Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

coronin, putative

Species:

Leishmania braziliensis

UniProt:

A4HCY7_LEIBR

TriTrypDb:

LbrM.23.1260 , LBRM2903_230022500

Length:

510

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0005815	microtubule organizing center	2	1
GO:0020016	ciliary pocket	2	1
GO:0036064	ciliary basal body	3	1
GO:0000139	Golgi membrane	5	1
GO:0005829	cytosol	2	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

A4HCY7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCY7

PDB structure(s): 6icr_A , 6icr_B , 6icr_C , 6icr_D

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007015	actin filament organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0097435	supramolecular fiber organization	4	1

Molecular functions
Term	Name	Level	Count
GO:0003779	actin binding	4	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008017	microtubule binding	5	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1
GO:0019894	kinesin binding	4	1
GO:0044877	protein-containing complex binding	2	1
GO:0051015	actin filament binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.366
CLV_NRD_NRD_1	221	223	PF00675	0.316
CLV_NRD_NRD_1	244	246	PF00675	0.405
CLV_NRD_NRD_1	319	321	PF00675	0.404
CLV_NRD_NRD_1	343	345	PF00675	0.252
CLV_NRD_NRD_1	467	469	PF00675	0.611
CLV_NRD_NRD_1	489	491	PF00675	0.498
CLV_PCSK_FUR_1	468	472	PF00082	0.343
CLV_PCSK_KEX2_1	221	223	PF00082	0.316
CLV_PCSK_KEX2_1	426	428	PF00082	0.599
CLV_PCSK_KEX2_1	470	472	PF00082	0.489
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.353
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.599
CLV_PCSK_PC1ET2_1	470	472	PF00082	0.332
CLV_PCSK_SKI1_1	138	142	PF00082	0.304
CLV_PCSK_SKI1_1	18	22	PF00082	0.319
CLV_PCSK_SKI1_1	237	241	PF00082	0.412
CLV_PCSK_SKI1_1	353	357	PF00082	0.365
CLV_PCSK_SKI1_1	490	494	PF00082	0.540
CLV_PCSK_SKI1_1	90	94	PF00082	0.319
DEG_SPOP_SBC_1	23	27	PF00917	0.397
DOC_CKS1_1	404	409	PF01111	0.465
DOC_CKS1_1	433	438	PF01111	0.476
DOC_CYCLIN_RxL_1	12	25	PF00134	0.302
DOC_MAPK_gen_1	125	133	PF00069	0.316
DOC_MAPK_gen_1	15	23	PF00069	0.374
DOC_MAPK_gen_1	221	229	PF00069	0.328
DOC_MAPK_gen_1	245	256	PF00069	0.463
DOC_MAPK_gen_1	344	351	PF00069	0.187
DOC_MAPK_HePTP_8	60	72	PF00069	0.272
DOC_MAPK_MEF2A_6	63	72	PF00069	0.397
DOC_PP2B_PxIxI_1	76	82	PF00149	0.313
DOC_USP7_MATH_1	197	201	PF00917	0.479
DOC_USP7_MATH_1	361	365	PF00917	0.396
DOC_USP7_UBL2_3	122	126	PF12436	0.485
DOC_USP7_UBL2_3	414	418	PF12436	0.581
DOC_WW_Pin1_4	113	118	PF00397	0.433
DOC_WW_Pin1_4	375	380	PF00397	0.392
DOC_WW_Pin1_4	389	394	PF00397	0.496
DOC_WW_Pin1_4	403	408	PF00397	0.535
DOC_WW_Pin1_4	412	417	PF00397	0.640
DOC_WW_Pin1_4	432	437	PF00397	0.668
LIG_14-3-3_CanoR_1	198	203	PF00244	0.282
LIG_14-3-3_CanoR_1	344	351	PF00244	0.329
LIG_14-3-3_CanoR_1	449	456	PF00244	0.585
LIG_14-3-3_CanoR_1	5	13	PF00244	0.297
LIG_AP2alpha_2	84	86	PF02296	0.437
LIG_APCC_ABBA_1	264	269	PF00400	0.319
LIG_BIR_II_1	1	5	PF00653	0.336
LIG_BRCT_BRCA1_1	259	263	PF00533	0.392
LIG_BRCT_BRCA1_1	384	388	PF00533	0.533
