Sucrose-6-phosphate hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

sucrose hydrolase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HCW0_LEIBR

TriTrypDb:

LbrM.23.0990 , LBRM2903_230018500

Length:

460

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

A4HCW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCW0

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	20
GO:0008152	metabolic process	1	20
GO:0044238	primary metabolic process	2	20
GO:0071704	organic substance metabolic process	2	20

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	20
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	4	20
GO:0004564	beta-fructofuranosidase activity	5	18
GO:0016787	hydrolase activity	2	20
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	327	331	PF00656	0.285
CLV_NRD_NRD_1	261	263	PF00675	0.302
CLV_PCSK_KEX2_1	261	263	PF00082	0.302
CLV_PCSK_KEX2_1	373	375	PF00082	0.325
CLV_PCSK_KEX2_1	44	46	PF00082	0.184
CLV_PCSK_PC1ET2_1	373	375	PF00082	0.305
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.184
CLV_PCSK_SKI1_1	144	148	PF00082	0.322
CLV_PCSK_SKI1_1	178	182	PF00082	0.323
CLV_PCSK_SKI1_1	198	202	PF00082	0.188
CLV_PCSK_SKI1_1	374	378	PF00082	0.313
CLV_PCSK_SKI1_1	47	51	PF00082	0.233
DEG_Nend_UBRbox_3	1	3	PF02207	0.180
DEG_SPOP_SBC_1	22	26	PF00917	0.189
DOC_MAPK_MEF2A_6	408	415	PF00069	0.250
DOC_PP1_RVXF_1	196	203	PF00149	0.242
DOC_PP2B_LxvP_1	286	289	PF13499	0.309
DOC_PP4_FxxP_1	125	128	PF00568	0.309
DOC_PP4_FxxP_1	248	251	PF00568	0.264
DOC_USP7_MATH_1	101	105	PF00917	0.352
DOC_USP7_MATH_1	22	26	PF00917	0.217
DOC_USP7_MATH_1	256	260	PF00917	0.184
DOC_USP7_UBL2_3	207	211	PF12436	0.184
DOC_WW_Pin1_4	270	275	PF00397	0.415
LIG_14-3-3_CanoR_1	313	321	PF00244	0.336
LIG_14-3-3_CanoR_1	436	441	PF00244	0.359
LIG_Actin_WH2_2	297	315	PF00022	0.313
LIG_APCC_ABBA_1	402	407	PF00400	0.272
LIG_BRCT_BRCA1_1	423	427	PF00533	0.313
LIG_FHA_1	145	151	PF00498	0.436
LIG_FHA_1	156	162	PF00498	0.271
LIG_FHA_1	296	302	PF00498	0.284
LIG_FHA_1	3	9	PF00498	0.224
LIG_FHA_2	155	161	PF00498	0.273
LIG_FHA_2	336	342	PF00498	0.304
LIG_FHA_2	34	40	PF00498	0.295
LIG_KLC1_Yacidic_2	365	369	PF13176	0.388
LIG_LIR_Apic_2	247	251	PF02991	0.264
LIG_LIR_Gen_1	13	22	PF02991	0.231
LIG_LIR_Gen_1	166	174	PF02991	0.309
LIG_LIR_Nem_3	13	17	PF02991	0.324
