Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCW5_LEIBR

TriTrypDb:

LbrM.23.1040 , LBRM2903_230019000

Length:

678

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HCW5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCW5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	202	204	PF00675	0.429
CLV_NRD_NRD_1	236	238	PF00675	0.551
CLV_NRD_NRD_1	343	345	PF00675	0.464
CLV_NRD_NRD_1	36	38	PF00675	0.410
CLV_NRD_NRD_1	438	440	PF00675	0.492
CLV_NRD_NRD_1	514	516	PF00675	0.531
CLV_PCSK_KEX2_1	236	238	PF00082	0.551
CLV_PCSK_KEX2_1	343	345	PF00082	0.433
CLV_PCSK_KEX2_1	35	37	PF00082	0.403
CLV_PCSK_KEX2_1	438	440	PF00082	0.510
CLV_PCSK_KEX2_1	513	515	PF00082	0.530
CLV_PCSK_KEX2_1	589	591	PF00082	0.570
CLV_PCSK_PC1ET2_1	589	591	PF00082	0.525
CLV_PCSK_PC7_1	32	38	PF00082	0.434
CLV_PCSK_PC7_1	585	591	PF00082	0.524
CLV_PCSK_SKI1_1	37	41	PF00082	0.499
CLV_PCSK_SKI1_1	383	387	PF00082	0.463
CLV_PCSK_SKI1_1	439	443	PF00082	0.503
CLV_PCSK_SKI1_1	503	507	PF00082	0.565
CLV_PCSK_SKI1_1	540	544	PF00082	0.395
DEG_COP1_1	394	403	PF00400	0.738
DEG_SCF_FBW7_1	90	97	PF00400	0.484
DEG_SPOP_SBC_1	292	296	PF00917	0.673
DOC_ANK_TNKS_1	312	319	PF00023	0.502
DOC_CKS1_1	299	304	PF01111	0.701
DOC_CKS1_1	400	405	PF01111	0.720
DOC_CYCLIN_yCln2_LP_2	526	529	PF00134	0.684
DOC_MAPK_MEF2A_6	6	14	PF00069	0.364
DOC_PP1_RVXF_1	437	444	PF00149	0.710
DOC_PP1_RVXF_1	538	544	PF00149	0.599
DOC_PP2B_LxvP_1	333	336	PF13499	0.640
DOC_PP2B_LxvP_1	526	529	PF13499	0.603
DOC_PP2B_LxvP_1	67	70	PF13499	0.686
DOC_PP4_FxxP_1	102	105	PF00568	0.630
DOC_PP4_FxxP_1	543	546	PF00568	0.577
DOC_USP7_MATH_1	218	222	PF00917	0.801
DOC_USP7_MATH_1	242	246	PF00917	0.693
DOC_USP7_MATH_1	401	405	PF00917	0.659
DOC_USP7_MATH_1	547	551	PF00917	0.671
DOC_USP7_MATH_1	70	74	PF00917	0.659
DOC_WW_Pin1_4	205	210	PF00397	0.785
DOC_WW_Pin1_4	283	288	PF00397	0.629
DOC_WW_Pin1_4	298	303	PF00397	0.543
DOC_WW_Pin1_4	305	310	PF00397	0.619
DOC_WW_Pin1_4	356	361	PF00397	0.574
DOC_WW_Pin1_4	399	404	PF00397	0.701
DOC_WW_Pin1_4	59	64	PF00397	0.655
DOC_WW_Pin1_4	592	597	PF00397	0.791
DOC_WW_Pin1_4	90	95	PF00397	0.557
LIG_14-3-3_CanoR_1	261	266	PF00244	0.735
LIG_14-3-3_CanoR_1	313	317	PF00244	0.564
LIG_14-3-3_CanoR_1	377	385	PF00244	0.650
LIG_14-3-3_CanoR_1	406	416	PF00244	0.674