LIG_Clathr_ClatBox_1	335	339	PF01394	0.382
LIG_deltaCOP1_diTrp_1	175	183	PF00928	0.420
LIG_eIF4E_1	382	388	PF01652	0.430
LIG_FHA_1	105	111	PF00498	0.425
LIG_FHA_1	242	248	PF00498	0.264
LIG_FHA_1	449	455	PF00498	0.480
LIG_FHA_1	8	14	PF00498	0.280
LIG_FHA_2	170	176	PF00498	0.426
LIG_FHA_2	184	190	PF00498	0.223
LIG_FHA_2	357	363	PF00498	0.287
LIG_FHA_2	376	382	PF00498	0.122
LIG_FHA_2	450	456	PF00498	0.561
LIG_FHA_2	91	97	PF00498	0.294
LIG_LIR_Gen_1	248	256	PF02991	0.340
LIG_LIR_Gen_1	323	332	PF02991	0.459
LIG_LIR_Gen_1	40	50	PF02991	0.252
LIG_LIR_Nem_3	248	254	PF02991	0.393
LIG_LIR_Nem_3	260	266	PF02991	0.444
LIG_LIR_Nem_3	323	327	PF02991	0.469
LIG_LIR_Nem_3	331	335	PF02991	0.344
LIG_LIR_Nem_3	385	391	PF02991	0.510
LIG_LIR_Nem_3	40	45	PF02991	0.252
LIG_LIR_Nem_3	80	86	PF02991	0.298
LIG_Pex14_2	356	360	PF04695	0.329
LIG_REV1ctd_RIR_1	369	377	PF16727	0.334
LIG_SH2_CRK	332	336	PF00017	0.431
LIG_SH2_NCK_1	251	255	PF00017	0.242
LIG_SH2_STAP1	267	271	PF00017	0.405
LIG_SH3_1	63	69	PF00018	0.448
LIG_SH3_3	10	16	PF00018	0.394
LIG_SH3_3	40	46	PF00018	0.350
LIG_SH3_3	430	436	PF00018	0.637
LIG_SH3_3	63	69	PF00018	0.450
LIG_SH3_4	15	22	PF00018	0.264
LIG_SUMO_SIM_par_1	252	257	PF11976	0.316
LIG_SUMO_SIM_par_1	272	278	PF11976	0.315
LIG_SUMO_SIM_par_1	334	339	PF11976	0.292
LIG_TRAF2_1	420	423	PF00917	0.718
LIG_TRAF2_1	492	495	PF00917	0.420
LIG_TYR_ITIM	330	335	PF00017	0.424
LIG_UBA3_1	226	233	PF00899	0.426
LIG_UBA3_1	273	279	PF00899	0.406
LIG_WRC_WIRS_1	130	135	PF05994	0.312
MOD_CDC14_SPxK_1	415	418	PF00782	0.666
MOD_CDK_SPK_2	375	380	PF00069	0.217
MOD_CDK_SPK_2	389	394	PF00069	0.411
MOD_CDK_SPxK_1	412	418	PF00069	0.676
MOD_CK1_1	112	118	PF00069	0.374
MOD_CK1_1	165	171	PF00069	0.421
MOD_CK1_1	205	211	PF00069	0.387
MOD_CK1_1	259	265	PF00069	0.417
MOD_CK1_1	334	340	PF00069	0.374
MOD_CK1_1	364	370	PF00069	0.327
MOD_CK1_1	399	405	PF00069	0.675
MOD_CK2_1	169	175	PF00069	0.419
MOD_CK2_1	201	207	PF00069	0.496
MOD_CK2_1	275	281	PF00069	0.349
MOD_CK2_1	344	350	PF00069	0.332
MOD_CK2_1	364	370	PF00069	0.329
MOD_CK2_1	375	381	PF00069	0.298
MOD_CK2_1	90	96	PF00069	0.291
MOD_GlcNHglycan	135	138	PF01048	0.309
MOD_GlcNHglycan	142	145	PF01048	0.275
MOD_GlcNHglycan	210	213	PF01048	0.383
MOD_GlcNHglycan	259	262	PF01048	0.494
MOD_GlcNHglycan	362	366	PF01048	0.365
MOD_GlcNHglycan	59	63	PF01048	0.420
MOD_GSK3_1	109	116	PF00069	0.263
MOD_GSK3_1	129	136	PF00069	0.320
MOD_GSK3_1	165	172	PF00069	0.394
MOD_GSK3_1	178	185	PF00069	0.246
MOD_GSK3_1	197	204	PF00069	0.334
MOD_GSK3_1	275	282	PF00069	0.300
MOD_GSK3_1	294	301	PF00069	0.328
MOD_GSK3_1	30	37	PF00069	0.387
MOD_GSK3_1	399	406	PF00069	0.590
MOD_GSK3_1	421	428	PF00069	0.578
MOD_GSK3_1	443	450	PF00069	0.576
MOD_GSK3_1	46	53	PF00069	0.454
MOD_GSK3_1	92	99	PF00069	0.319
MOD_N-GLC_1	112	117	PF02516	0.369
MOD_N-GLC_1	165	170	PF02516	0.424
MOD_N-GLC_1	198	203	PF02516	0.377
MOD_N-GLC_1	21	26	PF02516	0.294
MOD_N-GLC_1	231	236	PF02516	0.280
MOD_N-GLC_1	375	380	PF02516	0.185
MOD_NEK2_1	1	6	PF00069	0.251
MOD_NEK2_1	178	183	PF00069	0.296
