BAR domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCW8_LEIBR

TriTrypDb:

LbrM.23.1070 , LBRM2903_230020200

Length:

749

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCW8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCW8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	432	436	PF00656	0.806
CLV_NRD_NRD_1	159	161	PF00675	0.530
CLV_NRD_NRD_1	187	189	PF00675	0.382
CLV_NRD_NRD_1	291	293	PF00675	0.576
CLV_NRD_NRD_1	322	324	PF00675	0.790
CLV_NRD_NRD_1	406	408	PF00675	0.664
CLV_NRD_NRD_1	504	506	PF00675	0.683
CLV_NRD_NRD_1	600	602	PF00675	0.680
CLV_PCSK_KEX2_1	187	189	PF00082	0.469
CLV_PCSK_KEX2_1	291	293	PF00082	0.829
CLV_PCSK_KEX2_1	322	324	PF00082	0.697
CLV_PCSK_KEX2_1	406	408	PF00082	0.664
CLV_PCSK_KEX2_1	600	602	PF00082	0.682
CLV_PCSK_PC1ET2_1	600	602	PF00082	0.580
CLV_PCSK_SKI1_1	122	126	PF00082	0.341
CLV_PCSK_SKI1_1	171	175	PF00082	0.487
CLV_PCSK_SKI1_1	28	32	PF00082	0.447
CLV_PCSK_SKI1_1	438	442	PF00082	0.556
CLV_PCSK_SKI1_1	662	666	PF00082	0.671
DEG_APCC_DBOX_1	551	559	PF00400	0.684
DEG_COP1_1	607	617	PF00400	0.550
DEG_Nend_Nbox_1	1	3	PF02207	0.724
DEG_SCF_TRCP1_1	688	693	PF00400	0.542
DOC_MAPK_DCC_7	552	560	PF00069	0.689
DOC_MAPK_gen_1	196	204	PF00069	0.337
DOC_MAPK_MEF2A_6	418	425	PF00069	0.531
DOC_MAPK_MEF2A_6	548	555	PF00069	0.558
DOC_MAPK_NFAT4_5	418	426	PF00069	0.532
DOC_PP2B_LxvP_1	396	399	PF13499	0.684
DOC_PP2B_LxvP_1	491	494	PF13499	0.551
DOC_PP2B_LxvP_1	498	501	PF13499	0.535
DOC_SPAK_OSR1_1	418	422	PF12202	0.535
DOC_USP7_MATH_1	152	156	PF00917	0.400
DOC_USP7_MATH_1	303	307	PF00917	0.705
DOC_USP7_MATH_1	576	580	PF00917	0.777
DOC_USP7_MATH_1	640	644	PF00917	0.770
DOC_USP7_MATH_1	9	13	PF00917	0.599
DOC_USP7_UBL2_3	133	137	PF12436	0.449
DOC_USP7_UBL2_3	146	150	PF12436	0.573
DOC_USP7_UBL2_3	157	161	PF12436	0.465
DOC_USP7_UBL2_3	177	181	PF12436	0.440
DOC_USP7_UBL2_3	24	28	PF12436	0.313
DOC_USP7_UBL2_3	598	602	PF12436	0.671
DOC_WW_Pin1_4	285	290	PF00397	0.685
DOC_WW_Pin1_4	294	299	PF00397	0.660
DOC_WW_Pin1_4	3	8	PF00397	0.682
DOC_WW_Pin1_4	353	358	PF00397	0.706
DOC_WW_Pin1_4	363	368	PF00397	0.746
DOC_WW_Pin1_4	390	395	PF00397	0.703
DOC_WW_Pin1_4	483	488	PF00397	0.583
DOC_WW_Pin1_4	547	552	PF00397	0.562
DOC_WW_Pin1_4	720	725	PF00397	0.717
DOC_WW_Pin1_4	744	749	PF00397	0.675
LIG_14-3-3_CanoR_1	171	180	PF00244	0.654
LIG_14-3-3_CanoR_1	273	282	PF00244	0.588
LIG_14-3-3_CanoR_1	308	318	PF00244	0.559
LIG_14-3-3_CanoR_1	322	328	PF00244	0.490
LIG_14-3-3_CanoR_1	331	339	PF00244	0.575
