Beta-fructosidase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

sucrose hydrolase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HCV9_LEIBR

TriTrypDb:

LbrM.23.0980 , LBRM2903_230018400

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4HCV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCV9

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	20
GO:0008152	metabolic process	1	20
GO:0044238	primary metabolic process	2	20
GO:0071704	organic substance metabolic process	2	20

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	20
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	4	20
GO:0004564	beta-fructofuranosidase activity	5	18
GO:0016787	hydrolase activity	2	20
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.258
CLV_C14_Caspase3-7	343	347	PF00656	0.193
CLV_NRD_NRD_1	265	267	PF00675	0.263
CLV_NRD_NRD_1	399	401	PF00675	0.295
CLV_PCSK_KEX2_1	399	401	PF00082	0.295
CLV_PCSK_KEX2_1	40	42	PF00082	0.262
CLV_PCSK_KEX2_1	459	461	PF00082	0.321
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.246
CLV_PCSK_PC1ET2_1	459	461	PF00082	0.321
CLV_PCSK_SKI1_1	205	209	PF00082	0.343
CLV_PCSK_SKI1_1	239	243	PF00082	0.344
CLV_PCSK_SKI1_1	255	259	PF00082	0.201
CLV_PCSK_SKI1_1	316	320	PF00082	0.213
CLV_PCSK_SKI1_1	460	464	PF00082	0.369
DOC_ANK_TNKS_1	307	314	PF00023	0.193
DOC_CYCLIN_RxL_1	374	385	PF00134	0.290
DOC_CYCLIN_yCln2_LP_2	289	295	PF00134	0.193
DOC_MAPK_MEF2A_6	494	501	PF00069	0.283
DOC_PP2B_LxvP_1	373	376	PF13499	0.320
DOC_PP4_FxxP_1	186	189	PF00568	0.320
DOC_PP4_FxxP_1	336	339	PF00568	0.278
DOC_PP4_MxPP_1	390	393	PF00568	0.330
DOC_USP7_MATH_1	106	110	PF00917	0.196
DOC_USP7_MATH_1	162	166	PF00917	0.377
DOC_WW_Pin1_4	258	263	PF00397	0.290
DOC_WW_Pin1_4	3	8	PF00397	0.467
DOC_WW_Pin1_4	357	362	PF00397	0.343
LIG_14-3-3_CanoR_1	316	322	PF00244	0.263
LIG_14-3-3_CanoR_1	522	527	PF00244	0.385
LIG_APCC_ABBA_1	488	493	PF00400	0.283
LIG_BRCT_BRCA1_1	509	513	PF00533	0.333
LIG_deltaCOP1_diTrp_1	79	86	PF00928	0.292
LIG_EH_1	74	78	PF12763	0.293
LIG_FHA_1	19	25	PF00498	0.307
LIG_FHA_1	206	212	PF00498	0.372
LIG_FHA_1	217	223	PF00498	0.283
LIG_FHA_1	285	291	PF00498	0.312
LIG_FHA_1	383	389	PF00498	0.400
LIG_FHA_1	403	409	PF00498	0.290
LIG_FHA_1	413	419	PF00498	0.353
LIG_FHA_2	216	222	PF00498	0.288
LIG_FHA_2	317	323	PF00498	0.218
LIG_FHA_2	422	428	PF00498	0.308
LIG_FHA_2	88	94	PF00498	0.306
LIG_KLC1_Yacidic_2	451	455	PF13176	0.418
LIG_LIR_Apic_2	335	339	PF02991	0.278
LIG_LIR_Apic_2	356	361	PF02991	0.263
LIG_LIR_Gen_1	227	235	PF02991	0.320
LIG_LIR_Nem_3	195	201	PF02991	0.347
LIG_LIR_Nem_3	227	233	PF02991	0.320
LIG_LIR_Nem_3	248	252	PF02991	0.263
LIG_LIR_Nem_3	324	330	PF02991	0.318
LIG_LIR_Nem_3	52	57	PF02991	0.318
LIG_NRBOX	210	216	PF00104	0.343
LIG_Pex14_1	317	321	PF04695	0.263
LIG_Pex14_1	42	46	PF04695	0.341
LIG_Pex14_2	77	81	PF04695	0.289
LIG_PTB_Apo_2	122	129	PF02174	0.273
LIG_PTB_Apo_2	461	468	PF02174	0.317
