F-box/LRR-repeat protein 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine Rich repeats (2 copies), putative

Species:

Leishmania braziliensis

UniProt:

A4HCY0_LEIBR

TriTrypDb:

LbrM.23.1190 , LBRM2903_230021400

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 30
NetGPI	no	yes: 0, no: 30

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	31
GO:0042995	cell projection	2	31
GO:0043226	organelle	2	31
GO:0043227	membrane-bounded organelle	3	31
GO:0110165	cellular anatomical entity	1	31
GO:0120025	plasma membrane bounded cell projection	3	31
GO:0005743	mitochondrial inner membrane	5	2
GO:0016020	membrane	2	2
GO:0019866	organelle inner membrane	4	2
GO:0031090	organelle membrane	3	2
GO:0031966	mitochondrial membrane	4	2
GO:0000151	ubiquitin ligase complex	3	1
GO:0019005	SCF ubiquitin ligase complex	5	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4HCY0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCY0

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	3
GO:0006796	phosphate-containing compound metabolic process	4	3
GO:0008152	metabolic process	1	4
GO:0009987	cellular process	1	4
GO:0016310	phosphorylation	5	3
GO:0044237	cellular metabolic process	2	4
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	7	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0003824	catalytic activity	1	5
GO:0016301	kinase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	3
GO:0016787	hydrolase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	380	382	PF00675	0.359
CLV_NRD_NRD_1	70	72	PF00675	0.447
CLV_NRD_NRD_1	8	10	PF00675	0.535
CLV_PCSK_KEX2_1	380	382	PF00082	0.353
CLV_PCSK_KEX2_1	8	10	PF00082	0.520
CLV_PCSK_SKI1_1	125	129	PF00082	0.351
CLV_PCSK_SKI1_1	163	167	PF00082	0.306
CLV_PCSK_SKI1_1	380	384	PF00082	0.327
CLV_PCSK_SKI1_1	9	13	PF00082	0.588
CLV_PCSK_SKI1_1	94	98	PF00082	0.338
DEG_APCC_DBOX_1	7	15	PF00400	0.535
DEG_Nend_UBRbox_1	1	4	PF02207	0.428
DEG_SCF_FBW7_1	243	250	PF00400	0.473
DOC_CKS1_1	244	249	PF01111	0.216
DOC_CYCLIN_RxL_1	158	171	PF00134	0.378
DOC_MAPK_gen_1	135	144	PF00069	0.386
DOC_MAPK_gen_1	158	167	PF00069	0.337
DOC_MAPK_gen_1	262	269	PF00069	0.208
DOC_MAPK_MEF2A_6	137	146	PF00069	0.419
DOC_PP1_RVXF_1	284	290	PF00149	0.426
DOC_PP2B_LxvP_1	241	244	PF13499	0.445
DOC_PP4_FxxP_1	106	109	PF00568	0.487
DOC_USP7_MATH_1	148	152	PF00917	0.444
DOC_USP7_MATH_1	178	182	PF00917	0.476
DOC_USP7_MATH_1	20	24	PF00917	0.640
DOC_USP7_MATH_1	234	238	PF00917	0.432
DOC_USP7_MATH_1	247	251	PF00917	0.354
DOC_USP7_MATH_1	280	284	PF00917	0.454
DOC_WW_Pin1_4	24	29	PF00397	0.645
DOC_WW_Pin1_4	243	248	PF00397	0.394
DOC_WW_Pin1_4	350	355	PF00397	0.500
