Actin interacting protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

actin interacting protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4HCV1_LEIBR

TriTrypDb:

LbrM.23.0900 , LBRM2903_230019800

Length:

524

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HCV1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCV1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0050660	flavin adenine dinucleotide binding	4	11
GO:0071949	FAD binding	5	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0008762	UDP-N-acetylmuramate dehydrogenase activity	5	1
GO:0016491	oxidoreductase activity	2	1
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	1
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	280	284	PF00656	0.284
CLV_C14_Caspase3-7	447	451	PF00656	0.329
CLV_NRD_NRD_1	211	213	PF00675	0.393
CLV_NRD_NRD_1	42	44	PF00675	0.480
CLV_PCSK_KEX2_1	478	480	PF00082	0.392
CLV_PCSK_KEX2_1	498	500	PF00082	0.128
CLV_PCSK_PC1ET2_1	478	480	PF00082	0.408
CLV_PCSK_PC1ET2_1	498	500	PF00082	0.128
CLV_PCSK_SKI1_1	221	225	PF00082	0.332
CLV_PCSK_SKI1_1	407	411	PF00082	0.329
CLV_PCSK_SKI1_1	46	50	PF00082	0.430
DEG_MDM2_SWIB_1	57	65	PF02201	0.404
DEG_SPOP_SBC_1	37	41	PF00917	0.398
DOC_CYCLIN_yCln2_LP_2	155	161	PF00134	0.303
DOC_MAPK_gen_1	478	484	PF00069	0.284
DOC_MAPK_gen_1	486	495	PF00069	0.284
DOC_MAPK_MEF2A_6	374	381	PF00069	0.331
DOC_MAPK_MEF2A_6	486	495	PF00069	0.194
DOC_MAPK_NFAT4_5	488	496	PF00069	0.194
DOC_USP7_MATH_1	126	130	PF00917	0.364
DOC_USP7_MATH_1	364	368	PF00917	0.194
DOC_USP7_UBL2_3	21	25	PF12436	0.420
DOC_WW_Pin1_4	1	6	PF00397	0.576
DOC_WW_Pin1_4	13	18	PF00397	0.520
DOC_WW_Pin1_4	287	292	PF00397	0.305
DOC_WW_Pin1_4	66	71	PF00397	0.415
LIG_BRCT_BRCA1_1	15	19	PF00533	0.504
LIG_BRCT_BRCA1_2	15	21	PF00533	0.504
LIG_eIF4E_1	218	224	PF01652	0.358
LIG_FHA_1	100	106	PF00498	0.284
LIG_FHA_1	130	136	PF00498	0.389
LIG_FHA_1	228	234	PF00498	0.314
LIG_FHA_1	404	410	PF00498	0.408
LIG_FHA_1	49	55	PF00498	0.581
LIG_FHA_1	67	73	PF00498	0.234
LIG_FHA_1	76	82	PF00498	0.235
LIG_FHA_2	2	8	PF00498	0.551
LIG_FHA_2	442	448	PF00498	0.194
LIG_FHA_2	47	53	PF00498	0.442
LIG_IBAR_NPY_1	508	510	PF08397	0.284
LIG_LIR_Gen_1	16	27	PF02991	0.454
LIG_LIR_Gen_1	257	265	PF02991	0.275
LIG_LIR_Gen_1	277	287	PF02991	0.227
LIG_LIR_Gen_1	329	339	PF02991	0.277
LIG_LIR_Gen_1	397	404	PF02991	0.212
LIG_LIR_Nem_3	16	22	PF02991	0.459
LIG_LIR_Nem_3	257	261	PF02991	0.287
LIG_LIR_Nem_3	329	335	PF02991	0.347
LIG_LIR_Nem_3	397	403	PF02991	0.303
LIG_LIR_Nem_3	480	484	PF02991	0.362
LIG_LYPXL_S_1	453	457	PF13949	0.408
LIG_LYPXL_yS_3	454	457	PF13949	0.408
LIG_Pex14_2	57	61	PF04695	0.401
LIG_SH2_CRK	510	514	PF00017	0.362
LIG_SH2_NCK_1	400	404	PF00017	0.298
