5-formyltetrahydrofolate cyclo-ligase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

5-formyltetrahydrofolate cyclo-ligase family, putative

Species:

Leishmania braziliensis

UniProt:

A4HCX6_LEIBR

TriTrypDb:

LbrM.23.1150 , LBRM2903_230020900

Length:

449

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HCX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCX6

Function

Biological processes
Term	Name	Level	Count
GO:0006575	cellular modified amino acid metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006730	one-carbon metabolic process	3	1
GO:0006760	folic acid-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009396	folic acid-containing compound biosynthetic process	5	1
GO:0009987	cellular process	1	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0035999	tetrahydrofolate interconversion	4	1
GO:0042398	cellular modified amino acid biosynthetic process	4	1
GO:0042558	pteridine-containing compound metabolic process	4	1
GO:0042559	pteridine-containing compound biosynthetic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046653	tetrahydrofolate metabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016874	ligase activity	2	2
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	1
GO:0016882	cyclo-ligase activity	4	1
GO:0030272	5-formyltetrahydrofolate cyclo-ligase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	413	417	PF00656	0.720
CLV_NRD_NRD_1	13	15	PF00675	0.360
CLV_NRD_NRD_1	22	24	PF00675	0.353
CLV_PCSK_FUR_1	20	24	PF00082	0.428
CLV_PCSK_KEX2_1	22	24	PF00082	0.411
CLV_PCSK_SKI1_1	10	14	PF00082	0.378
CLV_PCSK_SKI1_1	23	27	PF00082	0.396
DEG_Nend_UBRbox_3	1	3	PF02207	0.638
DEG_SPOP_SBC_1	404	408	PF00917	0.528
DOC_CKS1_1	119	124	PF01111	0.449
DOC_CKS1_1	311	316	PF01111	0.453
DOC_CYCLIN_yCln2_LP_2	154	160	PF00134	0.522
DOC_CYCLIN_yCln2_LP_2	202	208	PF00134	0.467
DOC_CYCLIN_yCln2_LP_2	78	84	PF00134	0.500
DOC_MAPK_gen_1	10	21	PF00069	0.509
DOC_MAPK_MEF2A_6	169	177	PF00069	0.467
DOC_MAPK_MEF2A_6	387	395	PF00069	0.233
DOC_MAPK_RevD_3	7	23	PF00069	0.435
DOC_PP2B_LxvP_1	162	165	PF13499	0.500
DOC_PP2B_LxvP_1	78	81	PF13499	0.638
DOC_PP2B_LxvP_1	82	85	PF13499	0.488
DOC_USP7_MATH_1	149	153	PF00917	0.685
DOC_USP7_MATH_1	167	171	PF00917	0.545
DOC_USP7_MATH_1	349	353	PF00917	0.577
DOC_USP7_MATH_1	405	409	PF00917	0.657
DOC_USP7_UBL2_3	11	15	PF12436	0.514
DOC_WW_Pin1_4	118	123	PF00397	0.353
DOC_WW_Pin1_4	221	226	PF00397	0.630
DOC_WW_Pin1_4	287	292	PF00397	0.732
DOC_WW_Pin1_4	310	315	PF00397	0.415
DOC_WW_Pin1_4	376	381	PF00397	0.668
DOC_WW_Pin1_4	434	439	PF00397	0.389
DOC_WW_Pin1_4	80	85	PF00397	0.598
LIG_14-3-3_CanoR_1	23	29	PF00244	0.481
LIG_14-3-3_CanoR_1	335	340	PF00244	0.385
LIG_Actin_WH2_2	155	171	PF00022	0.608
LIG_AP2alpha_1	332	336	PF02296	0.492
LIG_APCC_ABBA_1	93	98	PF00400	0.330
LIG_BIR_III_2	374	378	PF00653	0.522
LIG_eIF4E_1	270	276	PF01652	0.498
LIG_eIF4E_1	96	102	PF01652	0.271
LIG_FHA_1	119	125	PF00498	0.392
LIG_FHA_1	296	302	PF00498	0.500
LIG_FHA_1	311	317	PF00498	0.407
LIG_FHA_1	4	10	PF00498	0.443
LIG_FHA_2	411	417	PF00498	0.507
LIG_HCF-1_HBM_1	41	44	PF13415	0.450
LIG_Integrin_RGD_1	232	234	PF01839	0.473