MOD_NEK2_1	21	26	PF00069	0.400
MOD_NEK2_1	241	246	PF00069	0.368
MOD_NEK2_1	256	261	PF00069	0.473
MOD_NEK2_1	372	377	PF00069	0.295
MOD_NEK2_1	396	401	PF00069	0.571
MOD_NEK2_1	50	55	PF00069	0.314
MOD_NEK2_2	129	134	PF00069	0.312
MOD_PIKK_1	211	217	PF00454	0.432
MOD_PIKK_1	231	237	PF00454	0.366
MOD_PIKK_1	299	305	PF00454	0.371
MOD_PIKK_1	495	501	PF00454	0.380
MOD_PK_1	249	255	PF00069	0.316
MOD_PKA_1	222	228	PF00069	0.367
MOD_PKA_1	344	350	PF00069	0.382
MOD_PKA_2	197	203	PF00069	0.463
MOD_PKA_2	372	378	PF00069	0.308
MOD_PKA_2	448	454	PF00069	0.646
MOD_PKA_2	6	12	PF00069	0.251
MOD_PKB_1	5	13	PF00069	0.382
MOD_Plk_1	198	204	PF00069	0.359
MOD_Plk_1	361	367	PF00069	0.327
MOD_Plk_1	421	427	PF00069	0.726
MOD_Plk_4	145	151	PF00069	0.260
MOD_Plk_4	178	184	PF00069	0.325
MOD_Plk_4	198	204	PF00069	0.432
MOD_Plk_4	222	228	PF00069	0.367
MOD_Plk_4	249	255	PF00069	0.305
MOD_Plk_4	259	265	PF00069	0.209
MOD_Plk_4	331	337	PF00069	0.300
MOD_Plk_4	96	102	PF00069	0.311
MOD_ProDKin_1	113	119	PF00069	0.427
MOD_ProDKin_1	375	381	PF00069	0.392
MOD_ProDKin_1	389	395	PF00069	0.488
MOD_ProDKin_1	403	409	PF00069	0.535
MOD_ProDKin_1	412	418	PF00069	0.642
MOD_ProDKin_1	432	438	PF00069	0.667
MOD_SUMO_for_1	420	423	PF00179	0.658
MOD_SUMO_rev_2	392	402	PF00179	0.355
MOD_SUMO_rev_2	75	83	PF00179	0.430
TRG_DiLeu_BaEn_1	269	274	PF01217	0.417
TRG_DiLeu_BaLyEn_6	391	396	PF01217	0.273
TRG_ENDOCYTIC_2	251	254	PF00928	0.417
TRG_ENDOCYTIC_2	332	335	PF00928	0.447
TRG_NLS_MonoCore_2	467	472	PF00514	0.344
TRG_NLS_MonoExtC_3	468	474	PF00514	0.475
TRG_NLS_MonoExtN_4	122	129	PF00514	0.254
TRG_NLS_MonoExtN_4	468	473	PF00514	0.341
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	491	495	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGC0	Leptomonas seymouri	61%	99%
A0A0S4IT51	Bodo saltans	49%	100%
A0A1X0NWV5	Trypanosomatidae	42%	96%
A0A3Q8IEM1	Leishmania donovani	79%	100%
A0A3R7K7Y6	Trypanosoma rangeli	46%	100%
A4I0H2	Leishmania infantum	79%	100%
A8WGE3	Xenopus tropicalis	34%	100%
B0R0D7	Danio rerio	35%	100%
C9ZV95	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	98%
E9AWD4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
O13923	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	85%
O89046	Rattus norvegicus	35%	100%
O89053	Mus musculus	35%	100%
P27133	Dictyostelium discoideum	34%	100%
P31146	Homo sapiens	36%	100%
Q06440	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	78%
Q21624	Caenorhabditis elegans	30%	84%
Q32LP9	Bos taurus	32%	97%
Q4QB38	Leishmania major	78%	100%
Q4R4J2	Macaca fascicularis	37%	100%
Q5NVK4	Pongo abelii	35%	100%
Q6DJD8	Xenopus laevis	34%	100%
Q6QEF8	Homo sapiens	36%	100%
Q8BH44	Mus musculus	33%	100%
Q8C0P5	Mus musculus	31%	97%
Q91ZN1	Rattus norvegicus	37%	100%
Q920J3	Rattus norvegicus	37%	100%
Q920M5	Mus musculus	36%	100%
Q92176	Bos taurus	36%	100%
Q92828	Homo sapiens	30%	97%
Q9BR76	Homo sapiens	35%	100%
Q9ULV4	Homo sapiens	35%	100%
Q9UQ03	Homo sapiens	32%	100%
Q9WUM3	Mus musculus	35%	100%
Q9WUM4	Mus musculus	35%	100%
Q9XS70	Oryctolagus cuniculus	35%	100%