Putative mitochondrial RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial RNA binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HCU6_LEIBR

TriTrypDb:

LbrM.23.0850 , LBRM2903_230017400

Length:

348

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HCU6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HCU6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0003677	DNA binding	4	3
GO:0003697	single-stranded DNA binding	5	3
GO:0005488	binding	1	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.363
CLV_C14_Caspase3-7	293	297	PF00656	0.328
CLV_NRD_NRD_1	104	106	PF00675	0.487
CLV_NRD_NRD_1	182	184	PF00675	0.505
CLV_NRD_NRD_1	212	214	PF00675	0.530
CLV_NRD_NRD_1	3	5	PF00675	0.621
CLV_NRD_NRD_1	310	312	PF00675	0.440
CLV_PCSK_KEX2_1	182	184	PF00082	0.584
CLV_PCSK_KEX2_1	212	214	PF00082	0.504
CLV_PCSK_KEX2_1	3	5	PF00082	0.621
CLV_PCSK_KEX2_1	309	311	PF00082	0.409
CLV_PCSK_PC1ET2_1	309	311	PF00082	0.385
CLV_PCSK_PC7_1	305	311	PF00082	0.219
DEG_APCC_DBOX_1	3	11	PF00400	0.711
DEG_APCC_KENBOX_2	137	141	PF00400	0.602
DEG_Nend_Nbox_1	1	3	PF02207	0.632
DOC_MAPK_gen_1	309	315	PF00069	0.357
DOC_PP1_RVXF_1	109	115	PF00149	0.504
DOC_PP1_RVXF_1	211	218	PF00149	0.350
DOC_PP2B_LxvP_1	88	91	PF13499	0.339
DOC_USP7_MATH_1	147	151	PF00917	0.472
DOC_USP7_MATH_1	273	277	PF00917	0.613
DOC_USP7_MATH_1	314	318	PF00917	0.315
DOC_USP7_MATH_1	97	101	PF00917	0.483
DOC_USP7_UBL2_3	155	159	PF12436	0.542
DOC_USP7_UBL2_3	280	284	PF12436	0.418
DOC_WW_Pin1_4	218	223	PF00397	0.347
DOC_WW_Pin1_4	318	323	PF00397	0.219
DOC_WW_Pin1_4	43	48	PF00397	0.350
DOC_WW_Pin1_4	86	91	PF00397	0.314
LIG_14-3-3_CanoR_1	122	126	PF00244	0.620
LIG_14-3-3_CanoR_1	3	8	PF00244	0.663
LIG_BRCT_BRCA1_1	200	204	PF00533	0.587
LIG_Clathr_ClatBox_1	327	331	PF01394	0.418
LIG_Clathr_ClatBox_1	81	85	PF01394	0.370
LIG_DLG_GKlike_1	3	10	PF00625	0.718
LIG_FHA_1	24	30	PF00498	0.531
LIG_FHA_1	264	270	PF00498	0.502
LIG_FHA_1	69	75	PF00498	0.316
LIG_FHA_2	19	25	PF00498	0.682
LIG_FHA_2	291	297	PF00498	0.431
LIG_LIR_Apic_2	298	303	PF02991	0.352
LIG_LIR_Gen_1	190	199	PF02991	0.417
LIG_LIR_Nem_3	190	195	PF02991	0.424
LIG_LIR_Nem_3	216	220	PF02991	0.458
LIG_Pex14_2	282	286	PF04695	0.591
LIG_REV1ctd_RIR_1	215	221	PF16727	0.445
LIG_SH2_STAT5	209	212	PF00017	0.406
LIG_SH3_3	259	265	PF00018	0.490
LIG_SUMO_SIM_par_1	24	31	PF11976	0.540
LIG_TRFH_1	218	222	PF08558	0.517
LIG_UBA3_1	191	200	PF00899	0.305
LIG_WRC_WIRS_1	264	269	PF05994	0.507
MOD_CK1_1	100	106	PF00069	0.462
MOD_CK1_1	124	130	PF00069	0.561
MOD_CK1_1	164	170	PF00069	0.516
MOD_CK1_1	178	184	PF00069	0.367
MOD_CK1_1	276	282	PF00069	0.605
MOD_CK1_1	316	322	PF00069	0.467
MOD_CK2_1	86	92	PF00069	0.314
MOD_GlcNHglycan	166	169	PF01048	0.492
MOD_GlcNHglycan	177	180	PF01048	0.360
MOD_GlcNHglycan	205	208	PF01048	0.431
MOD_GlcNHglycan	269	272	PF01048	0.523
MOD_GlcNHglycan	316	319	PF01048	0.390
MOD_GlcNHglycan	65	68	PF01048	0.219
MOD_GlcNHglycan	7	10	PF01048	0.691
MOD_GSK3_1	147	154	PF00069	0.451
MOD_GSK3_1	160	167	PF00069	0.400
MOD_GSK3_1	19	26	PF00069	0.681
MOD_GSK3_1	263	270	PF00069	0.557
MOD_GSK3_1	313	320	PF00069	0.452
MOD_GSK3_1	97	104	PF00069	0.467
MOD_NEK2_1	153	158	PF00069	0.503
MOD_NEK2_1	160	165	PF00069	0.384
MOD_NEK2_1	208	213	PF00069	0.406
MOD_NEK2_1	290	295	PF00069	0.403
MOD_NEK2_1	5	10	PF00069	0.584
MOD_PIKK_1	153	159	PF00454	0.536
MOD_PIKK_1	161	167	PF00454	0.382
MOD_PIKK_1	28	34	PF00454	0.352
MOD_PIKK_1	68	74	PF00454	0.352
MOD_PKA_1	3	9	PF00069	0.661
MOD_PKA_2	121	127	PF00069	0.592
MOD_PKA_2	147	153	PF00069	0.461
MOD_PKA_2	3	9	PF00069	0.655
MOD_PKA_2	304	310	PF00069	0.219
MOD_Plk_1	23	29	PF00069	0.636
MOD_Plk_4	147	153	PF00069	0.461
MOD_Plk_4	263	269	PF00069	0.497
MOD_ProDKin_1	218	224	PF00069	0.352
MOD_ProDKin_1	318	324	PF00069	0.219
MOD_ProDKin_1	43	49	PF00069	0.350
MOD_ProDKin_1	86	92	PF00069	0.314
MOD_SUMO_for_1	62	65	PF00179	0.450
TRG_ENDOCYTIC_2	325	328	PF00928	0.418
TRG_ER_diArg_1	182	184	PF00400	0.584
TRG_ER_diArg_1	2	4	PF00400	0.618

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8F7	Leptomonas seymouri	81%	100%
A0A0S4IYJ9	Bodo saltans	44%	100%
A0A1X0NXK3	Trypanosomatidae	69%	100%
A0A3Q8IB02	Leishmania donovani	93%	100%
A0A3R7MG63	Trypanosoma rangeli	70%	100%
A4I0C7	Leishmania infantum	93%	100%
C9ZV43	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
C9ZV45	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	78%
E9AW91	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QB87	Leishmania major	93%	100%
V5BBM3	Trypanosoma cruzi	70%	93%