DUF676 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative serine esterase (DUF676), putative

Species:

Leishmania braziliensis

UniProt:

A4HCU8_LEIBR

TriTrypDb:

LbrM.23.0870 , LBRM2903_230019200

Length:

915

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HCU8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCU8

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0051536	iron-sulfur cluster binding	3	2
GO:0051537	2 iron, 2 sulfur cluster binding	4	2
GO:0051540	metal cluster binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	214	218	PF00656	0.616
CLV_C14_Caspase3-7	232	236	PF00656	0.627
CLV_C14_Caspase3-7	36	40	PF00656	0.657
CLV_C14_Caspase3-7	691	695	PF00656	0.674
CLV_NRD_NRD_1	245	247	PF00675	0.452
CLV_NRD_NRD_1	295	297	PF00675	0.362
CLV_NRD_NRD_1	319	321	PF00675	0.312
CLV_NRD_NRD_1	327	329	PF00675	0.312
CLV_NRD_NRD_1	452	454	PF00675	0.388
CLV_NRD_NRD_1	468	470	PF00675	0.183
CLV_NRD_NRD_1	648	650	PF00675	0.562
CLV_NRD_NRD_1	763	765	PF00675	0.586
CLV_NRD_NRD_1	856	858	PF00675	0.523
CLV_PCSK_FUR_1	243	247	PF00082	0.380
CLV_PCSK_KEX2_1	105	107	PF00082	0.480
CLV_PCSK_KEX2_1	21	23	PF00082	0.513
CLV_PCSK_KEX2_1	245	247	PF00082	0.452
CLV_PCSK_KEX2_1	295	297	PF00082	0.395
CLV_PCSK_KEX2_1	319	321	PF00082	0.312
CLV_PCSK_KEX2_1	452	454	PF00082	0.505
CLV_PCSK_KEX2_1	467	469	PF00082	0.193
CLV_PCSK_KEX2_1	763	765	PF00082	0.586
CLV_PCSK_KEX2_1	856	858	PF00082	0.523
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.480
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.513
CLV_PCSK_PC7_1	448	454	PF00082	0.376
CLV_PCSK_SKI1_1	153	157	PF00082	0.523
CLV_PCSK_SKI1_1	295	299	PF00082	0.356
CLV_PCSK_SKI1_1	3	7	PF00082	0.473
CLV_PCSK_SKI1_1	363	367	PF00082	0.388
CLV_PCSK_SKI1_1	452	456	PF00082	0.388
CLV_PCSK_SKI1_1	468	472	PF00082	0.183
CLV_PCSK_SKI1_1	477	481	PF00082	0.312
CLV_PCSK_SKI1_1	523	527	PF00082	0.648
CLV_PCSK_SKI1_1	880	884	PF00082	0.439
DEG_APCC_DBOX_1	294	302	PF00400	0.376
DEG_APCC_DBOX_1	362	370	PF00400	0.312
DEG_APCC_DBOX_1	390	398	PF00400	0.312
DEG_Nend_Nbox_1	1	3	PF02207	0.549
DEG_SPOP_SBC_1	10	14	PF00917	0.450
DEG_SPOP_SBC_1	31	35	PF00917	0.467
DEG_SPOP_SBC_1	617	621	PF00917	0.719
DEG_SPOP_SBC_1	642	646	PF00917	0.695
DOC_ANK_TNKS_1	212	219	PF00023	0.533
DOC_CKS1_1	407	412	PF01111	0.312
DOC_CKS1_1	592	597	PF01111	0.523
DOC_CKS1_1	755	760	PF01111	0.600
DOC_CYCLIN_RxL_1	448	457	PF00134	0.387
DOC_CYCLIN_RxL_1	466	475	PF00134	0.312
