Stealth_CR2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HCY1_LEIBR

TriTrypDb:

LbrM.23.1200 , LBRM2903_230021500

Length:

690

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HCY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCY1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0016740	transferase activity	2	13
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.478
CLV_NRD_NRD_1	163	165	PF00675	0.521
CLV_NRD_NRD_1	404	406	PF00675	0.586
CLV_NRD_NRD_1	429	431	PF00675	0.476
CLV_NRD_NRD_1	456	458	PF00675	0.594
CLV_NRD_NRD_1	462	464	PF00675	0.713
CLV_NRD_NRD_1	668	670	PF00675	0.349
CLV_NRD_NRD_1	88	90	PF00675	0.583
CLV_PCSK_FUR_1	460	464	PF00082	0.593
CLV_PCSK_KEX2_1	101	103	PF00082	0.478
CLV_PCSK_KEX2_1	163	165	PF00082	0.521
CLV_PCSK_KEX2_1	429	431	PF00082	0.476
CLV_PCSK_KEX2_1	462	464	PF00082	0.730
CLV_PCSK_KEX2_1	668	670	PF00082	0.349
CLV_PCSK_KEX2_1	88	90	PF00082	0.583
CLV_PCSK_SKI1_1	188	192	PF00082	0.501
CLV_PCSK_SKI1_1	225	229	PF00082	0.495
CLV_PCSK_SKI1_1	253	257	PF00082	0.489
CLV_PCSK_SKI1_1	281	285	PF00082	0.461
CLV_PCSK_SKI1_1	383	387	PF00082	0.476
CLV_PCSK_SKI1_1	546	550	PF00082	0.670
CLV_PCSK_SKI1_1	66	70	PF00082	0.483
CLV_PCSK_SKI1_1	668	672	PF00082	0.398
CLV_Separin_Metazoa	384	388	PF03568	0.215
DEG_APCC_DBOX_1	109	117	PF00400	0.409
DEG_APCC_DBOX_1	300	308	PF00400	0.498
DEG_Nend_Nbox_1	1	3	PF02207	0.560
DOC_CKS1_1	337	342	PF01111	0.447
DOC_CKS1_1	67	72	PF01111	0.466
DOC_CYCLIN_RxL_1	235	244	PF00134	0.268
DOC_CYCLIN_RxL_1	543	553	PF00134	0.518
DOC_CYCLIN_RxL_1	664	675	PF00134	0.398
DOC_CYCLIN_yCln2_LP_2	245	251	PF00134	0.414
DOC_CYCLIN_yCln2_LP_2	337	343	PF00134	0.483
DOC_MAPK_gen_1	163	169	PF00069	0.333
DOC_MAPK_MEF2A_6	578	586	PF00069	0.475
DOC_MAPK_MEF2A_6	626	634	PF00069	0.381
DOC_MAPK_MEF2A_6	66	75	PF00069	0.449
DOC_PP1_RVXF_1	236	243	PF00149	0.278
DOC_PP1_RVXF_1	666	673	PF00149	0.513
DOC_PP2B_LxvP_1	203	206	PF13499	0.204
DOC_PP2B_LxvP_1	249	252	PF13499	0.484
DOC_PP4_FxxP_1	79	82	PF00568	0.535
DOC_USP7_MATH_1	299	303	PF00917	0.528
DOC_USP7_MATH_1	625	629	PF00917	0.439
DOC_USP7_MATH_1	82	86	PF00917	0.290
DOC_USP7_MATH_2	471	477	PF00917	0.587
DOC_USP7_UBL2_3	402	406	PF12436	0.204
DOC_WW_Pin1_4	1	6	PF00397	0.670
DOC_WW_Pin1_4	247	252	PF00397	0.533
DOC_WW_Pin1_4	336	341	PF00397	0.478
DOC_WW_Pin1_4	35	40	PF00397	0.537
DOC_WW_Pin1_4	413	418	PF00397	0.343
DOC_WW_Pin1_4	525	530	PF00397	0.646
DOC_WW_Pin1_4	66	71	PF00397	0.478
LIG_14-3-3_CanoR_1	110	114	PF00244	0.409
LIG_14-3-3_CanoR_1	139	147	PF00244	0.350