LIG_14-3-3_CanoR_1	39	47	PF00244	0.599
LIG_14-3-3_CanoR_1	418	424	PF00244	0.628
LIG_14-3-3_CanoR_1	577	585	PF00244	0.777
LIG_Actin_WH2_2	117	135	PF00022	0.595
LIG_BRCT_BRCA1_1	311	315	PF00533	0.707
LIG_BRCT_BRCA1_1	711	715	PF00533	0.554
LIG_CaM_IQ_9	125	141	PF13499	0.352
LIG_Clathr_ClatBox_1	560	564	PF01394	0.801
LIG_eIF4E_1	20	26	PF01652	0.317
LIG_FHA_1	197	203	PF00498	0.577
LIG_FHA_1	225	231	PF00498	0.472
LIG_FHA_1	274	280	PF00498	0.697
LIG_FHA_1	469	475	PF00498	0.707
LIG_FHA_1	484	490	PF00498	0.714
LIG_FHA_1	548	554	PF00498	0.737
LIG_FHA_1	601	607	PF00498	0.643
LIG_FHA_2	430	436	PF00498	0.802
LIG_FHA_2	592	598	PF00498	0.537
LIG_Integrin_RGD_1	407	409	PF01839	0.548
LIG_LIR_Gen_1	163	173	PF02991	0.399
LIG_LIR_Gen_1	201	212	PF02991	0.487
LIG_LIR_Gen_1	220	230	PF02991	0.287
LIG_LIR_Gen_1	57	65	PF02991	0.531
LIG_LIR_Gen_1	646	656	PF02991	0.562
LIG_LIR_Gen_1	77	85	PF02991	0.710
LIG_LIR_Nem_3	111	116	PF02991	0.451
LIG_LIR_Nem_3	201	207	PF02991	0.483
LIG_LIR_Nem_3	220	225	PF02991	0.490
LIG_LIR_Nem_3	312	318	PF02991	0.700
LIG_LIR_Nem_3	57	61	PF02991	0.520
LIG_LIR_Nem_3	646	652	PF02991	0.558
LIG_LIR_Nem_3	77	81	PF02991	0.719
LIG_PDZ_Class_1	744	749	PF00595	0.704
LIG_Pex14_2	200	204	PF04695	0.322
LIG_Pex14_4	218	223	PF04695	0.340
LIG_SH2_CRK	649	653	PF00017	0.640
LIG_SH2_GRB2like	319	322	PF00017	0.780
LIG_SH2_STAP1	14	18	PF00017	0.524
LIG_SH2_STAP1	193	197	PF00017	0.470
LIG_SH2_STAP1	415	419	PF00017	0.538
LIG_SH2_STAT3	179	182	PF00017	0.547
LIG_SH2_STAT3	569	572	PF00017	0.560
LIG_SH2_STAT5	113	116	PF00017	0.377
LIG_SH2_STAT5	179	182	PF00017	0.489
LIG_SH2_STAT5	213	216	PF00017	0.503
LIG_SH2_STAT5	229	232	PF00017	0.370
LIG_SH2_STAT5	349	352	PF00017	0.557
LIG_SH2_STAT5	36	39	PF00017	0.565
LIG_SH2_STAT5	569	572	PF00017	0.560
LIG_SH2_STAT5	78	81	PF00017	0.728
LIG_SH3_1	548	554	PF00018	0.559
LIG_SH3_3	384	390	PF00018	0.721
LIG_SH3_3	396	402	PF00018	0.714
LIG_SH3_3	486	492	PF00018	0.691
LIG_SH3_3	531	537	PF00018	0.553
LIG_SH3_3	548	554	PF00018	0.559
LIG_SH3_3	742	748	PF00018	0.594
LIG_SH3_CIN85_PxpxPR_1	726	731	PF14604	0.571
LIG_SUMO_SIM_anti_2	49	55	PF11976	0.494
LIG_SUMO_SIM_par_1	561	568	PF11976	0.757
LIG_TRAF2_2	658	663	PF00917	0.584
LIG_TYR_ITIM	18	23	PF00017	0.321
LIG_WRC_WIRS_1	197	202	PF05994	0.483
LIG_WRC_WIRS_1	78	83	PF05994	0.723
MOD_CDK_SPK_2	547	552	PF00069	0.562
MOD_CDK_SPxK_1	285	291	PF00069	0.749
MOD_CDK_SPxK_1	294	300	PF00069	0.681
MOD_CDK_SPxK_1	353	359	PF00069	0.798
MOD_CDK_SPxK_1	363	369	PF00069	0.658
MOD_CDK_SPxxK_3	285	292	PF00069	0.811
