Calponin-homology (CH) domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCY2_LEIBR

TriTrypDb:

LbrM.23.1210 , LBRM2903_230021700

Length:

443

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0005874	microtubule	6	1
GO:0005881	cytoplasmic microtubule	7	1
GO:0035371	microtubule plus-end	3	1
GO:0051233	spindle midzone	2	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	1
GO:1990752	microtubule end	2	1

Expansion

Sequence features

A4HCY2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCY2

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0007051	spindle organization	3	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0022607	cellular component assembly	4	1
GO:0031110	regulation of microtubule polymerization or depolymerization	6	1
GO:0032886	regulation of microtubule-based process	4	1
GO:0033036	macromolecule localization	2	1
GO:0033043	regulation of organelle organization	5	1
GO:0033365	protein localization to organelle	5	1
GO:0035372	protein localization to microtubule	8	1
GO:0044380	protein localization to cytoskeleton	6	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051179	localization	1	1
GO:0051225	spindle assembly	4	1
GO:0051493	regulation of cytoskeleton organization	6	1
GO:0051641	cellular localization	2	1
GO:0065007	biological regulation	1	1
GO:0070507	regulation of microtubule cytoskeleton organization	5	1
GO:0070727	cellular macromolecule localization	3	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0072698	protein localization to microtubule cytoskeleton	7	1
GO:0140694	non-membrane-bounded organelle assembly	6	1
GO:1904825	protein localization to microtubule plus-end	10	1
GO:1905725	protein localization to microtubule end	9	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0005515	protein binding	2	8
GO:0008017	microtubule binding	5	8
GO:0008092	cytoskeletal protein binding	3	8
GO:0015631	tubulin binding	4	8
GO:0051010	microtubule plus-end binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	31	35	PF00656	0.324
CLV_NRD_NRD_1	10	12	PF00675	0.519
CLV_NRD_NRD_1	194	196	PF00675	0.705
CLV_NRD_NRD_1	220	222	PF00675	0.630
CLV_NRD_NRD_1	380	382	PF00675	0.498
CLV_PCSK_KEX2_1	194	196	PF00082	0.698
CLV_PCSK_KEX2_1	220	222	PF00082	0.586
CLV_PCSK_KEX2_1	380	382	PF00082	0.498
CLV_PCSK_SKI1_1	12	16	PF00082	0.466
CLV_PCSK_SKI1_1	130	134	PF00082	0.480
CLV_PCSK_SKI1_1	159	163	PF00082	0.457
CLV_PCSK_SKI1_1	303	307	PF00082	0.702
CLV_PCSK_SKI1_1	342	346	PF00082	0.614
CLV_Separin_Metazoa	304	308	PF03568	0.678
DEG_APCC_DBOX_1	326	334	PF00400	0.526
DEG_COP1_1	316	325	PF00400	0.502
