Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCV7_LEIBR

TriTrypDb:

LbrM.23.0960 , LBRM2903_230018100

Length:

785

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCV7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCV7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	208	212	PF00656	0.589
CLV_C14_Caspase3-7	575	579	PF00656	0.638
CLV_NRD_NRD_1	187	189	PF00675	0.569
CLV_NRD_NRD_1	403	405	PF00675	0.387
CLV_NRD_NRD_1	421	423	PF00675	0.518
CLV_NRD_NRD_1	601	603	PF00675	0.631
CLV_NRD_NRD_1	642	644	PF00675	0.613
CLV_PCSK_FUR_1	188	192	PF00082	0.361
CLV_PCSK_KEX2_1	187	189	PF00082	0.569
CLV_PCSK_KEX2_1	190	192	PF00082	0.551
CLV_PCSK_KEX2_1	421	423	PF00082	0.585
CLV_PCSK_KEX2_1	601	603	PF00082	0.630
CLV_PCSK_KEX2_1	631	633	PF00082	0.639
CLV_PCSK_KEX2_1	642	644	PF00082	0.613
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.374
CLV_PCSK_PC1ET2_1	631	633	PF00082	0.639
CLV_PCSK_SKI1_1	118	122	PF00082	0.516
CLV_PCSK_SKI1_1	179	183	PF00082	0.541
CLV_PCSK_SKI1_1	187	191	PF00082	0.464
CLV_PCSK_SKI1_1	22	26	PF00082	0.663
CLV_PCSK_SKI1_1	231	235	PF00082	0.563
CLV_PCSK_SKI1_1	405	409	PF00082	0.331
CLV_PCSK_SKI1_1	582	586	PF00082	0.581
CLV_PCSK_SKI1_1	720	724	PF00082	0.665
CLV_PCSK_SKI1_1	752	756	PF00082	0.585
CLV_PCSK_SKI1_1	770	774	PF00082	0.658
CLV_PCSK_SKI1_1	87	91	PF00082	0.646
DEG_APCC_DBOX_1	230	238	PF00400	0.562
DEG_COP1_1	541	550	PF00400	0.546
DEG_SCF_FBW7_1	284	289	PF00400	0.651
DEG_SCF_FBW7_1	314	319	PF00400	0.709
DEG_SPOP_SBC_1	278	282	PF00917	0.606
DOC_CYCLIN_RxL_1	176	185	PF00134	0.543
DOC_CYCLIN_RxL_1	19	29	PF00134	0.669
DOC_CYCLIN_RxL_1	228	235	PF00134	0.570
DOC_MAPK_gen_1	404	412	PF00069	0.419
DOC_MAPK_gen_1	744	753	PF00069	0.776
DOC_MAPK_MEF2A_6	404	412	PF00069	0.541
DOC_MAPK_NFAT4_5	405	413	PF00069	0.312
DOC_MAPK_RevD_3	173	188	PF00069	0.552
DOC_MAPK_RevD_3	406	422	PF00069	0.538
DOC_PP2B_PxIxI_1	227	233	PF00149	0.576
DOC_SPAK_OSR1_1	356	360	PF12202	0.579
DOC_USP7_MATH_1	212	216	PF00917	0.568
DOC_USP7_MATH_1	279	283	PF00917	0.794
DOC_USP7_MATH_1	286	290	PF00917	0.799
DOC_USP7_MATH_1	292	296	PF00917	0.754
DOC_USP7_MATH_1	444	448	PF00917	0.569
DOC_USP7_MATH_1	467	471	PF00917	0.581
DOC_USP7_MATH_1	494	498	PF00917	0.577
DOC_USP7_MATH_1	535	539	PF00917	0.624
DOC_USP7_MATH_1	561	565	PF00917	0.702
DOC_USP7_UBL2_3	627	631	PF12436	0.634
DOC_WW_Pin1_4	111	116	PF00397	0.772
DOC_WW_Pin1_4	133	138	PF00397	0.819
DOC_WW_Pin1_4	156	161	PF00397	0.496
DOC_WW_Pin1_4	272	277	PF00397	0.821
DOC_WW_Pin1_4	280	285	PF00397	0.716
DOC_WW_Pin1_4	288	293	PF00397	0.821
DOC_WW_Pin1_4	294	299	PF00397	0.714
DOC_WW_Pin1_4	312	317	PF00397	0.516
DOC_WW_Pin1_4	322	327	PF00397	0.427
DOC_WW_Pin1_4	397	402	PF00397	0.553
DOC_WW_Pin1_4	476	481	PF00397	0.521
DOC_WW_Pin1_4	484	489	PF00397	0.545
DOC_WW_Pin1_4	490	495	PF00397	0.502
DOC_WW_Pin1_4	593	598	PF00397	0.610
DOC_WW_Pin1_4	705	710	PF00397	0.679
LIG_14-3-3_CanoR_1	317	322	PF00244	0.606
LIG_14-3-3_CanoR_1	466	472	PF00244	0.615
LIG_14-3-3_CanoR_1	653	659	PF00244	0.549
LIG_14-3-3_CanoR_1	679	684	PF00244	0.584
LIG_14-3-3_CanoR_1	752	760	PF00244	0.570
LIG_Actin_WH2_1	432	448	PF00022	0.540
LIG_Actin_WH2_2	431	448	PF00022	0.541
LIG_APCC_ABBA_1	623	628	PF00400	0.596
LIG_BRCT_BRCA1_1	354	358	PF00533	0.564
LIG_BRCT_BRCA1_1	429	433	PF00533	0.526
LIG_Clathr_ClatBox_1	216	220	PF01394	0.344
LIG_EH1_1	649	657	PF00400	0.571
LIG_FHA_1	124	130	PF00498	0.709
LIG_FHA_1	170	176	PF00498	0.580
LIG_FHA_1	35	41	PF00498	0.616
LIG_FHA_1	618	624	PF00498	0.562
LIG_FHA_1	83	89	PF00498	0.660
LIG_FHA_2	169	175	PF00498	0.594
LIG_FHA_2	206	212	PF00498	0.586
LIG_FHA_2	219	225	PF00498	0.421
LIG_FHA_2	346	352	PF00498	0.375
LIG_FHA_2	51	57	PF00498	0.649
LIG_FHA_2	518	524	PF00498	0.636
LIG_FHA_2	695	701	PF00498	0.631
LIG_GBD_Chelix_1	329	337	PF00786	0.544
LIG_LIR_Apic_2	733	738	PF02991	0.714
LIG_LIR_Gen_1	239	245	PF02991	0.377
LIG_LIR_Gen_1	315	326	PF02991	0.719
LIG_LIR_Gen_1	33	43	PF02991	0.389
LIG_LIR_Gen_1	370	381	PF02991	0.340
LIG_LIR_Gen_1	430	441	PF02991	0.535
LIG_LIR_Gen_1	583	593	PF02991	0.574
LIG_LIR_Gen_1	669	678	PF02991	0.384
LIG_LIR_Nem_3	114	120	PF02991	0.717
LIG_LIR_Nem_3	185	189	PF02991	0.555
LIG_LIR_Nem_3	196	202	PF02991	0.414
LIG_LIR_Nem_3	239	244	PF02991	0.373
LIG_LIR_Nem_3	29	35	PF02991	0.644
LIG_LIR_Nem_3	315	321	PF02991	0.816
LIG_LIR_Nem_3	370	376	PF02991	0.476
LIG_LIR_Nem_3	379	385	PF02991	0.473
LIG_LIR_Nem_3	430	436	PF02991	0.546
LIG_LIR_Nem_3	583	589	PF02991	0.610
LIG_LIR_Nem_3	665	671	PF02991	0.398
LIG_MLH1_MIPbox_1	354	358	PF16413	0.564
LIG_NRBOX	67	73	PF00104	0.606
LIG_Pex14_2	390	394	PF04695	0.603
LIG_PTB_Apo_2	235	242	PF02174	0.355
LIG_PTB_Phospho_1	235	241	PF10480	0.351
LIG_SH2_CRK	186	190	PF00017	0.419
LIG_SH2_CRK	200	204	PF00017	0.529
LIG_SH2_CRK	241	245	PF00017	0.381
LIG_SH2_CRK	318	322	PF00017	0.768
LIG_SH2_CRK	35	39	PF00017	0.607
LIG_SH2_CRK	373	377	PF00017	0.337
LIG_SH2_CRK	4	8	PF00017	0.727
LIG_SH2_CRK	735	739	PF00017	0.733
LIG_SH2_GRB2like	236	239	PF00017	0.356
LIG_SH2_GRB2like	588	591	PF00017	0.348
LIG_SH2_NCK_1	4	8	PF00017	0.727
LIG_SH2_STAP1	200	204	PF00017	0.581
LIG_SH2_STAP1	241	245	PF00017	0.602
LIG_SH2_STAP1	373	377	PF00017	0.542
LIG_SH2_STAP1	671	675	PF00017	0.348
LIG_SH2_STAT3	148	151	PF00017	0.720
LIG_SH2_STAT5	148	151	PF00017	0.720
LIG_SH2_STAT5	180	183	PF00017	0.538
LIG_SH2_STAT5	236	239	PF00017	0.400
LIG_SH2_STAT5	318	321	PF00017	0.777
LIG_SH2_STAT5	32	35	PF00017	0.629
LIG_SH2_STAT5	588	591	PF00017	0.569
LIG_SH3_1	134	140	PF00018	0.808
LIG_SH3_3	134	140	PF00018	0.808
LIG_SH3_3	273	279	PF00018	0.657
LIG_SH3_3	531	537	PF00018	0.570
LIG_SH3_3	76	82	PF00018	0.651
LIG_SH3_CIN85_PxpxPR_1	480	485	PF14604	0.551
LIG_SUMO_SIM_anti_2	619	625	PF11976	0.564
LIG_SUMO_SIM_par_1	214	221	PF11976	0.576
LIG_TRAF2_1	538	541	PF00917	0.582
LIG_TYR_ITIM	184	189	PF00017	0.556
LIG_TYR_ITIM	198	203	PF00017	0.357
LIG_UBA3_1	88	92	PF00899	0.451
MOD_CDK_SPK_2	133	138	PF00069	0.565
MOD_CDK_SPK_2	312	317	PF00069	0.560
MOD_CDK_SPK_2	476	481	PF00069	0.485
MOD_CDK_SPxxK_3	111	118	PF00069	0.736
MOD_CDK_SPxxK_3	397	404	PF00069	0.540
MOD_CK1_1	282	288	PF00069	0.849
MOD_CK1_1	290	296	PF00069	0.812
MOD_CK1_1	332	338	PF00069	0.546
MOD_CK1_1	487	493	PF00069	0.694
MOD_CK1_1	495	501	PF00069	0.634
MOD_CK1_1	565	571	PF00069	0.776
MOD_CK2_1	212	218	PF00069	0.571
MOD_CK2_1	322	328	PF00069	0.430
MOD_CK2_1	345	351	PF00069	0.596
MOD_CK2_1	50	56	PF00069	0.435
MOD_CK2_1	517	523	PF00069	0.639
MOD_CK2_1	535	541	PF00069	0.556
MOD_CK2_1	694	700	PF00069	0.622
MOD_Cter_Amidation	599	602	PF01082	0.601
MOD_DYRK1A_RPxSP_1	312	316	PF00069	0.558
MOD_GlcNHglycan	446	449	PF01048	0.497
MOD_GlcNHglycan	489	492	PF01048	0.726
MOD_GlcNHglycan	509	512	PF01048	0.715
MOD_GlcNHglycan	541	545	PF01048	0.580
MOD_GSK3_1	106	113	PF00069	0.539
MOD_GSK3_1	165	172	PF00069	0.635
MOD_GSK3_1	278	285	PF00069	0.731
MOD_GSK3_1	286	293	PF00069	0.812
MOD_GSK3_1	30	37	PF00069	0.448
MOD_GSK3_1	312	319	PF00069	0.661
MOD_GSK3_1	393	400	PF00069	0.602
MOD_GSK3_1	440	447	PF00069	0.539
MOD_GSK3_1	45	52	PF00069	0.568
MOD_GSK3_1	490	497	PF00069	0.630
MOD_GSK3_1	513	520	PF00069	0.632
MOD_GSK3_1	542	549	PF00069	0.574
MOD_GSK3_1	561	568	PF00069	0.760
MOD_LATS_1	500	506	PF00433	0.551
MOD_N-GLC_1	467	472	PF02516	0.581
MOD_NEK2_1	182	187	PF00069	0.545
MOD_NEK2_1	30	35	PF00069	0.491
MOD_NEK2_1	406	411	PF00069	0.530
MOD_NEK2_1	43	48	PF00069	0.556
MOD_NEK2_1	507	512	PF00069	0.793
MOD_NEK2_1	694	699	PF00069	0.618
MOD_NEK2_1	778	783	PF00069	0.498
MOD_NEK2_2	34	39	PF00069	0.609
MOD_NEK2_2	467	472	PF00069	0.581
MOD_PIKK_1	147	153	PF00454	0.714
MOD_PIKK_1	50	56	PF00454	0.656
MOD_PIKK_1	562	568	PF00454	0.580
MOD_PIKK_1	752	758	PF00454	0.565
MOD_PIKK_1	82	88	PF00454	0.658
MOD_PK_1	3	9	PF00069	0.735
MOD_PK_1	513	519	PF00069	0.562
MOD_PKA_2	316	322	PF00069	0.607
MOD_PKB_1	677	685	PF00069	0.587
MOD_Plk_1	165	171	PF00069	0.636
MOD_Plk_1	467	473	PF00069	0.548
MOD_Plk_1	768	774	PF00069	0.512
MOD_Plk_2-3	687	693	PF00069	0.637
MOD_Plk_4	165	171	PF00069	0.660
MOD_Plk_4	212	218	PF00069	0.602
MOD_Plk_4	329	335	PF00069	0.537
MOD_Plk_4	406	412	PF00069	0.527
MOD_Plk_4	467	473	PF00069	0.438
MOD_Plk_4	679	685	PF00069	0.588
MOD_Plk_4	768	774	PF00069	0.512
MOD_ProDKin_1	111	117	PF00069	0.769
MOD_ProDKin_1	133	139	PF00069	0.819
MOD_ProDKin_1	156	162	PF00069	0.494
MOD_ProDKin_1	272	278	PF00069	0.821
MOD_ProDKin_1	280	286	PF00069	0.715
MOD_ProDKin_1	288	294	PF00069	0.820
MOD_ProDKin_1	312	318	PF00069	0.782
MOD_ProDKin_1	322	328	PF00069	0.422
MOD_ProDKin_1	397	403	PF00069	0.546
MOD_ProDKin_1	476	482	PF00069	0.530
MOD_ProDKin_1	484	490	PF00069	0.545
MOD_ProDKin_1	492	498	PF00069	0.481
MOD_ProDKin_1	593	599	PF00069	0.607
MOD_ProDKin_1	705	711	PF00069	0.686
MOD_SUMO_rev_2	545	555	PF00179	0.565
TRG_DiLeu_BaEn_1	26	31	PF01217	0.454
TRG_DiLeu_BaEn_1	619	624	PF01217	0.561
TRG_DiLeu_BaEn_1	67	72	PF01217	0.598
TRG_DiLeu_BaLyEn_6	741	746	PF01217	0.550
TRG_DiLeu_BaLyEn_6	84	89	PF01217	0.482
TRG_ENDOCYTIC_2	186	189	PF00928	0.561
TRG_ENDOCYTIC_2	200	203	PF00928	0.364
TRG_ENDOCYTIC_2	241	244	PF00928	0.376
TRG_ENDOCYTIC_2	318	321	PF00928	0.777
TRG_ENDOCYTIC_2	35	38	PF00928	0.601
TRG_ENDOCYTIC_2	373	376	PF00928	0.342
TRG_ENDOCYTIC_2	4	7	PF00928	0.728
TRG_ENDOCYTIC_2	424	427	PF00928	0.348
TRG_ENDOCYTIC_2	671	674	PF00928	0.528
TRG_ENDOCYTIC_2	678	681	PF00928	0.577
TRG_ER_diArg_1	186	188	PF00400	0.566
TRG_ER_diArg_1	228	231	PF00400	0.580
TRG_ER_diArg_1	421	423	PF00400	0.585
TRG_ER_diArg_1	472	475	PF00400	0.626
TRG_ER_diArg_1	601	603	PF00400	0.626
TRG_NES_CRM1_1	62	78	PF08389	0.614
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.663
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.563
TRG_Pf-PMV_PEXEL_1	243	247	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	367	372	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	421	425	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	601	606	PF00026	0.598
TRG_Pf-PMV_PEXEL_1	632	636	PF00026	0.619
TRG_Pf-PMV_PEXEL_1	744	748	PF00026	0.773
TRG_Pf-PMV_PEXEL_1	752	756	PF00026	0.687

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICJ7	Leishmania donovani	80%	100%
A4I0D7	Leishmania infantum	80%	100%
E9AWA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QB78	Leishmania major	81%	99%