MOD_CDK_SPxxK_3	390	397	PF00069	0.564
MOD_CDK_SPxxK_3	724	731	PF00069	0.566
MOD_CK1_1	325	331	PF00069	0.586
MOD_CK1_1	363	369	PF00069	0.823
MOD_CK1_1	372	378	PF00069	0.649
MOD_CK1_1	38	44	PF00069	0.458
MOD_CK1_1	477	483	PF00069	0.700
MOD_CK1_1	485	491	PF00069	0.554
MOD_CK1_1	49	55	PF00069	0.549
MOD_CK1_1	510	516	PF00069	0.554
MOD_CK1_1	542	548	PF00069	0.669
MOD_CK1_1	568	574	PF00069	0.657
MOD_CK1_1	579	585	PF00069	0.712
MOD_CK1_1	607	613	PF00069	0.553
MOD_CK1_1	630	636	PF00069	0.745
MOD_CK1_1	641	647	PF00069	0.706
MOD_CK1_1	709	715	PF00069	0.805
MOD_CK1_1	77	83	PF00069	0.507
MOD_CK1_1	8	14	PF00069	0.510
MOD_CK1_1	95	101	PF00069	0.395
MOD_CK2_1	383	389	PF00069	0.812
MOD_CK2_1	54	60	PF00069	0.483
MOD_GlcNHglycan	133	136	PF01048	0.472
MOD_GlcNHglycan	253	256	PF01048	0.685
MOD_GlcNHglycan	327	330	PF01048	0.631
MOD_GlcNHglycan	371	374	PF01048	0.685
MOD_GlcNHglycan	509	512	PF01048	0.584
MOD_GlcNHglycan	513	516	PF01048	0.534
MOD_GlcNHglycan	544	547	PF01048	0.677
MOD_GlcNHglycan	606	609	PF01048	0.633
MOD_GlcNHglycan	620	623	PF01048	0.817
MOD_GlcNHglycan	688	691	PF01048	0.717
MOD_GlcNHglycan	708	711	PF01048	0.470
MOD_GlcNHglycan	715	718	PF01048	0.710
MOD_GlcNHglycan	94	97	PF01048	0.494
MOD_GSK3_1	1	8	PF00069	0.701
MOD_GSK3_1	224	231	PF00069	0.528
MOD_GSK3_1	269	276	PF00069	0.612
MOD_GSK3_1	299	306	PF00069	0.622
MOD_GSK3_1	309	316	PF00069	0.765
MOD_GSK3_1	349	356	PF00069	0.682
MOD_GSK3_1	419	426	PF00069	0.701
MOD_GSK3_1	447	454	PF00069	0.637
MOD_GSK3_1	464	471	PF00069	0.831
MOD_GSK3_1	507	514	PF00069	0.638
MOD_GSK3_1	576	583	PF00069	0.757
MOD_GSK3_1	600	607	PF00069	0.647
MOD_GSK3_1	630	637	PF00069	0.749
MOD_GSK3_1	65	72	PF00069	0.559
MOD_GSK3_1	665	672	PF00069	0.793
MOD_GSK3_1	686	693	PF00069	0.735
MOD_GSK3_1	709	716	PF00069	0.728
MOD_GSK3_1	720	727	PF00069	0.788
MOD_GSK3_1	88	95	PF00069	0.639
MOD_GSK3_1	99	106	PF00069	0.472
MOD_N-GLC_1	116	121	PF02516	0.586
MOD_N-GLC_1	285	290	PF02516	0.721
MOD_N-GLC_1	313	318	PF02516	0.802
MOD_N-GLC_1	363	368	PF02516	0.822
MOD_N-GLC_1	65	70	PF02516	0.528
MOD_N-GLC_1	713	718	PF02516	0.567
MOD_N-GLC_2	283	285	PF02516	0.531
MOD_NEK2_1	1	6	PF00069	0.685
MOD_NEK2_1	173	178	PF00069	0.563
MOD_NEK2_1	251	256	PF00069	0.466
MOD_NEK2_1	419	424	PF00069	0.702
MOD_NEK2_1	715	720	PF00069	0.725
MOD_NEK2_2	116	121	PF00069	0.586
MOD_NEK2_2	70	75	PF00069	0.490
MOD_PIKK_1	152	158	PF00454	0.514
MOD_PIKK_1	273	279	PF00454	0.553
MOD_PIKK_1	38	44	PF00454	0.597
MOD_PIKK_1	499	505	PF00454	0.573
MOD_PIKK_1	519	525	PF00454	0.548