LIG_LIR_Nem_3	134	140	PF02991	0.350
LIG_LIR_Nem_3	166	172	PF02991	0.324
LIG_LIR_Nem_3	187	191	PF02991	0.316
LIG_LIR_Nem_3	238	242	PF02991	0.311
LIG_LIR_Nem_3	71	77	PF02991	0.270
LIG_NRBOX	149	155	PF00104	0.322
LIG_PTB_Apo_2	375	382	PF02174	0.305
LIG_PTB_Phospho_1	375	381	PF10480	0.305
LIG_SH2_NCK_1	294	298	PF00017	0.242
LIG_SH2_SRC	18	21	PF00017	0.224
LIG_SH2_SRC	367	370	PF00017	0.428
LIG_SH2_STAP1	23	27	PF00017	0.317
LIG_SH2_STAP1	340	344	PF00017	0.302
LIG_SH2_STAT3	249	252	PF00017	0.309
LIG_SH2_STAT3	95	98	PF00017	0.289
LIG_SH2_STAT5	122	125	PF00017	0.346
LIG_SH2_STAT5	222	225	PF00017	0.322
LIG_SH2_STAT5	367	370	PF00017	0.453
LIG_SH2_STAT5	74	77	PF00017	0.338
LIG_SH2_STAT5	9	12	PF00017	0.261
LIG_SH3_1	85	91	PF00018	0.184
LIG_SH3_3	112	118	PF00018	0.333
LIG_SH3_3	226	232	PF00018	0.271
LIG_SH3_3	85	91	PF00018	0.233
LIG_TRAF2_1	305	308	PF00917	0.256
LIG_WW_1	119	122	PF00397	0.322
MOD_CK1_1	315	321	PF00069	0.319
MOD_CK2_1	335	341	PF00069	0.303
MOD_CK2_1	348	354	PF00069	0.305
MOD_CK2_1	359	365	PF00069	0.305
MOD_CK2_1	406	412	PF00069	0.336
MOD_Cter_Amidation	205	208	PF01082	0.242
MOD_GlcNHglycan	282	285	PF01048	0.413
MOD_GlcNHglycan	361	364	PF01048	0.313
MOD_GlcNHglycan	386	389	PF01048	0.336
MOD_GlcNHglycan	62	65	PF01048	0.298
MOD_GSK3_1	270	277	PF00069	0.318
MOD_GSK3_1	280	287	PF00069	0.316
MOD_GSK3_1	311	318	PF00069	0.301
MOD_GSK3_1	345	352	PF00069	0.202
MOD_GSK3_1	384	391	PF00069	0.305
MOD_NEK2_1	10	15	PF00069	0.203
MOD_NEK2_1	154	159	PF00069	0.213
MOD_NEK2_1	324	329	PF00069	0.383
MOD_NEK2_1	454	459	PF00069	0.470
MOD_NEK2_1	62	67	PF00069	0.309
MOD_PIKK_1	155	161	PF00454	0.202
MOD_PK_1	436	442	PF00069	0.279
MOD_PKA_1	207	213	PF00069	0.242
MOD_PKA_2	10	16	PF00069	0.184
MOD_PKA_2	312	318	PF00069	0.347
MOD_PKA_2	407	413	PF00069	0.272
MOD_Plk_1	335	341	PF00069	0.370
MOD_Plk_1	406	412	PF00069	0.305
MOD_Plk_1	418	424	PF00069	0.305
MOD_Plk_1	45	51	PF00069	0.194
MOD_Plk_1	454	460	PF00069	0.386
MOD_Plk_2-3	407	413	PF00069	0.305
MOD_Plk_4	250	256	PF00069	0.381
MOD_Plk_4	447	453	PF00069	0.380
MOD_ProDKin_1	270	276	PF00069	0.415
MOD_SUMO_rev_2	65	73	PF00179	0.200
TRG_ENDOCYTIC_2	122	125	PF00928	0.353
TRG_ENDOCYTIC_2	14	17	PF00928	0.309
TRG_ER_diArg_1	214	217	PF00400	0.308
TRG_ER_diArg_1	261	263	PF00400	0.302
TRG_NES_CRM1_1	393	407	PF08389	0.359

