Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HCV5_LEIBR

TriTrypDb:

LbrM.23.0940 , LBRM2903_230017900

Length:

512

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 0
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HCV5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCV5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.351
CLV_C14_Caspase3-7	204	208	PF00656	0.374
CLV_C14_Caspase3-7	449	453	PF00656	0.462
CLV_NRD_NRD_1	258	260	PF00675	0.581
CLV_NRD_NRD_1	359	361	PF00675	0.663
CLV_PCSK_KEX2_1	355	357	PF00082	0.649
CLV_PCSK_KEX2_1	359	361	PF00082	0.661
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.569
CLV_PCSK_SKI1_1	372	376	PF00082	0.655
CLV_PCSK_SKI1_1	93	97	PF00082	0.600
CLV_Separin_Metazoa	256	260	PF03568	0.389
DEG_Nend_UBRbox_1	1	4	PF02207	0.714
DEG_SCF_FBW7_1	95	100	PF00400	0.357
DEG_SCF_FBW7_2	59	66	PF00400	0.329
DEG_SPOP_SBC_1	248	252	PF00917	0.392
DOC_CKS1_1	293	298	PF01111	0.409
DOC_CKS1_1	60	65	PF01111	0.333
DOC_CYCLIN_yCln2_LP_2	49	55	PF00134	0.396
DOC_PP2B_LxvP_1	49	52	PF13499	0.443
DOC_PP4_FxxP_1	197	200	PF00568	0.461
DOC_PP4_FxxP_1	293	296	PF00568	0.384
DOC_USP7_MATH_1	128	132	PF00917	0.448
DOC_USP7_MATH_1	133	137	PF00917	0.397
DOC_USP7_MATH_1	16	20	PF00917	0.446
DOC_USP7_MATH_1	161	165	PF00917	0.397
DOC_USP7_MATH_1	192	196	PF00917	0.357
DOC_USP7_MATH_1	248	252	PF00917	0.459
DOC_USP7_MATH_1	80	84	PF00917	0.412
DOC_USP7_MATH_2	404	410	PF00917	0.374
DOC_WW_Pin1_4	218	223	PF00397	0.510
DOC_WW_Pin1_4	292	297	PF00397	0.466
DOC_WW_Pin1_4	400	405	PF00397	0.521
DOC_WW_Pin1_4	59	64	PF00397	0.335
DOC_WW_Pin1_4	93	98	PF00397	0.399
LIG_14-3-3_CanoR_1	130	137	PF00244	0.373
LIG_14-3-3_CanoR_1	259	264	PF00244	0.407
LIG_14-3-3_CanoR_1	359	363	PF00244	0.495
LIG_14-3-3_CanoR_1	396	404	PF00244	0.397
LIG_14-3-3_CanoR_1	461	465	PF00244	0.496
LIG_14-3-3_CanoR_1	6	16	PF00244	0.530
LIG_BIR_III_4	452	456	PF00653	0.462
LIG_BRCT_BRCA1_1	174	178	PF00533	0.481
LIG_BRCT_BRCA1_1	283	287	PF00533	0.378
LIG_CSL_BTD_1	293	296	PF09270	0.378
LIG_CSL_BTD_1	401	404	PF09270	0.436
LIG_CtBP_PxDLS_1	404	408	PF00389	0.381
LIG_EH_1	299	303	PF12763	0.588
LIG_FHA_1	115	121	PF00498	0.396
LIG_FHA_1	222	228	PF00498	0.529
LIG_FHA_1	373	379	PF00498	0.433
LIG_FHA_1	417	423	PF00498	0.436
LIG_FHA_1	457	463	PF00498	0.537
LIG_FHA_1	76	82	PF00498	0.308
LIG_FHA_1	94	100	PF00498	0.408
LIG_FHA_2	248	254	PF00498	0.505
LIG_FHA_2	260	266	PF00498	0.401
LIG_FHA_2	270	276	PF00498	0.482
LIG_FHA_2	447	453	PF00498	0.552
LIG_GBD_Chelix_1	490	498	PF00786	0.283
LIG_Integrin_RGD_1	328	330	PF01839	0.564
LIG_IRF3_LxIS_1	81	87	PF10401	0.335
LIG_LIR_Apic_2	195	200	PF02991	0.466
LIG_LIR_Apic_2	290	296	PF02991	0.378
LIG_LIR_Apic_2	96	101	PF02991	0.376
LIG_LIR_Gen_1	176	187	PF02991	0.525
LIG_LIR_Gen_1	322	331	PF02991	0.410
LIG_LIR_LC3C_4	144	149	PF02991	0.377
LIG_LIR_LC3C_4	488	491	PF02991	0.291
LIG_LIR_Nem_3	175	181	PF02991	0.432
LIG_LIR_Nem_3	230	236	PF02991	0.397
LIG_LIR_Nem_3	265	269	PF02991	0.382
LIG_LIR_Nem_3	275	280	PF02991	0.472
LIG_LIR_Nem_3	320	326	PF02991	0.433
LIG_LIR_Nem_3	333	337	PF02991	0.353
LIG_LYPXL_yS_3	277	280	PF13949	0.499
LIG_MLH1_MIPbox_1	174	178	PF16413	0.481
LIG_NRBOX	19	25	PF00104	0.419
LIG_PAM2_1	47	59	PF00658	0.378
LIG_SH2_PTP2	98	101	PF00017	0.383
LIG_SH2_SRC	464	467	PF00017	0.479
LIG_SH2_STAP1	236	240	PF00017	0.325
LIG_SH2_STAP1	283	287	PF00017	0.433
LIG_SH2_STAP1	464	468	PF00017	0.516
LIG_SH2_STAP1	67	71	PF00017	0.313
LIG_SH2_STAT5	216	219	PF00017	0.408
LIG_SH2_STAT5	233	236	PF00017	0.492
LIG_SH2_STAT5	323	326	PF00017	0.426
LIG_SH2_STAT5	504	507	PF00017	0.730
LIG_SH2_STAT5	98	101	PF00017	0.383
LIG_SH3_3	10	16	PF00018	0.687
LIG_SH3_3	298	304	PF00018	0.492
LIG_SH3_3	438	444	PF00018	0.463
LIG_SUMO_SIM_anti_2	146	152	PF11976	0.369
LIG_SUMO_SIM_anti_2	488	494	PF11976	0.414
LIG_TRAF2_1	403	406	PF00917	0.525
MOD_CK1_1	100	106	PF00069	0.477
MOD_CK1_1	114	120	PF00069	0.452
MOD_CK1_1	249	255	PF00069	0.592
MOD_CK1_1	348	354	PF00069	0.401
MOD_CK1_1	367	373	PF00069	0.510
MOD_CK1_1	425	431	PF00069	0.463
MOD_CK2_1	249	255	PF00069	0.508
MOD_CK2_1	259	265	PF00069	0.413
MOD_CK2_1	348	354	PF00069	0.567
MOD_CK2_1	373	379	PF00069	0.500
MOD_CK2_1	400	406	PF00069	0.636
MOD_CK2_1	58	64	PF00069	0.380
MOD_GlcNHglycan	102	105	PF01048	0.494
MOD_GlcNHglycan	126	129	PF01048	0.404
MOD_GlcNHglycan	131	134	PF01048	0.375
MOD_GlcNHglycan	143	146	PF01048	0.419
MOD_GlcNHglycan	159	162	PF01048	0.455
MOD_GlcNHglycan	190	193	PF01048	0.431
MOD_GlcNHglycan	297	300	PF01048	0.575
MOD_GlcNHglycan	345	348	PF01048	0.426
MOD_GlcNHglycan	350	353	PF01048	0.607
MOD_GlcNHglycan	369	372	PF01048	0.482
MOD_GlcNHglycan	415	419	PF01048	0.592
MOD_GlcNHglycan	424	427	PF01048	0.523
MOD_GlcNHglycan	85	89	PF01048	0.536
MOD_GSK3_1	109	116	PF00069	0.331
MOD_GSK3_1	120	127	PF00069	0.520
MOD_GSK3_1	129	136	PF00069	0.462
MOD_GSK3_1	157	164	PF00069	0.434
MOD_GSK3_1	188	195	PF00069	0.546
MOD_GSK3_1	228	235	PF00069	0.569
MOD_GSK3_1	269	276	PF00069	0.570
MOD_GSK3_1	392	399	PF00069	0.440
MOD_GSK3_1	453	460	PF00069	0.602
MOD_GSK3_1	464	471	PF00069	0.653
MOD_GSK3_1	55	62	PF00069	0.509
MOD_GSK3_1	76	83	PF00069	0.376
MOD_GSK3_1	84	91	PF00069	0.432
MOD_GSK3_1	93	100	PF00069	0.358
MOD_N-GLC_1	227	232	PF02516	0.508
MOD_N-GLC_1	317	322	PF02516	0.696
MOD_NEK2_1	113	118	PF00069	0.474
MOD_NEK2_1	120	125	PF00069	0.455
MOD_NEK2_1	140	145	PF00069	0.501
MOD_NEK2_1	182	187	PF00069	0.519
MOD_NEK2_1	232	237	PF00069	0.403
MOD_NEK2_1	273	278	PF00069	0.453
MOD_NEK2_1	343	348	PF00069	0.432
MOD_NEK2_1	422	427	PF00069	0.696
MOD_NEK2_1	457	462	PF00069	0.682
MOD_NEK2_1	84	89	PF00069	0.432
MOD_NEK2_2	269	274	PF00069	0.398
MOD_NEK2_2	88	93	PF00069	0.351
MOD_PIKK_1	120	126	PF00454	0.414
MOD_PIKK_1	416	422	PF00454	0.497
MOD_PKA_1	259	265	PF00069	0.424
MOD_PKA_2	129	135	PF00069	0.436
MOD_PKA_2	258	264	PF00069	0.423
MOD_PKA_2	358	364	PF00069	0.547
MOD_PKA_2	395	401	PF00069	0.495
MOD_PKA_2	460	466	PF00069	0.617
MOD_Plk_1	209	215	PF00069	0.600
MOD_Plk_1	227	233	PF00069	0.385
MOD_Plk_1	43	49	PF00069	0.334
MOD_Plk_1	464	470	PF00069	0.559
MOD_Plk_4	143	149	PF00069	0.522
MOD_Plk_4	16	22	PF00069	0.678
MOD_Plk_4	173	179	PF00069	0.508
MOD_Plk_4	192	198	PF00069	0.467
MOD_Plk_4	212	218	PF00069	0.497
MOD_Plk_4	228	234	PF00069	0.474
MOD_Plk_4	364	370	PF00069	0.614
MOD_Plk_4	406	412	PF00069	0.418
MOD_Plk_4	43	49	PF00069	0.475
MOD_Plk_4	55	61	PF00069	0.436
MOD_ProDKin_1	218	224	PF00069	0.631
MOD_ProDKin_1	292	298	PF00069	0.573
MOD_ProDKin_1	400	406	PF00069	0.636
MOD_ProDKin_1	59	65	PF00069	0.369
MOD_ProDKin_1	93	99	PF00069	0.474
TRG_DiLeu_BaEn_1	406	411	PF01217	0.419
TRG_ENDOCYTIC_2	277	280	PF00928	0.502
TRG_ENDOCYTIC_2	283	286	PF00928	0.535
TRG_ENDOCYTIC_2	323	326	PF00928	0.593
TRG_ER_diArg_1	340	343	PF00400	0.652

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4Q7	Leptomonas seymouri	34%	93%
A0A3S5H7C0	Leishmania donovani	53%	97%
A4I0D6	Leishmania infantum	53%	97%
E9AW99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	97%
Q4QB79	Leishmania major	53%	100%