Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HCV0_LEIBR

TriTrypDb:

LbrM.23.0890 , LBRM2903_230019700

Length:

212

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HCV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCV0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	83	85	PF00675	0.370
CLV_PCSK_KEX2_1	162	164	PF00082	0.602
CLV_PCSK_KEX2_1	61	63	PF00082	0.454
CLV_PCSK_KEX2_1	83	85	PF00082	0.368
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.564
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.424
CLV_PCSK_SKI1_1	182	186	PF00082	0.520
DEG_APCC_DBOX_1	181	189	PF00400	0.287
DOC_MAPK_gen_1	179	187	PF00069	0.291
DOC_PP2B_LxvP_1	93	96	PF13499	0.248
DOC_PP4_FxxP_1	177	180	PF00568	0.404
DOC_USP7_MATH_1	12	16	PF00917	0.734
DOC_USP7_MATH_1	206	210	PF00917	0.443
DOC_USP7_UBL2_3	38	42	PF12436	0.639
DOC_WW_Pin1_4	129	134	PF00397	0.368
LIG_14-3-3_CanoR_1	171	180	PF00244	0.361
LIG_14-3-3_CanoR_1	199	206	PF00244	0.346
LIG_14-3-3_CanoR_1	88	96	PF00244	0.528
LIG_BIR_II_1	1	5	PF00653	0.622
LIG_Clathr_ClatBox_1	187	191	PF01394	0.344
LIG_FHA_1	143	149	PF00498	0.455
LIG_FHA_1	88	94	PF00498	0.484
LIG_LIR_Apic_2	175	180	PF02991	0.404
LIG_NRBOX	121	127	PF00104	0.390
LIG_SH2_STAP1	138	142	PF00017	0.473
LIG_SH2_STAP1	165	169	PF00017	0.390
LIG_SH2_STAP1	89	93	PF00017	0.338
LIG_SH2_STAT5	86	89	PF00017	0.554
LIG_SH3_3	200	206	PF00018	0.453
LIG_UBA3_1	187	195	PF00899	0.319
MOD_CDK_SPK_2	129	134	PF00069	0.368
MOD_CDK_SPxxK_3	129	136	PF00069	0.391
MOD_CK1_1	132	138	PF00069	0.381
MOD_CK1_1	22	28	PF00069	0.751
MOD_CK2_1	172	178	PF00069	0.368
MOD_CK2_1	50	56	PF00069	0.606
MOD_CK2_1	63	69	PF00069	0.605
MOD_GlcNHglycan	174	177	PF01048	0.616
MOD_GSK3_1	128	135	PF00069	0.388
MOD_GSK3_1	22	29	PF00069	0.712
MOD_GSK3_1	87	94	PF00069	0.484
MOD_NEK2_1	100	105	PF00069	0.292
MOD_NEK2_1	170	175	PF00069	0.426
MOD_NEK2_1	50	55	PF00069	0.581
MOD_PKA_2	170	176	PF00069	0.400
MOD_PKA_2	178	184	PF00069	0.387
MOD_PKA_2	19	25	PF00069	0.638
MOD_PKA_2	198	204	PF00069	0.294
MOD_PKA_2	2	8	PF00069	0.775
MOD_PKA_2	50	56	PF00069	0.594
MOD_PKA_2	63	69	PF00069	0.669
MOD_PKA_2	87	93	PF00069	0.484
MOD_Plk_2-3	52	58	PF00069	0.586
MOD_Plk_2-3	63	69	PF00069	0.583
MOD_ProDKin_1	129	135	PF00069	0.366
TRG_ENDOCYTIC_2	89	92	PF00928	0.278
TRG_ER_diArg_1	18	21	PF00400	0.604
TRG_ER_diArg_1	82	84	PF00400	0.621
TRG_NLS_MonoExtC_3	39	44	PF00514	0.598
TRG_NLS_MonoExtN_4	38	44	PF00514	0.601

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P744	Leptomonas seymouri	65%	87%
A0A0S4IT91	Bodo saltans	46%	76%
C9ZV39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	89%
E9AW95	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	91%
Q4QB83	Leishmania major	76%	100%