Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HCX5_LEIBR

TriTrypDb:

LbrM.23.1140 , LBRM2903_230020800

Length:

692

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCX5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.527
CLV_C14_Caspase3-7	270	274	PF00656	0.657
CLV_NRD_NRD_1	10	12	PF00675	0.531
CLV_NRD_NRD_1	129	131	PF00675	0.602
CLV_NRD_NRD_1	327	329	PF00675	0.508
CLV_NRD_NRD_1	463	465	PF00675	0.628
CLV_NRD_NRD_1	466	468	PF00675	0.622
CLV_NRD_NRD_1	471	473	PF00675	0.636
CLV_NRD_NRD_1	636	638	PF00675	0.499
CLV_NRD_NRD_1	88	90	PF00675	0.557
CLV_PCSK_FUR_1	483	487	PF00082	0.551
CLV_PCSK_KEX2_1	10	12	PF00082	0.531
CLV_PCSK_KEX2_1	128	130	PF00082	0.629
CLV_PCSK_KEX2_1	463	465	PF00082	0.670
CLV_PCSK_KEX2_1	471	473	PF00082	0.676
CLV_PCSK_KEX2_1	485	487	PF00082	0.632
CLV_PCSK_KEX2_1	636	638	PF00082	0.499
CLV_PCSK_KEX2_1	88	90	PF00082	0.557
CLV_PCSK_PC1ET2_1	485	487	PF00082	0.688
CLV_PCSK_PC7_1	467	473	PF00082	0.514
CLV_PCSK_SKI1_1	171	175	PF00082	0.623
CLV_PCSK_SKI1_1	180	184	PF00082	0.563
CLV_PCSK_SKI1_1	323	327	PF00082	0.466
CLV_PCSK_SKI1_1	447	451	PF00082	0.595
CLV_PCSK_SKI1_1	637	641	PF00082	0.529
DEG_APCC_DBOX_1	353	361	PF00400	0.503
DEG_APCC_DBOX_1	635	643	PF00400	0.496
DEG_COP1_1	436	445	PF00400	0.541
DEG_Nend_UBRbox_3	1	3	PF02207	0.585
DEG_SPOP_SBC_1	194	198	PF00917	0.490
DEG_SPOP_SBC_1	420	424	PF00917	0.641
DEG_SPOP_SBC_1	449	453	PF00917	0.509
DEG_SPOP_SBC_1	97	101	PF00917	0.517
DOC_CKS1_1	137	142	PF01111	0.499
DOC_CKS1_1	205	210	PF01111	0.731
DOC_CKS1_1	442	447	PF01111	0.543
DOC_CYCLIN_RxL_1	631	644	PF00134	0.512
DOC_MAPK_gen_1	10	16	PF00069	0.528
DOC_MAPK_gen_1	636	642	PF00069	0.503
DOC_PP2B_LxvP_1	49	52	PF13499	0.697
DOC_PP4_FxxP_1	211	214	PF00568	0.670
DOC_USP7_MATH_1	114	118	PF00917	0.612
DOC_USP7_MATH_1	194	198	PF00917	0.500
DOC_USP7_MATH_1	215	219	PF00917	0.493
DOC_USP7_MATH_1	259	263	PF00917	0.547
DOC_USP7_MATH_1	285	289	PF00917	0.551
DOC_USP7_MATH_1	293	297	PF00917	0.510
DOC_USP7_MATH_1	318	322	PF00917	0.640
DOC_USP7_MATH_1	341	345	PF00917	0.519
DOC_USP7_MATH_1	364	368	PF00917	0.588
DOC_USP7_MATH_1	387	391	PF00917	0.621
DOC_USP7_MATH_1	420	424	PF00917	0.681
DOC_USP7_MATH_1	427	431	PF00917	0.608
DOC_USP7_MATH_1	443	447	PF00917	0.649
DOC_USP7_MATH_1	466	470	PF00917	0.495
DOC_USP7_MATH_1	528	532	PF00917	0.478
DOC_USP7_MATH_1	547	551	PF00917	0.606
DOC_USP7_MATH_1	613	617	PF00917	0.649
DOC_WW_Pin1_4	133	138	PF00397	0.784
DOC_WW_Pin1_4	204	209	PF00397	0.752
DOC_WW_Pin1_4	302	307	PF00397	0.625
DOC_WW_Pin1_4	349	354	PF00397	0.536
DOC_WW_Pin1_4	441	446	PF00397	0.581
DOC_WW_Pin1_4	450	455	PF00397	0.735
DOC_WW_Pin1_4	486	491	PF00397	0.571
DOC_WW_Pin1_4	542	547	PF00397	0.713
DOC_WW_Pin1_4	604	609	PF00397	0.616
DOC_WW_Pin1_4	64	69	PF00397	0.619
DOC_WW_Pin1_4	655	660	PF00397	0.686
DOC_WW_Pin1_4	93	98	PF00397	0.620
LIG_14-3-3_CanoR_1	130	140	PF00244	0.567
LIG_14-3-3_CanoR_1	163	169	PF00244	0.600
LIG_14-3-3_CanoR_1	210	214	PF00244	0.700
LIG_14-3-3_CanoR_1	221	229	PF00244	0.668
LIG_14-3-3_CanoR_1	309	316	PF00244	0.611
LIG_14-3-3_CanoR_1	328	333	PF00244	0.381
LIG_14-3-3_CanoR_1	378	386	PF00244	0.625
LIG_14-3-3_CanoR_1	447	455	PF00244	0.543
LIG_14-3-3_CanoR_1	46	52	PF00244	0.702
LIG_14-3-3_CanoR_1	467	475	PF00244	0.469
LIG_14-3-3_CanoR_1	514	522	PF00244	0.472
LIG_14-3-3_CanoR_1	636	640	PF00244	0.545
LIG_14-3-3_CanoR_1	89	98	PF00244	0.541
LIG_Actin_WH2_2	620	638	PF00022	0.519
LIG_CtBP_PxDLS_1	554	558	PF00389	0.528
LIG_deltaCOP1_diTrp_1	250	256	PF00928	0.542
LIG_EH_1	253	257	PF12763	0.610
LIG_EVH1_2	661	665	PF00568	0.524
LIG_FHA_1	149	155	PF00498	0.533
LIG_FHA_1	194	200	PF00498	0.519
LIG_FHA_1	228	234	PF00498	0.557
LIG_FHA_1	322	328	PF00498	0.483
LIG_FHA_1	360	366	PF00498	0.608
LIG_FHA_1	377	383	PF00498	0.620
LIG_FHA_1	38	44	PF00498	0.607
LIG_FHA_1	517	523	PF00498	0.471
LIG_FHA_1	543	549	PF00498	0.626
LIG_FHA_1	577	583	PF00498	0.601
LIG_FHA_1	61	67	PF00498	0.613
LIG_FHA_1	618	624	PF00498	0.498
LIG_FHA_1	668	674	PF00498	0.549
LIG_FHA_1	97	103	PF00498	0.520
LIG_FHA_2	268	274	PF00498	0.615
LIG_FHA_2	412	418	PF00498	0.499
LIG_FHA_2	51	57	PF00498	0.678
LIG_FHA_2	605	611	PF00498	0.700
LIG_FHA_2	636	642	PF00498	0.604
LIG_IRF3_LxIS_1	415	422	PF10401	0.630
LIG_LIR_Gen_1	218	227	PF02991	0.546
LIG_LIR_Gen_1	4	14	PF02991	0.440
LIG_LIR_Gen_1	414	421	PF02991	0.623
LIG_LIR_Gen_1	503	513	PF02991	0.645
LIG_LIR_Gen_1	518	528	PF02991	0.471
LIG_LIR_Gen_1	664	673	PF02991	0.502
LIG_LIR_Nem_3	135	141	PF02991	0.514
LIG_LIR_Nem_3	218	222	PF02991	0.616
LIG_LIR_Nem_3	250	256	PF02991	0.542
LIG_LIR_Nem_3	4	9	PF02991	0.443
LIG_LIR_Nem_3	414	419	PF02991	0.551
LIG_LIR_Nem_3	503	509	PF02991	0.568
LIG_LIR_Nem_3	518	523	PF02991	0.555
LIG_LIR_Nem_3	558	563	PF02991	0.681
LIG_LIR_Nem_3	664	668	PF02991	0.516
LIG_MYND_1	33	37	PF01753	0.534
LIG_PCNA_yPIPBox_3	18	27	PF02747	0.499
LIG_Pex14_1	621	625	PF04695	0.559
LIG_SH2_CRK	143	147	PF00017	0.503
LIG_SH2_CRK	560	564	PF00017	0.519
LIG_SH2_CRK	6	10	PF00017	0.443
LIG_SH2_NCK_1	560	564	PF00017	0.519
LIG_SH2_NCK_1	586	590	PF00017	0.509
LIG_SH2_PTP2	13	16	PF00017	0.563
LIG_SH2_SRC	284	287	PF00017	0.560
LIG_SH2_SRC	418	421	PF00017	0.642
LIG_SH2_SRC	560	563	PF00017	0.519
LIG_SH2_STAP1	227	231	PF00017	0.590
LIG_SH2_STAT5	13	16	PF00017	0.563
LIG_SH2_STAT5	138	141	PF00017	0.517
LIG_SH2_STAT5	395	398	PF00017	0.707
LIG_SH2_STAT5	418	421	PF00017	0.642
LIG_SH2_STAT5	586	589	PF00017	0.584
LIG_SH3_2	83	88	PF14604	0.679
LIG_SH3_3	134	140	PF00018	0.522
LIG_SH3_3	211	217	PF00018	0.587
LIG_SH3_3	350	356	PF00018	0.620
LIG_SH3_3	439	445	PF00018	0.704
LIG_SH3_3	656	662	PF00018	0.537
LIG_SH3_3	80	86	PF00018	0.716
LIG_SH3_CIN85_PxpxPR_1	83	88	PF14604	0.517
LIG_Sin3_3	520	527	PF02671	0.469
LIG_SUMO_SIM_anti_2	496	504	PF11976	0.496
LIG_SUMO_SIM_par_1	496	504	PF11976	0.658
LIG_SUMO_SIM_par_1	638	644	PF11976	0.613
LIG_WRC_WIRS_1	216	221	PF05994	0.552
LIG_WW_3	85	89	PF00397	0.535
MOD_CDK_SPK_2	349	354	PF00069	0.536
MOD_CDK_SPxK_1	204	210	PF00069	0.705
MOD_CDK_SPxK_1	441	447	PF00069	0.543
MOD_CDK_SPxxK_3	302	309	PF00069	0.544
MOD_CDK_SPxxK_3	450	457	PF00069	0.650
MOD_CK1_1	109	115	PF00069	0.659
MOD_CK1_1	136	142	PF00069	0.666
MOD_CK1_1	197	203	PF00069	0.677
MOD_CK1_1	302	308	PF00069	0.585
MOD_CK1_1	321	327	PF00069	0.470
MOD_CK1_1	346	352	PF00069	0.537
MOD_CK1_1	388	394	PF00069	0.666
MOD_CK1_1	50	56	PF00069	0.650
MOD_CK1_1	531	537	PF00069	0.586
MOD_CK1_1	58	64	PF00069	0.586
MOD_CK1_1	653	659	PF00069	0.656
MOD_CK1_1	671	677	PF00069	0.497
MOD_CK1_1	684	690	PF00069	0.604
MOD_CK1_1	93	99	PF00069	0.590
MOD_CK2_1	234	240	PF00069	0.682
MOD_CK2_1	284	290	PF00069	0.654
MOD_CK2_1	411	417	PF00069	0.526
MOD_CK2_1	50	56	PF00069	0.697
MOD_CK2_1	567	573	PF00069	0.672
MOD_CK2_1	604	610	PF00069	0.633
MOD_CK2_1	635	641	PF00069	0.591
MOD_DYRK1A_RPxSP_1	486	490	PF00069	0.573
MOD_GlcNHglycan	108	111	PF01048	0.651
MOD_GlcNHglycan	201	204	PF01048	0.612
MOD_GlcNHglycan	211	214	PF01048	0.630
MOD_GlcNHglycan	236	239	PF01048	0.606
MOD_GlcNHglycan	295	298	PF01048	0.599
MOD_GlcNHglycan	348	351	PF01048	0.796
MOD_GlcNHglycan	387	390	PF01048	0.553
MOD_GlcNHglycan	430	433	PF01048	0.609
MOD_GlcNHglycan	438	441	PF01048	0.564
MOD_GlcNHglycan	479	482	PF01048	0.555
MOD_GlcNHglycan	49	52	PF01048	0.599
MOD_GlcNHglycan	537	540	PF01048	0.604
MOD_GlcNHglycan	557	560	PF01048	0.714
MOD_GlcNHglycan	56	60	PF01048	0.650
MOD_GlcNHglycan	674	677	PF01048	0.468
MOD_GlcNHglycan	80	83	PF01048	0.607
MOD_GlcNHglycan	92	95	PF01048	0.667
MOD_GSK3_1	102	109	PF00069	0.609
MOD_GSK3_1	132	139	PF00069	0.770
MOD_GSK3_1	148	155	PF00069	0.563
MOD_GSK3_1	193	200	PF00069	0.630
MOD_GSK3_1	229	236	PF00069	0.524
MOD_GSK3_1	317	324	PF00069	0.589
MOD_GSK3_1	37	44	PF00069	0.617
MOD_GSK3_1	376	383	PF00069	0.554
MOD_GSK3_1	385	392	PF00069	0.637
MOD_GSK3_1	47	54	PF00069	0.617
MOD_GSK3_1	531	538	PF00069	0.587
MOD_GSK3_1	594	601	PF00069	0.670
MOD_GSK3_1	60	67	PF00069	0.551
MOD_GSK3_1	604	611	PF00069	0.723
MOD_GSK3_1	613	620	PF00069	0.531
MOD_GSK3_1	663	670	PF00069	0.628
MOD_GSK3_1	680	687	PF00069	0.459