MOD_PIKK_1	568	574	PF00454	0.560
MOD_PIKK_1	634	640	PF00454	0.808
MOD_PIKK_1	665	671	PF00454	0.594
MOD_PIKK_1	738	744	PF00454	0.824
MOD_PKA_1	161	167	PF00069	0.600
MOD_PKA_1	322	328	PF00069	0.545
MOD_PKA_1	600	606	PF00069	0.611
MOD_PKA_2	322	328	PF00069	0.545
MOD_PKA_2	378	384	PF00069	0.657
MOD_PKA_2	38	44	PF00069	0.597
MOD_PKA_2	468	474	PF00069	0.686
MOD_PKA_2	507	513	PF00069	0.641
MOD_PKA_2	532	538	PF00069	0.769
MOD_PKA_2	576	582	PF00069	0.769
MOD_PKA_2	600	606	PF00069	0.616
MOD_PKA_2	669	675	PF00069	0.786
MOD_PKB_1	273	281	PF00069	0.516
MOD_Plk_1	408	414	PF00069	0.545
MOD_Plk_1	539	545	PF00069	0.574
MOD_Plk_1	565	571	PF00069	0.749
MOD_Plk_1	625	631	PF00069	0.733
MOD_Plk_1	638	644	PF00069	0.712
MOD_Plk_1	738	744	PF00069	0.824
MOD_Plk_4	203	209	PF00069	0.596
MOD_Plk_4	224	230	PF00069	0.432
MOD_Plk_4	277	283	PF00069	0.518
MOD_Plk_4	408	414	PF00069	0.575
MOD_Plk_4	447	453	PF00069	0.547
MOD_Plk_4	49	55	PF00069	0.490
MOD_Plk_4	565	571	PF00069	0.584
MOD_Plk_4	580	586	PF00069	0.557
MOD_Plk_4	74	80	PF00069	0.542
MOD_Plk_4	95	101	PF00069	0.516
MOD_ProDKin_1	285	291	PF00069	0.689
MOD_ProDKin_1	294	300	PF00069	0.661
MOD_ProDKin_1	3	9	PF00069	0.675
MOD_ProDKin_1	353	359	PF00069	0.709
MOD_ProDKin_1	363	369	PF00069	0.748
MOD_ProDKin_1	390	396	PF00069	0.707
MOD_ProDKin_1	483	489	PF00069	0.584
MOD_ProDKin_1	547	553	PF00069	0.561
MOD_ProDKin_1	720	726	PF00069	0.716
MOD_SUMO_for_1	525	528	PF00179	0.535
MOD_SUMO_rev_2	140	148	PF00179	0.614
MOD_SUMO_rev_2	190	197	PF00179	0.502
MOD_SUMO_rev_2	435	443	PF00179	0.558
TRG_DiLeu_BaEn_1	203	208	PF01217	0.476
TRG_DiLeu_BaEn_1	21	26	PF01217	0.574
TRG_ENDOCYTIC_2	166	169	PF00928	0.432
TRG_ENDOCYTIC_2	20	23	PF00928	0.314
TRG_ENDOCYTIC_2	58	61	PF00928	0.466
TRG_ENDOCYTIC_2	649	652	PF00928	0.562
TRG_ENDOCYTIC_2	78	81	PF00928	0.728
TRG_ER_diArg_1	186	188	PF00400	0.378
TRG_ER_diArg_1	290	292	PF00400	0.738
TRG_ER_diArg_1	405	407	PF00400	0.671
TRG_NLS_MonoCore_2	598	603	PF00514	0.578
TRG_NLS_MonoExtN_4	598	604	PF00514	0.773
TRG_Pf-PMV_PEXEL_1	139	144	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	171	175	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	337	342	PF00026	0.713
TRG_Pf-PMV_PEXEL_1	662	666	PF00026	0.600
TRG_Pf-PMV_PEXEL_1	731	736	PF00026	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4R4	Leptomonas seymouri	39%	99%
A0A3Q8ICQ5	Leishmania donovani	60%	100%
A4I0E8	Leishmania infantum	60%	100%
E9AWB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%
Q4QB64	Leishmania major	60%	100%