DOC_CYCLIN_yCln2_LP_2	418	424	PF00134	0.312
DOC_CYCLIN_yCln2_LP_2	592	598	PF00134	0.523
DOC_MAPK_gen_1	391	399	PF00069	0.312
DOC_MAPK_gen_1	668	675	PF00069	0.535
DOC_MAPK_HePTP_8	450	462	PF00069	0.302
DOC_MAPK_MEF2A_6	363	370	PF00069	0.312
DOC_MAPK_MEF2A_6	393	401	PF00069	0.444
DOC_MAPK_MEF2A_6	453	462	PF00069	0.312
DOC_MAPK_NFAT4_5	363	371	PF00069	0.312
DOC_PP1_RVXF_1	466	473	PF00149	0.312
DOC_PP1_RVXF_1	779	786	PF00149	0.442
DOC_PP1_RVXF_1	867	873	PF00149	0.348
DOC_PP4_MxPP_1	756	759	PF00568	0.526
DOC_USP7_MATH_1	138	142	PF00917	0.656
DOC_USP7_MATH_1	237	241	PF00917	0.457
DOC_USP7_MATH_1	31	35	PF00917	0.576
DOC_USP7_MATH_1	37	41	PF00917	0.617
DOC_USP7_MATH_1	513	517	PF00917	0.418
DOC_USP7_MATH_1	569	573	PF00917	0.547
DOC_USP7_MATH_1	583	587	PF00917	0.684
DOC_USP7_MATH_1	617	621	PF00917	0.735
DOC_USP7_MATH_1	696	700	PF00917	0.629
DOC_USP7_MATH_1	712	716	PF00917	0.498
DOC_USP7_MATH_1	759	763	PF00917	0.520
DOC_USP7_MATH_1	765	769	PF00917	0.491
DOC_USP7_MATH_1	95	99	PF00917	0.474
DOC_WW_Pin1_4	115	120	PF00397	0.741
DOC_WW_Pin1_4	12	17	PF00397	0.508
DOC_WW_Pin1_4	155	160	PF00397	0.556
DOC_WW_Pin1_4	274	279	PF00397	0.391
DOC_WW_Pin1_4	406	411	PF00397	0.312
DOC_WW_Pin1_4	591	596	PF00397	0.602
DOC_WW_Pin1_4	609	614	PF00397	0.621
DOC_WW_Pin1_4	627	632	PF00397	0.731
DOC_WW_Pin1_4	636	641	PF00397	0.664
DOC_WW_Pin1_4	689	694	PF00397	0.531
DOC_WW_Pin1_4	726	731	PF00397	0.670
DOC_WW_Pin1_4	754	759	PF00397	0.701
DOC_WW_Pin1_4	797	802	PF00397	0.765
DOC_WW_Pin1_4	835	840	PF00397	0.583
DOC_WW_Pin1_4	897	902	PF00397	0.479
LIG_14-3-3_CanoR_1	153	159	PF00244	0.642
LIG_14-3-3_CanoR_1	337	345	PF00244	0.316
LIG_14-3-3_CanoR_1	396	402	PF00244	0.239
LIG_14-3-3_CanoR_1	556	561	PF00244	0.633
LIG_14-3-3_CanoR_1	614	623	PF00244	0.635
LIG_14-3-3_CanoR_1	668	674	PF00244	0.666
LIG_14-3-3_CanoR_1	713	719	PF00244	0.585
LIG_14-3-3_CanoR_1	764	770	PF00244	0.579
LIG_14-3-3_CanoR_1	774	783	PF00244	0.557
LIG_14-3-3_CanoR_1	867	873	PF00244	0.619
LIG_BRCT_BRCA1_1	486	490	PF00533	0.448
LIG_BRCT_BRCA1_1	619	623	PF00533	0.543
LIG_CSL_BTD_1	418	421	PF09270	0.312
LIG_deltaCOP1_diTrp_1	416	424	PF00928	0.312
LIG_eIF4E_1	560	566	PF01652	0.499
LIG_FHA_1	116	122	PF00498	0.541
LIG_FHA_1	250	256	PF00498	0.395
LIG_FHA_1	483	489	PF00498	0.312
LIG_FHA_1	496	502	PF00498	0.524
LIG_FHA_1	516	522	PF00498	0.383
LIG_FHA_1	557	563	PF00498	0.427
LIG_FHA_1	628	634	PF00498	0.637
