Ribosomal protein S9

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCY8_LEIBR

TriTrypDb:

LbrM.23.1270 , LBRM2903_230022600

Length:

441

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	5
GO:0032991	protein-containing complex	1	5
GO:0043226	organelle	2	5
GO:0043228	non-membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043232	intracellular non-membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	5
GO:1990904	ribonucleoprotein complex	2	5

Expansion

Sequence features

A4HCY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCY8

PDB structure(s): 7ane_d

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	5
GO:0006518	peptide metabolic process	4	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0009058	biosynthetic process	2	5
GO:0009059	macromolecule biosynthetic process	4	5
GO:0009987	cellular process	1	5
GO:0019538	protein metabolic process	3	5
GO:0034641	cellular nitrogen compound metabolic process	3	5
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	5
GO:0043043	peptide biosynthetic process	5	5
GO:0043170	macromolecule metabolic process	3	5
GO:0043603	amide metabolic process	3	5
GO:0043604	amide biosynthetic process	4	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0044249	cellular biosynthetic process	3	5
GO:0044260	obsolete cellular macromolecule metabolic process	3	5
GO:0044271	cellular nitrogen compound biosynthetic process	4	5
GO:0071704	organic substance metabolic process	2	5
GO:1901564	organonitrogen compound metabolic process	3	5
GO:1901566	organonitrogen compound biosynthetic process	4	5
GO:1901576	organic substance biosynthetic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	5
GO:0005198	structural molecule activity	1	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.438
CLV_C14_Caspase3-7	66	70	PF00656	0.612
CLV_NRD_NRD_1	162	164	PF00675	0.550
CLV_NRD_NRD_1	234	236	PF00675	0.431
CLV_NRD_NRD_1	276	278	PF00675	0.421
CLV_NRD_NRD_1	419	421	PF00675	0.472
CLV_NRD_NRD_1	435	437	PF00675	0.398
CLV_PCSK_KEX2_1	234	236	PF00082	0.431
CLV_PCSK_KEX2_1	418	420	PF00082	0.474
CLV_PCSK_KEX2_1	435	437	PF00082	0.472
CLV_PCSK_KEX2_1	44	46	PF00082	0.350
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.488
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.365
CLV_PCSK_SKI1_1	191	195	PF00082	0.470
CLV_PCSK_SKI1_1	2	6	PF00082	0.543
CLV_PCSK_SKI1_1	221	225	PF00082	0.408
CLV_PCSK_SKI1_1	243	247	PF00082	0.423
CLV_PCSK_SKI1_1	314	318	PF00082	0.475
CLV_PCSK_SKI1_1	437	441	PF00082	0.519
DEG_Nend_UBRbox_1	1	4	PF02207	0.570
DOC_MAPK_gen_1	234	246	PF00069	0.421
DOC_MAPK_gen_1	409	416	PF00069	0.435
DOC_MAPK_gen_1	44	51	PF00069	0.362
DOC_MAPK_gen_1	59	67	PF00069	0.454
DOC_MAPK_MEF2A_6	239	246	PF00069	0.431
DOC_MAPK_MEF2A_6	285	292	PF00069	0.499
DOC_MAPK_MEF2A_6	59	67	PF00069	0.418
DOC_PP1_RVXF_1	241	247	PF00149	0.426
DOC_PP1_RVXF_1	33	39	PF00149	0.349
DOC_PP1_RVXF_1	358	364	PF00149	0.545
DOC_USP7_MATH_1	259	263	PF00917	0.485
DOC_USP7_MATH_1	376	380	PF00917	0.439
DOC_USP7_UBL2_3	433	437	PF12436	0.551
DOC_WW_Pin1_4	181	186	PF00397	0.563
DOC_WW_Pin1_4	3	8	PF00397	0.404
LIG_14-3-3_CanoR_1	17	23	PF00244	0.342
LIG_14-3-3_CanoR_1	191	200	PF00244	0.469
LIG_14-3-3_CanoR_1	216	223	PF00244	0.410
LIG_14-3-3_CanoR_1	35	39	PF00244	0.333
LIG_Actin_WH2_2	108	123	PF00022	0.337
LIG_Actin_WH2_2	393	411	PF00022	0.441
LIG_APCC_ABBA_1	353	358	PF00400	0.378
LIG_BIR_III_4	196	200	PF00653	0.524
LIG_BRCT_BRCA1_1	338	342	PF00533	0.501
LIG_Clathr_ClatBox_1	353	357	PF01394	0.390
LIG_Clathr_ClatBox_1	413	417	PF01394	0.437
LIG_eIF4E_1	165	171	PF01652	0.424
LIG_eIF4E_1	315	321	PF01652	0.385
LIG_FHA_1	170	176	PF00498	0.496
LIG_FHA_1	206	212	PF00498	0.433
LIG_FHA_1	316	322	PF00498	0.409
LIG_FHA_1	396	402	PF00498	0.438
LIG_FXI_DFP_1	363	367	PF00024	0.406