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8F7	Leptomonas seymouri	54%	94%
A0A0N1PBT6	Leptomonas seymouri	25%	71%
A0A1X0NFY9	Trypanosomatidae	26%	96%
A0A1X0NTL0	Trypanosomatidae	23%	73%
A0A1X0NTM3	Trypanosomatidae	28%	73%
A0A1X0NY19	Trypanosomatidae	28%	73%
A0A1X0P322	Trypanosomatidae	26%	73%
A0A1X0P5Y7	Trypanosomatidae	26%	72%
A0A3Q8IB13	Leishmania donovani	66%	83%
A0A3Q8IFU7	Leishmania donovani	78%	87%
A0A3S5H595	Leishmania donovani	27%	72%
A0A3S5H7I4	Leishmania donovani	50%	94%
A0A3S7WXQ4	Leishmania donovani	83%	90%
A0A3S7WXS2	Leishmania donovani	78%	87%
A1STJ9	Psychromonas ingrahamii (strain 37)	34%	84%
A2R0E0	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	24%	86%
A2X5P7	Oryza sativa subsp. indica	27%	80%
A2YZ01	Oryza sativa subsp. indica	25%	77%
A4H3V1	Leishmania braziliensis	27%	72%
A4HCV9	Leishmania braziliensis	68%	84%
A4HG14	Leishmania braziliensis	50%	94%
A4HS26	Leishmania infantum	27%	72%
A4I0D9	Leishmania infantum	65%	83%
A4I0E0	Leishmania infantum	84%	90%
A4I336	Leishmania infantum	50%	94%
A5ABL2	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	24%	89%
A5DHM6	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	26%	89%
A5EZZ8	Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)	32%	84%
A8W7I5	Meyerozyma guilliermondii	26%	89%
B6DXP5	Leymus chinensis	27%	77%
B6DZC8	Triticum aestivum	27%	77%
B6DZD0	Triticum urartu	28%	77%
B6DZD1	Aegilops speltoides	28%	77%
B6DZD2	Aegilops tauschii	28%	77%
D2IGW7	Bromus pictus	27%	76%
E1ABX2	Aspergillus ficuum	24%	86%
E8NHF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	88%
E8NHF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	95%
E9ACV4	Leishmania major	51%	100%
E9AK13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	72%
E9AWA3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
E9AZE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	94%
F8DVG5	Zymomonas mobilis subsp. mobilis (strain ATCC 10988 / DSM 424 / LMG 404 / NCIMB 8938 / NRRL B-806 / ZM1)	42%	90%
H2DF87	Rosa hybrid cultivar	28%	78%
H2DF88	Rosa hybrid cultivar	26%	72%
K0E681	Aspergillus rugulosus	25%	91%
O07003	Bacillus subtilis (strain 168)	26%	89%
O24509	Phaseolus vulgaris	27%	71%
O33833	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	32%	100%
O42878	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	91%
O59852	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	79%
O74641	Aspergillus niger	25%	89%
O74642	Aspergillus niger	25%	89%
O94220	Aspergillus ficuum	25%	89%
P00724	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	86%
P05656	Bacillus subtilis (strain 168)	29%	68%
P07819	Bacillus subtilis (strain 168)	37%	96%
P0DJA7	Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)	41%	90%
P10594	Saccharomyces cerevisiae	23%	86%
P10596	Saccharomyces cerevisiae	23%	86%
P13394	Vibrio alginolyticus	31%	95%
P13522	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	30%	96%
P16553	Escherichia coli	48%	97%
P24133	Schwanniomyces occidentalis	25%	86%
P26792	Daucus carota	28%	78%
P27217	Klebsiella pneumoniae	36%	99%
P28999	Kluyveromyces marxianus	23%	83%
P29000	Solanum lycopersicum	26%	72%
P29001	Vigna radiata var. radiata	27%	71%
P37075	Salmonella typhimurium	35%	99%
P40714	Escherichia coli	48%	96%
P40912	Wickerhamomyces anomalus	23%	84%
P43471	Pediococcus pentosaceus	28%	92%
P49174	Zea mays	27%	78%
P49175	Zea mays	26%	69%
P80065	Daucus carota	26%	70%
P92916	Allium cepa	25%	75%
P93761	Capsicum annuum	25%	72%
P94469	Geobacillus stearothermophilus	27%	100%
Q01IS7	Oryza sativa subsp. indica	26%	77%
Q01IS8	Oryza sativa subsp. indica	25%	78%
Q04937	Lactococcus lactis subsp. lactis	28%	97%
Q05936	Staphylococcus xylosus	32%	93%
Q0E0P0	Oryza sativa subsp. japonica	28%	80%
Q0J360	Oryza sativa subsp. japonica	25%	77%
Q0JDC5	Oryza sativa subsp. japonica	26%	77%
Q0JDC6	Oryza sativa subsp. japonica	25%	78%
Q1PEF8	Arabidopsis thaliana	27%	78%
Q2UXF7	Triticum aestivum	25%	77%
Q39041	Arabidopsis thaliana	29%	69%
Q39692	Daucus carota	29%	78%
Q39693	Daucus carota	29%	79%
Q43089	Pisum sativum	25%	83%
Q43348	Arabidopsis thaliana	26%	71%
Q43857	Vicia faba	24%	72%
Q43866	Arabidopsis thaliana	28%	79%
Q4QB75	Leishmania major	85%	100%
Q4QB76	Leishmania major	66%	100%
Q56660	Vibrio cholerae	32%	84%
Q56UD0	Oryza sativa subsp. japonica	30%	77%
Q56UD1	Oryza sativa subsp. japonica	25%	85%
Q5FC15	Asparagus officinalis	26%	75%
Q5JJV0	Oryza sativa subsp. japonica	28%	78%
Q67XZ3	Arabidopsis thaliana	28%	77%
Q6BJW6	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	24%	86%
Q70AT7	Hordeum vulgare	28%	77%
Q70XE6	Beta vulgaris	28%	76%
Q76HP6	Aspergillus niger	24%	86%
Q84LA1	Triticum aestivum	28%	77%
Q84PN8	Triticum aestivum	28%	77%
Q8W413	Arabidopsis thaliana	28%	78%
Q8W4S6	Arabidopsis thaliana	26%	84%
Q96TU3	Aspergillus awamori	23%	86%
Q9FSV7	Festuca arundinacea	25%	70%
Q9KLT6	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	32%	84%
Q9LIB9	Arabidopsis thaliana	27%	80%
Q9XTP3	Leishmania major	26%	72%