HIT domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HIT domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HCX7_LEIBR

TriTrypDb:

LbrM.23.1160 , LBRM2903_230021000 , LBRM2903_230021100

Length:

351

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCX7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCX7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0047710	bis(5'-adenosyl)-triphosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.629
CLV_C14_Caspase3-7	172	176	PF00656	0.554
CLV_NRD_NRD_1	250	252	PF00675	0.379
CLV_NRD_NRD_1	3	5	PF00675	0.649
CLV_NRD_NRD_1	316	318	PF00675	0.584
CLV_PCSK_KEX2_1	250	252	PF00082	0.328
CLV_PCSK_KEX2_1	3	5	PF00082	0.649
CLV_PCSK_KEX2_1	315	317	PF00082	0.593
CLV_PCSK_SKI1_1	24	28	PF00082	0.729
CLV_PCSK_SKI1_1	3	7	PF00082	0.590
CLV_PCSK_SKI1_1	333	337	PF00082	0.536
DOC_CKS1_1	319	324	PF01111	0.630
DOC_PP1_RVXF_1	331	337	PF00149	0.420
DOC_PP4_FxxP_1	14	17	PF00568	0.655
DOC_USP7_MATH_1	135	139	PF00917	0.546
DOC_USP7_MATH_1	157	161	PF00917	0.577
DOC_USP7_MATH_1	188	192	PF00917	0.394
DOC_USP7_MATH_1	193	197	PF00917	0.335
DOC_USP7_MATH_1	255	259	PF00917	0.534
DOC_USP7_MATH_1	266	270	PF00917	0.519
DOC_USP7_MATH_1	342	346	PF00917	0.594
DOC_USP7_MATH_1	74	78	PF00917	0.753
DOC_WW_Pin1_4	103	108	PF00397	0.722
DOC_WW_Pin1_4	13	18	PF00397	0.553
DOC_WW_Pin1_4	162	167	PF00397	0.711
DOC_WW_Pin1_4	27	32	PF00397	0.674
DOC_WW_Pin1_4	318	323	PF00397	0.643
DOC_WW_Pin1_4	49	54	PF00397	0.652
LIG_14-3-3_CanoR_1	178	182	PF00244	0.462
LIG_14-3-3_CanoR_1	24	31	PF00244	0.519
LIG_14-3-3_CanoR_1	3	8	PF00244	0.605
LIG_BIR_II_1	1	5	PF00653	0.706
LIG_BRCT_BRCA1_1	195	199	PF00533	0.496
LIG_FHA_1	18	24	PF00498	0.711
LIG_FHA_1	240	246	PF00498	0.480
LIG_FHA_1	262	268	PF00498	0.585
LIG_FHA_1	327	333	PF00498	0.449
LIG_FHA_1	91	97	PF00498	0.633
LIG_FHA_2	114	120	PF00498	0.670
LIG_FHA_2	124	130	PF00498	0.600
LIG_FHA_2	226	232	PF00498	0.513
LIG_FHA_2	50	56	PF00498	0.546
LIG_FHA_2	76	82	PF00498	0.732
LIG_LIR_Apic_2	180	185	PF02991	0.513
LIG_LIR_Gen_1	196	207	PF02991	0.482
LIG_LIR_Nem_3	180	184	PF02991	0.405
LIG_LIR_Nem_3	196	202	PF02991	0.431
LIG_LIR_Nem_3	233	238	PF02991	0.509
LIG_SH2_CRK	63	67	PF00017	0.578
LIG_SH2_CRK	69	73	PF00017	0.661
LIG_SH2_NCK_1	156	160	PF00017	0.594
LIG_SH2_NCK_1	339	343	PF00017	0.566
LIG_SH2_SRC	45	48	PF00017	0.589
LIG_SH2_STAP1	273	277	PF00017	0.562
LIG_SH2_STAP1	339	343	PF00017	0.594
LIG_SH2_STAT3	194	197	PF00017	0.585
LIG_SH2_STAT5	194	197	PF00017	0.523
LIG_SH2_STAT5	339	342	PF00017	0.532
