Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCX4_LEIBR

TriTrypDb:

LbrM.23.1130 , LBRM2903_230020700

Length:

557

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCX4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.514
CLV_NRD_NRD_1	207	209	PF00675	0.681
CLV_NRD_NRD_1	334	336	PF00675	0.711
CLV_NRD_NRD_1	358	360	PF00675	0.716
CLV_NRD_NRD_1	369	371	PF00675	0.731
CLV_NRD_NRD_1	378	380	PF00675	0.629
CLV_NRD_NRD_1	408	410	PF00675	0.651
CLV_NRD_NRD_1	499	501	PF00675	0.752
CLV_PCSK_KEX2_1	180	182	PF00082	0.560
CLV_PCSK_KEX2_1	206	208	PF00082	0.760
CLV_PCSK_KEX2_1	304	306	PF00082	0.662
CLV_PCSK_KEX2_1	334	336	PF00082	0.711
CLV_PCSK_KEX2_1	358	360	PF00082	0.716
CLV_PCSK_KEX2_1	369	371	PF00082	0.731
CLV_PCSK_KEX2_1	378	380	PF00082	0.629
CLV_PCSK_KEX2_1	407	409	PF00082	0.633
CLV_PCSK_KEX2_1	499	501	PF00082	0.579
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.560
CLV_PCSK_PC1ET2_1	304	306	PF00082	0.770
CLV_PCSK_PC7_1	403	409	PF00082	0.556
CLV_PCSK_SKI1_1	165	169	PF00082	0.560
CLV_PCSK_SKI1_1	381	385	PF00082	0.658
CLV_PCSK_SKI1_1	403	407	PF00082	0.613
CLV_PCSK_SKI1_1	429	433	PF00082	0.784
DEG_COP1_1	47	56	PF00400	0.577
DEG_SPOP_SBC_1	116	120	PF00917	0.441
DEG_SPOP_SBC_1	263	267	PF00917	0.689
DEG_SPOP_SBC_1	501	505	PF00917	0.605
DOC_CDC14_PxL_1	231	239	PF14671	0.705
DOC_MAPK_gen_1	108	115	PF00069	0.597
DOC_MAPK_MEF2A_6	239	248	PF00069	0.684
DOC_PP2B_LxvP_1	470	473	PF13499	0.678
DOC_PP2B_LxvP_1	509	512	PF13499	0.550
DOC_PP4_FxxP_1	58	61	PF00568	0.585
DOC_USP7_MATH_1	117	121	PF00917	0.620
DOC_USP7_MATH_1	202	206	PF00917	0.528
DOC_USP7_MATH_1	249	253	PF00917	0.650
DOC_USP7_MATH_1	307	311	PF00917	0.556
DOC_USP7_MATH_1	372	376	PF00917	0.576
DOC_USP7_MATH_1	478	482	PF00917	0.665
DOC_USP7_MATH_1	501	505	PF00917	0.605
DOC_USP7_MATH_1	512	516	PF00917	0.524
DOC_USP7_MATH_1	531	535	PF00917	0.663
DOC_USP7_MATH_1	6	10	PF00917	0.678
DOC_WW_Pin1_4	158	163	PF00397	0.640
DOC_WW_Pin1_4	42	47	PF00397	0.708
LIG_14-3-3_CanoR_1	163	170	PF00244	0.422
LIG_14-3-3_CanoR_1	206	214	PF00244	0.607
LIG_14-3-3_CanoR_1	264	269	PF00244	0.702
LIG_14-3-3_CanoR_1	378	387	PF00244	0.708
LIG_14-3-3_CanoR_1	499	509	PF00244	0.723
LIG_BIR_II_1	1	5	PF00653	0.573
LIG_BRCT_BRCA1_1	348	352	PF00533	0.552
LIG_eIF4E_1	268	274	PF01652	0.711
LIG_FHA_1	384	390	PF00498	0.551
LIG_FHA_1	430	436	PF00498	0.631
LIG_FHA_2	116	122	PF00498	0.543
LIG_FHA_2	164	170	PF00498	0.560
LIG_FHA_2	20	26	PF00498	0.419
LIG_FHA_2	47	53	PF00498	0.626
LIG_LIR_Apic_2	55	61	PF02991	0.587
LIG_LIR_Gen_1	382	392	PF02991	0.544
LIG_LIR_Nem_3	265	271	PF02991	0.643
LIG_LIR_Nem_3	313	317	PF02991	0.587
LIG_LIR_Nem_3	382	387	PF02991	0.655
LIG_LIR_Nem_3	67	72	PF02991	0.564
LIG_LYPXL_yS_3	243	246	PF13949	0.674
LIG_MYND_1	469	473	PF01753	0.562
LIG_NRBOX	153	159	PF00104	0.399
LIG_NRBOX	95	101	PF00104	0.519
LIG_SH2_CRK	268	272	PF00017	0.751
LIG_SH2_CRK	69	73	PF00017	0.596
LIG_SH2_SRC	554	557	PF00017	0.606
LIG_SH2_STAP1	295	299	PF00017	0.741
LIG_SH2_STAP1	327	331	PF00017	0.590
LIG_SH2_STAP1	73	77	PF00017	0.576
LIG_SH2_STAP1	89	93	PF00017	0.461
LIG_SH2_STAT3	68	71	PF00017	0.587
LIG_SH2_STAT3	77	80	PF00017	0.529
LIG_SH2_STAT5	21	24	PF00017	0.447
LIG_SH3_1	187	193	PF00018	0.446
LIG_SH3_1	239	245	PF00018	0.602
LIG_SH3_1	484	490	PF00018	0.767
LIG_SH3_3	187	193	PF00018	0.446
LIG_SH3_3	239	245	PF00018	0.593
