Arfaptin-like domain protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HCW9_LEIBR

TriTrypDb:

LbrM.23.1080 , LBRM2903_230020300

Length:

231

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 6

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCW9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCW9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	147	149	PF00082	0.473
CLV_PCSK_KEX2_1	189	191	PF00082	0.423
CLV_PCSK_KEX2_1	202	204	PF00082	0.390
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.473
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.363
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.287
CLV_PCSK_SKI1_1	10	14	PF00082	0.506
CLV_PCSK_SKI1_1	114	118	PF00082	0.489
CLV_PCSK_SKI1_1	124	128	PF00082	0.423
CLV_PCSK_SKI1_1	15	19	PF00082	0.507
CLV_PCSK_SKI1_1	157	161	PF00082	0.525
CLV_PCSK_SKI1_1	178	182	PF00082	0.469
CLV_PCSK_SKI1_1	189	193	PF00082	0.437
DEG_Nend_Nbox_1	1	3	PF02207	0.590
DEG_SPOP_SBC_1	191	195	PF00917	0.290
DOC_MAPK_gen_1	143	151	PF00069	0.302
DOC_MAPK_gen_1	29	37	PF00069	0.351
DOC_MAPK_RevD_3	2	16	PF00069	0.372
DOC_USP7_MATH_1	130	134	PF00917	0.293
DOC_USP7_MATH_1	191	195	PF00917	0.290
DOC_USP7_MATH_1	20	24	PF00917	0.436
DOC_USP7_MATH_1	77	81	PF00917	0.536
DOC_USP7_MATH_1	96	100	PF00917	0.540
DOC_USP7_UBL2_3	124	128	PF12436	0.387
DOC_USP7_UBL2_3	132	136	PF12436	0.430
DOC_USP7_UBL2_3	143	147	PF12436	0.520
DOC_USP7_UBL2_3	157	161	PF12436	0.357
DOC_USP7_UBL2_3	170	174	PF12436	0.417
DOC_WW_Pin1_4	2	7	PF00397	0.687
DOC_WW_Pin1_4	94	99	PF00397	0.500
LIG_14-3-3_CanoR_1	190	200	PF00244	0.397
LIG_14-3-3_CanoR_1	67	76	PF00244	0.461
LIG_14-3-3_CanoR_1	90	95	PF00244	0.701
LIG_APCC_Cbox_2	73	79	PF00515	0.522
LIG_FHA_1	115	121	PF00498	0.377
LIG_FHA_1	193	199	PF00498	0.376
LIG_FHA_1	202	208	PF00498	0.458
LIG_FHA_1	9	15	PF00498	0.311
LIG_FHA_2	20	26	PF00498	0.277
LIG_FHA_2	68	74	PF00498	0.523
LIG_FHA_2	90	96	PF00498	0.527
LIG_LIR_Gen_1	193	200	PF02991	0.553
LIG_LIR_Nem_3	193	199	PF02991	0.499
LIG_SH2_CRK	196	200	PF00017	0.370
LIG_SH2_PTP2	222	225	PF00017	0.286
LIG_SH2_STAP1	196	200	PF00017	0.339
LIG_SH2_STAP1	217	221	PF00017	0.328
LIG_SH2_STAP1	24	28	PF00017	0.385
LIG_SH2_STAT5	222	225	PF00017	0.389
LIG_SH2_STAT5	31	34	PF00017	0.398
LIG_TRAF2_1	53	56	PF00917	0.340
LIG_UBA3_1	13	18	PF00899	0.350
MOD_CK1_1	110	116	PF00069	0.512
MOD_CK1_1	169	175	PF00069	0.347
MOD_CK1_1	194	200	PF00069	0.290
MOD_CK1_1	213	219	PF00069	0.313
MOD_CK2_1	37	43	PF00069	0.479
MOD_CK2_1	45	51	PF00069	0.490
MOD_CK2_1	89	95	PF00069	0.508
MOD_Cter_Amidation	187	190	PF01082	0.309
MOD_GlcNHglycan	217	220	PF01048	0.357
MOD_GlcNHglycan	83	86	PF01048	0.694
MOD_GlcNHglycan	99	102	PF01048	0.625
MOD_GSK3_1	110	117	PF00069	0.494
MOD_GSK3_1	126	133	PF00069	0.471
MOD_GSK3_1	166	173	PF00069	0.359
MOD_GSK3_1	190	197	PF00069	0.433
MOD_GSK3_1	201	208	PF00069	0.536
MOD_GSK3_1	221	228	PF00069	0.439
MOD_GSK3_1	77	84	PF00069	0.622
MOD_GSK3_1	90	97	PF00069	0.653
MOD_N-GLC_1	77	82	PF02516	0.602
MOD_NEK2_1	192	197	PF00069	0.389
MOD_NEK2_1	225	230	PF00069	0.440
MOD_NEK2_1	45	50	PF00069	0.398
MOD_PIKK_1	50	56	PF00454	0.497
MOD_PK_1	90	96	PF00069	0.666
MOD_PKA_2	89	95	PF00069	0.632
MOD_Plk_1	114	120	PF00069	0.426
MOD_Plk_1	38	44	PF00069	0.463
MOD_Plk_1	77	83	PF00069	0.537
MOD_Plk_1	8	14	PF00069	0.364
MOD_Plk_4	114	120	PF00069	0.335
MOD_Plk_4	194	200	PF00069	0.467
MOD_Plk_4	8	14	PF00069	0.364
MOD_ProDKin_1	2	8	PF00069	0.668
MOD_ProDKin_1	94	100	PF00069	0.492
MOD_SUMO_rev_2	121	126	PF00179	0.491
MOD_SUMO_rev_2	150	159	PF00179	0.498
MOD_SUMO_rev_2	5	12	PF00179	0.513
TRG_DiLeu_BaEn_1	9	14	PF01217	0.507
TRG_DiLeu_BaEn_4	55	61	PF01217	0.407
TRG_ENDOCYTIC_2	196	199	PF00928	0.453
TRG_ENDOCYTIC_2	222	225	PF00928	0.461
TRG_ER_diArg_1	62	65	PF00400	0.333
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCG3	Leptomonas seymouri	50%	99%
A0A1X0NYD1	Trypanosomatidae	27%	89%
A0A3Q8ICK8	Leishmania donovani	59%	100%
A0A3R7KGK2	Trypanosoma rangeli	23%	100%
A4I0E9	Leishmania infantum	59%	100%
E9AWB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
Q4QB63	Leishmania major	62%	100%