LIG_SH2_STAT5	45	48	PF00017	0.633
LIG_SH3_1	316	322	PF00018	0.652
LIG_SH3_3	187	193	PF00018	0.497
LIG_SH3_3	204	210	PF00018	0.366
LIG_SH3_3	293	299	PF00018	0.496
LIG_SH3_3	316	322	PF00018	0.652
LIG_SH3_3	70	76	PF00018	0.573
LIG_SH3_4	139	146	PF00018	0.613
LIG_TRAF2_1	106	109	PF00917	0.747
LIG_TRAF2_1	116	119	PF00917	0.521
LIG_TRAF2_1	228	231	PF00917	0.534
LIG_TRAF2_1	324	327	PF00917	0.587
LIG_TRFH_1	69	73	PF08558	0.732
LIG_TYR_ITIM	61	66	PF00017	0.504
LIG_UBA3_1	169	174	PF00899	0.721
LIG_WW_3	317	321	PF00397	0.606
MOD_CK1_1	258	264	PF00069	0.551
MOD_CK1_1	345	351	PF00069	0.700
MOD_CK2_1	103	109	PF00069	0.739
MOD_CK2_1	113	119	PF00069	0.575
MOD_CK2_1	123	129	PF00069	0.597
MOD_CK2_1	225	231	PF00069	0.482
MOD_CK2_1	75	81	PF00069	0.734
MOD_GlcNHglycan	108	113	PF01048	0.694
MOD_GlcNHglycan	257	260	PF01048	0.326
MOD_GlcNHglycan	261	264	PF01048	0.349
MOD_GlcNHglycan	32	35	PF01048	0.795
MOD_GSK3_1	113	120	PF00069	0.668
MOD_GSK3_1	13	20	PF00069	0.567
MOD_GSK3_1	157	164	PF00069	0.551
MOD_GSK3_1	255	262	PF00069	0.412
MOD_GSK3_1	90	97	PF00069	0.594
MOD_N-GLC_1	12	17	PF02516	0.599
MOD_N-GLC_1	162	167	PF02516	0.679
MOD_N-GLC_1	271	276	PF02516	0.362
MOD_NEK2_1	12	17	PF00069	0.539
MOD_NEK2_1	239	244	PF00069	0.497
MOD_NEK2_1	95	100	PF00069	0.529
MOD_NEK2_2	220	225	PF00069	0.508
MOD_PIKK_1	193	199	PF00454	0.479
MOD_PKA_1	3	9	PF00069	0.653
MOD_PKA_2	177	183	PF00069	0.532
MOD_PKA_2	239	245	PF00069	0.502
MOD_PKA_2	255	261	PF00069	0.541
MOD_PKA_2	3	9	PF00069	0.651
MOD_Plk_1	117	123	PF00069	0.648
MOD_Plk_1	271	277	PF00069	0.562
MOD_ProDKin_1	103	109	PF00069	0.722
MOD_ProDKin_1	13	19	PF00069	0.553
MOD_ProDKin_1	162	168	PF00069	0.717
MOD_ProDKin_1	27	33	PF00069	0.673
MOD_ProDKin_1	318	324	PF00069	0.637
MOD_ProDKin_1	49	55	PF00069	0.652
TRG_DiLeu_BaEn_4	327	333	PF01217	0.340
TRG_DiLeu_BaLyEn_6	330	335	PF01217	0.427
TRG_ENDOCYTIC_2	45	48	PF00928	0.684
TRG_ENDOCYTIC_2	63	66	PF00928	0.356
TRG_ENDOCYTIC_2	69	72	PF00928	0.582
TRG_ER_diArg_1	249	251	PF00400	0.579
TRG_ER_diArg_1	3	5	PF00400	0.650
TRG_ER_diArg_1	315	317	PF00400	0.647
TRG_Pf-PMV_PEXEL_1	333	338	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P352	Leptomonas seymouri	56%	81%
A0A0S4JIU0	Bodo saltans	31%	92%
A0A1X0NWV2	Trypanosomatidae	38%	77%
A0A3S7WXW4	Leishmania donovani	83%	100%
A4I0G0	Leishmania infantum	83%	100%
C9ZV80	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	84%
E9AWC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QB49	Leishmania major	81%	100%
V5BJC2	Trypanosoma cruzi	45%	86%