LIG_14-3-3_CanoR_1	491	496	PF00244	0.630
LIG_14-3-3_CanoR_1	551	557	PF00244	0.637
LIG_14-3-3_CanoR_1	84	90	PF00244	0.596
LIG_Actin_WH2_2	117	134	PF00022	0.503
LIG_BIR_II_1	1	5	PF00653	0.397
LIG_eIF4E_1	151	157	PF01652	0.612
LIG_eIF4E_1	614	620	PF01652	0.542
LIG_FHA_1	157	163	PF00498	0.578
LIG_FHA_1	225	231	PF00498	0.759
LIG_FHA_1	25	31	PF00498	0.454
LIG_FHA_1	274	280	PF00498	0.570
LIG_FHA_1	294	300	PF00498	0.586
LIG_FHA_1	408	414	PF00498	0.634
LIG_FHA_1	423	429	PF00498	0.583
LIG_FHA_1	457	463	PF00498	0.695
LIG_FHA_1	557	563	PF00498	0.531
LIG_FHA_1	626	632	PF00498	0.565
LIG_FHA_1	72	78	PF00498	0.706
LIG_FHA_2	292	298	PF00498	0.641
LIG_FHA_2	299	305	PF00498	0.591
LIG_FHA_2	425	431	PF00498	0.651
LIG_FHA_2	495	501	PF00498	0.624
LIG_FHA_2	553	559	PF00498	0.642
LIG_FHA_2	616	622	PF00498	0.689
LIG_FHA_2	84	90	PF00498	0.596
LIG_GSK3_LRP6_1	205	210	PF00069	0.616
LIG_LIR_Apic_2	322	328	PF02991	0.583
LIG_LIR_Apic_2	394	398	PF02991	0.661
LIG_LIR_Apic_2	97	103	PF02991	0.661
LIG_LIR_Gen_1	115	126	PF02991	0.497
LIG_LIR_Gen_1	427	434	PF02991	0.619
LIG_LIR_Nem_3	115	121	PF02991	0.531
LIG_LIR_Nem_3	154	158	PF02991	0.536
LIG_LIR_Nem_3	317	323	PF02991	0.598
LIG_LIR_Nem_3	427	432	PF02991	0.616
LIG_LIR_Nem_3	76	82	PF02991	0.560
LIG_LYPXL_yS_3	320	323	PF13949	0.612
LIG_MYND_1	336	340	PF01753	0.662
LIG_Pex14_2	632	636	PF04695	0.629
LIG_Pex14_2	669	673	PF04695	0.610
LIG_PTB_Apo_2	144	151	PF02174	0.741
LIG_PTB_Phospho_1	144	150	PF10480	0.750
LIG_SH2_CRK	158	162	PF00017	0.625
LIG_SH2_CRK	325	329	PF00017	0.564
LIG_SH2_CRK	665	669	PF00017	0.689
LIG_SH2_GRB2like	674	677	PF00017	0.732
LIG_SH2_NCK_1	325	329	PF00017	0.667
LIG_SH2_NCK_1	429	433	PF00017	0.653
LIG_SH2_PTP2	614	617	PF00017	0.524
LIG_SH2_SRC	609	612	PF00017	0.666
LIG_SH2_SRC	614	617	PF00017	0.653
LIG_SH2_STAP1	429	433	PF00017	0.650
LIG_SH2_STAT3	150	153	PF00017	0.583
LIG_SH2_STAT3	170	173	PF00017	0.640
LIG_SH2_STAT3	44	47	PF00017	0.575
LIG_SH2_STAT3	607	610	PF00017	0.609
LIG_SH2_STAT5	155	158	PF00017	0.544
LIG_SH2_STAT5	170	173	PF00017	0.517
LIG_SH2_STAT5	192	195	PF00017	0.595
LIG_SH2_STAT5	325	328	PF00017	0.569
LIG_SH2_STAT5	395	398	PF00017	0.729
LIG_SH2_STAT5	415	418	PF00017	0.447
LIG_SH2_STAT5	554	557	PF00017	0.567
LIG_SH2_STAT5	607	610	PF00017	0.641
LIG_SH2_STAT5	614	617	PF00017	0.630
