_Pex14_2 65 69 PF04695 0.380
LIG_REV1ctd_RIR_1 62 71 PF16727 0.378
LIG_SH2_CRK 13 17 PF00017 0.206
LIG_SH2_CRK 486 490 PF00017 0.381
LIG_SH2_GRB2like 229 232 PF00017 0.414
LIG_SH2_STAP1 180 184 PF00017 0.329
LIG_SH2_STAP1 229 233 PF00017 0.347
LIG_SH2_STAP1 520 524 PF00017 0.485
LIG_SH2_STAT3 232 235 PF00017 0.386
LIG_SH2_STAT5 143 146 PF00017 0.396
LIG_SH2_STAT5 226 229 PF00017 0.341
LIG_SH2_STAT5 232 235 PF00017 0.329
LIG_SH2_STAT5 277 280 PF00017 0.377
LIG_SH2_STAT5 329 332 PF00017 0.328
LIG_SH2_STAT5 479 482 PF00017 0.348
LIG_SH3_3 167 173 PF00018 0.386
LIG_SH3_3 247 253 PF00018 0.358
LIG_SH3_3 31 37 PF00018 0.730
LIG_SH3_3 548 554 PF00018 0.546
LIG_SH3_5 176 180 PF00018 0.275
LIG_SUMO_SIM_par_1 399 404 PF11976 0.347
LIG_TRAF2_1 53 56 PF00917 0.407
LIG_UBA3_1 291 299 PF00899 0.424
LIG_WRC_WIRS_1 582 587 PF05994 0.418
MOD_CDC14_SPxK_1 544 547 PF00782 0.338
MOD_CDK_SPK_2 49 54 PF00069 0.404
MOD_CDK_SPxK_1 541 547 PF00069 0.309
MOD_CK1_1 168 174 PF00069 0.400
MOD_CK1_1 187 193 PF00069 0.364
MOD_CK1_1 198 204 PF00069 0.370
MOD_CK1_1 279 285 PF00069 0.366
MOD_CK1_1 41 47 PF00069 0.381
MOD_CK1_1 410 416 PF00069 0.345
MOD_CK1_1 541 547 PF00069 0.460
MOD_CK1_1 74 80 PF00069 0.443
MOD_CK2_1 216 222 PF00069 0.391
MOD_CK2_1 426 432 PF00069 0.453
MOD_CK2_1 49 55 PF00069 0.405
MOD_GlcNHglycan 197 200 PF01048 0.535
MOD_GlcNHglycan 343 346 PF01048 0.590
MOD_GlcNHglycan 371 374 PF01048 0.552
MOD_GlcNHglycan 428 431 PF01048 0.585
MOD_GlcNHglycan 445 449 PF01048 0.493
MOD_GlcNHglycan 469 472 PF01048 0.588
MOD_GlcNHglycan 507 510 PF01048 0.612
MOD_GlcNHglycan 571 575 PF01048 0.783
MOD_GlcNHglycan 7 10 PF01048 0.340
MOD_GlcNHglycan 73 76 PF01048 0.645
MOD_GSK3_1 1 8 PF00069 0.564
MOD_GSK3_1 122 129 PF00069 0.432
MOD_GSK3_1 158 165 PF00069 0.380
MOD_GSK3_1 369 376 PF00069 0.334
MOD_GSK3_1 381 388 PF00069 0.302
MOD_GSK3_1 41 48 PF00069 0.383
MOD_GSK3_1 452 459 PF00069 0.304
MOD_GSK3_1 541 548 PF00069 0.458
MOD_GSK3_1 566 573 PF00069 0.617
MOD_GSK3_1 605 612 PF00069 0.670
MOD_N-GLC_1 130 135 PF02516 0.635
MOD_N-GLC_1 208 213 PF02516 0.542
MOD_N-GLC_1 279 284 PF02516 0.585
MOD_N-GLC_1 331 336 PF02516 0.540
MOD_N-GLC_1 407 412 PF02516 0.482
MOD_N-GLC_1 451 456 PF02516 0.586
MOD_N-GLC_2 456 458 PF02516 0.594
MOD_NEK2_1 152 157 PF00069 0.341
MOD_NEK2_1 158 163 PF00069 0.361
MOD_NEK2_1 227 232 PF00069 0.372
MOD_NEK2_1 25 30 PF00069 0.206
MOD_NEK2_1 360 365 PF00069 0.374
MOD_NEK2_1 397 402 PF00069 0.324
MOD_NEK2_1 409 414 PF00069 0.333
MOD_NEK2_1 444 449 PF00069 0.454
MOD_NEK2_1 527 532 PF00069 0.387
MOD_NEK2_1 63 68 PF00069 0.495
MOD_NEK2_1 71 76 PF00069 0.473
MOD_OFUCOSY 517 522 PF10250 0.567
MOD_OFUCOSY 535 542 PF10250 0.641
MOD_OGLYCOS 136 141 PF02709 0.517
MOD_PIKK_1 130 136 PF00454 0.402
MOD_PIKK_1 315 321 PF00454 0.337
MOD_PK_1 45 51 PF00069 0.396
MOD_PKA_2 187 193 PF00069 0.355
MOD_PKA_2 282 288 PF00069 0.387
MOD_PKA_2 456 462 PF00069 0.424
MOD_PKA_2 605 611 PF00069 0.672
MOD_PKA_2 71 77 PF00069 0.442
MOD_PKB_1 160 168 PF00069 0.428
MOD_PKB_1 514 522 PF00069 0.272
MOD_Plk_1 130 136 PF00069 0.417
MOD_Plk_1 165 171 PF00069 0.376
MOD_Plk_1 208 214 PF00069 0.388