DOC_CKS1_1	252	257	PF01111	0.708
DOC_CYCLIN_RxL_1	139	151	PF00134	0.489
DOC_PP1_RVXF_1	205	211	PF00149	0.521
DOC_PP1_RVXF_1	75	81	PF00149	0.373
DOC_PP4_FxxP_1	252	255	PF00568	0.680
DOC_USP7_MATH_1	245	249	PF00917	0.635
DOC_USP7_MATH_1	28	32	PF00917	0.426
DOC_USP7_MATH_1	44	48	PF00917	0.329
DOC_USP7_MATH_1	55	59	PF00917	0.544
DOC_USP7_MATH_1	93	97	PF00917	0.575
DOC_USP7_UBL2_3	160	164	PF12436	0.523
DOC_WW_Pin1_4	224	229	PF00397	0.713
DOC_WW_Pin1_4	251	256	PF00397	0.682
DOC_WW_Pin1_4	265	270	PF00397	0.580
DOC_WW_Pin1_4	279	284	PF00397	0.688
LIG_14-3-3_CanoR_1	123	127	PF00244	0.518
LIG_14-3-3_CanoR_1	187	197	PF00244	0.527
LIG_14-3-3_CanoR_1	279	283	PF00244	0.723
LIG_14-3-3_CanoR_1	286	290	PF00244	0.791
LIG_14-3-3_CanoR_1	327	331	PF00244	0.555
LIG_BIR_II_1	1	5	PF00653	0.660
LIG_BRCT_BRCA1_1	248	252	PF00533	0.602
LIG_BRCT_BRCA1_1	4	8	PF00533	0.412
LIG_Clathr_ClatBox_1	75	79	PF01394	0.281
LIG_FHA_1	126	132	PF00498	0.603
LIG_FHA_1	179	185	PF00498	0.610
LIG_FHA_1	261	267	PF00498	0.538
LIG_FHA_1	317	323	PF00498	0.608
LIG_FHA_1	386	392	PF00498	0.613
LIG_FHA_1	414	420	PF00498	0.470
LIG_FHA_1	81	87	PF00498	0.482
LIG_FHA_2	209	215	PF00498	0.792
LIG_FHA_2	38	44	PF00498	0.374
LIG_LIR_Apic_2	249	255	PF02991	0.673
LIG_LIR_Nem_3	25	29	PF02991	0.395
LIG_LIR_Nem_3	310	315	PF02991	0.524
LIG_LYPXL_yS_3	26	29	PF13949	0.352
LIG_NRBOX	393	399	PF00104	0.492
LIG_NRBOX	435	441	PF00104	0.523
LIG_Pex14_1	145	149	PF04695	0.380
LIG_PTB_Apo_2	20	27	PF02174	0.307
LIG_PTB_Phospho_1	20	26	PF10480	0.306
LIG_REV1ctd_RIR_1	323	331	PF16727	0.372
LIG_SH2_CRK	38	42	PF00017	0.331
LIG_SH2_NCK_1	408	412	PF00017	0.526
LIG_SH2_STAP1	157	161	PF00017	0.442
LIG_SH2_STAT5	147	150	PF00017	0.468
LIG_SH2_STAT5	315	318	PF00017	0.514
LIG_SH2_STAT5	38	41	PF00017	0.333
LIG_SH2_STAT5	74	77	PF00017	0.480
LIG_SH3_3	287	293	PF00018	0.606
LIG_SH3_3	425	431	PF00018	0.564
LIG_SUMO_SIM_anti_2	138	144	PF11976	0.440
LIG_SUMO_SIM_anti_2	435	441	PF11976	0.520
LIG_SUMO_SIM_par_1	318	324	PF11976	0.539
LIG_SUMO_SIM_par_1	387	393	PF11976	0.530
LIG_TRAF2_1	211	214	PF00917	0.530
LIG_TRAF2_1	390	393	PF00917	0.576
MOD_CDC14_SPxK_1	227	230	PF00782	0.621
MOD_CDK_SPK_2	229	234	PF00069	0.596
MOD_CDK_SPK_2	265	270	PF00069	0.714
MOD_CDK_SPK_2	281	286	PF00069	0.512
MOD_CDK_SPxK_1	224	230	PF00069	0.627
MOD_CDK_SPxxK_3	229	236	PF00069	0.629
MOD_CDK_SPxxK_3	279	286	PF00069	0.536
MOD_CK1_1	186	192	PF00069	0.552
MOD_CK1_1	2	8	PF00069	0.637
MOD_CK1_1	229	235	PF00069	0.760
MOD_CK1_1	281	287	PF00069	0.714
MOD_CK1_1	421	427	PF00069	0.613
MOD_CK2_1	208	214	PF00069	0.739
MOD_CK2_1	229	235	PF00069	0.779
