IMD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HCW7_LEIBR

TriTrypDb:

LbrM.23.1060 , LBRM2903_230020100

Length:

302

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 6

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCW7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCW7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.455
CLV_NRD_NRD_1	164	166	PF00675	0.458
CLV_NRD_NRD_1	82	84	PF00675	0.575
CLV_PCSK_KEX2_1	163	165	PF00082	0.436
CLV_PCSK_KEX2_1	82	84	PF00082	0.575
CLV_PCSK_SKI1_1	137	141	PF00082	0.358
CLV_PCSK_SKI1_1	150	154	PF00082	0.503
CLV_PCSK_SKI1_1	30	34	PF00082	0.495
DOC_MAPK_gen_1	135	144	PF00069	0.369
DOC_MAPK_gen_1	41	48	PF00069	0.446
DOC_MAPK_gen_1	94	104	PF00069	0.459
DOC_MAPK_HePTP_8	134	146	PF00069	0.324
DOC_MAPK_MEF2A_6	129	138	PF00069	0.323
DOC_MAPK_MEF2A_6	41	50	PF00069	0.333
DOC_MAPK_MEF2A_6	97	104	PF00069	0.435
DOC_USP7_MATH_1	257	261	PF00917	0.608
DOC_USP7_UBL2_3	168	172	PF12436	0.375
DOC_USP7_UBL2_3	191	195	PF12436	0.643
DOC_USP7_UBL2_3	287	291	PF12436	0.675
DOC_WW_Pin1_4	253	258	PF00397	0.581
DOC_WW_Pin1_4	290	295	PF00397	0.677
DOC_WW_Pin1_4	50	55	PF00397	0.482
LIG_14-3-3_CanoR_1	25	30	PF00244	0.455
LIG_14-3-3_CanoR_1	261	269	PF00244	0.547
LIG_Actin_WH2_2	43	60	PF00022	0.479
LIG_BRCT_BRCA1_1	18	22	PF00533	0.496
LIG_BRCT_BRCA1_1	224	228	PF00533	0.587
LIG_FHA_1	147	153	PF00498	0.339
LIG_FHA_1	230	236	PF00498	0.584
LIG_FHA_1	294	300	PF00498	0.757
LIG_FHA_2	112	118	PF00498	0.592
LIG_FHA_2	247	253	PF00498	0.488
LIG_FHA_2	51	57	PF00498	0.382
LIG_FHA_2	96	102	PF00498	0.461
LIG_LIR_Gen_1	215	224	PF02991	0.474
LIG_LIR_Gen_1	35	43	PF02991	0.584
LIG_LIR_Gen_1	62	71	PF02991	0.608
LIG_LIR_Nem_3	106	112	PF02991	0.597
LIG_LIR_Nem_3	215	221	PF02991	0.544
LIG_LIR_Nem_3	35	39	PF02991	0.487
LIG_LIR_Nem_3	62	67	PF02991	0.608
LIG_SH2_CRK	36	40	PF00017	0.538
LIG_SH2_GRB2like	64	67	PF00017	0.612
LIG_SH2_NCK_1	84	88	PF00017	0.553
LIG_SH2_SRC	218	221	PF00017	0.579
LIG_SH2_STAP1	207	211	PF00017	0.482
LIG_SH2_STAP1	218	222	PF00017	0.468
LIG_SH2_STAP1	64	68	PF00017	0.355
LIG_SH2_STAT5	130	133	PF00017	0.316
LIG_SUMO_SIM_anti_2	246	252	PF11976	0.354
LIG_SUMO_SIM_par_1	246	252	PF11976	0.535
LIG_TRAF2_1	174	177	PF00917	0.380
LIG_TRAF2_1	224	227	PF00917	0.345
LIG_TYR_ITIM	34	39	PF00017	0.590
LIG_TYR_ITSM	60	67	PF00017	0.604
LIG_WRC_WIRS_1	112	117	PF05994	0.520
MOD_CK1_1	230	236	PF00069	0.545
MOD_CK1_1	292	298	PF00069	0.774
MOD_CK1_1	37	43	PF00069	0.481
MOD_CK1_1	74	80	PF00069	0.637
MOD_CK2_1	171	177	PF00069	0.627
MOD_CK2_1	272	278	PF00069	0.507
MOD_Cter_Amidation	155	158	PF01082	0.597
MOD_GlcNHglycan	177	180	PF01048	0.506
MOD_GlcNHglycan	186	190	PF01048	0.363
MOD_GlcNHglycan	274	277	PF01048	0.541
MOD_GlcNHglycan	43	46	PF01048	0.320
MOD_GlcNHglycan	5	8	PF01048	0.639
MOD_GlcNHglycan	73	76	PF01048	0.581
MOD_GSK3_1	171	178	PF00069	0.541
MOD_GSK3_1	185	192	PF00069	0.471
MOD_GSK3_1	253	260	PF00069	0.600
MOD_GSK3_1	289	296	PF00069	0.696
MOD_GSK3_1	37	44	PF00069	0.498
MOD_GSK3_1	46	53	PF00069	0.456
MOD_GSK3_1	74	81	PF00069	0.509
MOD_N-GLC_1	95	100	PF02516	0.490
MOD_NEK2_1	146	151	PF00069	0.581
MOD_NEK2_1	187	192	PF00069	0.638
MOD_NEK2_1	228	233	PF00069	0.509
MOD_NEK2_1	32	37	PF00069	0.513
MOD_NEK2_1	71	76	PF00069	0.401
MOD_NMyristoyl	1	7	PF02799	0.732
MOD_PIKK_1	151	157	PF00454	0.367
MOD_PIKK_1	222	228	PF00454	0.430
MOD_PK_1	140	146	PF00069	0.423
MOD_PKA_1	164	170	PF00069	0.369
MOD_PKA_1	41	47	PF00069	0.328
MOD_PKA_1	82	88	PF00069	0.577
MOD_PKA_2	164	170	PF00069	0.515
MOD_PKA_2	199	205	PF00069	0.416
MOD_PKA_2	24	30	PF00069	0.326
MOD_PKA_2	82	88	PF00069	0.577
MOD_Plk_1	105	111	PF00069	0.596
MOD_Plk_1	140	146	PF00069	0.327
MOD_Plk_2-3	246	252	PF00069	0.354
MOD_Plk_4	189	195	PF00069	0.478
MOD_Plk_4	246	252	PF00069	0.460
MOD_Plk_4	34	40	PF00069	0.560
MOD_ProDKin_1	253	259	PF00069	0.586
MOD_ProDKin_1	290	296	PF00069	0.677
MOD_ProDKin_1	50	56	PF00069	0.488
MOD_SUMO_rev_2	117	124	PF00179	0.585
TRG_ENDOCYTIC_2	109	112	PF00928	0.572
TRG_ENDOCYTIC_2	218	221	PF00928	0.477
TRG_ENDOCYTIC_2	244	247	PF00928	0.485
TRG_ENDOCYTIC_2	26	29	PF00928	0.438
TRG_ENDOCYTIC_2	36	39	PF00928	0.542
TRG_ENDOCYTIC_2	64	67	PF00928	0.510
TRG_ER_diArg_1	163	165	PF00400	0.449
TRG_ER_diArg_1	82	84	PF00400	0.545
TRG_NES_CRM1_1	133	145	PF08389	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6C0	Leptomonas seymouri	34%	95%
A0A3S7WXR6	Leishmania donovani	57%	99%
A4I0E7	Leishmania infantum	57%	99%
E9AWB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
Q4QB65	Leishmania major	55%	100%