LIG_SH2_SRC	356	359	PF00017	0.387
LIG_SH2_STAP1	390	394	PF00017	0.383
LIG_SH2_STAP1	458	462	PF00017	0.284
LIG_SH2_STAT5	29	32	PF00017	0.373
LIG_SH2_STAT5	316	319	PF00017	0.303
LIG_SH2_STAT5	460	463	PF00017	0.411
LIG_SH2_STAT5	481	484	PF00017	0.329
LIG_SH2_STAT5	87	90	PF00017	0.284
LIG_SH3_3	389	395	PF00018	0.303
LIG_SH3_3	497	503	PF00018	0.329
LIG_SH3_3	509	515	PF00018	0.251
LIG_SH3_3	69	75	PF00018	0.303
LIG_SUMO_SIM_anti_2	419	425	PF11976	0.283
LIG_SUMO_SIM_anti_2	91	97	PF11976	0.354
LIG_SUMO_SIM_par_1	437	442	PF11976	0.408
LIG_UBA3_1	155	164	PF00899	0.327
LIG_UBA3_1	207	213	PF00899	0.390
LIG_UBA3_1	252	256	PF00899	0.360
LIG_UBA3_1	493	498	PF00899	0.212
MOD_CDC14_SPxK_1	290	293	PF00782	0.411
MOD_CDK_SPxK_1	287	293	PF00069	0.408
MOD_CDK_SPxxK_3	1	8	PF00069	0.567
MOD_CK1_1	129	135	PF00069	0.289
MOD_CK1_1	163	169	PF00069	0.298
MOD_CK1_1	187	193	PF00069	0.366
MOD_CK1_1	227	233	PF00069	0.301
MOD_CK1_1	286	292	PF00069	0.411
MOD_CK1_1	32	38	PF00069	0.370
MOD_CK1_1	99	105	PF00069	0.408
MOD_CK2_1	1	7	PF00069	0.574
MOD_CK2_1	257	263	PF00069	0.318
MOD_CK2_1	274	280	PF00069	0.231
MOD_CK2_1	398	404	PF00069	0.194
MOD_CK2_1	46	52	PF00069	0.347
MOD_GlcNHglycan	107	110	PF01048	0.274
MOD_GlcNHglycan	138	141	PF01048	0.354
MOD_GlcNHglycan	165	168	PF01048	0.219
MOD_GlcNHglycan	276	279	PF01048	0.284
MOD_GlcNHglycan	350	353	PF01048	0.446
MOD_GlcNHglycan	362	365	PF01048	0.344
MOD_GlcNHglycan	468	471	PF01048	0.288
MOD_GlcNHglycan	98	101	PF01048	0.358
MOD_GSK3_1	283	290	PF00069	0.303
MOD_GSK3_1	32	39	PF00069	0.463
MOD_GSK3_1	360	367	PF00069	0.283
MOD_GSK3_1	75	82	PF00069	0.216
MOD_N-GLC_1	171	176	PF02516	0.408
MOD_NEK2_1	115	120	PF00069	0.408
MOD_NEK2_1	160	165	PF00069	0.411
MOD_NEK2_1	207	212	PF00069	0.397
MOD_NEK2_1	267	272	PF00069	0.342
MOD_NEK2_1	320	325	PF00069	0.286
MOD_NEK2_1	360	365	PF00069	0.322
MOD_NEK2_1	441	446	PF00069	0.408
MOD_NEK2_1	482	487	PF00069	0.284
MOD_NEK2_2	297	302	PF00069	0.194
MOD_PIKK_1	358	364	PF00454	0.284
MOD_PIKK_1	38	44	PF00454	0.387
MOD_PK_1	398	404	PF00069	0.194
MOD_Plk_1	390	396	PF00069	0.284
MOD_Plk_2-3	257	263	PF00069	0.328
MOD_Plk_4	131	137	PF00069	0.194
MOD_Plk_4	257	263	PF00069	0.329
MOD_Plk_4	29	35	PF00069	0.377
MOD_Plk_4	398	404	PF00069	0.357
MOD_ProDKin_1	1	7	PF00069	0.574
MOD_ProDKin_1	13	19	PF00069	0.510
MOD_ProDKin_1	287	293	PF00069	0.305
MOD_ProDKin_1	66	72	PF00069	0.411
MOD_SUMO_rev_2	214	223	PF00179	0.377
TRG_DiLeu_BaEn_1	489	494	PF01217	0.329
TRG_ENDOCYTIC_2	185	188	PF00928	0.284
TRG_ENDOCYTIC_2	356	359	PF00928	0.387
TRG_ENDOCYTIC_2	400	403	PF00928	0.284
TRG_ENDOCYTIC_2	426	429	PF00928	0.284
TRG_ENDOCYTIC_2	454	457	PF00928	0.408
TRG_ENDOCYTIC_2	481	484	PF00928	0.303
TRG_ENDOCYTIC_2	510	513	PF00928	0.284

