LeishMANIAdb
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Probable methyltransferase BMT2 homolog

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Probable methyltransferase BMT2 homolog
Gene product:
Probable methyltransferase BTM2 homolog
Species:
Leishmania braziliensis
UniProt:
A4HCX9_LEIBR
TriTrypDb:
LbrM.23.1180 , LBRM2903_230021300 *
Length:
657

Annotations

LeishMANIAdb annotations

Homologous to S-adenosylmethionine sensor upstream of mTORC1. Does not appear to be membrane-associated.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCX9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCX9

Function

Biological processes
Term Name Level Count
GO:0008152 metabolic process 1 10
GO:0032259 methylation 2 10
GO:0009966 regulation of signal transduction 4 1
GO:0009968 negative regulation of signal transduction 5 1
GO:0010646 regulation of cell communication 4 1
GO:0010648 negative regulation of cell communication 5 1
GO:0023051 regulation of signaling 3 1
GO:0023057 negative regulation of signaling 4 1
GO:0032006 regulation of TOR signaling 6 1
GO:0032007 negative regulation of TOR signaling 7 1
GO:0048519 negative regulation of biological process 3 1
GO:0048523 negative regulation of cellular process 4 1
GO:0048583 regulation of response to stimulus 3 1
GO:0048585 negative regulation of response to stimulus 4 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
GO:1902531 regulation of intracellular signal transduction 5 1
GO:1902532 negative regulation of intracellular signal transduction 6 1
GO:1903432 regulation of TORC1 signaling 7 1
GO:1904262 negative regulation of TORC1 signaling 8 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0008168 methyltransferase activity 4 10
GO:0016740 transferase activity 2 11
GO:0016741 transferase activity, transferring one-carbon groups 3 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 323 327 PF00656 0.556
CLV_C14_Caspase3-7 340 344 PF00656 0.422
CLV_C14_Caspase3-7 433 437 PF00656 0.532
CLV_C14_Caspase3-7 510 514 PF00656 0.557
CLV_NRD_NRD_1 104 106 PF00675 0.518
CLV_NRD_NRD_1 114 116 PF00675 0.627
CLV_NRD_NRD_1 276 278 PF00675 0.538
CLV_NRD_NRD_1 358 360 PF00675 0.709
CLV_NRD_NRD_1 576 578 PF00675 0.419
CLV_NRD_NRD_1 618 620 PF00675 0.459
CLV_PCSK_KEX2_1 104 106 PF00082 0.518
CLV_PCSK_KEX2_1 114 116 PF00082 0.484
CLV_PCSK_KEX2_1 161 163 PF00082 0.834
CLV_PCSK_KEX2_1 276 278 PF00082 0.545
CLV_PCSK_KEX2_1 358 360 PF00082 0.709
CLV_PCSK_KEX2_1 575 577 PF00082 0.437
CLV_PCSK_KEX2_1 618 620 PF00082 0.465
CLV_PCSK_PC1ET2_1 161 163 PF00082 0.834
CLV_PCSK_SKI1_1 105 109 PF00082 0.603
CLV_PCSK_SKI1_1 270 274 PF00082 0.552
CLV_PCSK_SKI1_1 276 280 PF00082 0.547
CLV_PCSK_SKI1_1 285 289 PF00082 0.469
CLV_PCSK_SKI1_1 373 377 PF00082 0.578
CLV_PCSK_SKI1_1 7 11 PF00082 0.769