LIG_GBD_Chelix_1	393	401	PF00786	0.374
LIG_LIR_Gen_1	122	132	PF02991	0.412
LIG_LIR_Gen_1	137	146	PF02991	0.432
LIG_LIR_Gen_1	247	257	PF02991	0.491
LIG_LIR_Gen_1	262	272	PF02991	0.321
LIG_LIR_Gen_1	362	371	PF02991	0.321
LIG_LIR_Nem_3	122	127	PF02991	0.405
LIG_LIR_Nem_3	137	143	PF02991	0.423
LIG_LIR_Nem_3	262	268	PF02991	0.425
LIG_LIR_Nem_3	362	366	PF02991	0.407
LIG_LIR_Nem_3	88	92	PF02991	0.357
LIG_MAD2	173	181	PF02301	0.514
LIG_NRP_CendR_1	440	441	PF00754	0.536
LIG_PCNA_yPIPBox_3	163	175	PF02747	0.536
LIG_SH2_CRK	269	273	PF00017	0.402
LIG_SH2_GRB2like	207	210	PF00017	0.437
LIG_SH2_NCK_1	140	144	PF00017	0.435
LIG_SH2_SRC	96	99	PF00017	0.470
LIG_SH2_STAP1	165	169	PF00017	0.426
LIG_SH2_STAP1	207	211	PF00017	0.437
LIG_SH2_STAP1	265	269	PF00017	0.412
LIG_SH2_STAT3	165	168	PF00017	0.440
LIG_SH2_STAT5	132	135	PF00017	0.443
LIG_SH2_STAT5	207	210	PF00017	0.437
LIG_SH2_STAT5	269	272	PF00017	0.379
LIG_SH2_STAT5	96	99	PF00017	0.478
LIG_SH3_1	87	93	PF00018	0.365
LIG_SH3_3	349	355	PF00018	0.412
LIG_SH3_3	87	93	PF00018	0.365
LIG_SUMO_SIM_anti_2	330	335	PF11976	0.504
LIG_SUMO_SIM_anti_2	367	373	PF11976	0.423
LIG_SUMO_SIM_par_1	411	417	PF11976	0.430
LIG_SUMO_SIM_par_1	63	69	PF11976	0.466
LIG_UBA3_1	158	164	PF00899	0.566
MOD_CDC14_SPxK_1	184	187	PF00782	0.555
MOD_CDK_SPK_2	3	8	PF00069	0.404
MOD_CDK_SPxK_1	181	187	PF00069	0.556
MOD_CK1_1	113	119	PF00069	0.599
MOD_CK1_1	21	27	PF00069	0.359
MOD_CK1_1	253	259	PF00069	0.462
MOD_CK1_1	261	267	PF00069	0.428
MOD_CK1_1	369	375	PF00069	0.437
MOD_CK1_1	6	12	PF00069	0.364
MOD_CK2_1	116	122	PF00069	0.428
MOD_CK2_1	28	34	PF00069	0.362
MOD_CK2_1	49	55	PF00069	0.369
MOD_Cter_Amidation	430	433	PF01082	0.472
MOD_GlcNHglycan	127	130	PF01048	0.435
MOD_GlcNHglycan	155	158	PF01048	0.520
MOD_GlcNHglycan	410	413	PF01048	0.311
MOD_GSK3_1	183	190	PF00069	0.498
MOD_GSK3_1	259	266	PF00069	0.442
MOD_GSK3_1	34	41	PF00069	0.341
MOD_GSK3_1	408	415	PF00069	0.306
MOD_N-GLC_1	327	332	PF02516	0.472
MOD_NEK2_1	125	130	PF00069	0.475
MOD_NEK2_1	18	23	PF00069	0.320
MOD_NEK2_1	189	194	PF00069	0.461
MOD_NEK2_1	217	222	PF00069	0.420
MOD_NEK2_1	230	235	PF00069	0.402
MOD_NEK2_1	334	339	PF00069	0.314
MOD_NEK2_1	366	371	PF00069	0.410
MOD_NEK2_1	408	413	PF00069	0.334
MOD_NEK2_1	49	54	PF00069	0.362
MOD_PIKK_1	164	170	PF00454	0.308
MOD_PIKK_1	21	27	PF00454	0.487
MOD_PIKK_1	43	49	PF00454	0.430
MOD_PK_1	336	342	PF00069	0.514
MOD_PKA_2	125	131	PF00069	0.417
MOD_PKA_2	215	221	PF00069	0.422
MOD_PKA_2	34	40	PF00069	0.339
MOD_Plk_1	343	349	PF00069	0.484
MOD_Plk_1	366	372	PF00069	0.412
MOD_Plk_4	267	273	PF00069	0.392
MOD_Plk_4	34	40	PF00069	0.474
MOD_Plk_4	343	349	PF00069	0.405
MOD_Plk_4	366	372	PF00069	0.412
MOD_ProDKin_1	181	187	PF00069	0.562
MOD_ProDKin_1	3	9	PF00069	0.398
MOD_SUMO_for_1	107	110	PF00179	0.372
MOD_SUMO_for_1	223	226	PF00179	0.410
MOD_SUMO_rev_2	337	346	PF00179	0.456
MOD_SUMO_rev_2	367	377	PF00179	0.481
TRG_DiLeu_BaEn_1	166	171	PF01217	0.401
TRG_DiLeu_BaEn_1	247	252	PF01217	0.421
TRG_ENDOCYTIC_2	140	143	PF00928	0.425
TRG_ENDOCYTIC_2	207	210	PF00928	0.427
TRG_ENDOCYTIC_2	249	252	PF00928	0.426
TRG_ENDOCYTIC_2	265	268	PF00928	0.399
TRG_ENDOCYTIC_2	269	272	PF00928	0.199
TRG_ER_diArg_1	418	420	PF00400	0.488
TRG_NLS_Bipartite_1	418	439	PF00514	0.477
TRG_NLS_MonoExtC_3	431	436	PF00514	0.449
TRG_NLS_MonoExtN_4	432	439	PF00514	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRD2	Leptomonas seymouri	89%	100%
A0A0S4IXC2	Bodo saltans	73%	100%
A0A1X0NX23	Trypanosomatidae	77%	99%
A0A3Q8IBU6	Leishmania donovani	96%	100%
A0A422N7Q3	Trypanosoma rangeli	75%	98%
A4I0H3	Leishmania infantum	96%	100%
C9ZV98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	78%	100%
E9AWD5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QB37	Leishmania major	96%	100%
V5AZ95	Trypanosoma cruzi	76%	99%