MOD_GSK3_1	93	100	PF00069	0.623
MOD_N-GLC_1	234	239	PF02516	0.609
MOD_N-GLC_1	427	432	PF02516	0.548
MOD_NEK2_1	102	107	PF00069	0.527
MOD_NEK2_1	164	169	PF00069	0.616
MOD_NEK2_1	199	204	PF00069	0.644
MOD_NEK2_1	448	453	PF00069	0.542
MOD_NEK2_1	501	506	PF00069	0.492
MOD_NEK2_1	55	60	PF00069	0.659
MOD_NEK2_1	635	640	PF00069	0.633
MOD_NEK2_1	668	673	PF00069	0.658
MOD_NEK2_2	318	323	PF00069	0.485
MOD_PIKK_1	259	265	PF00454	0.550
MOD_PIKK_1	341	347	PF00454	0.668
MOD_PIKK_1	513	519	PF00454	0.481
MOD_PIKK_1	528	534	PF00454	0.627
MOD_PK_1	169	175	PF00069	0.465
MOD_PKA_1	328	334	PF00069	0.572
MOD_PKA_1	467	473	PF00069	0.515
MOD_PKA_2	114	120	PF00069	0.690
MOD_PKA_2	131	137	PF00069	0.494
MOD_PKA_2	209	215	PF00069	0.696
MOD_PKA_2	308	314	PF00069	0.593
MOD_PKA_2	377	383	PF00069	0.490
MOD_PKA_2	466	472	PF00069	0.508
MOD_PKA_2	513	519	PF00069	0.469
MOD_PKA_2	635	641	PF00069	0.568
MOD_PKB_1	130	138	PF00069	0.515
MOD_Plk_1	249	255	PF00069	0.539
MOD_Plk_2-3	594	600	PF00069	0.496
MOD_Plk_4	215	221	PF00069	0.593
MOD_Plk_4	31	37	PF00069	0.524
MOD_Plk_4	321	327	PF00069	0.469
MOD_Plk_4	411	417	PF00069	0.526
MOD_Plk_4	668	674	PF00069	0.501
MOD_Plk_4	98	104	PF00069	0.523
MOD_ProDKin_1	133	139	PF00069	0.785
MOD_ProDKin_1	204	210	PF00069	0.755
MOD_ProDKin_1	302	308	PF00069	0.624
MOD_ProDKin_1	349	355	PF00069	0.531
MOD_ProDKin_1	441	447	PF00069	0.585
MOD_ProDKin_1	450	456	PF00069	0.730
MOD_ProDKin_1	486	492	PF00069	0.569
MOD_ProDKin_1	542	548	PF00069	0.715
MOD_ProDKin_1	604	610	PF00069	0.617
MOD_ProDKin_1	64	70	PF00069	0.612
MOD_ProDKin_1	655	661	PF00069	0.683
MOD_ProDKin_1	93	99	PF00069	0.616
MOD_SUMO_for_1	173	176	PF00179	0.460
MOD_SUMO_rev_2	430	440	PF00179	0.702
TRG_ENDOCYTIC_2	13	16	PF00928	0.556
TRG_ENDOCYTIC_2	138	141	PF00928	0.517
TRG_ENDOCYTIC_2	143	146	PF00928	0.467
TRG_ENDOCYTIC_2	418	421	PF00928	0.562
TRG_ENDOCYTIC_2	560	563	PF00928	0.601
TRG_ENDOCYTIC_2	6	9	PF00928	0.501
TRG_ER_diArg_1	128	130	PF00400	0.610
TRG_ER_diArg_1	168	171	PF00400	0.615
TRG_ER_diArg_1	243	246	PF00400	0.559
TRG_ER_diArg_1	277	280	PF00400	0.687
TRG_ER_diArg_1	462	464	PF00400	0.588
TRG_ER_diArg_1	471	473	PF00400	0.578
TRG_ER_diArg_1	635	637	PF00400	0.484
TRG_ER_diArg_1	87	89	PF00400	0.547
TRG_ER_diArg_1	9	11	PF00400	0.532
TRG_NLS_MonoExtC_3	327	333	PF00514	0.424
TRG_Pf-PMV_PEXEL_1	10	15	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	637	641	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2R4	Leptomonas seymouri	27%	94%
A0A3Q8IBK4	Leishmania donovani	62%	100%
A4I0F8	Leishmania infantum	61%	100%
E9AWC1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	99%
Q4QB51	Leishmania major	61%	100%