CLV_Separin_Metazoa 462 466 PF03568 0.390
DEG_ODPH_VHL_1 410 422 PF01847 0.434
DOC_CKS1_1 298 303 PF01111 0.398
DOC_CKS1_1 541 546 PF01111 0.383
DOC_CYCLIN_yCln2_LP_2 239 245 PF00134 0.420
DOC_MAPK_DCC_7 406 415 PF00069 0.427
DOC_MAPK_gen_1 270 280 PF00069 0.427
DOC_MAPK_gen_1 370 378 PF00069 0.301
DOC_MAPK_gen_1 442 451 PF00069 0.246
DOC_MAPK_MEF2A_6 445 453 PF00069 0.332
DOC_MAPK_MEF2A_6 559 567 PF00069 0.335
DOC_PP1_RVXF_1 274 281 PF00149 0.445
DOC_PP1_RVXF_1 443 449 PF00149 0.238
DOC_PP1_RVXF_1 543 549 PF00149 0.401
DOC_PP2B_LxvP_1 239 242 PF13499 0.578
DOC_USP7_MATH_1 246 250 PF00917 0.517
DOC_USP7_MATH_1 290 294 PF00917 0.368
DOC_USP7_MATH_1 30 34 PF00917 0.591
DOC_USP7_MATH_1 311 315 PF00917 0.552
DOC_USP7_MATH_1 325 329 PF00917 0.439
DOC_USP7_MATH_1 36 40 PF00917 0.593
DOC_USP7_MATH_1 430 434 PF00917 0.468
DOC_USP7_MATH_1 50 54 PF00917 0.282
DOC_USP7_MATH_1 514 518 PF00917 0.542
DOC_USP7_MATH_1 9 13 PF00917 0.540
DOC_WW_Pin1_4 244 249 PF00397 0.545
DOC_WW_Pin1_4 25 30 PF00397 0.613
DOC_WW_Pin1_4 297 302 PF00397 0.454
DOC_WW_Pin1_4 376 381 PF00397 0.511
DOC_WW_Pin1_4 540 545 PF00397 0.390
DOC_WW_Pin1_4 609 614 PF00397 0.641
LIG_14-3-3_CanoR_1 104 108 PF00244 0.423
LIG_14-3-3_CanoR_1 114 123 PF00244 0.444
LIG_14-3-3_CanoR_1 162 172 PF00244 0.561
LIG_14-3-3_CanoR_1 204 208 PF00244 0.326
LIG_14-3-3_CanoR_1 285 292 PF00244 0.367
LIG_14-3-3_CanoR_1 349 353 PF00244 0.323
LIG_14-3-3_CanoR_1 465 473 PF00244 0.496
LIG_14-3-3_CanoR_1 618 622 PF00244 0.657
LIG_APCC_ABBA_1 252 257 PF00400 0.310
LIG_BIR_III_2 308 312 PF00653 0.409
LIG_BIR_III_4 650 654 PF00653 0.658
LIG_BRCT_BRCA1_1 248 252 PF00533 0.362
LIG_BRCT_BRCA1_1 318 322 PF00533 0.396
LIG_BRCT_BRCA1_1 588 592 PF00533 0.619
LIG_deltaCOP1_diTrp_1 447 454 PF00928 0.321
LIG_FHA_1 190 196 PF00498 0.573
LIG_FHA_1 39 45 PF00498 0.560
LIG_FHA_1 541 547 PF00498 0.382
LIG_FHA_1 582 588 PF00498 0.628
LIG_FHA_2 106 112 PF00498 0.418
LIG_FHA_2 141 147 PF00498 0.627
LIG_FHA_2 149 155 PF00498 0.486
LIG_FHA_2 166 172 PF00498 0.438
LIG_FHA_2 286 292 PF00498 0.363
LIG_FHA_2 349 355 PF00498 0.409
LIG_FHA_2 416 422 PF00498 0.326
LIG_FHA_2 473 479 PF00498 0.424
LIG_FHA_2 645 651 PF00498 0.606
LIG_LIR_Apic_2 128 133 PF02991 0.417
LIG_LIR_Gen_1 345 352 PF02991 0.273
LIG_LIR_Gen_1 447 454 PF02991 0.321
LIG_LIR_Gen_1 527 537 PF02991 0.376
LIG_LIR_Gen_1 589 599 PF02991 0.609
LIG_LIR_Gen_1 607 615 PF02991 0.612
LIG_LIR_Nem_3 260 264 PF02991 0.351
LIG_LIR_Nem_3 345 350 PF02991 0.381
LIG_LIR_Nem_3 394 399 PF02991 0.306
LIG_LIR_Nem_3 447 451 PF02991 0.246
LIG_LIR_Nem_3 527 532 PF02991 0.301
LIG_LIR_Nem_3 589 595 PF02991 0.601
LIG_LIR_Nem_3 607 611 PF02991 0.589
LIG_LYPXL_SIV_4 118 126 PF13949 0.444
LIG_OCRL_FandH_1 278 290 PF00620 0.275
LIG_PCNA_yPIPBox_3 480 493 PF02747 0.326
LIG_REV1ctd_RIR_1 277 286 PF16727 0.460