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Q0	Leptomonas seymouri	81%	100%
A0A0N1PE88	Leptomonas seymouri	25%	100%
A0A0N1PEY1	Leptomonas seymouri	21%	84%
A0A0S4IT80	Bodo saltans	50%	100%
A0A0S4JD99	Bodo saltans	25%	100%
A0A1X0NXE7	Trypanosomatidae	66%	100%
A0A1X0P026	Trypanosomatidae	25%	100%
A0A3Q8IDH3	Leishmania donovani	26%	100%
A0A3Q8IDH5	Leishmania donovani	25%	100%
A0A3Q8IEJ5	Leishmania donovani	87%	100%
A0A422N8Z9	Trypanosoma rangeli	67%	100%
A1L258	Danio rerio	41%	98%
A4HFX9	Leishmania braziliensis	26%	100%
A4I0D2	Leishmania infantum	87%	100%
A4I309	Leishmania infantum	25%	100%
A4I481	Leishmania infantum	26%	100%
A4VGK4	Pseudomonas stutzeri (strain A1501)	35%	100%
B8B7X6	Oryza sativa subsp. indica	41%	94%
D4MUV9	Anaerostipes hadrus	29%	100%
E9ADI2	Leishmania major	25%	100%
E9ADN0	Leishmania major	25%	100%
E9AM50	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AW96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9AZA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
F1QXM5	Danio rerio	27%	100%
H6LBS1	Acetobacterium woodii (strain ATCC 29683 / DSM 1030 / JCM 2381 / KCTC 1655 / WB1)	28%	100%
O00116	Homo sapiens	25%	80%
O23240	Arabidopsis thaliana	41%	94%
O29853	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	29%	100%
O45218	Caenorhabditis elegans	23%	88%
O96759	Dictyostelium discoideum	22%	86%
P0AEP9	Escherichia coli (strain K12)	27%	100%
P0AEQ0	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	27%	100%
P0DV35	Xanthomonas citri pv. viticola (strain LMG 965 / NCPPB 2475 / ICMP 3867 / CFBP 7660)	32%	100%
P32891	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	89%
P39976	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	100%
P46681	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	99%
P84850	Rattus norvegicus	39%	98%
P94535	Bacillus subtilis (strain 168)	29%	100%
P97275	Cavia porcellus	24%	80%
P9WIT0	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	27%	100%
P9WIT1	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	27%	100%
Q12627	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	27%	91%
Q1JPD3	Bos taurus	41%	96%
Q4QB82	Leishmania major	86%	100%
Q7TNG8	Mus musculus	26%	100%
Q7XI14	Oryza sativa subsp. japonica	41%	94%
Q86WU2	Homo sapiens	25%	100%
Q8C0I1	Mus musculus	24%	81%
Q8CIM3	Mus musculus	40%	98%
Q8N465	Homo sapiens	42%	100%
Q94AX4	Arabidopsis thaliana	27%	92%
Q9C1X2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	100%
Q9EQR2	Rattus norvegicus	23%	81%
Q9V778	Drosophila melanogaster	22%	83%
V5D7M3	Trypanosoma cruzi	67%	100%