LIG_FHA_1	670	676	PF00498	0.728
LIG_FHA_1	698	704	PF00498	0.595
LIG_FHA_1	804	810	PF00498	0.679
LIG_FHA_1	87	93	PF00498	0.381
LIG_FHA_2	13	19	PF00498	0.452
LIG_FHA_2	305	311	PF00498	0.307
LIG_FHA_2	435	441	PF00498	0.346
LIG_FHA_2	473	479	PF00498	0.312
LIG_FHA_2	559	565	PF00498	0.448
LIG_GBD_Chelix_1	862	870	PF00786	0.439
LIG_LIR_Apic_2	176	182	PF02991	0.566
LIG_LIR_Gen_1	364	374	PF02991	0.312
LIG_LIR_Gen_1	400	408	PF02991	0.321
LIG_LIR_Gen_1	437	446	PF02991	0.348
LIG_LIR_Gen_1	487	496	PF02991	0.491
LIG_LIR_Gen_1	52	58	PF02991	0.366
LIG_LIR_Gen_1	69	78	PF02991	0.378
LIG_LIR_Nem_3	18	23	PF02991	0.432
LIG_LIR_Nem_3	356	360	PF02991	0.312
LIG_LIR_Nem_3	364	370	PF02991	0.312
LIG_LIR_Nem_3	400	404	PF02991	0.357
LIG_LIR_Nem_3	416	422	PF02991	0.331
LIG_LIR_Nem_3	437	441	PF02991	0.348
LIG_LIR_Nem_3	478	483	PF02991	0.317
LIG_LIR_Nem_3	487	493	PF02991	0.534
LIG_LIR_Nem_3	498	503	PF02991	0.450
LIG_LIR_Nem_3	52	57	PF02991	0.367
LIG_LIR_Nem_3	69	73	PF02991	0.390
LIG_LIR_Nem_3	76	81	PF02991	0.372
LIG_NRBOX	365	371	PF00104	0.388
LIG_PDZ_Class_2	910	915	PF00595	0.485
LIG_Pex14_1	419	423	PF04695	0.312
LIG_PTB_Apo_2	779	786	PF02174	0.442
LIG_PTB_Apo_2	890	897	PF02174	0.465
LIG_REV1ctd_RIR_1	894	900	PF16727	0.428
LIG_SH2_CRK	54	58	PF00017	0.342
LIG_SH2_NCK_1	122	126	PF00017	0.532
LIG_SH2_PTP2	179	182	PF00017	0.531
LIG_SH2_STAP1	326	330	PF00017	0.312
LIG_SH2_STAP1	438	442	PF00017	0.312
LIG_SH2_STAT5	179	182	PF00017	0.531
LIG_SH2_STAT5	283	286	PF00017	0.480
LIG_SH2_STAT5	367	370	PF00017	0.314
LIG_SH2_STAT5	423	426	PF00017	0.317
LIG_SH2_STAT5	560	563	PF00017	0.431
LIG_SH2_STAT5	591	594	PF00017	0.624
LIG_SH2_STAT5	733	736	PF00017	0.509
LIG_SH3_3	404	410	PF00018	0.388
LIG_SH3_3	565	571	PF00018	0.461
LIG_SH3_3	675	681	PF00018	0.669
LIG_SUMO_SIM_anti_2	593	600	PF11976	0.582
LIG_SUMO_SIM_anti_2	830	838	PF11976	0.493
LIG_SxIP_EBH_1	130	140	PF03271	0.502
LIG_TRAF2_1	529	532	PF00917	0.647
LIG_UBA3_1	1	7	PF00899	0.554
LIG_WRC_WIRS_1	527	532	PF05994	0.560
LIG_WW_1	119	122	PF00397	0.521
LIG_WW_3	757	761	PF00397	0.518
MOD_CDK_SPK_2	609	614	PF00069	0.553
MOD_CDK_SPxK_1	754	760	PF00069	0.599
MOD_CDK_SPxK_1	797	803	PF00069	0.505
MOD_CK1_1	115	121	PF00069	0.553
MOD_CK1_1	157	163	PF00069	0.594
MOD_CK1_1	171	177	PF00069	0.703
MOD_CK1_1	231	237	PF00069	0.538
MOD_CK1_1	277	283	PF00069	0.406
MOD_CK1_1	33	39	PF00069	0.503
MOD_CK1_1	386	392	PF00069	0.237
MOD_CK1_1	41	47	PF00069	0.453