LIG_PTB_Phospho_1	122	128	PF10480	0.273
LIG_PTB_Phospho_1	461	467	PF10480	0.317
LIG_RPA_C_Fungi	270	282	PF08784	0.263
LIG_SH2_GRB2like	123	126	PF00017	0.193
LIG_SH2_GRB2like	270	273	PF00017	0.218
LIG_SH2_GRB2like	96	99	PF00017	0.193
LIG_SH2_SRC	453	456	PF00017	0.438
LIG_SH2_STAP1	123	127	PF00017	0.254
LIG_SH2_STAP1	426	430	PF00017	0.313
LIG_SH2_STAT3	156	159	PF00017	0.300
LIG_SH2_STAT3	260	263	PF00017	0.263
LIG_SH2_STAT3	337	340	PF00017	0.320
LIG_SH2_STAT5	128	131	PF00017	0.320
LIG_SH2_STAT5	183	186	PF00017	0.344
LIG_SH2_STAT5	280	283	PF00017	0.343
LIG_SH2_STAT5	453	456	PF00017	0.463
LIG_SH3_3	173	179	PF00018	0.320
LIG_SH3_3	256	262	PF00018	0.193
LIG_SH3_3	289	295	PF00018	0.265
LIG_SH3_3	299	305	PF00018	0.218
LIG_WRC_WIRS_1	318	323	PF05994	0.263
LIG_WW_1	180	183	PF00397	0.343
MOD_CDK_SPK_2	3	8	PF00069	0.460
MOD_CK1_1	117	123	PF00069	0.275
MOD_CK1_1	284	290	PF00069	0.258
MOD_CK1_1	36	42	PF00069	0.262
MOD_CK2_1	16	22	PF00069	0.474
MOD_CK2_1	285	291	PF00069	0.239
MOD_CK2_1	421	427	PF00069	0.324
MOD_CK2_1	434	440	PF00069	0.362
MOD_CK2_1	445	451	PF00069	0.333
MOD_CK2_1	492	498	PF00069	0.321
MOD_CK2_1	6	12	PF00069	0.508
MOD_GlcNHglycan	116	119	PF01048	0.310
MOD_GlcNHglycan	145	148	PF01048	0.364
MOD_GlcNHglycan	277	280	PF01048	0.263
MOD_GlcNHglycan	369	372	PF01048	0.362
MOD_GlcNHglycan	447	450	PF01048	0.333
MOD_GlcNHglycan	472	475	PF01048	0.317
MOD_GlcNHglycan	51	54	PF01048	0.257
MOD_GSK3_1	2	9	PF00069	0.511
MOD_GSK3_1	281	288	PF00069	0.303
MOD_GSK3_1	317	324	PF00069	0.197
MOD_GSK3_1	357	364	PF00069	0.316
MOD_GSK3_1	367	374	PF00069	0.328
MOD_GSK3_1	380	387	PF00069	0.255
MOD_GSK3_1	431	438	PF00069	0.257
MOD_GSK3_1	470	477	PF00069	0.317
MOD_N-GLC_1	16	21	PF02516	0.361
MOD_N-GLC_1	27	32	PF02516	0.329
MOD_NEK2_1	116	121	PF00069	0.320
MOD_NEK2_1	215	220	PF00069	0.225
MOD_NEK2_1	321	326	PF00069	0.290
MOD_NEK2_1	384	389	PF00069	0.346
MOD_NEK2_1	540	545	PF00069	0.512
MOD_PIKK_1	216	222	PF00454	0.208
MOD_PIKK_1	321	327	PF00454	0.263
MOD_PK_1	522	528	PF00069	0.290
MOD_PKA_2	493	499	PF00069	0.283
MOD_PKB_1	273	281	PF00069	0.290
MOD_Plk_1	27	33	PF00069	0.349
MOD_Plk_1	285	291	PF00069	0.269
MOD_Plk_1	421	427	PF00069	0.343
MOD_Plk_1	492	498	PF00069	0.317
MOD_Plk_1	504	510	PF00069	0.317
MOD_Plk_1	540	546	PF00069	0.365
MOD_Plk_2-3	493	499	PF00069	0.317
MOD_Plk_4	151	157	PF00069	0.273
MOD_Plk_4	27	33	PF00069	0.273
MOD_Plk_4	285	291	PF00069	0.263
MOD_Plk_4	533	539	PF00069	0.365
MOD_ProDKin_1	258	264	PF00069	0.290
MOD_ProDKin_1	3	9	PF00069	0.465
MOD_ProDKin_1	357	363	PF00069	0.343
MOD_SUMO_for_1	297	300	PF00179	0.193
MOD_SUMO_rev_2	119	127	PF00179	0.205
TRG_DiLeu_BaLyEn_6	414	419	PF01217	0.341
TRG_ENDOCYTIC_2	183	186	PF00928	0.347
TRG_ENDOCYTIC_2	68	71	PF00928	0.334
TRG_ER_diArg_1	273	276	PF00400	0.321
TRG_NES_CRM1_1	479	493	PF08389	0.385
TRG_Pf-PMV_PEXEL_1	377	382	PF00026	0.290
TRG_Pf-PMV_PEXEL_1	417	421	PF00026	0.291

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8F7	Leptomonas seymouri	50%	100%
A0A0N1PBT6	Leptomonas seymouri	25%	85%
A0A1X0NFY9	Trypanosomatidae	24%	100%
A0A1X0NTL0	Trypanosomatidae	23%	86%
A0A1X0NTM3	Trypanosomatidae	24%	86%
A0A1X0NY19	Trypanosomatidae	26%	86%
A0A1X0P322	Trypanosomatidae	23%	87%
A0A1X0P5Y7	Trypanosomatidae	25%	85%
A0A3Q8IB13	Leishmania donovani	82%	99%
A0A3Q8IFU7	Leishmania donovani	69%	100%
A0A3S5H595	Leishmania donovani	24%	85%
A0A3S5H7I4	Leishmania donovani	49%	100%
A0A3S7WXQ4	Leishmania donovani	64%	100%
A0A3S7WXS2	Leishmania donovani	69%	100%
A1STJ9	Psychromonas ingrahamii (strain 37)	32%	100%
A2R0E0	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	26%	100%
A2X5P7	Oryza sativa subsp. indica	26%	95%
A2YZ01	Oryza sativa subsp. indica	24%	92%
A4H3V1	Leishmania braziliensis	24%	85%
A4HCW0	Leishmania braziliensis	68%	93%
A4HG14	Leishmania braziliensis	48%	93%
A4HS26	Leishmania infantum	24%	85%
A4I0D9	Leishmania infantum	82%	99%
A4I0E0	Leishmania infantum	64%	100%
A4I336	Leishmania infantum	49%	100%
A4IAW1	Leishmania infantum	25%	78%
A5ABL2	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	25%	100%
A5DHM6	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	25%	100%
A5EZZ8	Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)	30%	100%
A8W7I5	Meyerozyma guilliermondii	24%	100%
B6DXP5	Leymus chinensis	24%	91%
B6DZC8	Triticum aestivum	23%	92%
B6DZD0	Triticum urartu	25%	91%
B6DZD1	Aegilops speltoides	24%	92%
B6DZD2	Aegilops tauschii	25%	92%
D2IGW7	Bromus pictus	24%	91%
E1ABX2	Aspergillus ficuum	26%	100%
E8NHF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
E8NHF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
E9ACV4	Leishmania major	50%	93%
E9AK13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	86%
E9AWA3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
E9AZE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
F8DVG5	Zymomonas mobilis subsp. mobilis (strain ATCC 10988 / DSM 424 / LMG 404 / NCIMB 8938 / NRRL B-806 / ZM1)	39%	100%
H2DF87	Rosa hybrid cultivar	26%	93%
H2DF88	Rosa hybrid cultivar	24%	85%
K0E681	Aspergillus rugulosus	25%	100%
O07003	Bacillus subtilis (strain 168)	24%	100%
O24509	Phaseolus vulgaris	26%	84%
O33833	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	31%	100%
O42878	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
O59852	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	94%
O74641	Aspergillus niger	25%	100%
