Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HCY5_LEIBR

TriTrypDb:

LbrM.23.1240

Length:

466

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCY5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCY5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	399	403	PF00656	0.434
CLV_NRD_NRD_1	264	266	PF00675	0.513
CLV_NRD_NRD_1	324	326	PF00675	0.502
CLV_NRD_NRD_1	441	443	PF00675	0.431
CLV_PCSK_FUR_1	262	266	PF00082	0.380
CLV_PCSK_KEX2_1	162	164	PF00082	0.602
CLV_PCSK_KEX2_1	205	207	PF00082	0.623
CLV_PCSK_KEX2_1	264	266	PF00082	0.384
CLV_PCSK_KEX2_1	30	32	PF00082	0.692
CLV_PCSK_KEX2_1	428	430	PF00082	0.413
CLV_PCSK_KEX2_1	90	92	PF00082	0.514
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.602
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.602
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.692
CLV_PCSK_PC1ET2_1	428	430	PF00082	0.413
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.534
CLV_PCSK_SKI1_1	106	110	PF00082	0.470
CLV_PCSK_SKI1_1	208	212	PF00082	0.473
CLV_PCSK_SKI1_1	428	432	PF00082	0.574
CLV_PCSK_SKI1_1	442	446	PF00082	0.536
DEG_APCC_DBOX_1	249	257	PF00400	0.381
DEG_SPOP_SBC_1	221	225	PF00917	0.375
DOC_CDC14_PxL_1	155	163	PF14671	0.414
DOC_MAPK_gen_1	144	152	PF00069	0.502
DOC_MAPK_gen_1	262	270	PF00069	0.502
DOC_MAPK_gen_1	385	393	PF00069	0.443
DOC_MAPK_MEF2A_6	385	393	PF00069	0.522
DOC_MAPK_RevD_3	75	91	PF00069	0.381
DOC_PP2B_LxvP_1	165	168	PF13499	0.444
DOC_USP7_MATH_1	371	375	PF00917	0.479
LIG_14-3-3_CanoR_1	144	150	PF00244	0.514
LIG_14-3-3_CanoR_1	218	226	PF00244	0.507
LIG_14-3-3_CanoR_1	282	290	PF00244	0.448
LIG_14-3-3_CanoR_1	314	323	PF00244	0.405
LIG_14-3-3_CanoR_1	37	43	PF00244	0.582
LIG_14-3-3_CanoR_1	442	447	PF00244	0.554
LIG_Actin_WH2_2	148	164	PF00022	0.396
LIG_Actin_WH2_2	203	220	PF00022	0.348
LIG_Actin_WH2_2	437	454	PF00022	0.407
LIG_BIR_II_1	1	5	PF00653	0.534
LIG_BIR_III_4	308	312	PF00653	0.434
LIG_FHA_1	222	228	PF00498	0.609
LIG_FHA_1	232	238	PF00498	0.593
LIG_FHA_1	315	321	PF00498	0.408
LIG_FHA_2	120	126	PF00498	0.651
LIG_FHA_2	173	179	PF00498	0.702
LIG_FHA_2	443	449	PF00498	0.561
LIG_FHA_2	56	62	PF00498	0.559
LIG_FHA_2	93	99	PF00498	0.524
LIG_GBD_Chelix_1	245	253	PF00786	0.539
LIG_LIR_Gen_1	369	376	PF02991	0.534
LIG_LIR_Gen_1	448	457	PF02991	0.377
LIG_LIR_Gen_1	92	101	PF02991	0.402
LIG_LIR_Nem_3	369	375	PF02991	0.536
LIG_LIR_Nem_3	448	453	PF02991	0.384
LIG_LIR_Nem_3	92	97	PF02991	0.395
LIG_NRBOX	346	352	PF00104	0.537
LIG_PCNA_yPIPBox_3	59	67	PF02747	0.412
LIG_SH2_CRK	372	376	PF00017	0.531
LIG_SH2_STAP1	183	187	PF00017	0.398
LIG_SH2_STAT3	170	173	PF00017	0.465
LIG_SH2_STAT5	416	419	PF00017	0.466
LIG_SH2_STAT5	450	453	PF00017	0.601
LIG_SH3_3	153	159	PF00018	0.395
LIG_SH3_3	51	57	PF00018	0.406
LIG_SUMO_SIM_par_1	231	240	PF11976	0.501