LIG_14-3-3_CanoR_1	188	196	PF00244	0.285
LIG_14-3-3_CanoR_1	238	243	PF00244	0.290
LIG_14-3-3_CanoR_1	30	36	PF00244	0.468
LIG_14-3-3_CanoR_1	301	305	PF00244	0.511
LIG_14-3-3_CanoR_1	387	394	PF00244	0.204
LIG_14-3-3_CanoR_1	429	437	PF00244	0.476
LIG_14-3-3_CanoR_1	443	449	PF00244	0.443
LIG_14-3-3_CanoR_1	460	468	PF00244	0.563
LIG_14-3-3_CanoR_1	480	490	PF00244	0.613
LIG_14-3-3_CanoR_1	578	583	PF00244	0.550
LIG_14-3-3_CanoR_1	626	631	PF00244	0.459
LIG_14-3-3_CanoR_1	659	667	PF00244	0.451
LIG_Actin_WH2_2	172	190	PF00022	0.284
LIG_AP2alpha_1	242	246	PF02296	0.278
LIG_APCC_ABBA_1	282	287	PF00400	0.354
LIG_APCC_ABBA_1	386	391	PF00400	0.204
LIG_APCC_ABBAyCdc20_2	281	287	PF00400	0.385
LIG_BRCT_BRCA1_1	122	126	PF00533	0.315
LIG_BRCT_BRCA1_1	223	227	PF00533	0.321
LIG_Clathr_ClatBox_2	681	686	PF01394	0.331
LIG_DLG_GKlike_1	238	245	PF00625	0.321
LIG_FHA_1	324	330	PF00498	0.438
LIG_FHA_1	431	437	PF00498	0.481
LIG_FHA_1	627	633	PF00498	0.363
LIG_FHA_2	189	195	PF00498	0.268
LIG_FHA_2	633	639	PF00498	0.435
LIG_Integrin_RGD_1	349	351	PF01839	0.464
LIG_LIR_Apic_2	292	298	PF02991	0.567
LIG_LIR_Apic_2	37	43	PF02991	0.443
LIG_LIR_Apic_2	675	679	PF02991	0.347
LIG_LIR_Apic_2	78	82	PF02991	0.362
LIG_LIR_Gen_1	105	113	PF02991	0.373
LIG_LIR_Gen_1	224	235	PF02991	0.373
LIG_LIR_Gen_1	241	251	PF02991	0.242
LIG_LIR_Gen_1	25	36	PF02991	0.563
LIG_LIR_Gen_1	371	381	PF02991	0.374
LIG_LIR_Gen_1	594	605	PF02991	0.519
LIG_LIR_Gen_1	74	84	PF02991	0.365
LIG_LIR_Nem_3	105	109	PF02991	0.402
LIG_LIR_Nem_3	123	129	PF02991	0.476
LIG_LIR_Nem_3	181	187	PF02991	0.324
LIG_LIR_Nem_3	224	230	PF02991	0.315
LIG_LIR_Nem_3	241	246	PF02991	0.217
LIG_LIR_Nem_3	25	31	PF02991	0.640
LIG_LIR_Nem_3	414	418	PF02991	0.279
LIG_LIR_Nem_3	561	565	PF02991	0.764
LIG_LIR_Nem_3	594	600	PF02991	0.558
LIG_LIR_Nem_3	603	608	PF02991	0.444
LIG_LIR_Nem_3	74	80	PF02991	0.356
LIG_MLH1_MIPbox_1	223	227	PF16413	0.321
LIG_PDZ_Class_2	685	690	PF00595	0.454
LIG_Pex14_1	672	676	PF04695	0.339
LIG_Pex14_2	226	230	PF04695	0.287
LIG_Pex14_2	242	246	PF04695	0.268
LIG_Pex14_2	286	290	PF04695	0.410
LIG_SH2_CRK	562	566	PF00017	0.494
LIG_SH2_CRK	676	680	PF00017	0.314
LIG_SH2_CRK	77	81	PF00017	0.354
LIG_SH2_GRB2like	229	232	PF00017	0.291
LIG_SH2_GRB2like	47	50	PF00017	0.415
LIG_SH2_PTP2	295	298	PF00017	0.504
LIG_SH2_SRC	295	298	PF00017	0.474
LIG_SH2_SRC	539	542	PF00017	0.621
LIG_SH2_STAP1	421	425	PF00017	0.340
LIG_SH2_STAP1	493	497	PF00017	0.520
LIG_SH2_STAT3	359	362	PF00017	0.454
LIG_SH2_STAT5	166	169	PF00017	0.278
LIG_SH2_STAT5	229	232	PF00017	0.257
LIG_SH2_STAT5	295	298	PF00017	0.579
LIG_SH2_STAT5	35	38	PF00017	0.549
LIG_SH2_STAT5	359	362	PF00017	0.489
LIG_SH2_STAT5	408	411	PF00017	0.280
LIG_SH2_STAT5	77	80	PF00017	0.363
LIG_SH3_1	676	682	PF00018	0.318
LIG_SH3_2	248	253	PF14604	0.537
LIG_SH3_3	245	251	PF00018	0.414
LIG_SH3_3	293	299	PF00018	0.526
LIG_SH3_3	33	39	PF00018	0.561
LIG_SH3_3	447	453	PF00018	0.461
LIG_SH3_3	465	471	PF00018	0.567
LIG_SH3_3	64	70	PF00018	0.493
LIG_SH3_3	676	682	PF00018	0.460
LIG_TRAF2_1	197	200	PF00917	0.254
LIG_TRAF2_1	492	495	PF00917	0.516
LIG_TRAF2_2	346	351	PF00917	0.455
LIG_TYR_ITIM	560	565	PF00017	0.508
LIG_TYR_ITIM	75	80	PF00017	0.409
LIG_WRC_WIRS_1	412	417	PF05994	0.222
LIG_WRC_WIRS_1	421	426	PF05994	0.226
LIG_WRC_WIRS_1	76	81	PF05994	0.420
LIG_WW_3	250	254	PF00397	0.488
MOD_CDC14_SPxK_1	250	253	PF00782	0.557
MOD_CDK_SPxK_1	247	253	PF00069	0.534
MOD_CDK_SPxK_1	336	342	PF00069	0.419
MOD_CDK_SPxK_1	66	72	PF00069	0.312
MOD_CK1_1	112	118	PF00069	0.410
MOD_CK1_1	277	283	PF00069	0.462
MOD_CK1_1	300	306	PF00069	0.655
MOD_CK1_1	34	40	PF00069	0.441
MOD_CK1_1	499	505	PF00069	0.598
MOD_CK1_1	512	518	PF00069	0.690
MOD_CK1_1	519	525	PF00069	0.729
MOD_CK1_1	550	556	PF00069	0.618
MOD_CK1_1	6	12	PF00069	0.623
MOD_CK1_1	660	666	PF00069	0.431
MOD_CK2_1	19	25	PF00069	0.708
MOD_CK2_1	194	200	PF00069	0.288
MOD_CK2_1	341	347	PF00069	0.505
MOD_CK2_1	35	41	PF00069	0.457
MOD_CK2_1	489	495	PF00069	0.502
MOD_CK2_1	504	510	PF00069	0.510
MOD_CK2_1	610	616	PF00069	0.442
MOD_CMANNOS	683	686	PF00535	0.336
MOD_DYRK1A_RPxSP_1	247	251	PF00069	0.523
MOD_DYRK1A_RPxSP_1	66	70	PF00069	0.483
MOD_GlcNHglycan	122	125	PF01048	0.425
MOD_GlcNHglycan	14	17	PF01048	0.793
MOD_GlcNHglycan	196	199	PF01048	0.623
MOD_GlcNHglycan	214	217	PF01048	0.397
MOD_GlcNHglycan	394	397	PF01048	0.433
MOD_GlcNHglycan	5	8	PF01048	0.682
MOD_GlcNHglycan	506	509	PF01048	0.628
MOD_GlcNHglycan	518	521	PF01048	0.810
MOD_GlcNHglycan	530	533	PF01048	0.534
MOD_GlcNHglycan	565	568	PF01048	0.682
MOD_GlcNHglycan	620	623	PF01048	0.556
MOD_GlcNHglycan	641	644	PF01048	0.437
MOD_GSK3_1	1	8	PF00069	0.540
MOD_GSK3_1	285	292	PF00069	0.487
MOD_GSK3_1	31	38	PF00069	0.586
MOD_GSK3_1	496	503	PF00069	0.564
MOD_GSK3_1	504	511	PF00069	0.618
MOD_GSK3_1	512	519	PF00069	0.772
MOD_GSK3_1	574	581	PF00069	0.517
MOD_GSK3_1	62	69	PF00069	0.530
MOD_N-GLC_1	147	152	PF02516	0.508
MOD_N-GLC_1	657	662	PF02516	0.549
MOD_NEK2_1	109	114	PF00069	0.353
MOD_NEK2_1	12	17	PF00069	0.550
MOD_NEK2_1	285	290	PF00069	0.443
MOD_NEK2_1	516	521	PF00069	0.583