LIG_REV1ctd_RIR_1 397 406 PF16727 0.367
LIG_SH2_CRK 347 351 PF00017 0.275
LIG_SH2_CRK 529 533 PF00017 0.338
LIG_SH2_GRB2like 130 133 PF00017 0.519
LIG_SH2_NCK_1 347 351 PF00017 0.275
LIG_SH2_NCK_1 529 533 PF00017 0.325
LIG_SH2_SRC 119 122 PF00017 0.442
LIG_SH2_STAP1 119 123 PF00017 0.352
LIG_SH2_STAP1 371 375 PF00017 0.308
LIG_SH2_STAP1 529 533 PF00017 0.338
LIG_SH2_STAT3 207 210 PF00017 0.373
LIG_SH2_STAT3 483 486 PF00017 0.470
LIG_SH2_STAT5 207 210 PF00017 0.367
LIG_SH2_STAT5 216 219 PF00017 0.304
LIG_SH2_STAT5 371 374 PF00017 0.454
LIG_SH3_1 406 412 PF00018 0.461
LIG_SH3_3 135 141 PF00018 0.467
LIG_SH3_3 23 29 PF00018 0.566
LIG_SH3_3 238 244 PF00018 0.470
LIG_SH3_3 268 274 PF00018 0.413
LIG_SH3_3 295 301 PF00018 0.464
LIG_SH3_3 377 383 PF00018 0.396
LIG_SH3_3 406 412 PF00018 0.461
LIG_SH3_3 435 441 PF00018 0.474
LIG_SH3_CIN85_PxpxPR_1 2 7 PF14604 0.435
LIG_Sin3_3 534 541 PF02671 0.231
LIG_SUMO_SIM_par_1 562 569 PF11976 0.335
LIG_TRAF2_1 351 354 PF00917 0.297
LIG_TRAF2_1 95 98 PF00917 0.410
LIG_WW_3 300 304 PF00397 0.329
MOD_CDK_SPK_2 540 545 PF00069 0.390
MOD_CDK_SPxK_1 297 303 PF00069 0.457
MOD_CDK_SPxxK_3 540 547 PF00069 0.385
MOD_CK1_1 165 171 PF00069 0.544
MOD_CK1_1 191 197 PF00069 0.523
MOD_CK1_1 211 217 PF00069 0.408
MOD_CK1_1 324 330 PF00069 0.548
MOD_CK1_1 488 494 PF00069 0.514
MOD_CK1_1 517 523 PF00069 0.426
MOD_CK1_1 568 574 PF00069 0.582
MOD_CK1_1 620 626 PF00069 0.598
MOD_CK1_1 633 639 PF00069 0.547
MOD_CK1_1 68 74 PF00069 0.468
MOD_CK1_1 75 81 PF00069 0.526
MOD_CK1_1 84 90 PF00069 0.564
MOD_CK1_1 92 98 PF00069 0.328
MOD_CK2_1 105 111 PF00069 0.437
MOD_CK2_1 148 154 PF00069 0.449
MOD_CK2_1 285 291 PF00069 0.361
MOD_CK2_1 328 334 PF00069 0.542
MOD_CK2_1 348 354 PF00069 0.229
MOD_CK2_1 36 42 PF00069 0.580
MOD_CK2_1 472 478 PF00069 0.456
MOD_CK2_1 92 98 PF00069 0.478
MOD_Cter_Amidation 159 162 PF01082 0.656
MOD_DYRK1A_RPxSP_1 297 301 PF00069 0.317
MOD_GlcNHglycan 11 14 PF01048 0.677
MOD_GlcNHglycan 116 119 PF01048 0.644
MOD_GlcNHglycan 2 5 PF01048 0.746
MOD_GlcNHglycan 313 316 PF01048 0.705
MOD_GlcNHglycan 32 35 PF01048 0.755
MOD_GlcNHglycan 323 326 PF01048 0.746
MOD_GlcNHglycan 427 430 PF01048 0.615
MOD_GlcNHglycan 432 435 PF01048 0.658
MOD_GlcNHglycan 498 501 PF01048 0.769
MOD_GlcNHglycan 508 512 PF01048 0.745
MOD_GlcNHglycan 613 616 PF01048 0.431
MOD_GlcNHglycan 637 640 PF01048 0.431
MOD_GlcNHglycan 67 70 PF01048 0.663
MOD_GlcNHglycan 72 75 PF01048 0.717
MOD_GlcNHglycan 80 83 PF01048 0.738
MOD_GlcNHglycan 88 91 PF01048 0.785
MOD_GSK3_1 150 157 PF00069 0.562
MOD_GSK3_1 162 169 PF00069 0.532
MOD_GSK3_1 185 192 PF00069 0.555
MOD_GSK3_1 30 37 PF00069 0.579
MOD_GSK3_1 311 318 PF00069 0.469
MOD_GSK3_1 320 327 PF00069 0.502
MOD_GSK3_1 348 355 PF00069 0.426
MOD_GSK3_1 360 367 PF00069 0.450
MOD_GSK3_1 38 45 PF00069 0.526