MOD_CK1_1	584	590	PF00069	0.608
MOD_CK1_1	603	609	PF00069	0.676
MOD_CK1_1	634	640	PF00069	0.673
MOD_CK1_1	699	705	PF00069	0.693
MOD_CK1_1	716	722	PF00069	0.591
MOD_CK1_1	724	730	PF00069	0.489
MOD_CK1_1	8	14	PF00069	0.587
MOD_CK1_1	827	833	PF00069	0.623
MOD_CK2_1	434	440	PF00069	0.346
MOD_CK2_1	526	532	PF00069	0.556
MOD_CK2_1	843	849	PF00069	0.575
MOD_GlcNHglycan	114	117	PF01048	0.621
MOD_GlcNHglycan	131	134	PF01048	0.569
MOD_GlcNHglycan	136	139	PF01048	0.649
MOD_GlcNHglycan	160	163	PF01048	0.611
MOD_GlcNHglycan	165	168	PF01048	0.659
MOD_GlcNHglycan	220	223	PF01048	0.667
MOD_GlcNHglycan	269	272	PF01048	0.447
MOD_GlcNHglycan	338	341	PF01048	0.321
MOD_GlcNHglycan	35	38	PF01048	0.622
MOD_GlcNHglycan	39	43	PF01048	0.634
MOD_GlcNHglycan	551	554	PF01048	0.587
MOD_GlcNHglycan	572	575	PF01048	0.706
MOD_GlcNHglycan	586	589	PF01048	0.619
MOD_GlcNHglycan	65	68	PF01048	0.395
MOD_GlcNHglycan	652	655	PF01048	0.788
MOD_GlcNHglycan	694	697	PF01048	0.662
MOD_GlcNHglycan	738	741	PF01048	0.671
MOD_GlcNHglycan	845	848	PF01048	0.687
MOD_GlcNHglycan	884	887	PF01048	0.359
MOD_GlcNHglycan	92	95	PF01048	0.464
MOD_GSK3_1	1	8	PF00069	0.540
MOD_GSK3_1	12	19	PF00069	0.506
MOD_GSK3_1	134	141	PF00069	0.712
MOD_GSK3_1	151	158	PF00069	0.572
MOD_GSK3_1	168	175	PF00069	0.742
MOD_GSK3_1	283	290	PF00069	0.453
MOD_GSK3_1	33	40	PF00069	0.638
MOD_GSK3_1	41	48	PF00069	0.482
MOD_GSK3_1	515	522	PF00069	0.463
MOD_GSK3_1	526	533	PF00069	0.595
MOD_GSK3_1	545	552	PF00069	0.660
MOD_GSK3_1	603	610	PF00069	0.681
MOD_GSK3_1	623	630	PF00069	0.695
MOD_GSK3_1	632	639	PF00069	0.675
MOD_GSK3_1	641	648	PF00069	0.621
MOD_GSK3_1	657	664	PF00069	0.568
MOD_GSK3_1	692	699	PF00069	0.563
MOD_GSK3_1	702	709	PF00069	0.661
MOD_GSK3_1	712	719	PF00069	0.648
MOD_GSK3_1	824	831	PF00069	0.655
MOD_GSK3_1	86	93	PF00069	0.409
MOD_GSK3_1	878	885	PF00069	0.418
MOD_N-GLC_2	433	435	PF02516	0.346
MOD_NEK2_1	1	6	PF00069	0.497
MOD_NEK2_1	114	119	PF00069	0.530
MOD_NEK2_1	170	175	PF00069	0.625
MOD_NEK2_1	267	272	PF00069	0.393
MOD_NEK2_1	32	37	PF00069	0.517
MOD_NEK2_1	353	358	PF00069	0.325
MOD_NEK2_1	376	381	PF00069	0.262
MOD_NEK2_1	383	388	PF00069	0.212
MOD_NEK2_1	472	477	PF00069	0.345
MOD_NEK2_1	519	524	PF00069	0.547
MOD_NEK2_1	623	628	PF00069	0.657
MOD_NEK2_1	655	660	PF00069	0.672
MOD_NEK2_1	795	800	PF00069	0.520
MOD_NEK2_1	809	814	PF00069	0.622
MOD_NEK2_1	843	848	PF00069	0.600
MOD_NEK2_2	16	21	PF00069	0.349
MOD_NEK2_2	669	674	PF00069	0.560
