Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCW3_LEIBR

TriTrypDb:

LbrM.23.1020 , LBRM2903_230018800

Length:

157

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HCW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCW3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	140	142	PF00675	0.625
CLV_NRD_NRD_1	39	41	PF00675	0.362
CLV_NRD_NRD_1	46	48	PF00675	0.330
CLV_PCSK_FUR_1	121	125	PF00082	0.533
CLV_PCSK_KEX2_1	123	125	PF00082	0.539
CLV_PCSK_KEX2_1	140	142	PF00082	0.574
CLV_PCSK_KEX2_1	39	41	PF00082	0.375
CLV_PCSK_KEX2_1	46	48	PF00082	0.345
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.539
CLV_PCSK_SKI1_1	100	104	PF00082	0.629
CLV_PCSK_SKI1_1	24	28	PF00082	0.325
DEG_APCC_DBOX_1	99	107	PF00400	0.452
DEG_APCC_KENBOX_2	95	99	PF00400	0.472
DEG_Nend_Nbox_1	1	3	PF02207	0.703
DOC_CYCLIN_yCln2_LP_2	83	86	PF00134	0.457
DOC_PP2B_LxvP_1	83	86	PF13499	0.447
DOC_PP4_FxxP_1	33	36	PF00568	0.471
DOC_USP7_MATH_1	61	65	PF00917	0.197
LIG_FHA_1	60	66	PF00498	0.308
LIG_FHA_2	108	114	PF00498	0.329
LIG_LIR_Gen_1	73	84	PF02991	0.322
LIG_LIR_Nem_3	22	28	PF02991	0.555
LIG_LIR_Nem_3	29	34	PF02991	0.497
LIG_LIR_Nem_3	73	79	PF02991	0.322
LIG_NRBOX	148	154	PF00104	0.460
LIG_PCNA_TLS_4	48	55	PF02747	0.619
LIG_SH2_STAP1	28	32	PF00017	0.601
LIG_SH2_STAT5	28	31	PF00017	0.580
LIG_SH2_STAT5	32	35	PF00017	0.618
LIG_SH2_STAT5	75	78	PF00017	0.305
LIG_TRFH_1	32	36	PF08558	0.610
LIG_TYR_ITSM	71	78	PF00017	0.322
MOD_CK1_1	59	65	PF00069	0.197
MOD_CK2_1	107	113	PF00069	0.403
MOD_CK2_1	91	97	PF00069	0.430
MOD_GSK3_1	12	19	PF00069	0.599
MOD_GSK3_1	70	77	PF00069	0.351
MOD_NEK2_1	152	157	PF00069	0.429
MOD_NEK2_1	7	12	PF00069	0.572
MOD_NEK2_1	70	75	PF00069	0.336
MOD_PKA_2	56	62	PF00069	0.496
MOD_Plk_1	91	97	PF00069	0.424
MOD_Plk_4	2	8	PF00069	0.626
MOD_Plk_4	26	32	PF00069	0.526
MOD_Plk_4	61	67	PF00069	0.397
MOD_Plk_4	70	76	PF00069	0.286
MOD_SUMO_for_1	122	125	PF00179	0.328
TRG_DiLeu_BaEn_1	101	106	PF01217	0.445
TRG_DiLeu_BaEn_4	144	150	PF01217	0.388
TRG_ENDOCYTIC_2	117	120	PF00928	0.433
TRG_ENDOCYTIC_2	75	78	PF00928	0.279
TRG_ER_diArg_1	139	141	PF00400	0.476
TRG_ER_diArg_1	38	40	PF00400	0.566
TRG_ER_diArg_1	45	47	PF00400	0.542
TRG_ER_diArg_1	8	11	PF00400	0.686

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZH6	Leptomonas seymouri	80%	100%
A0A0S4JBZ8	Bodo saltans	38%	99%
A0A1X0NWU3	Trypanosomatidae	57%	100%
A0A3Q8IBS8	Leishmania donovani	88%	100%
A0A422N7L6	Trypanosoma rangeli	57%	100%
A4I0E3	Leishmania infantum	88%	100%
C9ZV92	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AWA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QB69	Leishmania major	89%	100%