LIG_14-3-3_CanoR_1	125	131	PF00244	0.371
LIG_14-3-3_CanoR_1	19	28	PF00244	0.657
LIG_14-3-3_CanoR_1	294	298	PF00244	0.430
LIG_14-3-3_CanoR_1	71	81	PF00244	0.452
LIG_14-3-3_CanoR_1	8	17	PF00244	0.541
LIG_Actin_WH2_2	412	428	PF00022	0.347
LIG_APCC_ABBA_1	188	193	PF00400	0.477
LIG_BRCT_BRCA1_1	17	21	PF00533	0.648
LIG_BRCT_BRCA1_1	201	205	PF00533	0.426
LIG_BRCT_BRCA1_1	321	325	PF00533	0.369
LIG_BRCT_BRCA1_2	321	327	PF00533	0.371
LIG_Clathr_ClatBox_1	347	351	PF01394	0.346
LIG_FHA_1	213	219	PF00498	0.351
LIG_FHA_1	230	236	PF00498	0.481
LIG_FHA_1	237	243	PF00498	0.454
LIG_FHA_1	356	362	PF00498	0.371
LIG_FHA_2	219	225	PF00498	0.464
LIG_FHA_2	306	312	PF00498	0.356
LIG_IRF3_LxIS_1	361	368	PF10401	0.260
LIG_LIR_Apic_2	103	109	PF02991	0.496
LIG_LIR_Gen_1	343	350	PF02991	0.510
LIG_LIR_Nem_3	105	110	PF02991	0.346
LIG_LIR_Nem_3	143	149	PF02991	0.418
LIG_LIR_Nem_3	202	208	PF02991	0.401
LIG_LIR_Nem_3	343	348	PF02991	0.516
LIG_LIR_Nem_3	59	64	PF02991	0.516
LIG_MLH1_MIPbox_1	202	206	PF16413	0.246
LIG_NRBOX	237	243	PF00104	0.461
LIG_PCNA_yPIPBox_3	437	446	PF02747	0.288
LIG_PTB_Apo_2	101	108	PF02174	0.294
LIG_SH2_CRK	345	349	PF00017	0.505
LIG_SH2_CRK	84	88	PF00017	0.561
LIG_SH2_STAT5	208	211	PF00017	0.458
LIG_SH2_STAT5	3	6	PF00017	0.436
LIG_SH2_STAT5	345	348	PF00017	0.508
LIG_SH2_STAT5	366	369	PF00017	0.467
LIG_SH3_3	14	20	PF00018	0.557
LIG_SH3_3	142	148	PF00018	0.366
LIG_SH3_3	22	28	PF00018	0.516
LIG_SH3_3	241	247	PF00018	0.458
LIG_SUMO_SIM_anti_2	118	123	PF11976	0.431
LIG_SUMO_SIM_anti_2	140	146	PF11976	0.423
LIG_SUMO_SIM_anti_2	293	300	PF11976	0.272
LIG_SUMO_SIM_anti_2	447	455	PF11976	0.505
LIG_SUMO_SIM_par_1	357	362	PF11976	0.307
LIG_TRAF2_1	402	405	PF00917	0.491
LIG_TRAF2_1	455	458	PF00917	0.387
LIG_TYR_ITSM	341	348	PF00017	0.491
MOD_CK1_1	171	177	PF00069	0.445
MOD_CK1_1	237	243	PF00069	0.375
MOD_CK1_1	27	33	PF00069	0.554
MOD_CK1_1	293	299	PF00069	0.404
MOD_CK1_1	59	65	PF00069	0.454
MOD_CK2_1	102	108	PF00069	0.399
MOD_CK2_1	305	311	PF00069	0.344
MOD_CK2_1	444	450	PF00069	0.447
MOD_CK2_1	452	458	PF00069	0.465
MOD_Cter_Amidation	69	72	PF01082	0.470
MOD_GlcNHglycan	202	205	PF01048	0.407
MOD_GlcNHglycan	209	212	PF01048	0.456
MOD_GlcNHglycan	22	25	PF01048	0.600
MOD_GlcNHglycan	277	281	PF01048	0.418
MOD_GlcNHglycan	76	79	PF01048	0.440
MOD_GSK3_1	148	155	PF00069	0.339
MOD_GSK3_1	20	27	PF00069	0.601
MOD_GSK3_1	212	219	PF00069	0.379
MOD_GSK3_1	225	232	PF00069	0.338
MOD_GSK3_1	243	250	PF00069	0.410
MOD_GSK3_1	252	259	PF00069	0.381
MOD_GSK3_1	276	283	PF00069	0.405
MOD_GSK3_1	315	322	PF00069	0.315
MOD_GSK3_1	355	362	PF00069	0.379
MOD_N-GLC_1	216	221	PF02516	0.224
MOD_N-GLC_1	411	416	PF02516	0.364
