Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCX8_LEIBR

TriTrypDb:

LbrM.23.1170 , LBRM2903_230021200

Length:

471

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HCX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCX8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	35	39	PF00656	0.377
CLV_NRD_NRD_1	263	265	PF00675	0.612
CLV_NRD_NRD_1	469	471	PF00675	0.510
CLV_PCSK_KEX2_1	247	249	PF00082	0.503
CLV_PCSK_KEX2_1	263	265	PF00082	0.582
CLV_PCSK_KEX2_1	458	460	PF00082	0.458
CLV_PCSK_KEX2_1	469	471	PF00082	0.561
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.503
CLV_PCSK_PC1ET2_1	458	460	PF00082	0.458
CLV_PCSK_PC7_1	465	471	PF00082	0.503
CLV_PCSK_SKI1_1	129	133	PF00082	0.410
CLV_PCSK_SKI1_1	194	198	PF00082	0.472
DEG_APCC_DBOX_1	193	201	PF00400	0.467
DEG_APCC_DBOX_1	329	337	PF00400	0.456
DEG_COP1_1	107	118	PF00400	0.452
DEG_SCF_FBW7_1	277	284	PF00400	0.534
DEG_SPOP_SBC_1	239	243	PF00917	0.479
DEG_SPOP_SBC_1	389	393	PF00917	0.599
DOC_CDC14_PxL_1	333	341	PF14671	0.466
DOC_CKS1_1	278	283	PF01111	0.752
DOC_CYCLIN_RxL_1	189	198	PF00134	0.474
DOC_CYCLIN_yCln2_LP_2	429	432	PF00134	0.464
DOC_CYCLIN_yCln2_LP_2	68	74	PF00134	0.462
DOC_MAPK_gen_1	227	236	PF00069	0.517
DOC_MAPK_gen_1	263	270	PF00069	0.527
DOC_MAPK_gen_1	409	417	PF00069	0.554
DOC_PP2B_LxvP_1	429	432	PF13499	0.464
DOC_PP2B_LxvP_1	68	71	PF13499	0.476
DOC_PP2B_PxIxI_1	120	126	PF00149	0.415
DOC_PP4_FxxP_1	14	17	PF00568	0.373
DOC_PP4_FxxP_1	417	420	PF00568	0.562
DOC_PP4_FxxP_1	83	86	PF00568	0.363
DOC_USP7_MATH_1	346	350	PF00917	0.647
DOC_USP7_MATH_1	395	399	PF00917	0.632
DOC_USP7_MATH_1	53	57	PF00917	0.465
DOC_USP7_UBL2_3	45	49	PF12436	0.349
DOC_WW_Pin1_4	13	18	PF00397	0.375
DOC_WW_Pin1_4	277	282	PF00397	0.688
DOC_WW_Pin1_4	313	318	PF00397	0.658
DOC_WW_Pin1_4	49	54	PF00397	0.398
DOC_WW_Pin1_4	66	71	PF00397	0.555
LIG_14-3-3_CanoR_1	103	113	PF00244	0.544
LIG_14-3-3_CanoR_1	136	141	PF00244	0.345
LIG_14-3-3_CanoR_1	216	226	PF00244	0.490
LIG_14-3-3_CanoR_1	330	334	PF00244	0.447
LIG_14-3-3_CanoR_1	412	418	PF00244	0.544
LIG_14-3-3_CanoR_1	51	61	PF00244	0.467
LIG_14-3-3_CanoR_1	98	102	PF00244	0.472
LIG_Actin_WH2_2	143	158	PF00022	0.461
LIG_Actin_WH2_2	306	324	PF00022	0.512
LIG_CtBP_PxDLS_1	272	276	PF00389	0.530
LIG_EVH1_2	421	425	PF00568	0.393
LIG_FHA_1	23	29	PF00498	0.406
LIG_FHA_1	233	239	PF00498	0.463
LIG_FHA_1	241	247	PF00498	0.557
LIG_FHA_1	338	344	PF00498	0.609
LIG_FHA_1	79	85	PF00498	0.445
LIG_FHA_2	125	131	PF00498	0.346
LIG_FHA_2	340	346	PF00498	0.607
LIG_FHA_2	451	457	PF00498	0.480
LIG_FXI_DFP_1	6	10	PF00024	0.320
LIG_GBD_Chelix_1	42	50	PF00786	0.318
LIG_LIR_Apic_2	12	17	PF02991	0.367
LIG_LIR_Apic_2	332	337	PF02991	0.459
LIG_LIR_Apic_2	416	420	PF02991	0.567
LIG_LIR_Apic_2	81	86	PF02991	0.433
LIG_LIR_Gen_1	135	146	PF02991	0.429
LIG_LIR_Gen_1	205	215	PF02991	0.512
LIG_LIR_Gen_1	316	326	PF02991	0.462
LIG_LIR_Nem_3	12	18	PF02991	0.410
LIG_LIR_Nem_3	135	141	PF02991	0.423
LIG_LIR_Nem_3	205	211	PF02991	0.577
LIG_LIR_Nem_3	316	321	PF02991	0.467
LIG_SH2_CRK	15	19	PF00017	0.266
LIG_SH2_CRK	177	181	PF00017	0.464
LIG_SH2_CRK	318	322	PF00017	0.456
LIG_SH2_CRK	334	338	PF00017	0.544
LIG_SH2_CRK	62	66	PF00017	0.466
LIG_SH2_NCK_1	15	19	PF00017	0.261
LIG_SH2_NCK_1	334	338	PF00017	0.465
LIG_SH2_STAP1	134	138	PF00017	0.342
LIG_SH2_STAP1	186	190	PF00017	0.380
LIG_SH2_STAT5	124	127	PF00017	0.330
LIG_SH3_2	71	76	PF14604	0.410