LIG_SH2_STAT5	626	629	PF00017	0.590
LIG_SH2_STAT5	674	677	PF00017	0.732
LIG_SH3_1	203	209	PF00018	0.622
LIG_SH3_1	395	401	PF00018	0.741
LIG_SH3_3	203	209	PF00018	0.794
LIG_SH3_3	276	282	PF00018	0.626
LIG_SH3_3	328	334	PF00018	0.503
LIG_SH3_3	395	401	PF00018	0.639
LIG_SH3_3	563	569	PF00018	0.642
LIG_SH3_3	605	611	PF00018	0.502
LIG_SH3_3	628	634	PF00018	0.590
LIG_SUMO_SIM_par_1	454	460	PF11976	0.662
LIG_TRAF2_1	86	89	PF00917	0.679
LIG_TYR_ITSM	425	432	PF00017	0.641
MOD_CDC14_SPxK_1	359	362	PF00782	0.584
MOD_CDK_SPxK_1	356	362	PF00069	0.576
MOD_CDK_SPxxK_3	399	406	PF00069	0.697
MOD_CK1_1	134	140	PF00069	0.746
MOD_CK1_1	272	278	PF00069	0.661
MOD_CK1_1	319	325	PF00069	0.605
MOD_CK1_1	368	374	PF00069	0.721
MOD_CK1_1	379	385	PF00069	0.546
MOD_CK1_1	481	487	PF00069	0.692
MOD_CK1_1	494	500	PF00069	0.527
MOD_CK1_1	52	58	PF00069	0.627
MOD_CK1_1	576	582	PF00069	0.791
MOD_CK1_1	73	79	PF00069	0.736
MOD_CK1_1	95	101	PF00069	0.670
MOD_CK2_1	285	291	PF00069	0.682
MOD_CK2_1	298	304	PF00069	0.608
MOD_CK2_1	424	430	PF00069	0.656
MOD_CK2_1	532	538	PF00069	0.608
MOD_CK2_1	615	621	PF00069	0.677
MOD_CK2_1	83	89	PF00069	0.592
MOD_Cter_Amidation	587	590	PF01082	0.593
MOD_GlcNHglycan	220	223	PF01048	0.494
MOD_GlcNHglycan	256	260	PF01048	0.552
MOD_GlcNHglycan	265	268	PF01048	0.589
MOD_GlcNHglycan	271	274	PF01048	0.546
MOD_GlcNHglycan	287	290	PF01048	0.404
MOD_GlcNHglycan	367	370	PF01048	0.510
MOD_GlcNHglycan	389	392	PF01048	0.442
MOD_GlcNHglycan	40	43	PF01048	0.351
MOD_GlcNHglycan	443	446	PF01048	0.354
MOD_GlcNHglycan	480	483	PF01048	0.505
MOD_GlcNHglycan	656	659	PF01048	0.512
MOD_GlcNHglycan	97	100	PF01048	0.508
MOD_GSK3_1	134	141	PF00069	0.722
MOD_GSK3_1	261	268	PF00069	0.727
MOD_GSK3_1	269	276	PF00069	0.783
MOD_GSK3_1	312	319	PF00069	0.581
MOD_GSK3_1	334	341	PF00069	0.694
MOD_GSK3_1	361	368	PF00069	0.733
MOD_GSK3_1	387	394	PF00069	0.668
MOD_GSK3_1	466	473	PF00069	0.662
MOD_GSK3_1	481	488	PF00069	0.713
MOD_GSK3_1	55	62	PF00069	0.771
MOD_GSK3_1	552	559	PF00069	0.571
MOD_GSK3_1	615	622	PF00069	0.601
MOD_GSK3_1	650	657	PF00069	0.747
MOD_GSK3_1	90	97	PF00069	0.590
MOD_N-GLC_1	434	439	PF02516	0.478
MOD_N-GLC_1	556	561	PF02516	0.454
MOD_N-GLC_1	576	581	PF02516	0.510
MOD_NEK2_1	131	136	PF00069	0.707
MOD_NEK2_1	156	161	PF00069	0.585
