LeishMANIAdb
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Hydrophilic acylated surface protein a

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hydrophilic acylated surface protein a
Gene product:
Protein of unknown function (DUF2946), putative
Species:
Leishmania braziliensis
UniProt:
A4HCX1_LEIBR
TriTrypDb:
Length:
100

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 3
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 3
NetGPI no yes: 0, no: 3
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCX1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCX1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 90 94 PF00082 0.523
DOC_USP7_UBL2_3 61 65 PF12436 0.555
LIG_BIR_III_4 82 86 PF00653 0.526
LIG_TRAF2_1 12 15 PF00917 0.618
LIG_TRAF2_1 92 95 PF00917 0.528
MOD_GSK3_1 67 74 PF00069 0.610
MOD_NEK2_1 1 6 PF00069 0.599
MOD_NMyristoyl 1 7 PF02799 0.793
MOD_PIKK_1 37 43 PF00454 0.607
MOD_PIKK_1 67 73 PF00454 0.543
MOD_SUMO_for_1 12 15 PF00179 0.618
MOD_SUMO_rev_2 51 59 PF00179 0.580
MOD_SUMO_rev_2 62 66 PF00179 0.612
MOD_SUMO_rev_2 86 93 PF00179 0.525
TRG_Pf-PMV_PEXEL_1 91 95 PF00026 0.527

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8ICK5 Leishmania donovani 39% 100%
A4I0F1 Leishmania infantum 35% 76%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS