Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCW6_LEIBR

TriTrypDb:

LbrM.23.1050 , LBRM2903_230019100

Length:

385

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCW6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCW6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.455
CLV_NRD_NRD_1	181	183	PF00675	0.479
CLV_NRD_NRD_1	285	287	PF00675	0.447
CLV_NRD_NRD_1	288	290	PF00675	0.475
CLV_NRD_NRD_1	307	309	PF00675	0.559
CLV_NRD_NRD_1	371	373	PF00675	0.576
CLV_NRD_NRD_1	376	378	PF00675	0.524
CLV_PCSK_FUR_1	286	290	PF00082	0.443
CLV_PCSK_FUR_1	374	378	PF00082	0.428
CLV_PCSK_KEX2_1	287	289	PF00082	0.450
CLV_PCSK_KEX2_1	307	309	PF00082	0.430
CLV_PCSK_KEX2_1	371	373	PF00082	0.576
CLV_PCSK_KEX2_1	376	378	PF00082	0.524
CLV_PCSK_KEX2_1	380	382	PF00082	0.602
CLV_PCSK_PC1ET2_1	287	289	PF00082	0.425
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.636
CLV_PCSK_PC7_1	372	378	PF00082	0.423
CLV_PCSK_SKI1_1	275	279	PF00082	0.405
CLV_PCSK_SKI1_1	288	292	PF00082	0.489
CLV_PCSK_SKI1_1	367	371	PF00082	0.490
CLV_PCSK_SKI1_1	46	50	PF00082	0.374
DEG_Nend_Nbox_1	1	3	PF02207	0.576
DOC_MAPK_gen_1	249	258	PF00069	0.420
DOC_MAPK_gen_1	286	293	PF00069	0.458
DOC_MAPK_gen_1	63	73	PF00069	0.329
DOC_MAPK_MEF2A_6	116	124	PF00069	0.375
DOC_MAPK_MEF2A_6	66	73	PF00069	0.332
DOC_PP2B_LxvP_1	71	74	PF13499	0.462
DOC_USP7_MATH_1	199	203	PF00917	0.597
DOC_USP7_MATH_1	213	217	PF00917	0.383
DOC_USP7_MATH_1	295	299	PF00917	0.515
DOC_USP7_MATH_1	319	323	PF00917	0.697
DOC_USP7_MATH_1	335	339	PF00917	0.546
DOC_USP7_MATH_1	375	379	PF00917	0.593
DOC_USP7_MATH_1	8	12	PF00917	0.532
DOC_WW_Pin1_4	11	16	PF00397	0.588
DOC_WW_Pin1_4	298	303	PF00397	0.566
LIG_14-3-3_CanoR_1	255	259	PF00244	0.397
LIG_14-3-3_CanoR_1	374	382	PF00244	0.605
LIG_14-3-3_CanoR_1	6	16	PF00244	0.517
LIG_BIR_III_2	92	96	PF00653	0.450
LIG_DCNL_PONY_1	1	4	PF03556	0.642
LIG_deltaCOP1_diTrp_1	164	169	PF00928	0.495
LIG_deltaCOP1_diTrp_1	304	312	PF00928	0.565
LIG_eIF4E_1	44	50	PF01652	0.390
LIG_FHA_1	12	18	PF00498	0.578
LIG_FHA_1	144	150	PF00498	0.551
LIG_FHA_1	45	51	PF00498	0.397
LIG_FHA_2	106	112	PF00498	0.564
LIG_FHA_2	299	305	PF00498	0.476
LIG_FHA_2	321	327	PF00498	0.600
LIG_FHA_2	81	87	PF00498	0.443
LIG_LIR_Gen_1	306	315	PF02991	0.546
LIG_LIR_Nem_3	10	16	PF02991	0.488
LIG_LIR_Nem_3	306	312	PF02991	0.570
LIG_LYPXL_SIV_4	41	49	PF13949	0.385
LIG_NRBOX	67	73	PF00104	0.412
LIG_PTB_Apo_2	36	43	PF02174	0.404
LIG_PTB_Phospho_1	36	42	PF10480	0.415
LIG_SH2_CRK	13	17	PF00017	0.542
LIG_SH2_CRK	236	240	PF00017	0.360
LIG_SH2_CRK	38	42	PF00017	0.488
LIG_SH2_NCK_1	38	42	PF00017	0.448
LIG_SH2_PTP2	42	45	PF00017	0.389
LIG_SH2_SRC	42	45	PF00017	0.389
LIG_SH2_STAP1	31	35	PF00017	0.469
LIG_SH2_STAT5	13	16	PF00017	0.617
LIG_SH2_STAT5	42	45	PF00017	0.421
LIG_SH2_STAT5	64	67	PF00017	0.423
LIG_Sin3_3	366	373	PF02671	0.390
LIG_SUMO_SIM_anti_2	254	261	PF11976	0.406
LIG_SUMO_SIM_anti_2	83	89	PF11976	0.420
LIG_TRAF2_1	277	280	PF00917	0.397
LIG_TRAF2_1	302	305	PF00917	0.479
LIG_TRAF2_1	356	359	PF00917	0.559
LIG_TYR_ITIM	234	239	PF00017	0.356
LIG_WRC_WIRS_1	217	222	PF05994	0.448
MOD_CK1_1	11	17	PF00069	0.501
MOD_CK1_1	132	138	PF00069	0.605
MOD_CK1_1	216	222	PF00069	0.487
MOD_CK1_1	29	35	PF00069	0.497
MOD_CK1_1	298	304	PF00069	0.533
MOD_CK1_1	75	81	PF00069	0.520
MOD_CK2_1	105	111	PF00069	0.601
MOD_CK2_1	199	205	PF00069	0.520
MOD_CK2_1	298	304	PF00069	0.479
MOD_CK2_1	320	326	PF00069	0.533
MOD_CK2_1	80	86	PF00069	0.452
MOD_GlcNHglycan	100	103	PF01048	0.763
MOD_GlcNHglycan	105	108	PF01048	0.674
MOD_GlcNHglycan	131	134	PF01048	0.547
MOD_GlcNHglycan	221	224	PF01048	0.529
MOD_GlcNHglycan	266	269	PF01048	0.493
MOD_GlcNHglycan	31	34	PF01048	0.477
MOD_GlcNHglycan	316	319	PF01048	0.750
MOD_GSK3_1	128	135	PF00069	0.626
MOD_GSK3_1	221	228	PF00069	0.480
MOD_GSK3_1	254	261	PF00069	0.386
MOD_GSK3_1	310	317	PF00069	0.616
MOD_GSK3_1	53	60	PF00069	0.341
MOD_GSK3_1	7	14	PF00069	0.605
MOD_N-GLC_1	103	108	PF02516	0.635
MOD_N-GLC_1	298	303	PF02516	0.642
MOD_N-GLC_1	320	325	PF02516	0.555
MOD_N-GLC_1	80	85	PF02516	0.440
MOD_NEK2_1	123	128	PF00069	0.462
MOD_NEK2_1	2	7	PF00069	0.547
MOD_NEK2_1	258	263	PF00069	0.407
MOD_NEK2_1	26	31	PF00069	0.543
MOD_NEK2_1	50	55	PF00069	0.398
MOD_NEK2_1	57	62	PF00069	0.398
MOD_PIKK_1	75	81	PF00454	0.482
MOD_PK_1	281	287	PF00069	0.412
MOD_PKA_1	376	382	PF00069	0.459
MOD_PKA_2	169	175	PF00069	0.614
MOD_PKA_2	254	260	PF00069	0.401
MOD_PKA_2	375	381	PF00069	0.549
MOD_PKA_2	8	14	PF00069	0.501
MOD_PKB_1	374	382	PF00069	0.448
MOD_Plk_1	350	356	PF00069	0.445
MOD_Plk_2-3	105	111	PF00069	0.606
MOD_Plk_4	213	219	PF00069	0.503
MOD_Plk_4	221	227	PF00069	0.437
MOD_Plk_4	254	260	PF00069	0.351
MOD_Plk_4	44	50	PF00069	0.374
MOD_Plk_4	53	59	PF00069	0.423
MOD_ProDKin_1	11	17	PF00069	0.581
MOD_ProDKin_1	298	304	PF00069	0.566
TRG_DiLeu_BaEn_1	254	259	PF01217	0.405
TRG_DiLeu_BaEn_2	85	91	PF01217	0.422
TRG_DiLeu_BaLyEn_6	286	291	PF01217	0.523
TRG_ENDOCYTIC_2	13	16	PF00928	0.498
TRG_ENDOCYTIC_2	236	239	PF00928	0.358
TRG_ENDOCYTIC_2	42	45	PF00928	0.389
TRG_ER_diArg_1	200	203	PF00400	0.435
TRG_ER_diArg_1	285	288	PF00400	0.418
TRG_ER_diArg_1	307	309	PF00400	0.562
TRG_ER_diArg_1	370	372	PF00400	0.483
TRG_ER_diArg_1	374	377	PF00400	0.510
TRG_NLS_MonoCore_2	285	290	PF00514	0.433
TRG_NLS_MonoExtN_4	286	291	PF00514	0.474
TRG_Pf-PMV_PEXEL_1	232	237	PF00026	0.374
TRG_Pf-PMV_PEXEL_1	66	70	PF00026	0.320

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDP9	Leptomonas seymouri	51%	100%
A0A3S5H7C1	Leishmania donovani	70%	98%
A4I0E6	Leishmania infantum	71%	99%
E9AWA9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	99%
Q4QB66	Leishmania major	74%	100%