GRIP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCY4_LEIBR

TriTrypDb:

LbrM.23.1230 , LBRM2903_230022100

Length:

521

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0005814	centriole	5	3
GO:0005874	microtubule	6	3
GO:0043226	organelle	2	3
GO:0043228	non-membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043232	intracellular non-membrane-bounded organelle	4	3
GO:0099080	supramolecular complex	2	3
GO:0099081	supramolecular polymer	3	3
GO:0099512	supramolecular fiber	4	3
GO:0099513	polymeric cytoskeletal fiber	5	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HCY4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCY4

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	3
GO:0016043	cellular component organization	3	3
GO:0030030	cell projection organization	4	3
GO:0071840	cellular component organization or biogenesis	2	3

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.452
CLV_C14_Caspase3-7	299	303	PF00656	0.499
CLV_C14_Caspase3-7	421	425	PF00656	0.705
CLV_NRD_NRD_1	163	165	PF00675	0.543
CLV_NRD_NRD_1	276	278	PF00675	0.443
CLV_NRD_NRD_1	289	291	PF00675	0.498
CLV_NRD_NRD_1	87	89	PF00675	0.613
CLV_PCSK_KEX2_1	163	165	PF00082	0.402
CLV_PCSK_KEX2_1	237	239	PF00082	0.481
CLV_PCSK_KEX2_1	275	277	PF00082	0.455
CLV_PCSK_KEX2_1	289	291	PF00082	0.441
CLV_PCSK_KEX2_1	458	460	PF00082	0.467
CLV_PCSK_KEX2_1	501	503	PF00082	0.458
CLV_PCSK_KEX2_1	86	88	PF00082	0.621
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.481
CLV_PCSK_PC1ET2_1	458	460	PF00082	0.420
CLV_PCSK_PC1ET2_1	501	503	PF00082	0.458
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.489
CLV_PCSK_SKI1_1	308	312	PF00082	0.708
DEG_Nend_UBRbox_2	1	3	PF02207	0.387
DOC_MAPK_gen_1	101	110	PF00069	0.428
DOC_MAPK_gen_1	214	224	PF00069	0.443
DOC_MAPK_gen_1	237	245	PF00069	0.388
DOC_MAPK_gen_1	482	493	PF00069	0.426
DOC_MAPK_gen_1	501	507	PF00069	0.312
DOC_MAPK_gen_1	86	93	PF00069	0.493
DOC_PP2B_LxvP_1	265	268	PF13499	0.571
DOC_SPAK_OSR1_1	502	506	PF12202	0.451
DOC_USP7_MATH_1	151	155	PF00917	0.507
DOC_USP7_MATH_1	291	295	PF00917	0.601
DOC_USP7_MATH_1	300	304	PF00917	0.690
DOC_USP7_MATH_1	41	45	PF00917	0.580
DOC_USP7_MATH_1	54	58	PF00917	0.546
DOC_USP7_UBL2_3	463	467	PF12436	0.492
DOC_USP7_UBL2_3	482	486	PF12436	0.326
DOC_WW_Pin1_4	333	338	PF00397	0.503
LIG_14-3-3_CanoR_1	253	261	PF00244	0.536
LIG_14-3-3_CanoR_1	362	366	PF00244	0.499
LIG_Actin_WH2_2	274	291	PF00022	0.455
LIG_BIR_III_4	319	323	PF00653	0.525
LIG_FAT_LD_1	507	515	PF03623	0.377
LIG_FHA_1	245	251	PF00498	0.465
LIG_FHA_1	340	346	PF00498	0.446
LIG_FHA_1	487	493	PF00498	0.463
LIG_FHA_2	255	261	PF00498	0.490
LIG_LIR_Gen_1	33	41	PF02991	0.454
LIG_LIR_Nem_3	33	39	PF02991	0.444
LIG_NRBOX	506	512	PF00104	0.376
LIG_PCNA_yPIPBox_3	501	511	PF02747	0.449
LIG_SH2_STAP1	442	446	PF00017	0.515
LIG_SH2_STAT5	455	458	PF00017	0.390
LIG_SH3_4	326	333	PF00018	0.669
LIG_SUMO_SIM_anti_2	512	518	PF11976	0.300