O74642	Aspergillus niger	25%	100%
O94220	Aspergillus ficuum	25%	100%
P00724	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P05656	Bacillus subtilis (strain 168)	28%	81%
P07819	Bacillus subtilis (strain 168)	35%	100%
P0DJA7	Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)	38%	100%
P10594	Saccharomyces cerevisiae	22%	100%
P10596	Saccharomyces cerevisiae	22%	100%
P13394	Vibrio alginolyticus	28%	100%
P13522	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	26%	100%
P16553	Escherichia coli	44%	100%
P26792	Daucus carota	26%	92%
P27217	Klebsiella pneumoniae	34%	100%
P29000	Solanum lycopersicum	24%	86%
P29001	Vigna radiata var. radiata	26%	84%
P37075	Salmonella typhimurium	32%	100%
P40714	Escherichia coli	43%	100%
P40912	Wickerhamomyces anomalus	22%	99%
P43471	Pediococcus pentosaceus	24%	100%
P49174	Zea mays	24%	93%
P49175	Zea mays	24%	81%
P80065	Daucus carota	26%	83%
P92916	Allium cepa	24%	89%
P93761	Capsicum annuum	25%	85%
P94469	Geobacillus stearothermophilus	24%	100%
Q01IS7	Oryza sativa subsp. indica	23%	91%
Q04937	Lactococcus lactis subsp. lactis	24%	100%
Q05936	Staphylococcus xylosus	29%	100%
Q0E0P0	Oryza sativa subsp. japonica	26%	95%
Q0J360	Oryza sativa subsp. japonica	24%	92%
Q0JDC5	Oryza sativa subsp. japonica	23%	91%
Q1PEF8	Arabidopsis thaliana	26%	93%
Q2UXF7	Triticum aestivum	23%	91%
Q39041	Arabidopsis thaliana	26%	82%
Q39692	Daucus carota	27%	92%
Q39693	Daucus carota	27%	94%
Q43089	Pisum sativum	23%	98%
Q43348	Arabidopsis thaliana	27%	84%
Q43857	Vicia faba	23%	85%
Q43866	Arabidopsis thaliana	26%	93%
Q4QB75	Leishmania major	62%	96%
Q4QB76	Leishmania major	82%	100%
Q56660	Vibrio cholerae	30%	100%
Q56UD0	Oryza sativa subsp. japonica	25%	92%
Q56UD1	Oryza sativa subsp. japonica	22%	100%
Q5FC15	Asparagus officinalis	25%	90%
Q5JJV0	Oryza sativa subsp. japonica	23%	93%
Q67XZ3	Arabidopsis thaliana	26%	92%
Q6BJW6	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	23%	100%
Q70AT7	Hordeum vulgare	24%	91%
Q70XE6	Beta vulgaris	25%	90%
Q76HP6	Aspergillus niger	26%	100%
Q84LA1	Triticum aestivum	25%	92%
Q84PN8	Triticum aestivum	25%	91%
Q8W413	Arabidopsis thaliana	25%	92%
Q8W4S6	Arabidopsis thaliana	25%	99%
Q96TU3	Aspergillus awamori	25%	100%
Q9FSV7	Festuca arundinacea	23%	83%
Q9KLT6	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	30%	100%
Q9LIB9	Arabidopsis thaliana	25%	95%
Q9XTP3	Leishmania major	24%	85%
Q9Y746	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	21%	90%