MOD_OFUCOSY	144	149	PF10250	0.487
MOD_PIKK_1	287	293	PF00454	0.503
MOD_PIKK_1	546	552	PF00454	0.618
MOD_PIKK_1	634	640	PF00454	0.723
MOD_PIKK_1	716	722	PF00454	0.575
MOD_PK_1	878	884	PF00069	0.397
MOD_PK_1	899	905	PF00069	0.520
MOD_PKA_2	129	135	PF00069	0.737
MOD_PKA_2	336	342	PF00069	0.316
MOD_PKA_2	376	382	PF00069	0.391
MOD_PKA_2	712	718	PF00069	0.585
MOD_PKA_2	759	765	PF00069	0.585
MOD_PKB_1	556	564	PF00069	0.501
MOD_Plk_1	804	810	PF00069	0.662
MOD_Plk_1	827	833	PF00069	0.524
MOD_Plk_4	304	310	PF00069	0.514
MOD_Plk_4	348	354	PF00069	0.225
MOD_Plk_4	383	389	PF00069	0.303
MOD_Plk_4	484	490	PF00069	0.445
MOD_Plk_4	594	600	PF00069	0.681
MOD_Plk_4	618	624	PF00069	0.570
MOD_Plk_4	706	712	PF00069	0.673
MOD_Plk_4	729	735	PF00069	0.591
MOD_Plk_4	765	771	PF00069	0.564
MOD_Plk_4	804	810	PF00069	0.579
MOD_Plk_4	878	884	PF00069	0.397
MOD_Plk_4	899	905	PF00069	0.520
MOD_ProDKin_1	115	121	PF00069	0.741
MOD_ProDKin_1	12	18	PF00069	0.502
MOD_ProDKin_1	155	161	PF00069	0.557
MOD_ProDKin_1	274	280	PF00069	0.396
MOD_ProDKin_1	406	412	PF00069	0.312
MOD_ProDKin_1	591	597	PF00069	0.601
MOD_ProDKin_1	609	615	PF00069	0.614
MOD_ProDKin_1	627	633	PF00069	0.735
MOD_ProDKin_1	636	642	PF00069	0.657
MOD_ProDKin_1	689	695	PF00069	0.531
MOD_ProDKin_1	726	732	PF00069	0.672
MOD_ProDKin_1	754	760	PF00069	0.699
MOD_ProDKin_1	797	803	PF00069	0.769
MOD_ProDKin_1	835	841	PF00069	0.584
MOD_ProDKin_1	897	903	PF00069	0.468
MOD_SUMO_for_1	79	82	PF00179	0.292
TRG_DiLeu_BaEn_1	364	369	PF01217	0.312
TRG_DiLeu_BaEn_3	909	915	PF01217	0.404
TRG_DiLeu_BaLyEn_6	450	455	PF01217	0.312
TRG_ENDOCYTIC_2	367	370	PF00928	0.312
TRG_ENDOCYTIC_2	438	441	PF00928	0.352
TRG_ENDOCYTIC_2	54	57	PF00928	0.342
TRG_ER_diArg_1	243	246	PF00400	0.382
TRG_ER_diArg_1	295	297	PF00400	0.395
TRG_ER_diArg_1	390	393	PF00400	0.312
TRG_ER_diArg_1	452	454	PF00400	0.482
TRG_ER_diArg_1	466	469	PF00400	0.202
TRG_ER_diArg_1	555	558	PF00400	0.485
TRG_ER_diArg_1	855	857	PF00400	0.657
TRG_ER_diArg_1	872	875	PF00400	0.368
TRG_Pf-PMV_PEXEL_1	213	217	PF00026	0.667
TRG_Pf-PMV_PEXEL_1	296	300	PF00026	0.379
TRG_Pf-PMV_PEXEL_1	452	456	PF00026	0.336
TRG_Pf-PMV_PEXEL_1	748	752	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Q8	Leptomonas seymouri	47%	97%
A0A3Q8IFT8	Leishmania donovani	66%	98%
A4I0C9	Leishmania infantum	67%	98%
E9AW93	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	99%
Q4QB85	Leishmania major	66%	100%