Alcohol dehydrogenase, zinc-containing-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

quinone oxidoreductase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HCV8_LEIBR

TriTrypDb:

LbrM.23.0970 , LBRM2903_230018200

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCV8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCV8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	19
GO:0003960	NADPH:quinone reductase activity	5	8
GO:0016491	oxidoreductase activity	2	19
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	9
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	4	8
GO:0000166	nucleotide binding	3	2
GO:0005488	binding	1	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0050661	NADP binding	4	2
GO:0070402	NADPH binding	4	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	54	58	PF00656	0.167
CLV_PCSK_SKI1_1	207	211	PF00082	0.427
CLV_PCSK_SKI1_1	327	331	PF00082	0.299
DEG_MDM2_SWIB_1	127	134	PF02201	0.294
DEG_ODPH_VHL_1	235	246	PF01847	0.402
DEG_SPOP_SBC_1	171	175	PF00917	0.373
DOC_CYCLIN_RxL_1	204	214	PF00134	0.452
DOC_MAPK_gen_1	139	148	PF00069	0.415
DOC_MAPK_gen_1	261	268	PF00069	0.282
DOC_MAPK_gen_1	27	34	PF00069	0.390
DOC_MAPK_MEF2A_6	27	36	PF00069	0.318
DOC_USP7_MATH_1	150	154	PF00917	0.342
DOC_USP7_MATH_1	185	189	PF00917	0.424
DOC_USP7_MATH_1	292	296	PF00917	0.460
DOC_USP7_MATH_1	44	48	PF00917	0.365
DOC_USP7_UBL2_3	23	27	PF12436	0.344
DOC_WW_Pin1_4	172	177	PF00397	0.336
LIG_14-3-3_CanoR_1	168	176	PF00244	0.483
LIG_14-3-3_CanoR_1	43	53	PF00244	0.254
LIG_APCC_ABBA_1	257	262	PF00400	0.254
LIG_BRCT_BRCA1_1	303	307	PF00533	0.271
LIG_Clathr_ClatBox_1	62	66	PF01394	0.336
LIG_deltaCOP1_diTrp_1	196	202	PF00928	0.228
LIG_FHA_1	28	34	PF00498	0.342
LIG_FHA_1	304	310	PF00498	0.343
LIG_FHA_2	114	120	PF00498	0.403
LIG_FHA_2	15	21	PF00498	0.244
LIG_FHA_2	172	178	PF00498	0.389
LIG_FHA_2	282	288	PF00498	0.415
LIG_FHA_2	329	335	PF00498	0.432
LIG_LIR_Apic_2	51	56	PF02991	0.254
LIG_LIR_Nem_3	129	134	PF02991	0.307
LIG_LIR_Nem_3	267	271	PF02991	0.297
LIG_LIR_Nem_3	324	328	PF02991	0.408
LIG_MAD2	327	335	PF02301	0.457
LIG_Pex14_1	49	53	PF04695	0.161
LIG_Pex14_2	127	131	PF04695	0.294
LIG_SH2_CRK	186	190	PF00017	0.321
LIG_SH2_CRK	325	329	PF00017	0.364
LIG_SH2_NCK_1	186	190	PF00017	0.321
LIG_SH2_NCK_1	53	57	PF00017	0.254
LIG_SH2_STAP1	186	190	PF00017	0.321
LIG_SH2_STAP1	97	101	PF00017	0.298
LIG_SH2_STAT5	115	118	PF00017	0.405
LIG_SH2_STAT5	166	169	PF00017	0.342
LIG_SH2_STAT5	227	230	PF00017	0.276
LIG_SH3_3	231	237	PF00018	0.355
LIG_SH3_3	329	335	PF00018	0.406
LIG_SUMO_SIM_par_1	328	334	PF11976	0.400
LIG_TRAF2_1	175	178	PF00917	0.344
LIG_TRAF2_1	308	311	PF00917	0.336
LIG_UBA3_1	15	23	PF00899	0.358
LIG_WRC_WIRS_1	283	288	PF05994	0.317
MOD_CDK_SPxxK_3	172	179	PF00069	0.227
MOD_CK2_1	113	119	PF00069	0.344
MOD_CK2_1	14	20	PF00069	0.344
MOD_CK2_1	171	177	PF00069	0.434
MOD_CK2_1	281	287	PF00069	0.339
MOD_CK2_1	328	334	PF00069	0.385
MOD_GlcNHglycan	156	159	PF01048	0.406
MOD_GlcNHglycan	313	316	PF01048	0.331
MOD_GSK3_1	150	157	PF00069	0.324
MOD_GSK3_1	167	174	PF00069	0.372
MOD_GSK3_1	185	192	PF00069	0.262
MOD_GSK3_1	297	304	PF00069	0.280
MOD_GSK3_1	333	340	PF00069	0.548
MOD_NEK2_1	167	172	PF00069	0.399
MOD_NEK2_1	223	228	PF00069	0.358
MOD_PIKK_1	44	50	PF00454	0.276
MOD_PKA_1	27	33	PF00069	0.392
MOD_PKA_2	167	173	PF00069	0.327
MOD_Plk_1	211	217	PF00069	0.390
MOD_Plk_2-3	14	20	PF00069	0.301
MOD_Plk_4	218	224	PF00069	0.300
MOD_Plk_4	298	304	PF00069	0.340
MOD_Plk_4	58	64	PF00069	0.173
MOD_ProDKin_1	172	178	PF00069	0.345
MOD_SUMO_rev_2	175	180	PF00179	0.396
TRG_ENDOCYTIC_2	186	189	PF00928	0.325
TRG_ENDOCYTIC_2	325	328	PF00928	0.350
TRG_ER_diArg_1	143	146	PF00400	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Q4	Leptomonas seymouri	70%	100%
A0A0N1I9E8	Leptomonas seymouri	53%	100%
A0A0N1PDX1	Leptomonas seymouri	56%	97%
A0A0S4INW1	Bodo saltans	44%	78%
A0A0S4IT20	Bodo saltans	23%	99%
A0A0S4JJT8	Bodo saltans	24%	87%
A0A0S4KHW9	Bodo saltans	25%	100%
A0A1X0NRR2	Trypanosomatidae	28%	70%
A0A1X0NZZ5	Trypanosomatidae	53%	100%
A0A3Q8ICJ5	Leishmania donovani	85%	100%
A0A3S7X2E3	Leishmania donovani	57%	97%
A0A422NF38	Trypanosoma rangeli	52%	100%
A0A451EJQ8	Leishmania donovani	24%	100%
A4HHB3	Leishmania braziliensis	56%	97%
A4I0D8	Leishmania infantum	85%	100%
A4I4G0	Leishmania infantum	58%	97%
A6QQF5	Bos taurus	28%	97%
A7RK30	Nematostella vectensis	26%	93%
B0BNC9	Rattus norvegicus	24%	97%
C9ZLK8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9ACK2	Leishmania major	24%	99%
E9ADV9	Leishmania major	57%	100%
E9AG46	Leishmania infantum	24%	100%
E9AJU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9ALX1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	97%
E9AWA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
K4BW79	Solanum lycopersicum	27%	88%
O35045	Bacillus subtilis (strain 168)	24%	100%
O42909	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	98%
O74489	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
O94564	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	98%
O97764	Bos taurus	27%	100%
P11415	Cavia porcellus	27%	100%
P19333	Tetronarce californica	26%	90%
P28304	Escherichia coli (strain K12)	26%	100%
P40783	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	24%	100%
P43903	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	26%	100%
P47199	Mus musculus	25%	100%
P63475	Staphylococcus aureus (strain Mu50 / ATCC 700699)	25%	100%
P99173	Staphylococcus aureus (strain N315)	25%	100%
Q08257	Homo sapiens	27%	100%
Q0MVN8	Sus scrofa	28%	100%
Q28452	Lama guanicoe	28%	100%
Q3MIE4	Rattus norvegicus	25%	84%
Q3UNZ8	Mus musculus	25%	97%
Q4QB77	Leishmania major	82%	100%
Q53FA7	Homo sapiens	36%	100%
Q54II4	Dictyostelium discoideum	22%	97%
Q59I44	Burkholderia sp.	27%	100%
Q5HE19	Staphylococcus aureus (strain COL)	25%	100%
Q5HM44	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	25%	100%
Q5R4S7	Pongo abelii	27%	100%
Q62465	Mus musculus	26%	84%
Q6AYT0	Rattus norvegicus	25%	100%
Q6G7C8	Staphylococcus aureus (strain MSSA476)	25%	100%
Q6GEP3	Staphylococcus aureus (strain MRSA252)	25%	100%
Q7T3C7	Danio rerio	28%	88%
Q80TB8	Mus musculus	26%	82%
Q8CRJ7	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	24%	100%
Q8JFV8	Danio rerio	25%	70%
Q8NVD1	Staphylococcus aureus (strain MW2)	25%	100%
Q99536	Homo sapiens	25%	87%
Q9HCJ6	Homo sapiens	26%	81%
Q9ZUC1	Arabidopsis thaliana	25%	88%
V5B1P3	Trypanosoma cruzi	52%	100%
V5BXF0	Trypanosoma cruzi	26%	100%