LIG_TRAF2_1	177	180	PF00917	0.509
LIG_TRAF2_1	332	335	PF00917	0.488
LIG_TRAF2_1	434	437	PF00917	0.566
LIG_TRAF2_1	69	72	PF00917	0.601
MOD_CK1_1	19	25	PF00069	0.460
MOD_CK1_1	2	8	PF00069	0.543
MOD_CK1_1	299	305	PF00069	0.473
MOD_CK1_1	374	380	PF00069	0.572
MOD_CK1_1	392	398	PF00069	0.361
MOD_CK1_1	41	47	PF00069	0.624
MOD_CK1_1	422	428	PF00069	0.559
MOD_CK2_1	273	279	PF00069	0.423
MOD_CK2_1	55	61	PF00069	0.572
MOD_CK2_1	65	71	PF00069	0.491
MOD_CK2_1	92	98	PF00069	0.524
MOD_GlcNHglycan	18	21	PF01048	0.507
MOD_GlcNHglycan	231	234	PF01048	0.515
MOD_GlcNHglycan	26	30	PF01048	0.643
MOD_GlcNHglycan	43	46	PF01048	0.425
MOD_GlcNHglycan	68	71	PF01048	0.581
MOD_GSK3_1	1	8	PF00069	0.577
MOD_GSK3_1	102	109	PF00069	0.528
MOD_GSK3_1	115	122	PF00069	0.496
MOD_GSK3_1	217	224	PF00069	0.553
MOD_GSK3_1	231	238	PF00069	0.542
MOD_GSK3_1	37	44	PF00069	0.449
MOD_GSK3_1	415	422	PF00069	0.550
MOD_N-GLC_1	291	296	PF02516	0.395
MOD_N-GLC_1	422	427	PF02516	0.432
MOD_N-GLC_2	133	135	PF02516	0.571
MOD_NEK2_1	1	6	PF00069	0.460
MOD_NEK2_1	145	150	PF00069	0.584
MOD_NEK2_1	172	177	PF00069	0.486
MOD_NEK2_1	229	234	PF00069	0.466
MOD_NEK2_1	245	250	PF00069	0.602
MOD_NEK2_1	38	43	PF00069	0.562
MOD_NEK2_2	319	324	PF00069	0.399
MOD_NEK2_2	50	55	PF00069	0.419
MOD_PIKK_1	193	199	PF00454	0.354
MOD_PIKK_1	283	289	PF00454	0.595
MOD_PIKK_1	296	302	PF00454	0.500
MOD_PKA_1	442	448	PF00069	0.419
MOD_PKA_2	217	223	PF00069	0.493
MOD_PKB_1	206	214	PF00069	0.511
MOD_Plk_1	179	185	PF00069	0.542
MOD_Plk_1	208	214	PF00069	0.350
MOD_Plk_1	221	227	PF00069	0.442
MOD_Plk_1	291	297	PF00069	0.411
MOD_Plk_1	422	428	PF00069	0.398
MOD_Plk_2-3	273	279	PF00069	0.366
MOD_Plk_4	222	228	PF00069	0.568
MOD_Plk_4	231	237	PF00069	0.540
MOD_Plk_4	273	279	PF00069	0.393
MOD_Plk_4	346	352	PF00069	0.371
MOD_Plk_4	371	377	PF00069	0.529
MOD_Plk_4	422	428	PF00069	0.559
MOD_Plk_4	442	448	PF00069	0.411
MOD_SUMO_rev_2	353	362	PF00179	0.506
MOD_SUMO_rev_2	374	381	PF00179	0.366
TRG_DiLeu_BaEn_1	222	227	PF01217	0.477
TRG_DiLeu_BaLyEn_6	156	161	PF01217	0.403
TRG_DiLeu_BaLyEn_6	34	39	PF01217	0.402
TRG_ENDOCYTIC_2	344	347	PF00928	0.462
TRG_ENDOCYTIC_2	372	375	PF00928	0.535
TRG_ENDOCYTIC_2	450	453	PF00928	0.546
TRG_ENDOCYTIC_2	83	86	PF00928	0.524
TRG_ER_diArg_1	262	265	PF00400	0.381
TRG_ER_diArg_1	407	410	PF00400	0.401
TRG_NLS_MonoExtN_4	262	269	PF00514	0.535
TRG_Pf-PMV_PEXEL_1	208	213	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	282	287	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	409	413	PF00026	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9S1	Leptomonas seymouri	26%	100%
A0A3Q8IFW4	Leishmania donovani	69%	100%
A4I0H0	Leishmania infantum	68%	100%
E9AWD2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4QB40	Leishmania major	69%	100%