Protein arginine methyltransferase NDUFAF7

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative S-adenosyl-L-methionine-dependent methyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HCW1_LEIBR

TriTrypDb:

LbrM.23.1000 , LBRM2903_230018600

Length:

416

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HCW1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCW1

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0010257	NADH dehydrogenase complex assembly	6	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0032981	mitochondrial respiratory chain complex I assembly	7	1
GO:0033108	mitochondrial respiratory chain complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0008168	methyltransferase activity	4	10
GO:0008170	N-methyltransferase activity	5	10
GO:0008276	protein methyltransferase activity	3	10
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	10
GO:0016273	arginine N-methyltransferase activity	6	10
GO:0016274	protein-arginine N-methyltransferase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016741	transferase activity, transferring one-carbon groups	3	10
GO:0035243	protein-arginine omega-N symmetric methyltransferase activity	5	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	146	148	PF00675	0.370
CLV_NRD_NRD_1	329	331	PF00675	0.328
CLV_NRD_NRD_1	373	375	PF00675	0.357
CLV_PCSK_KEX2_1	146	148	PF00082	0.370
CLV_PCSK_KEX2_1	151	153	PF00082	0.370
CLV_PCSK_KEX2_1	329	331	PF00082	0.328
CLV_PCSK_KEX2_1	373	375	PF00082	0.357
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.325
CLV_PCSK_PC7_1	147	153	PF00082	0.325
CLV_PCSK_SKI1_1	118	122	PF00082	0.254
CLV_PCSK_SKI1_1	151	155	PF00082	0.254
CLV_PCSK_SKI1_1	22	26	PF00082	0.356
CLV_PCSK_SKI1_1	319	323	PF00082	0.266
CLV_PCSK_SKI1_1	330	334	PF00082	0.288
DEG_APCC_DBOX_1	318	326	PF00400	0.278
DEG_Nend_UBRbox_3	1	3	PF02207	0.459
DOC_CKS1_1	8	13	PF01111	0.488
DOC_CKS1_1	98	103	PF01111	0.254
DOC_CYCLIN_RxL_1	97	108	PF00134	0.278
DOC_MAPK_gen_1	163	170	PF00069	0.255
DOC_MAPK_gen_1	242	251	PF00069	0.370
DOC_PP1_RVXF_1	161	167	PF00149	0.255
DOC_PP1_RVXF_1	314	321	PF00149	0.254
DOC_PP1_RVXF_1	328	335	PF00149	0.299
DOC_PP4_FxxP_1	297	300	PF00568	0.254
DOC_USP7_MATH_1	226	230	PF00917	0.266
DOC_USP7_UBL2_3	118	122	PF12436	0.168
DOC_USP7_UBL2_3	21	25	PF12436	0.499
DOC_USP7_UBL2_3	363	367	PF12436	0.386
DOC_WW_Pin1_4	300	305	PF00397	0.254
DOC_WW_Pin1_4	396	401	PF00397	0.302
DOC_WW_Pin1_4	7	12	PF00397	0.449
DOC_WW_Pin1_4	97	102	PF00397	0.254
LIG_14-3-3_CanoR_1	13	17	PF00244	0.599
LIG_14-3-3_CanoR_1	197	204	PF00244	0.254
LIG_Actin_WH2_2	306	321	PF00022	0.254
LIG_BIR_III_2	189	193	PF00653	0.254
LIG_BRCT_BRCA1_1	171	175	PF00533	0.278
LIG_BRCT_BRCA1_1	398	402	PF00533	0.312
LIG_eIF4E_1	126	132	PF01652	0.254
LIG_FHA_1	178	184	PF00498	0.227
LIG_FHA_1	98	104	PF00498	0.286
LIG_FHA_2	204	210	PF00498	0.254
LIG_FHA_2	337	343	PF00498	0.318
LIG_FHA_2	74	80	PF00498	0.355
LIG_GBD_Chelix_1	131	139	PF00786	0.174
LIG_LIR_Apic_2	231	236	PF02991	0.254
LIG_LIR_Gen_1	186	196	PF02991	0.254
LIG_LIR_Gen_1	310	318	PF02991	0.254
LIG_LIR_Gen_1	399	410	PF02991	0.395
LIG_LIR_Gen_1	93	103	PF02991	0.288
LIG_LIR_Nem_3	186	191	PF02991	0.254