LIG_SUMO_SIM_par_1	412	418	PF11976	0.436
LIG_SUMO_SIM_par_1	445	451	PF11976	0.480
LIG_TRAF2_1	239	242	PF00917	0.607
LIG_UBA3_1	414	422	PF00899	0.459
MOD_CK1_1	128	134	PF00069	0.414
MOD_CK1_1	256	262	PF00069	0.340
MOD_CK1_1	409	415	PF00069	0.643
MOD_CK1_1	418	424	PF00069	0.599
MOD_CK1_1	431	437	PF00069	0.459
MOD_CK1_1	62	68	PF00069	0.600
MOD_CK2_1	194	200	PF00069	0.457
MOD_CK2_1	254	260	PF00069	0.488
MOD_CK2_1	333	339	PF00069	0.523
MOD_CK2_1	344	350	PF00069	0.477
MOD_CK2_1	401	407	PF00069	0.568
MOD_CK2_1	458	464	PF00069	0.447
MOD_GlcNHglycan	111	114	PF01048	0.735
MOD_GlcNHglycan	208	211	PF01048	0.671
MOD_GlcNHglycan	293	296	PF01048	0.511
MOD_GlcNHglycan	298	301	PF01048	0.492
MOD_GlcNHglycan	302	305	PF01048	0.715
MOD_GlcNHglycan	396	399	PF01048	0.507
MOD_GlcNHglycan	47	50	PF01048	0.475
MOD_GlcNHglycan	64	67	PF01048	0.477
MOD_GSK3_1	196	203	PF00069	0.409
MOD_GSK3_1	291	298	PF00069	0.420
MOD_GSK3_1	340	347	PF00069	0.518
MOD_GSK3_1	41	48	PF00069	0.439
MOD_LATS_1	192	198	PF00433	0.577
MOD_N-GLC_1	125	130	PF02516	0.431
MOD_N-GLC_1	62	67	PF02516	0.537
MOD_NEK2_1	135	140	PF00069	0.530
MOD_NEK2_1	201	206	PF00069	0.469
MOD_NEK2_1	406	411	PF00069	0.626
MOD_NEK2_1	415	420	PF00069	0.450
MOD_NEK2_1	45	50	PF00069	0.547
MOD_NEK2_1	99	104	PF00069	0.573
MOD_PIKK_1	135	141	PF00454	0.525
MOD_PIKK_1	409	415	PF00454	0.643
MOD_PIKK_1	458	464	PF00454	0.337
MOD_PIKK_1	495	501	PF00454	0.455
MOD_PK_1	140	146	PF00069	0.503
MOD_PK_1	194	200	PF00069	0.457
MOD_PK_1	369	375	PF00069	0.489
MOD_PKA_1	163	169	PF00069	0.485
MOD_PKA_1	194	200	PF00069	0.457
MOD_PKA_1	458	464	PF00069	0.337
MOD_PKA_2	135	141	PF00069	0.525
MOD_PKA_2	163	169	PF00069	0.356
MOD_PKA_2	361	367	PF00069	0.450
MOD_PKA_2	431	437	PF00069	0.501
MOD_PKA_2	458	464	PF00069	0.389
MOD_Plk_1	128	134	PF00069	0.424
MOD_Plk_1	340	346	PF00069	0.569
MOD_Plk_1	401	407	PF00069	0.487
MOD_Plk_1	442	448	PF00069	0.551
MOD_Plk_4	344	350	PF00069	0.511
MOD_Plk_4	361	367	PF00069	0.386
MOD_Plk_4	41	47	PF00069	0.466
MOD_Plk_4	442	448	PF00069	0.533
MOD_Plk_4	512	518	PF00069	0.458
MOD_ProDKin_1	333	339	PF00069	0.496
MOD_SUMO_rev_2	16	25	PF00179	0.532
MOD_SUMO_rev_2	241	250	PF00179	0.486
MOD_SUMO_rev_2	35	44	PF00179	0.306
MOD_SUMO_rev_2	378	386	PF00179	0.486
MOD_SUMO_rev_2	461	468	PF00179	0.488
MOD_SUMO_rev_2	479	484	PF00179	0.362
MOD_SUMO_rev_2	490	498	PF00179	0.291
TRG_DiLeu_BaEn_1	487	492	PF01217	0.478
TRG_DiLeu_BaEn_4	401	407	PF01217	0.481
TRG_ER_diArg_1	163	165	PF00400	0.431
TRG_ER_diArg_1	274	277	PF00400	0.412
TRG_ER_diArg_1	288	290	PF00400	0.457
TRG_NES_CRM1_1	178	193	PF08389	0.332
TRG_Pf-PMV_PEXEL_1	279	284	PF00026	0.343

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NWV0	Trypanosomatidae	28%	68%
A0A3Q8IB33	Leishmania donovani	80%	83%
A0A422NPG5	Trypanosoma rangeli	27%	69%
A4I0G9	Leishmania infantum	80%	83%
E9AWD1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	83%
Q4QB41	Leishmania major	80%	100%
V5BB81	Trypanosoma cruzi	28%	69%