MOD_CK2_1	298	304	PF00069	0.680
MOD_CK2_1	37	43	PF00069	0.425
MOD_CK2_1	387	393	PF00069	0.573
MOD_CK2_1	95	101	PF00069	0.424
MOD_Cter_Amidation	9	12	PF01082	0.517
MOD_GlcNHglycan	1	4	PF01048	0.702
MOD_GlcNHglycan	300	303	PF01048	0.726
MOD_GlcNHglycan	420	423	PF01048	0.590
MOD_GlcNHglycan	79	83	PF01048	0.460
MOD_GlcNHglycan	8	11	PF01048	0.431
MOD_GlcNHglycan	88	91	PF01048	0.501
MOD_GSK3_1	122	129	PF00069	0.352
MOD_GSK3_1	183	190	PF00069	0.623
MOD_GSK3_1	2	9	PF00069	0.614
MOD_GSK3_1	224	231	PF00069	0.691
MOD_GSK3_1	247	254	PF00069	0.664
MOD_GSK3_1	277	284	PF00069	0.676
MOD_N-GLC_1	178	183	PF02516	0.609
MOD_N-GLC_2	20	22	PF02516	0.304
MOD_NEK2_1	148	153	PF00069	0.477
MOD_NEK2_1	178	183	PF00069	0.559
MOD_NEK2_1	298	303	PF00069	0.712
MOD_NEK2_1	326	331	PF00069	0.508
MOD_NEK2_1	78	83	PF00069	0.450
MOD_NEK2_2	28	33	PF00069	0.424
MOD_PIKK_1	421	427	PF00454	0.548
MOD_PK_1	366	372	PF00069	0.600
MOD_PKA_2	122	128	PF00069	0.510
MOD_PKA_2	186	192	PF00069	0.468
MOD_PKA_2	245	251	PF00069	0.730
MOD_PKA_2	278	284	PF00069	0.699
MOD_PKA_2	285	291	PF00069	0.676
MOD_PKA_2	316	322	PF00069	0.600
MOD_PKA_2	326	332	PF00069	0.536
MOD_PKA_2	385	391	PF00069	0.613
MOD_PKB_1	185	193	PF00069	0.631
MOD_Plk_1	126	132	PF00069	0.323
MOD_Plk_1	178	184	PF00069	0.599
MOD_Plk_1	213	219	PF00069	0.529
MOD_Plk_1	246	252	PF00069	0.510
MOD_Plk_1	307	313	PF00069	0.673
MOD_Plk_2-3	387	393	PF00069	0.588
MOD_Plk_2-3	95	101	PF00069	0.471
MOD_Plk_4	247	253	PF00069	0.590
MOD_Plk_4	285	291	PF00069	0.606
MOD_Plk_4	326	332	PF00069	0.458
MOD_Plk_4	37	43	PF00069	0.333
MOD_ProDKin_1	224	230	PF00069	0.715
MOD_ProDKin_1	251	257	PF00069	0.696
MOD_ProDKin_1	265	271	PF00069	0.582
MOD_ProDKin_1	279	285	PF00069	0.686
MOD_SUMO_rev_2	158	166	PF00179	0.525
TRG_DiLeu_BaEn_1	393	398	PF01217	0.547
TRG_DiLeu_BaEn_4	399	405	PF01217	0.476
TRG_DiLeu_BaLyEn_6	105	110	PF01217	0.430
TRG_DiLeu_BaLyEn_6	428	433	PF01217	0.550
TRG_ENDOCYTIC_2	147	150	PF00928	0.468
TRG_ENDOCYTIC_2	26	29	PF00928	0.352
TRG_ENDOCYTIC_2	38	41	PF00928	0.333
TRG_ENDOCYTIC_2	408	411	PF00928	0.531
TRG_ER_diArg_1	184	187	PF00400	0.675
TRG_ER_diArg_1	219	221	PF00400	0.597
TRG_Pf-PMV_PEXEL_1	220	225	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	434	438	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBZ6	Leptomonas seymouri	53%	100%
A0A1X0NWV1	Trypanosomatidae	32%	100%
A0A3S7WXV0	Leishmania donovani	81%	100%
A4I0G7	Leishmania infantum	81%	100%
C9ZV68	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AWC9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QB43	Leishmania major	80%	100%