LIG_LIR_Nem_3	217	223	PF02991	0.254
LIG_LIR_Nem_3	310	315	PF02991	0.254
LIG_LIR_Nem_3	383	388	PF02991	0.309
LIG_LIR_Nem_3	392	398	PF02991	0.297
LIG_MLH1_MIPbox_1	398	402	PF16413	0.312
LIG_MYND_1	300	304	PF01753	0.254
LIG_NRP_CendR_1	414	416	PF00754	0.668
LIG_PTB_Apo_2	182	189	PF02174	0.254
LIG_SH2_CRK	126	130	PF00017	0.254
LIG_SH2_CRK	372	376	PF00017	0.325
LIG_SH2_GRB2like	126	129	PF00017	0.254
LIG_SH2_SRC	233	236	PF00017	0.254
LIG_SH2_STAT5	187	190	PF00017	0.254
LIG_SH2_STAT5	198	201	PF00017	0.254
LIG_SH2_STAT5	233	236	PF00017	0.254
LIG_SH3_3	220	226	PF00018	0.254
LIG_SH3_3	403	409	PF00018	0.403
LIG_TRFH_1	175	179	PF08558	0.278
LIG_UBA3_1	116	122	PF00899	0.254
LIG_UBA3_1	262	271	PF00899	0.254
MOD_CDK_SPK_2	97	102	PF00069	0.254
MOD_CDK_SPxK_1	7	13	PF00069	0.427
MOD_CK1_1	6	12	PF00069	0.488
MOD_CK2_1	203	209	PF00069	0.254
MOD_CK2_1	300	306	PF00069	0.278
MOD_CK2_1	73	79	PF00069	0.351
MOD_GlcNHglycan	17	20	PF01048	0.603
MOD_GlcNHglycan	226	229	PF01048	0.254
MOD_GlcNHglycan	230	233	PF01048	0.254
MOD_GlcNHglycan	244	247	PF01048	0.254
MOD_GSK3_1	112	119	PF00069	0.370
MOD_GSK3_1	169	176	PF00069	0.244
MOD_GSK3_1	209	216	PF00069	0.348
MOD_GSK3_1	224	231	PF00069	0.179
MOD_GSK3_1	238	245	PF00069	0.254
MOD_GSK3_1	3	10	PF00069	0.496
MOD_GSK3_1	307	314	PF00069	0.254
MOD_N-GLC_1	396	401	PF02516	0.305
MOD_NEK2_1	116	121	PF00069	0.325
MOD_NEK2_1	285	290	PF00069	0.254
MOD_NEK2_1	381	386	PF00069	0.308
MOD_NEK2_2	311	316	PF00069	0.370
MOD_PIKK_1	336	342	PF00454	0.304
MOD_PIKK_1	408	414	PF00454	0.378
MOD_PIKK_1	42	48	PF00454	0.319
MOD_PKA_2	112	118	PF00069	0.254
MOD_PKA_2	12	18	PF00069	0.567
MOD_PKA_2	196	202	PF00069	0.254
MOD_Plk_1	307	313	PF00069	0.266
MOD_Plk_4	112	118	PF00069	0.254
MOD_Plk_4	177	183	PF00069	0.280
MOD_Plk_4	258	264	PF00069	0.387
MOD_ProDKin_1	300	306	PF00069	0.254
MOD_ProDKin_1	396	402	PF00069	0.311
MOD_ProDKin_1	7	13	PF00069	0.447
MOD_ProDKin_1	97	103	PF00069	0.254
MOD_SUMO_for_1	357	360	PF00179	0.396
MOD_SUMO_rev_2	148	153	PF00179	0.278
MOD_SUMO_rev_2	18	27	PF00179	0.401
MOD_SUMO_rev_2	359	365	PF00179	0.398
TRG_DiLeu_BaEn_2	177	183	PF01217	0.278
TRG_DiLeu_BaEn_2	69	75	PF01217	0.425
TRG_DiLeu_BaLyEn_6	297	302	PF01217	0.254
TRG_ENDOCYTIC_2	372	375	PF00928	0.333
TRG_ENDOCYTIC_2	385	388	PF00928	0.293
TRG_ENDOCYTIC_2	41	44	PF00928	0.312
TRG_ER_diArg_1	372	374	PF00400	0.370
TRG_ER_FFAT_2	70	79	PF00635	0.408
TRG_Pf-PMV_PEXEL_1	373	377	PF00026	0.349

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBT9	Leptomonas seymouri	91%	84%
A0A1X0NXJ4	Trypanosomatidae	81%	97%
A0A3S7WXU3	Leishmania donovani	96%	93%
A4I0E1	Leishmania infantum	96%	93%
C9ZV33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	79%	97%
E9AWA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	89%
Q08BY0	Danio rerio	30%	99%
Q09644	Caenorhabditis elegans	28%	98%
Q2KHV5	Bos taurus	30%	94%
Q4QB74	Leishmania major	95%	100%
Q54S83	Dictyostelium discoideum	35%	86%
Q5BKM6	Xenopus tropicalis	31%	97%
Q5XI79	Rattus norvegicus	31%	95%
Q6GQ37	Xenopus laevis	30%	95%
Q7L592	Homo sapiens	33%	94%
Q9CWG8	Mus musculus	33%	95%
Q9VGR2	Drosophila melanogaster	28%	95%
V5D7M8	Trypanosoma cruzi	80%	97%