MOD_NEK2_1	265	270	PF00069	0.649
MOD_NEK2_1	323	328	PF00069	0.552
MOD_NEK2_1	329	334	PF00069	0.557
MOD_NEK2_1	416	421	PF00069	0.556
MOD_NEK2_1	532	537	PF00069	0.584
MOD_NEK2_1	619	624	PF00069	0.731
MOD_PIKK_1	138	144	PF00454	0.675
MOD_PIKK_1	338	344	PF00454	0.700
MOD_PIKK_1	422	428	PF00454	0.626
MOD_PIKK_1	619	625	PF00454	0.680
MOD_PK_1	377	383	PF00069	0.486
MOD_PK_1	491	497	PF00069	0.703
MOD_PKA_2	131	137	PF00069	0.728
MOD_PKA_2	260	266	PF00069	0.756
MOD_PKA_2	312	318	PF00069	0.563
MOD_PKA_2	376	382	PF00069	0.662
MOD_PKA_2	407	413	PF00069	0.699
MOD_PKA_2	478	484	PF00069	0.689
MOD_PKA_2	83	89	PF00069	0.565
MOD_Plk_1	362	368	PF00069	0.591
MOD_Plk_4	24	30	PF00069	0.391
MOD_Plk_4	319	325	PF00069	0.564
MOD_Plk_4	334	340	PF00069	0.625
MOD_Plk_4	362	368	PF00069	0.616
MOD_Plk_4	391	397	PF00069	0.644
MOD_Plk_4	424	430	PF00069	0.601
MOD_Plk_4	494	500	PF00069	0.579
MOD_Plk_4	603	609	PF00069	0.596
MOD_Plk_4	615	621	PF00069	0.580
MOD_Plk_4	73	79	PF00069	0.578
MOD_ProDKin_1	205	211	PF00069	0.787
MOD_ProDKin_1	283	289	PF00069	0.635
MOD_ProDKin_1	298	304	PF00069	0.551
MOD_ProDKin_1	305	311	PF00069	0.615
MOD_ProDKin_1	356	362	PF00069	0.576
MOD_ProDKin_1	399	405	PF00069	0.699
MOD_ProDKin_1	59	65	PF00069	0.655
MOD_ProDKin_1	592	598	PF00069	0.786
MOD_ProDKin_1	90	96	PF00069	0.558
MOD_SUMO_rev_2	200	206	PF00179	0.622
MOD_SUMO_rev_2	535	542	PF00179	0.607
TRG_DiLeu_BaLyEn_6	210	215	PF01217	0.798
TRG_ENDOCYTIC_2	118	121	PF00928	0.629
TRG_ENDOCYTIC_2	320	323	PF00928	0.612
TRG_ENDOCYTIC_2	429	432	PF00928	0.582
TRG_ENDOCYTIC_2	614	617	PF00928	0.524
TRG_ENDOCYTIC_2	665	668	PF00928	0.672
TRG_ENDOCYTIC_2	79	82	PF00928	0.618
TRG_ER_diArg_1	110	113	PF00400	0.623
TRG_ER_diArg_1	35	37	PF00400	0.619
TRG_ER_diArg_1	405	408	PF00400	0.643
TRG_ER_diArg_1	513	515	PF00400	0.744
TRG_NLS_MonoExtN_4	438	443	PF00514	0.689

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Q7	Leptomonas seymouri	55%	100%
A0A1X0NWT3	Trypanosomatidae	33%	100%
A0A3Q8IM61	Leishmania donovani	73%	98%
A0A3R7NT57	Trypanosoma rangeli	34%	100%
A4I0E5	Leishmania infantum	73%	98%
C9ZV90	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AWA8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	97%
Q4QB67	Leishmania major	71%	100%
V5BEP2	Trypanosoma cruzi	33%	100%