LIG_SH3_3	110	116	PF00018	0.569
LIG_SH3_3	15	21	PF00018	0.420
LIG_SH3_3	267	273	PF00018	0.654
LIG_SH3_3	402	408	PF00018	0.678
LIG_SH3_3	416	422	PF00018	0.515
LIG_SH3_3	425	431	PF00018	0.321
LIG_SH3_3	68	74	PF00018	0.398
LIG_SUMO_SIM_anti_2	274	280	PF11976	0.527
LIG_TRAF2_1	202	205	PF00917	0.485
LIG_TRAF2_1	453	456	PF00917	0.478
LIG_TYR_ITIM	13	18	PF00017	0.258
LIG_TYR_ITIM	206	211	PF00017	0.544
LIG_WRC_WIRS_1	233	238	PF05994	0.453
MOD_CK1_1	221	227	PF00069	0.612
MOD_CK1_1	316	322	PF00069	0.451
MOD_CK1_1	372	378	PF00069	0.468
MOD_CK1_1	391	397	PF00069	0.507
MOD_CK1_1	52	58	PF00069	0.363
MOD_CK1_1	64	70	PF00069	0.393
MOD_CK2_1	238	244	PF00069	0.472
MOD_CK2_1	335	341	PF00069	0.592
MOD_CK2_1	350	356	PF00069	0.456
MOD_CK2_1	371	377	PF00069	0.462
MOD_CK2_1	450	456	PF00069	0.471
MOD_GlcNHglycan	397	400	PF01048	0.592
MOD_GlcNHglycan	438	441	PF01048	0.426
MOD_GlcNHglycan	55	58	PF01048	0.422
MOD_GSK3_1	104	111	PF00069	0.460
MOD_GSK3_1	217	224	PF00069	0.509
MOD_GSK3_1	273	280	PF00069	0.674
MOD_GSK3_1	28	35	PF00069	0.430
MOD_GSK3_1	292	299	PF00069	0.735
MOD_GSK3_1	305	312	PF00069	0.518
MOD_GSK3_1	335	342	PF00069	0.607
MOD_GSK3_1	346	353	PF00069	0.674
MOD_GSK3_1	391	398	PF00069	0.647
MOD_GSK3_1	436	443	PF00069	0.478
MOD_GSK3_1	49	56	PF00069	0.355
MOD_GSK3_1	9	16	PF00069	0.368
MOD_N-GLC_2	255	257	PF02516	0.513
MOD_NEK2_1	309	314	PF00069	0.468
MOD_NEK2_1	339	344	PF00069	0.566
MOD_NEK2_1	369	374	PF00069	0.592
MOD_NEK2_1	9	14	PF00069	0.362
MOD_PIKK_1	108	114	PF00454	0.543
MOD_PIKK_1	350	356	PF00454	0.424
MOD_PKA_2	104	110	PF00069	0.524
MOD_PKA_2	215	221	PF00069	0.555
MOD_PKA_2	292	298	PF00069	0.530
MOD_PKA_2	329	335	PF00069	0.446
MOD_PKA_2	436	442	PF00069	0.479
MOD_PKA_2	97	103	PF00069	0.483
MOD_PKB_1	103	111	PF00069	0.499
MOD_Plk_1	221	227	PF00069	0.563
MOD_Plk_1	32	38	PF00069	0.343
MOD_Plk_1	78	84	PF00069	0.540
MOD_Plk_2-3	266	272	PF00069	0.526
MOD_Plk_2-3	335	341	PF00069	0.475
MOD_Plk_4	221	227	PF00069	0.489
MOD_Plk_4	273	279	PF00069	0.581
MOD_Plk_4	281	287	PF00069	0.530
MOD_Plk_4	305	311	PF00069	0.589
MOD_Plk_4	316	322	PF00069	0.453
MOD_Plk_4	329	335	PF00069	0.530
MOD_Plk_4	9	15	PF00069	0.329
MOD_Plk_4	97	103	PF00069	0.336
MOD_ProDKin_1	13	19	PF00069	0.377
MOD_ProDKin_1	277	283	PF00069	0.679
MOD_ProDKin_1	313	319	PF00069	0.650
MOD_ProDKin_1	49	55	PF00069	0.405
MOD_ProDKin_1	66	72	PF00069	0.551
MOD_SUMO_for_1	246	249	PF00179	0.495
MOD_SUMO_rev_2	341	349	PF00179	0.599
MOD_SUMO_rev_2	455	460	PF00179	0.503
TRG_DiLeu_BaEn_1	191	196	PF01217	0.324
TRG_DiLeu_BaEn_2	78	84	PF01217	0.445
TRG_DiLeu_BaLyEn_6	118	123	PF01217	0.454
TRG_DiLeu_LyEn_5	191	196	PF01217	0.324
TRG_ENDOCYTIC_2	134	137	PF00928	0.411
TRG_ENDOCYTIC_2	15	18	PF00928	0.265
TRG_ENDOCYTIC_2	208	211	PF00928	0.563
TRG_ENDOCYTIC_2	318	321	PF00928	0.459
TRG_ENDOCYTIC_2	62	65	PF00928	0.435
TRG_ER_diArg_1	102	105	PF00400	0.468
TRG_ER_diArg_1	262	264	PF00400	0.608
TRG_ER_diArg_1	379	382	PF00400	0.550
TRG_NES_CRM1_1	198	213	PF08389	0.396
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.423
TRG_Pf-PMV_PEXEL_1	452	456	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	92	96	PF00026	0.315

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2R2	Leptomonas seymouri	44%	100%
A0A3Q8IBT7	Leishmania donovani	72%	100%
A4I0G1	Leishmania infantum	72%	100%
E9AWC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	87%
Q4QB48	Leishmania major	72%	100%