LIG_SH3_3	300	306	PF00018	0.616
LIG_SH3_3	484	490	PF00018	0.767
LIG_SH3_3	495	501	PF00018	0.591
LIG_SH3_3	58	64	PF00018	0.629
LIG_SH3_5	64	68	PF00018	0.462
LIG_SUMO_SIM_anti_2	320	326	PF11976	0.457
LIG_SUMO_SIM_par_1	156	161	PF11976	0.623
LIG_SUMO_SIM_par_1	244	250	PF11976	0.648
LIG_SUMO_SIM_par_1	271	278	PF11976	0.713
LIG_TRAF2_1	24	27	PF00917	0.637
LIG_TRAF2_1	392	395	PF00917	0.632
LIG_TYR_ITSM	264	271	PF00017	0.703
MOD_CDK_SPK_2	158	163	PF00069	0.430
MOD_CDK_SPxxK_3	158	165	PF00069	0.636
MOD_CK1_1	103	109	PF00069	0.462
MOD_CK1_1	226	232	PF00069	0.504
MOD_CK1_1	278	284	PF00069	0.735
MOD_CK1_1	348	354	PF00069	0.694
MOD_CK1_1	422	428	PF00069	0.585
MOD_CK1_1	504	510	PF00069	0.707
MOD_CK2_1	115	121	PF00069	0.545
MOD_CK2_1	19	25	PF00069	0.598
MOD_CK2_1	244	250	PF00069	0.564
MOD_CK2_1	6	12	PF00069	0.582
MOD_GlcNHglycan	214	217	PF01048	0.656
MOD_GlcNHglycan	317	320	PF01048	0.545
MOD_GlcNHglycan	352	355	PF01048	0.782
MOD_GlcNHglycan	374	377	PF01048	0.787
MOD_GlcNHglycan	459	462	PF01048	0.548
MOD_GlcNHglycan	480	483	PF01048	0.691
MOD_GlcNHglycan	494	497	PF01048	0.701
MOD_GlcNHglycan	504	507	PF01048	0.692
MOD_GlcNHglycan	533	536	PF01048	0.549
MOD_GlcNHglycan	8	11	PF01048	0.647
MOD_GSK3_1	202	209	PF00069	0.541
MOD_GSK3_1	251	258	PF00069	0.616
MOD_GSK3_1	285	292	PF00069	0.613
MOD_GSK3_1	346	353	PF00069	0.706
MOD_GSK3_1	379	386	PF00069	0.732
MOD_GSK3_1	38	45	PF00069	0.588
MOD_GSK3_1	415	422	PF00069	0.533
MOD_GSK3_1	500	507	PF00069	0.680
MOD_GSK3_1	525	532	PF00069	0.712
MOD_GSK3_1	533	540	PF00069	0.680
MOD_N-GLC_1	372	377	PF02516	0.808
MOD_N-GLC_2	451	453	PF02516	0.508
MOD_NEK2_1	275	280	PF00069	0.725
MOD_NEK2_1	352	357	PF00069	0.763
MOD_NEK2_1	361	366	PF00069	0.658
MOD_NEK2_1	439	444	PF00069	0.736
MOD_NEK2_1	502	507	PF00069	0.611
MOD_NEK2_2	173	178	PF00069	0.602
MOD_NEK2_2	383	388	PF00069	0.560
MOD_OFUCOSY	546	551	PF10250	0.495
MOD_PIKK_1	353	359	PF00454	0.760
MOD_PIKK_1	396	402	PF00454	0.641
MOD_PIKK_1	540	546	PF00454	0.518
MOD_PK_1	38	44	PF00069	0.416
MOD_PKA_1	206	212	PF00069	0.727
MOD_PKA_2	138	144	PF00069	0.465
MOD_PKA_2	206	212	PF00069	0.750
MOD_PKA_2	263	269	PF00069	0.699
MOD_PKA_2	517	523	PF00069	0.629
MOD_PKA_2	62	68	PF00069	0.446
MOD_Plk_1	129	135	PF00069	0.433
MOD_Plk_1	275	281	PF00069	0.718
MOD_Plk_1	320	326	PF00069	0.453
MOD_Plk_1	439	445	PF00069	0.543
MOD_Plk_4	255	261	PF00069	0.696
MOD_ProDKin_1	158	164	PF00069	0.634
MOD_ProDKin_1	42	48	PF00069	0.713
TRG_DiLeu_BaEn_2	148	154	PF01217	0.409
TRG_DiLeu_BaLyEn_6	195	200	PF01217	0.482
TRG_DiLeu_BaLyEn_6	233	238	PF01217	0.769
TRG_DiLeu_BaLyEn_6	466	471	PF01217	0.557
TRG_ENDOCYTIC_2	243	246	PF00928	0.674
TRG_ENDOCYTIC_2	268	271	PF00928	0.716
TRG_ENDOCYTIC_2	554	557	PF00928	0.618
TRG_ENDOCYTIC_2	69	72	PF00928	0.599
TRG_ER_diArg_1	136	139	PF00400	0.599
TRG_ER_diArg_1	162	165	PF00400	0.429
TRG_ER_diArg_1	206	208	PF00400	0.709
TRG_ER_diArg_1	333	335	PF00400	0.702
TRG_ER_diArg_1	406	409	PF00400	0.516
TRG_ER_diArg_1	498	500	PF00400	0.738
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.637
TRG_Pf-PMV_PEXEL_1	70	75	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I063	Leptomonas seymouri	48%	100%
A0A3S7WXT8	Leishmania donovani	67%	100%
A4I0F7	Leishmania infantum	67%	100%
E9AWC0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
Q4QB52	Leishmania major	67%	99%
V5AZA1	Trypanosoma cruzi	31%	100%