MOD_N-GLC_1	59	64	PF02516	0.485
MOD_N-GLC_2	429	431	PF02516	0.324
MOD_NEK2_1	157	162	PF00069	0.475
MOD_NEK2_1	216	221	PF00069	0.330
MOD_NEK2_1	222	227	PF00069	0.358
MOD_NEK2_1	248	253	PF00069	0.387
MOD_NEK2_1	256	261	PF00069	0.420
MOD_NEK2_1	290	295	PF00069	0.345
MOD_NEK2_1	335	340	PF00069	0.401
MOD_NEK2_1	365	370	PF00069	0.379
MOD_NEK2_1	408	413	PF00069	0.320
MOD_NEK2_1	444	449	PF00069	0.337
MOD_PKA_1	163	169	PF00069	0.439
MOD_PKA_2	157	163	PF00069	0.337
MOD_PKA_2	293	299	PF00069	0.486
MOD_PKA_2	7	13	PF00069	0.548
MOD_Plk_1	102	108	PF00069	0.432
MOD_Plk_1	276	282	PF00069	0.422
MOD_Plk_1	290	296	PF00069	0.255
MOD_Plk_1	343	349	PF00069	0.474
MOD_Plk_1	444	450	PF00069	0.428
MOD_Plk_1	59	65	PF00069	0.506
MOD_Plk_2-3	265	271	PF00069	0.289
MOD_Plk_2-3	445	451	PF00069	0.535
MOD_Plk_4	102	108	PF00069	0.392
MOD_Plk_4	140	146	PF00069	0.419
MOD_Plk_4	183	189	PF00069	0.424
MOD_Plk_4	218	224	PF00069	0.423
MOD_Plk_4	237	243	PF00069	0.442
MOD_Plk_4	293	299	PF00069	0.556
MOD_Plk_4	343	349	PF00069	0.390
MOD_Plk_4	355	361	PF00069	0.374
MOD_Plk_4	430	436	PF00069	0.420
MOD_ProDKin_1	24	30	PF00069	0.637
MOD_ProDKin_1	243	249	PF00069	0.397
MOD_ProDKin_1	350	356	PF00069	0.492
MOD_SUMO_rev_2	404	411	PF00179	0.421
TRG_DiLeu_BaEn_4	273	279	PF01217	0.299
TRG_DiLeu_BaEn_4	351	357	PF01217	0.480
TRG_DiLeu_BaLyEn_6	439	444	PF01217	0.536
TRG_ENDOCYTIC_2	345	348	PF00928	0.527
TRG_ENDOCYTIC_2	84	87	PF00928	0.529
TRG_ER_diArg_1	379	381	PF00400	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2F4	Leptomonas seymouri	70%	95%
A0A0N0P8N9	Leptomonas seymouri	25%	70%
A0A0N1IGA0	Leptomonas seymouri	25%	100%
A0A0S4IRL6	Bodo saltans	24%	100%
A0A0S4IS80	Bodo saltans	30%	90%
A0A0S4JR29	Bodo saltans	26%	91%
A0A0S4JR64	Bodo saltans	23%	71%
A0A1X0NEN5	Trypanosomatidae	28%	80%
A0A1X0NG16	Trypanosomatidae	28%	80%
A0A1X0NXB3	Trypanosomatidae	55%	95%
A0A1X0P4M6	Trypanosomatidae	24%	80%
A0A3Q8IAE2	Leishmania donovani	26%	74%
A0A3S5H5M6	Leishmania donovani	26%	87%
A0A3S5H7C2	Leishmania donovani	90%	95%
A0A422NP39	Trypanosoma rangeli	52%	95%
A4HSP5	Leishmania infantum	26%	87%
A4I0G3	Leishmania infantum	90%	95%
C9ZS86	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	85%
C9ZV75	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	95%
D0A0X4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	69%
E9AIU4	Leishmania braziliensis	25%	84%
E9AWC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	95%
Q4QB46	Leishmania major	89%	100%
Q4QD45	Leishmania major	26%	69%
Q4QFY4	Leishmania major	28%	100%
Q4QJ80	Leishmania major	26%	81%
V5BD47	Trypanosoma cruzi	24%	100%
V5BMQ2	Trypanosoma cruzi	27%	83%
V5DFL9	Trypanosoma cruzi	51%	95%