MOD_NEK2_1	530	535	PF00069	0.570
MOD_NEK2_1	595	600	PF00069	0.509
MOD_NEK2_1	632	637	PF00069	0.427
MOD_NEK2_2	444	449	PF00069	0.516
MOD_PIKK_1	473	479	PF00454	0.739
MOD_PIKK_1	509	515	PF00454	0.514
MOD_PIKK_1	539	545	PF00454	0.571
MOD_PKA_2	109	115	PF00069	0.408
MOD_PKA_2	138	144	PF00069	0.360
MOD_PKA_2	300	306	PF00069	0.550
MOD_PKA_2	323	329	PF00069	0.411
MOD_PKA_2	461	467	PF00069	0.780
MOD_PKA_2	625	631	PF00069	0.462
MOD_Plk_1	277	283	PF00069	0.420
MOD_Plk_1	574	580	PF00069	0.538
MOD_Plk_1	593	599	PF00069	0.582
MOD_Plk_1	657	663	PF00069	0.478
MOD_Plk_4	157	163	PF00069	0.337
MOD_Plk_4	238	244	PF00069	0.278
MOD_Plk_4	285	291	PF00069	0.518
MOD_Plk_4	31	37	PF00069	0.591
MOD_Plk_4	54	60	PF00069	0.456
MOD_Plk_4	578	584	PF00069	0.579
MOD_Plk_4	672	678	PF00069	0.329
MOD_Plk_4	75	81	PF00069	0.350
MOD_ProDKin_1	1	7	PF00069	0.673
MOD_ProDKin_1	247	253	PF00069	0.534
MOD_ProDKin_1	336	342	PF00069	0.484
MOD_ProDKin_1	35	41	PF00069	0.546
MOD_ProDKin_1	413	419	PF00069	0.343
MOD_ProDKin_1	525	531	PF00069	0.647
MOD_ProDKin_1	66	72	PF00069	0.475
MOD_SUMO_rev_2	265	273	PF00179	0.459
MOD_SUMO_rev_2	492	498	PF00179	0.513
TRG_DiLeu_BaEn_1	199	204	PF01217	0.204
TRG_DiLeu_BaLyEn_6	332	337	PF01217	0.374
TRG_DiLeu_BaLyEn_6	666	671	PF01217	0.471
TRG_ENDOCYTIC_2	166	169	PF00928	0.301
TRG_ENDOCYTIC_2	374	377	PF00928	0.350
TRG_ENDOCYTIC_2	421	424	PF00928	0.278
TRG_ENDOCYTIC_2	47	50	PF00928	0.509
TRG_ENDOCYTIC_2	562	565	PF00928	0.516
TRG_ENDOCYTIC_2	77	80	PF00928	0.354
TRG_ER_diArg_1	101	103	PF00400	0.481
TRG_ER_diArg_1	162	164	PF00400	0.321
TRG_ER_diArg_1	428	430	PF00400	0.451
TRG_ER_diArg_1	459	462	PF00400	0.618
TRG_ER_diArg_1	667	669	PF00400	0.350
TRG_ER_diArg_1	87	89	PF00400	0.567
TRG_NES_CRM1_1	138	151	PF08389	0.356
TRG_NES_CRM1_1	580	594	PF08389	0.438
TRG_Pf-PMV_PEXEL_1	114	118	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	536	540	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	546	551	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	647	651	PF00026	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYV0	Leptomonas seymouri	40%	91%
A0A0S4JLF5	Bodo saltans	28%	76%
A0A3Q8ICL5	Leishmania donovani	45%	100%
A0A3Q8ICR3	Leishmania donovani	77%	87%
A0A3S7WXU9	Leishmania donovani	45%	100%
A4I0G4	Leishmania infantum	77%	99%
A4I0G5	Leishmania infantum	45%	100%
E9AWC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	99%
E9AWC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
Q4QB44	Leishmania major	58%	100%
Q4QB45	Leishmania major	76%	100%