MOD_Plk_1 374 380 PF00069 0.333
MOD_Plk_1 410 416 PF00069 0.312
MOD_Plk_1 461 467 PF00069 0.379
MOD_Plk_4 165 171 PF00069 0.364
MOD_Plk_4 198 204 PF00069 0.402
MOD_Plk_4 209 215 PF00069 0.376
MOD_Plk_4 397 403 PF00069 0.332
MOD_Plk_4 76 82 PF00069 0.453
MOD_ProDKin_1 136 142 PF00069 0.449
MOD_ProDKin_1 33 39 PF00069 0.425
MOD_ProDKin_1 49 55 PF00069 0.400
MOD_ProDKin_1 541 547 PF00069 0.443
MOD_ProDKin_1 606 612 PF00069 0.743
MOD_ProDKin_1 74 80 PF00069 0.372
TRG_DiLeu_BaEn_1 223 228 PF01217 0.320
TRG_DiLeu_BaLyEn_6 305 310 PF01217 0.340
TRG_ENDOCYTIC_2 13 16 PF00928 0.202
TRG_ENDOCYTIC_2 2 5 PF00928 0.574
TRG_ENDOCYTIC_2 214 217 PF00928 0.359
TRG_ENDOCYTIC_2 239 242 PF00928 0.327
TRG_ENDOCYTIC_2 307 310 PF00928 0.395
TRG_ENDOCYTIC_2 479 482 PF00928 0.380
TRG_ENDOCYTIC_2 486 489 PF00928 0.377
TRG_ER_diArg_1 159 162 PF00400 0.393
TRG_ER_diArg_1 513 516 PF00400 0.357
TRG_NES_CRM1_1 391 404 PF08389 0.414
TRG_NES_CRM1_1 88 102 PF08389 0.307
TRG_NLS_MonoExtC_3 513 518 PF00514 0.261
TRG_NLS_MonoExtC_3 602 607 PF00514 0.749
TRG_NLS_MonoExtN_4 511 518 PF00514 0.243

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5Y5 Leptomonas seymouri 45% 100%
A0A0N1I756 Leptomonas seymouri 42% 100%
A0A0N1PEH4 Leptomonas seymouri 37% 100%
A0A0S4IRF5 Bodo saltans 24% 92%
A0A0S4IUV8 Bodo saltans 23% 100%
A0A0S4IV77 Bodo saltans 35% 100%
A0A0S4IXN9 Bodo saltans 23% 100%
A0A0S4JEA9 Bodo saltans 27% 100%
A0A0S4JJK3 Bodo saltans 28% 100%
A0A0S4JW09 Bodo saltans 27% 100%
A0A1X0NNY4 Trypanosomatidae 37% 100%
A0A1X0NQL4 Trypanosomatidae 28% 100%
A0A1X0NY34 Trypanosomatidae 24% 100%
A0A1X0P7V5 Trypanosomatidae 44% 100%
A0A3Q8IR23 Leishmania donovani 50% 100%
A0A3R7KSH4 Trypanosoma rangeli 25% 100%
A0A3R7MEN7 Trypanosoma rangeli 43% 100%
A0A3R7MHJ7 Trypanosoma rangeli 27% 100%
A0A3S5H827 Leishmania donovani 39% 100%
A0A3S7WXU0 Leishmania donovani 85% 100%
A0A3S7X1W4 Leishmania donovani 41% 100%
A4HGW8 Leishmania braziliensis 42% 100%
A4HPC1 Leishmania braziliensis 39% 100%
A4HPC5 Leishmania braziliensis 50% 100%
A4HQG6 Leishmania braziliensis 34% 100%
A4HQG9 Leishmania braziliensis 35% 100%
A4I0H5 Leishmania infantum 85% 100%
A4I3Z8 Leishmania infantum 41% 100%
A4ICA5 Leishmania infantum 36% 92%
A4ICG3 Leishmania infantum 39% 100%
A4ICG5 Leishmania infantum 50% 100%
D0A3E0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
D0A947 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
D0A948 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
D0A9J5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
E9AT34 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
E9AT36 Leishmania mexicana (strain MHOM/GT/2001/U1103) 50% 100%
E9AWD7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
E9B088 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
Q4Q0A9 Leishmania major 31% 99%
Q4Q1G2 Leishmania major 49% 100%
Q4Q1G4 Leishmania major 38% 100%
Q4Q7Z7 Leishmania major 42% 100%
Q4QB35 Leishmania major 87% 100%
V5BCI2 Trypanosoma cruzi 27% 100%
V5BIM1 Trypanosoma cruzi 22% 100%
V5BK91 Trypanosoma cruzi 42% 100%
V5BL75 Trypanosoma cruzi 28% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS