SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HCV2_LEIBR

TriTrypDb:

LbrM.23.0910 , LBRM2903_230019900

Length:

466

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HCV2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCV2

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	1
GO:0042054	histone methyltransferase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	391	395	PF00656	0.474
CLV_PCSK_SKI1_1	278	282	PF00082	0.374
CLV_PCSK_SKI1_1	32	36	PF00082	0.464
CLV_PCSK_SKI1_1	445	449	PF00082	0.426
DEG_Nend_UBRbox_2	1	3	PF02207	0.487
DOC_CKS1_1	249	254	PF01111	0.435
DOC_CKS1_1	63	68	PF01111	0.393
DOC_CYCLIN_RxL_1	275	283	PF00134	0.521
DOC_CYCLIN_yCln2_LP_2	63	69	PF00134	0.415
DOC_PP1_RVXF_1	188	195	PF00149	0.315
DOC_USP7_MATH_1	170	174	PF00917	0.661
DOC_USP7_MATH_1	178	182	PF00917	0.496
DOC_USP7_MATH_1	227	231	PF00917	0.548
DOC_USP7_MATH_1	269	273	PF00917	0.424
DOC_USP7_MATH_1	359	363	PF00917	0.533
DOC_USP7_MATH_1	36	40	PF00917	0.412
DOC_USP7_MATH_1	51	55	PF00917	0.264
DOC_USP7_MATH_1	56	60	PF00917	0.270
DOC_USP7_MATH_1	90	94	PF00917	0.687
DOC_WW_Pin1_4	174	179	PF00397	0.510
DOC_WW_Pin1_4	248	253	PF00397	0.434
DOC_WW_Pin1_4	255	260	PF00397	0.446
DOC_WW_Pin1_4	357	362	PF00397	0.451
DOC_WW_Pin1_4	54	59	PF00397	0.498
DOC_WW_Pin1_4	62	67	PF00397	0.559
LIG_14-3-3_CanoR_1	105	111	PF00244	0.503
LIG_14-3-3_CanoR_1	134	143	PF00244	0.323
LIG_14-3-3_CanoR_1	198	202	PF00244	0.411
LIG_14-3-3_CanoR_1	302	306	PF00244	0.374
LIG_14-3-3_CanoR_1	73	79	PF00244	0.397
LIG_Actin_WH2_2	386	404	PF00022	0.478
LIG_BRCT_BRCA1_1	63	67	PF00533	0.402
LIG_Clathr_ClatBox_1	328	332	PF01394	0.238
LIG_FHA_1	169	175	PF00498	0.571
LIG_FHA_1	230	236	PF00498	0.668
LIG_FHA_1	245	251	PF00498	0.474
LIG_FHA_1	35	41	PF00498	0.438
LIG_FHA_1	394	400	PF00498	0.477
LIG_FHA_1	402	408	PF00498	0.477
LIG_FHA_1	96	102	PF00498	0.567
LIG_FHA_2	177	183	PF00498	0.531
LIG_FHA_2	25	31	PF00498	0.559
LIG_LIR_Apic_2	54	58	PF02991	0.369
LIG_LIR_Gen_1	240	250	PF02991	0.400
LIG_LIR_Gen_1	251	260	PF02991	0.326
LIG_LIR_Gen_1	330	338	PF02991	0.322
LIG_LIR_Gen_1	350	359	PF02991	0.544
LIG_LIR_Gen_1	362	371	PF02991	0.449
LIG_LIR_Gen_1	42	52	PF02991	0.397
LIG_LIR_Nem_3	240	246	PF02991	0.395
LIG_LIR_Nem_3	251	256	PF02991	0.302
LIG_LIR_Nem_3	264	268	PF02991	0.404
LIG_LIR_Nem_3	330	334	PF02991	0.508
LIG_LIR_Nem_3	350	354	PF02991	0.470
LIG_LIR_Nem_3	362	367	PF02991	0.493
LIG_LIR_Nem_3	414	420	PF02991	0.441
LIG_LIR_Nem_3	42	47	PF02991	0.403
LIG_NRBOX	276	282	PF00104	0.512
LIG_NRBOX	372	378	PF00104	0.535
LIG_PAM2_1	357	369	PF00658	0.334
LIG_PCNA_PIPBox_1	431	440	PF02747	0.439
LIG_PCNA_yPIPBox_3	427	438	PF02747	0.424
LIG_PTB_Apo_2	433	440	PF02174	0.493
LIG_SH2_CRK	374	378	PF00017	0.535
LIG_SH2_PTP2	351	354	PF00017	0.471
LIG_SH2_PTP2	417	420	PF00017	0.370
LIG_SH2_STAP1	374	378	PF00017	0.467
LIG_SH2_STAT3	217	220	PF00017	0.425
LIG_SH2_STAT5	119	122	PF00017	0.393
LIG_SH2_STAT5	217	220	PF00017	0.355
LIG_SH2_STAT5	351	354	PF00017	0.554
LIG_SH2_STAT5	417	420	PF00017	0.355
LIG_SH2_STAT5	437	440	PF00017	0.382
LIG_SH3_3	158	164	PF00018	0.673
LIG_SH3_3	246	252	PF00018	0.351
LIG_SH3_3	254	260	PF00018	0.362
LIG_SH3_3	310	316	PF00018	0.615
LIG_SH3_3	349	355	PF00018	0.467
LIG_SH3_3	50	56	PF00018	0.328
LIG_SUMO_SIM_par_1	411	416	PF11976	0.493
LIG_SUMO_SIM_par_1	59	65	PF11976	0.416
LIG_TRFH_1	351	355	PF08558	0.481
LIG_TYR_ITIM	415	420	PF00017	0.499
LIG_WRC_WIRS_1	328	333	PF05994	0.404
MOD_CDK_SPxxK_3	248	255	PF00069	0.278
MOD_CK1_1	166	172	PF00069	0.756
MOD_CK1_1	173	179	PF00069	0.687
MOD_CK1_1	181	187	PF00069	0.381
MOD_CK1_1	237	243	PF00069	0.553
MOD_CK1_1	293	299	PF00069	0.564
MOD_CK1_1	330	336	PF00069	0.460
MOD_CK1_1	54	60	PF00069	0.408
MOD_CK1_1	93	99	PF00069	0.743
MOD_CK2_1	151	157	PF00069	0.503
MOD_CK2_1	176	182	PF00069	0.560
MOD_CK2_1	24	30	PF00069	0.521
MOD_CK2_1	295	301	PF00069	0.478
MOD_CK2_1	36	42	PF00069	0.473
MOD_CK2_1	423	429	PF00069	0.463
MOD_CK2_1	81	87	PF00069	0.696
MOD_GlcNHglycan	149	152	PF01048	0.705
MOD_GlcNHglycan	153	156	PF01048	0.739
MOD_GlcNHglycan	168	171	PF01048	0.771
MOD_GlcNHglycan	229	232	PF01048	0.675
MOD_GlcNHglycan	27	30	PF01048	0.489
MOD_GlcNHglycan	292	295	PF01048	0.414
MOD_GlcNHglycan	297	300	PF01048	0.435
MOD_GlcNHglycan	361	364	PF01048	0.484
MOD_GlcNHglycan	420	423	PF01048	0.527
MOD_GlcNHglycan	98	101	PF01048	0.692
MOD_GSK3_1	115	122	PF00069	0.352
MOD_GSK3_1	147	154	PF00069	0.695
MOD_GSK3_1	159	166	PF00069	0.749
MOD_GSK3_1	168	175	PF00069	0.655
MOD_GSK3_1	177	184	PF00069	0.385
MOD_GSK3_1	244	251	PF00069	0.447
MOD_GSK3_1	73	80	PF00069	0.424
MOD_GSK3_1	88	95	PF00069	0.614
MOD_N-GLC_1	380	385	PF02516	0.231
MOD_NEK2_1	135	140	PF00069	0.527
MOD_NEK2_1	290	295	PF00069	0.378
MOD_NEK2_1	380	385	PF00069	0.473
MOD_NEK2_1	401	406	PF00069	0.485
MOD_NEK2_1	413	418	PF00069	0.405
MOD_NEK2_1	61	66	PF00069	0.448
MOD_NEK2_1	72	77	PF00069	0.444
MOD_NEK2_2	36	41	PF00069	0.417
MOD_NEK2_2	437	442	PF00069	0.375
MOD_OFUCOSY	379	384	PF10250	0.278
MOD_PIKK_1	244	250	PF00454	0.504
MOD_PKA_2	197	203	PF00069	0.418
MOD_PKA_2	301	307	PF00069	0.446
MOD_PKA_2	72	78	PF00069	0.551
MOD_Plk_1	181	187	PF00069	0.452
MOD_Plk_1	380	386	PF00069	0.522
MOD_Plk_4	115	121	PF00069	0.361
MOD_Plk_4	269	275	PF00069	0.402
MOD_Plk_4	372	378	PF00069	0.482
MOD_Plk_4	56	62	PF00069	0.458
MOD_ProDKin_1	174	180	PF00069	0.503
MOD_ProDKin_1	248	254	PF00069	0.443
MOD_ProDKin_1	255	261	PF00069	0.456
MOD_ProDKin_1	357	363	PF00069	0.446
MOD_ProDKin_1	54	60	PF00069	0.496
MOD_ProDKin_1	62	68	PF00069	0.550
MOD_SUMO_rev_2	28	34	PF00179	0.427
TRG_DiLeu_BaEn_1	42	47	PF01217	0.269
TRG_DiLeu_BaLyEn_6	131	136	PF01217	0.424
TRG_ENDOCYTIC_2	243	246	PF00928	0.387
TRG_ENDOCYTIC_2	351	354	PF00928	0.381
TRG_ENDOCYTIC_2	374	377	PF00928	0.541
TRG_ENDOCYTIC_2	417	420	PF00928	0.419
TRG_NES_CRM1_1	10	23	PF08389	0.482
TRG_Pf-PMV_PEXEL_1	278	283	PF00026	0.368
TRG_Pf-PMV_PEXEL_1	335	340	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	445	449	PF00026	0.375

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL96	Leptomonas seymouri	52%	100%
A0A0S4IN59	Bodo saltans	31%	100%
A0A1X0NWW3	Trypanosomatidae	36%	100%
A0A3Q8IBR8	Leishmania donovani	78%	100%
A0A422N8X4	Trypanosoma rangeli	36%	100%
A4I0D3	Leishmania infantum	78%	100%
C9ZV37	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AW97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	91%
Q4QB81	Leishmania major	77%	100%
V5BBM7	Trypanosoma cruzi	36%	100%