LIG_LIR_Gen_1	256	263	PF02991	0.401
LIG_LIR_Nem_3	213	219	PF02991	0.446
LIG_LIR_Nem_3	256	261	PF02991	0.399
LIG_LIR_Nem_3	277	281	PF02991	0.364
LIG_LIR_Nem_3	334	339	PF02991	0.451
LIG_LIR_Nem_3	41	47	PF02991	0.318
LIG_Pex14_2	332	336	PF04695	0.492
LIG_SH2_CRK	258	262	PF00017	0.419
LIG_SH2_CRK	44	48	PF00017	0.337
LIG_SH2_STAP1	258	262	PF00017	0.419
LIG_SH2_STAP1	333	337	PF00017	0.440
LIG_SH2_STAT5	46	49	PF00017	0.399
LIG_SH2_STAT5	92	95	PF00017	0.349
LIG_SH2_STAT5	96	99	PF00017	0.351
LIG_SH3_3	157	163	PF00018	0.721
LIG_SH3_3	308	314	PF00018	0.471
LIG_SH3_3	374	380	PF00018	0.538
LIG_SH3_3	396	402	PF00018	0.321
LIG_SH3_3	432	438	PF00018	0.364
LIG_SH3_3	71	77	PF00018	0.560
LIG_SH3_3	78	84	PF00018	0.543
LIG_SH3_4	144	151	PF00018	0.484
LIG_SUMO_SIM_anti_2	98	103	PF11976	0.249
LIG_SUMO_SIM_par_1	308	313	PF11976	0.417
LIG_TRAF2_1	359	362	PF00917	0.677
LIG_TYR_ITIM	276	281	PF00017	0.352
LIG_TYR_ITIM	90	95	PF00017	0.371
LIG_UBA3_1	18	26	PF00899	0.491
LIG_WW_3	353	357	PF00397	0.491
MOD_CDK_SPK_2	287	292	PF00069	0.494
MOD_CK1_1	152	158	PF00069	0.735
MOD_CK1_1	224	230	PF00069	0.729
MOD_CK1_1	282	288	PF00069	0.534
MOD_CK1_1	3	9	PF00069	0.534
MOD_CK1_1	300	306	PF00069	0.312
MOD_CK1_1	403	409	PF00069	0.720
MOD_CK1_1	412	418	PF00069	0.662
MOD_CK2_1	198	204	PF00069	0.521
MOD_GlcNHglycan	151	154	PF01048	0.680
MOD_GlcNHglycan	169	172	PF01048	0.397
MOD_GlcNHglycan	272	275	PF01048	0.466
MOD_GlcNHglycan	341	344	PF01048	0.363
MOD_GlcNHglycan	402	405	PF01048	0.623
MOD_GSK3_1	139	146	PF00069	0.639
MOD_GSK3_1	148	155	PF00069	0.736
MOD_GSK3_1	211	218	PF00069	0.550
MOD_GSK3_1	279	286	PF00069	0.609
MOD_GSK3_1	335	342	PF00069	0.199
MOD_GSK3_1	400	407	PF00069	0.629
MOD_GSK3_1	410	417	PF00069	0.644
MOD_N-GLC_1	198	203	PF02516	0.363
MOD_NEK2_1	198	203	PF00069	0.481
MOD_NEK2_1	211	216	PF00069	0.533
MOD_NEK2_1	318	323	PF00069	0.213
MOD_NEK2_2	139	144	PF00069	0.477
MOD_PIKK_1	33	39	PF00454	0.491
MOD_PK_1	107	113	PF00069	0.336
MOD_PKA_2	270	276	PF00069	0.533
MOD_PKA_2	59	65	PF00069	0.554
MOD_Plk_1	198	204	PF00069	0.364
MOD_Plk_1	415	421	PF00069	0.580
MOD_Plk_4	198	204	PF00069	0.500
MOD_Plk_4	305	311	PF00069	0.417
MOD_ProDKin_1	118	124	PF00069	0.360
MOD_ProDKin_1	221	227	PF00069	0.633
MOD_ProDKin_1	287	293	PF00069	0.731
MOD_ProDKin_1	310	316	PF00069	0.242
MOD_ProDKin_1	376	382	PF00069	0.664
MOD_ProDKin_1	434	440	PF00069	0.393
MOD_ProDKin_1	80	86	PF00069	0.582
MOD_SUMO_for_1	386	389	PF00179	0.254
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.482
TRG_ENDOCYTIC_2	258	261	PF00928	0.459
TRG_ENDOCYTIC_2	278	281	PF00928	0.317
TRG_ENDOCYTIC_2	333	336	PF00928	0.284
TRG_ENDOCYTIC_2	44	47	PF00928	0.316
TRG_ENDOCYTIC_2	92	95	PF00928	0.309
TRG_ENDOCYTIC_2	96	99	PF00928	0.302
TRG_ER_diArg_1	19	22	PF00400	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1K4	Leptomonas seymouri	41%	100%
A0A1X0NWU1	Trypanosomatidae	27%	100%
A0A3Q8IEK9	Leishmania donovani	72%	100%
A0A3R7KPU1	Trypanosoma rangeli	28%	100%
A4I0F9	Leishmania infantum	72%	100%
C9ZV81	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AWC2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4QB50	Leishmania major	71%	100%
V5DFL5	Trypanosoma cruzi	29%	100%