MOD_GSK3_1 503 510 PF00069 0.558
MOD_GSK3_1 515 522 PF00069 0.293
MOD_GSK3_1 536 543 PF00069 0.391
MOD_GSK3_1 630 637 PF00069 0.631
MOD_GSK3_1 68 75 PF00069 0.503
MOD_GSK3_1 76 83 PF00069 0.557
MOD_LATS_1 283 289 PF00433 0.321
MOD_N-GLC_1 148 153 PF02516 0.739
MOD_N-GLC_1 311 316 PF02516 0.600
MOD_N-GLC_1 42 47 PF02516 0.730
MOD_N-GLC_1 466 471 PF02516 0.679
MOD_NEK2_1 185 190 PF00069 0.533
MOD_NEK2_1 415 420 PF00069 0.309
MOD_NEK2_1 519 524 PF00069 0.417
MOD_NEK2_1 536 541 PF00069 0.216
MOD_NEK2_1 62 67 PF00069 0.384
MOD_NEK2_1 634 639 PF00069 0.640
MOD_NEK2_1 80 85 PF00069 0.519
MOD_NEK2_1 86 91 PF00069 0.536
MOD_PIKK_1 290 296 PF00454 0.431
MOD_PIKK_1 36 42 PF00454 0.527
MOD_PIKK_1 512 518 PF00454 0.374
MOD_PIKK_1 568 574 PF00454 0.582
MOD_PKA_1 114 120 PF00069 0.275
MOD_PKA_2 103 109 PF00069 0.467
MOD_PKA_2 114 120 PF00069 0.455
MOD_PKA_2 163 169 PF00069 0.626
MOD_PKA_2 203 209 PF00069 0.403
MOD_PKA_2 348 354 PF00069 0.323
MOD_PKA_2 369 375 PF00069 0.433
MOD_PKA_2 503 509 PF00069 0.475
MOD_PKA_2 617 623 PF00069 0.633
MOD_PKA_2 644 650 PF00069 0.649
MOD_Plk_1 290 296 PF00069 0.332
MOD_Plk_1 352 358 PF00069 0.508
MOD_Plk_1 360 366 PF00069 0.444
MOD_Plk_1 466 472 PF00069 0.365
MOD_Plk_1 581 587 PF00069 0.450
MOD_Plk_4 125 131 PF00069 0.479
MOD_Plk_4 211 217 PF00069 0.411
MOD_Plk_4 488 494 PF00069 0.533
MOD_Plk_4 50 56 PF00069 0.474
MOD_Plk_4 536 542 PF00069 0.339
MOD_Plk_4 630 636 PF00069 0.586
MOD_ProDKin_1 244 250 PF00069 0.543
MOD_ProDKin_1 25 31 PF00069 0.615
MOD_ProDKin_1 297 303 PF00069 0.461
MOD_ProDKin_1 376 382 PF00069 0.508
MOD_ProDKin_1 540 546 PF00069 0.387
MOD_ProDKin_1 609 615 PF00069 0.644
MOD_SUMO_rev_2 165 175 PF00179 0.434
MOD_SUMO_rev_2 94 102 PF00179 0.443
TRG_DiLeu_BaEn_1 291 296 PF01217 0.416
TRG_DiLeu_BaEn_1 560 565 PF01217 0.408
TRG_ENDOCYTIC_2 347 350 PF00928 0.276
TRG_ENDOCYTIC_2 396 399 PF00928 0.301
TRG_ENDOCYTIC_2 529 532 PF00928 0.338
TRG_ER_diArg_1 103 105 PF00400 0.314
TRG_ER_diArg_1 113 115 PF00400 0.293
TRG_ER_diArg_1 275 277 PF00400 0.338
TRG_ER_diArg_1 357 359 PF00400 0.519
TRG_ER_diArg_1 480 483 PF00400 0.443
TRG_ER_diArg_1 544 547 PF00400 0.299
TRG_ER_diArg_1 574 577 PF00400 0.705
TRG_ER_diArg_1 617 619 PF00400 0.664
TRG_NES_CRM1_1 340 354 PF08389 0.277
TRG_Pf-PMV_PEXEL_1 276 281 PF00026 0.650
TRG_Pf-PMV_PEXEL_1 339 343 PF00026 0.647

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IHP2 Leptomonas seymouri 47% 100%
A0A1X0NWU4 Trypanosomatidae 30% 100%
A0A3Q8IM81 Leishmania donovani 74% 98%
A0A3R7NJ73 Trypanosoma rangeli 32% 100%
A4I0G2 Leishmania infantum 74% 98%
C9ZV78 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
E9AWC5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 73% 98%
Q4QB47 Leishmania major 73% 100%
V5BEP9 Trypanosoma cruzi 31% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS