Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4HCV4_LEIBR

TriTrypDb:

LbrM.23.0930 , LBRM2903_230017700

Length:

416

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 0
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HCV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCV4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.434
CLV_NRD_NRD_1	134	136	PF00675	0.656
CLV_NRD_NRD_1	140	142	PF00675	0.655
CLV_NRD_NRD_1	243	245	PF00675	0.600
CLV_PCSK_KEX2_1	140	142	PF00082	0.680
CLV_PCSK_KEX2_1	8	10	PF00082	0.595
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.595
CLV_PCSK_SKI1_1	13	17	PF00082	0.636
DEG_APCC_DBOX_1	12	20	PF00400	0.532
DEG_SPOP_SBC_1	219	223	PF00917	0.382
DEG_SPOP_SBC_1	404	408	PF00917	0.676
DOC_CDC14_PxL_1	106	114	PF14671	0.406
DOC_CKS1_1	227	232	PF01111	0.436
DOC_CKS1_1	47	52	PF01111	0.448
DOC_CYCLIN_yCln2_LP_2	20	26	PF00134	0.447
DOC_MAPK_MEF2A_6	13	21	PF00069	0.532
DOC_MAPK_NFAT4_5	13	21	PF00069	0.532
DOC_USP7_MATH_1	100	104	PF00917	0.526
DOC_USP7_MATH_1	364	368	PF00917	0.673
DOC_USP7_MATH_1	51	55	PF00917	0.508
DOC_WW_Pin1_4	19	24	PF00397	0.502
DOC_WW_Pin1_4	226	231	PF00397	0.507
DOC_WW_Pin1_4	29	34	PF00397	0.548
DOC_WW_Pin1_4	369	374	PF00397	0.660
DOC_WW_Pin1_4	46	51	PF00397	0.534
DOC_WW_Pin1_4	65	70	PF00397	0.428
DOC_WW_Pin1_4	77	82	PF00397	0.441
LIG_14-3-3_CanoR_1	135	140	PF00244	0.534
LIG_14-3-3_CanoR_1	155	160	PF00244	0.491
LIG_14-3-3_CanoR_1	299	305	PF00244	0.495
LIG_BRCT_BRCA1_1	53	57	PF00533	0.529
LIG_DLG_GKlike_1	231	238	PF00625	0.372
LIG_eIF4E_1	11	17	PF01652	0.685
LIG_eIF4E_1	185	191	PF01652	0.427
LIG_eIF4E_1	278	284	PF01652	0.390
LIG_FHA_1	12	18	PF00498	0.487
LIG_FHA_1	227	233	PF00498	0.461
LIG_FHA_1	267	273	PF00498	0.410
LIG_FHA_1	285	291	PF00498	0.465
LIG_FHA_1	301	307	PF00498	0.402
LIG_FHA_1	341	347	PF00498	0.366
LIG_FHA_1	73	79	PF00498	0.608
LIG_FHA_1	92	98	PF00498	0.593
LIG_FHA_2	123	129	PF00498	0.428
LIG_FHA_2	366	372	PF00498	0.719
LIG_FHA_2	405	411	PF00498	0.676
LIG_FHA_2	96	102	PF00498	0.501
LIG_LIR_Gen_1	277	285	PF02991	0.391
LIG_LIR_Nem_3	249	254	PF02991	0.352
LIG_LYPXL_yS_3	109	112	PF13949	0.404
LIG_NRBOX	15	21	PF00104	0.531
LIG_PCNA_PIPBox_1	159	168	PF02747	0.449
LIG_PCNA_yPIPBox_3	261	271	PF02747	0.421
LIG_PTB_Apo_2	179	186	PF02174	0.440
LIG_PTB_Phospho_1	179	185	PF10480	0.441
LIG_SH2_CRK	251	255	PF00017	0.342
LIG_SH2_STAP1	11	15	PF00017	0.535
LIG_SH2_STAP1	38	42	PF00017	0.547
LIG_SH2_STAT3	185	188	PF00017	0.479
LIG_SH2_STAT3	40	43	PF00017	0.455
LIG_SH2_STAT5	40	43	PF00017	0.523
LIG_SH3_2	81	86	PF14604	0.467
LIG_SH3_3	224	230	PF00018	0.393
LIG_SH3_3	27	33	PF00018	0.483
LIG_SH3_3	346	352	PF00018	0.276
LIG_SH3_3	39	45	PF00018	0.531
LIG_SH3_3	75	81	PF00018	0.466
LIG_SUMO_SIM_anti_2	14	20	PF11976	0.434
LIG_SUMO_SIM_anti_2	22	28	PF11976	0.455
LIG_SUMO_SIM_anti_2	60	68	PF11976	0.411
LIG_SUMO_SIM_par_1	16	22	PF11976	0.528
LIG_SUMO_SIM_par_1	254	259	PF11976	0.400
LIG_SUMO_SIM_par_1	336	341	PF11976	0.263
LIG_SUMO_SIM_par_1	342	347	PF11976	0.244
LIG_TRAF2_1	407	410	PF00917	0.676
LIG_TYR_ITIM	107	112	PF00017	0.408
MOD_CDK_SPK_2	226	231	PF00069	0.371
MOD_CDK_SPxK_1	65	71	PF00069	0.431
MOD_CK1_1	129	135	PF00069	0.482
MOD_CK1_1	158	164	PF00069	0.444
MOD_CK1_1	201	207	PF00069	0.417
MOD_CK1_1	22	28	PF00069	0.532
MOD_CK1_1	222	228	PF00069	0.427
MOD_CK1_1	266	272	PF00069	0.493
MOD_CK1_1	297	303	PF00069	0.496
MOD_CK2_1	299	305	PF00069	0.426
MOD_CK2_1	365	371	PF00069	0.649
MOD_CK2_1	403	409	PF00069	0.676
MOD_CK2_1	86	92	PF00069	0.492
MOD_CK2_1	95	101	PF00069	0.488
MOD_GlcNHglycan	102	105	PF01048	0.703
MOD_GlcNHglycan	128	131	PF01048	0.635
MOD_GlcNHglycan	191	194	PF01048	0.627
MOD_GlcNHglycan	204	207	PF01048	0.571
MOD_GlcNHglycan	362	365	PF01048	0.427
MOD_GlcNHglycan	51	54	PF01048	0.707
MOD_GlcNHglycan	98	101	PF01048	0.735
MOD_GSK3_1	112	119	PF00069	0.427
MOD_GSK3_1	122	129	PF00069	0.442
MOD_GSK3_1	196	203	PF00069	0.481
MOD_GSK3_1	204	211	PF00069	0.443
MOD_GSK3_1	218	225	PF00069	0.407
MOD_GSK3_1	262	269	PF00069	0.484
MOD_GSK3_1	284	291	PF00069	0.431
MOD_GSK3_1	295	302	PF00069	0.433
MOD_GSK3_1	306	313	PF00069	0.429
MOD_GSK3_1	338	345	PF00069	0.327
MOD_GSK3_1	34	41	PF00069	0.555
MOD_GSK3_1	360	367	PF00069	0.736
MOD_GSK3_1	371	378	PF00069	0.666
MOD_GSK3_1	393	400	PF00069	0.683
MOD_GSK3_1	60	67	PF00069	0.421
MOD_GSK3_1	91	98	PF00069	0.595
MOD_N-GLC_1	181	186	PF02516	0.656
MOD_N-GLC_1	285	290	PF02516	0.663
MOD_N-GLC_1	295	300	PF02516	0.641
MOD_N-GLC_1	375	380	PF02516	0.533
MOD_N-GLC_1	72	77	PF02516	0.658
MOD_NEK2_1	118	123	PF00069	0.435
MOD_NEK2_1	166	171	PF00069	0.505
MOD_NEK2_1	202	207	PF00069	0.438
MOD_NEK2_1	220	225	PF00069	0.418
MOD_NEK2_1	267	272	PF00069	0.434
MOD_NEK2_1	284	289	PF00069	0.464
MOD_NEK2_1	294	299	PF00069	0.439
MOD_NEK2_1	64	69	PF00069	0.458
MOD_PIKK_1	141	147	PF00454	0.508
MOD_PKA_1	135	141	PF00069	0.461
MOD_PKA_1	365	371	PF00069	0.649
MOD_PKA_2	134	140	PF00069	0.500
MOD_PKA_2	311	317	PF00069	0.446
MOD_PKA_2	360	366	PF00069	0.624
MOD_PKB_1	395	403	PF00069	0.671
MOD_Plk_1	100	106	PF00069	0.411
MOD_Plk_1	181	187	PF00069	0.430
MOD_Plk_1	256	262	PF00069	0.505
MOD_Plk_1	288	294	PF00069	0.400
MOD_Plk_1	72	78	PF00069	0.460
MOD_Plk_4	181	187	PF00069	0.362
MOD_Plk_4	204	210	PF00069	0.420
MOD_Plk_4	22	28	PF00069	0.640
MOD_Plk_4	231	237	PF00069	0.374
MOD_Plk_4	263	269	PF00069	0.391
MOD_Plk_4	277	283	PF00069	0.349
MOD_Plk_4	333	339	PF00069	0.276
MOD_Plk_4	51	57	PF00069	0.436
MOD_Plk_4	60	66	PF00069	0.393
MOD_ProDKin_1	19	25	PF00069	0.505
MOD_ProDKin_1	226	232	PF00069	0.504
MOD_ProDKin_1	29	35	PF00069	0.549
MOD_ProDKin_1	369	375	PF00069	0.660
MOD_ProDKin_1	46	52	PF00069	0.532
MOD_ProDKin_1	65	71	PF00069	0.431
MOD_ProDKin_1	77	83	PF00069	0.442
TRG_DiLeu_BaEn_1	60	65	PF01217	0.407
TRG_DiLeu_BaLyEn_6	268	273	PF01217	0.409
TRG_ENDOCYTIC_2	109	112	PF00928	0.423
TRG_ENDOCYTIC_2	251	254	PF00928	0.343
TRG_ENDOCYTIC_2	278	281	PF00928	0.389
TRG_ER_diArg_1	139	141	PF00400	0.465
TRG_ER_diArg_1	154	157	PF00400	0.445
TRG_ER_diArg_1	394	397	PF00400	0.668

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IM39	Leishmania donovani	44%	99%
A4I0D5	Leishmania infantum	44%	99%